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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045864
UUCD1 version UUC-HoS-01102
Ensembl Protein ID ENSP00000219473.7
UniProt Accession Q14694; B2RDJ8; B4DS84; Q9BWG7; Q9NSL7; UBP10_HUMAN
Genbank Protein ID BAA11507.1; BAG61546.1; BAG37945.1; CAB82392.2; CAD97644.1; AAH00263.1
Protein Name Ubiquitin carboxyl-terminal hydrolase 10; Deubiquitinating enzyme 10; Ubiquitin thioesterase 10; Ubiquitin-specific-processing protease 10
Genbank Nucleotide ID D80012; AK299618; AK315570; AL162049; BX537402; AC009116
Gene Name USP10; KIAA0190
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000103194.15 ENST00000219473.11 ENSP00000219473.7
ENSG00000103194.15 ENST00000563892.5 ENSP00000458089.1
ENSG00000103194.15 ENST00000540269.6 ENSP00000445589.2
ENSG00000103194.15 ENST00000562283.5 ENSP00000455712.1
ENSG00000103194.15 ENST00000563048.5 ENSP00000454902.1
ENSG00000103194.15 ENST00000570191.5 ENSP00000457411.1
ENSG00000103194.15 ENST00000563386.5 ENSP00000454943.1
ENSG00000103194.15 ENST00000569038.5 ENSP00000462762.1
ENSG00000103194.15 ENST00000570053.1 ENSP00000454751.1
ENSG00000103194.15 ENST00000569925.1 ENSP00000454987.1
ENSG00000103194.15 ENST00000567526.1 ENSP00000455865.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbcircBasecircRNADbCircNet
miRTarBasemicroRNATRANSFACTargetScan
RepTarmiRNAMapSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosSNPPhosphositePlus
dbPTMHPRDPhospho.ELMUniProt
PHOSIDABioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
DUB/USP USP 21245042; 20096447
Classification
Family E-value Score Start End
DUB/USP 2.90e-69 235.5 416 794
Active Site
Position(s) Description Evidence
424 Nucleophile
749 Proton acceptor ECO:0000255|PROSITE-ProRule:PRU10092,
ECO:0000255|PROSITE-ProRule:PRU10093}
Domain Profile

   DUB/USP
   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw......kskkk.............avsprell 74
           Gl N gN CY+N++LQ+L+++p++ +l++   +   +  +++ +++++++s+ +l++e++      k ++              a++p+ ++
   Q: 416  GLINKGNWCYINATLQALVACPPMYHLMKF-IPLYSK-VQRPCTSTPMIDSFVRLMNEFTnmpvppKPRQAlgdkivrdirpgaAFEPTYIY 505
           9***************************99.333333.334799***************7666654333337777888888888******** PP
   S: 75   kalkkeaeefs.gyeqqDaqEflaflldqleeelkk.................eknkpkeeeeeedkselsdeaeekkkkknk......... 139
           + l   ++++s + +q+Da+E+l f+l++l+ee+ +                  kn++++eee+e++ e s++++e+   +nk         
   Q: 506  RLLTVNKSSLSeKGRQEDAEEYLGFILNGLHEEMLNlkkllspsnekltisngPKNHSVNEEEQEEQGEGSEDEWEQVGPRNKtsvtrqadf 597
           ***99999866599********************5456689999999999999888888888888888888887777777777777777778 PP
   S: 140  ..slisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPev 229
             ++i+ +F+g+++ +++ ++  ++s + +pf++l+l++++++ +   ++qd+Les +++e+++g    y++k k+++e +++++l+klP+v
   Q: 598  vqTPITGIFGGHIR-SVVYQQSSKESATLQPFFTLQLDIQSDKIR---TVQDALESLVARESVQG----YTTKTKQEVEISRRVTLEKLPPV 681
           88***********9.688999999*******************99...****************8....99999****************** PP
   S: 230  LilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekqke...kkkYeLiavvvHsG.slssGHYvayvknekgk.WllfdDskVte 316
           L+lhLkRf ++++++++ k+ k++e+p  L++s+ + sp  k+k+   +++Y+L+avv+H+G s+ +GHY+++v +   + Wl++dD++V++
   Q: 682  LVLHLKRFVYEKTGGCQ-KLIKNIEYPVDLEISKELLSPGVKNKNfkcHRTYRLFAVVYHHGnSATGGHYTTDVFQIGLNgWLRIDDQTVKV 772
           **********9998886.****************999988777777879***************************87777*********** PP
   S: 317  vkeeevleetg.staYvlfYkr 337
           +++ +v++ t+ +taY+l+Y+r
   Q: 773  INQYQVVKPTAeRTAYLLYYRR 794
           ********9889********98 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, BECN1, SNX3 and CFTR. Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response. Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. In turn, PIK3C3/VPS34-containing complexes regulate USP10 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Does not deubiquitinate MDM2. Deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling. Involved in a TANK-dependent negative feedback response to attenuate NF-kappaB activation via deubiquitinating IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989).
 Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, BECN1, SNX3 and CFTR. Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response. Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. In turn, PIK3C3/VPS34-containing complexes regulate USP10 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Does not deubiquitinate MDM2. Deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling. Involved in a TANK-dependent negative feedback response to attenuate NF-kappaB activation via deubiquitinating IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989).
Protein Sequence
(Fasta)
MALHSPQYIF GDFSPDEFNQ FFVTPRSSVE LPPYSGTVLC GTQAVDKLPD GQEYQRIEFG 60
VDEVIEPSDT LPRTPSYSIS STLNPQAPEF ILGCTASKIT PDGITKEASY GSIDCQYPGS 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045864|DUB,USP|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCGCAGGCGC GGCGGCCGAT GCGAGTGTGT ATGTGCGGGC GAGAAGATGG CGGCGGCGGG 60
GGAAGCAGCG TGAGCAGCCG GAGGATCGCG GAGTCCCAAT GAAACGGGCA GCCATGGCCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045864|DUB,USP|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0072--Autophagy
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0227--DNA damage
KW-0234--DNA repair
KW-0967--Endosome
KW-0378--Hydrolase
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
Interpro

IPR009818--Ataxin-2_C
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
Pfam

PF07145--PAM2
PF00443--UCH
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005769--C:early endosome
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0043234--C:protein complex
GO:0004197--F:cysteine-type endopeptidase activity
GO:0044325--F:ion channel binding
GO:0002039--F:p53 binding
GO:0003723--F:RNA binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0006914--P:autophagy
GO:0006974--P:cellular response to DNA damage stimulus
GO:0071347--P:cellular response to interleukin-1
GO:0030330--P:DNA damage response, signal transduction by p53 class mediator
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0016579--P:protein deubiquitination
GO:0010506--P:regulation of autophagy
GO:0019985--P:translesion synthesis
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG hsa:9100
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000082 Aegilops tauschii 30.93 3.00e-45 176.00
IUUC-Aml-001584 Ailuropoda melanoleuca 88.51 0.00e+00 1333.00
IUUC-Atr-002927 Amborella trichopoda 35.22 6.00e-58 218.00
IUUC-Apl-003988 Anas platyrhynchos 78.87 0.00e+00 1152.00
IUUC-Aca-004461 Anolis carolinensis 89.22 3.00e-164 570.00
IUUC-Aly-006038 Arabidopsis lyrata 36.15 1.00e-54 207.00
IUUC-Ath-007328 Arabidopsis thaliana 35.90 2.00e-53 203.00
IUUC-Ago-007717 Ashbya gossypii 30.11 5.00e-43 169.00
IUUC-Acl-008188 Aspergillus clavatus 33.12 1.00e-62 234.00
IUUC-Afl-008456 Aspergillus flavus 38.08 2.00e-47 183.00
IUUC-Afu-009067 Aspergillus fumigatus 36.02 4.00e-65 243.00
IUUC-Ani-009483 Aspergillus nidulans 33.41 5.00e-62 233.00
IUUC-Ang-009639 Aspergillus niger 35.20 9.00e-60 225.00
IUUC-Aor-010040 Aspergillus oryzae 35.85 1.00e-59 225.00
IUUC-Ate-010310 Aspergillus terreus 31.79 2.00e-61 230.00
IUUC-Ame-011012 Astyanax mexicanus 73.96 2.00e-162 566.00
IUUC-Bgr-012311 Blumeria graminis 34.59 8.00e-43 169.00
IUUC-Bta-013299 Bos taurus 87.00 0.00e+00 1270.00
IUUC-Bci-013783 Botrytis cinerea 36.76 2.00e-58 220.00
IUUC-Bdi-015039 Brachypodium distachyon 32.06 1.00e-49 191.00
IUUC-Bol-015806 Brassica oleracea 37.50 1.00e-62 234.00
IUUC-Bra-017076 Brassica rapa 37.50 7.00e-63 234.00
IUUC-Cja-018715 Callithrix jacchus 95.83 0.00e+00 1480.00
IUUC-Cfa-020194 Canis familiaris 89.39 0.00e+00 1348.00
IUUC-Cpo-022272 Cavia porcellus 75.16 0.00e+00 1059.00
IUUC-Cre-022713 Chlamydomonas reinhardtii 34.11 3.00e-34 140.00
IUUC-Csa-023310 Chlorocebus sabaeus 97.98 0.00e+00 1507.00
IUUC-Cho-024966 Choloepus hoffmanni 78.73 0.00e+00 961.00
IUUC-Cin-025616 Ciona intestinalis 43.72 3.00e-105 376.00
IUUC-Csv-026043 Ciona savignyi 46.57 3.00e-98 352.00
IUUC-Cgl-026421 Colletotrichum gloeosporioides 33.87 3.00e-46 180.00
IUUC-Cne-026962 Cryptococcus neoformans 34.97 5.00e-50 193.00
IUUC-Cme-027113 Cyanidioschyzon merolae 30.45 2.00e-37 150.00
IUUC-Dre-028072 Danio rerio 78.49 0.00e+00 717.00
IUUC-Dno-029489 Dasypus novemcinctus 88.65 0.00e+00 1368.00
IUUC-Dor-031068 Dipodomys ordii 73.92 3.00e-138 485.00
IUUC-Dse-031553 Dothistroma septosporum 36.18 4.00e-56 213.00
IUUC-Dme-031759 Drosophila melanogaster 40.72 9.00e-83 302.00
IUUC-Ete-032549 Echinops telfairi 77.78 0.00e+00 883.00
IUUC-Eca-033380 Equus caballus 87.52 0.00e+00 1352.00
IUUC-Eeu-034818 Erinaceus europaeus 84.11 0.00e+00 1258.00
IUUC-Fca-035535 Felis catus 86.76 0.00e+00 1204.00
IUUC-Fal-036627 Ficedula albicollis 76.20 0.00e+00 1099.00
IUUC-Fox-037904 Fusarium oxysporum 36.49 1.00e-52 201.00
IUUC-Fso-038170 Fusarium solani 33.71 4.00e-52 200.00
IUUC-Gmo-039499 Gadus morhua 70.59 0.00e+00 667.00
IUUC-Ggr-040042 Gaeumannomyces graminis 35.64 2.00e-61 231.00
IUUC-Gga-040571 Gallus gallus 78.38 0.00e+00 1144.00
IUUC-Gac-041345 Gasterosteus aculeatus 76.51 0.00e+00 662.00
IUUC-Gma-044407 Glycine max 35.04 3.00e-58 219.00
IUUC-Ggo-044652 Gorilla gorilla 99.75 0.00e+00 1572.00
IUUC-Hvu-047071 Hordeum vulgare 32.75 2.00e-52 200.00
IUUC-Itr-048216 Ictidomys tridecemlineatus 90.05 0.00e+00 1014.00
IUUC-Kpa-049132 Komagataella pastoris 30.04 3.00e-45 176.00
IUUC-Lch-050040 Latimeria chalumnae 69.07 0.00e+00 922.00
IUUC-Loc-052449 Lepisosteus oculatus 74.85 0.00e+00 715.00
IUUC-Lma-053248 Leptosphaeria maculans 35.81 4.00e-57 216.00
IUUC-Laf-054121 Loxodonta africana 88.27 0.00e+00 1328.00
IUUC-Mcc-055514 Macaca mulatta 98.23 0.00e+00 1510.00
IUUC-Meu-056873 Macropus eugenii 72.37 0.00e+00 821.00
IUUC-Mor-057243 Magnaporthe oryzae 33.93 2.00e-58 221.00
IUUC-Mpo-057439 Magnaporthe poae 35.90 7.00e-61 229.00
IUUC-Mtr-058457 Medicago truncatula 33.33 1.00e-56 214.00
IUUC-Mla-058929 Melampsora laricipopulina 31.58 2.00e-56 214.00
IUUC-Mga-060157 Meleagris gallopavo 76.79 0.00e+00 1140.00
IUUC-Mvi-060442 Microbotryum violaceum 33.46 7.00e-56 213.00
IUUC-Mmr-061062 Microcebus murinus 92.26 0.00e+00 1456.00
IUUC-Mdo-062798 Monodelphis domestica 80.48 0.00e+00 1209.00
IUUC-Mmu-064050 Mus musculus 83.23 0.00e+00 1282.00
IUUC-Mac-065619 Musa acuminata 34.27 2.00e-53 203.00
IUUC-Mpu-066554 Mustela putorius furo 88.02 0.00e+00 1305.00
IUUC-Mlu-068003 Myotis lucifugus 86.59 0.00e+00 1320.00
IUUC-Nfi-068612 Neosartorya fischeri 34.46 3.00e-63 236.00
IUUC-Ncr-068878 Neurospora crassa 35.14 2.00e-52 201.00
IUUC-Nle-069661 Nomascus leucogenys 99.12 0.00e+00 1536.00
IUUC-Opr-070944 Ochotona princeps 76.27 2.00e-169 589.00
IUUC-Ont-071266 Oreochromis niloticus 58.40 0.00e+00 805.00
IUUC-Oan-073442 Ornithorhynchus anatinus 79.20 0.00e+00 1134.00
IUUC-Ocu-073788 Oryctolagus cuniculus 80.91 0.00e+00 1134.00
IUUC-Oba-075085 Oryza barthii 33.45 1.00e-37 150.00
IUUC-Obr-076663 Oryza brachyantha 32.91 4.00e-46 179.00
IUUC-Ogl-076937 Oryza glaberrima 29.85 5.00e-48 185.00
IUUC-Ogu-078909 Oryza glumaepatula 30.63 3.00e-46 180.00
IUUC-Oin-079617 Oryza indica 30.93 1.00e-47 184.00
IUUC-Olo-081043 Oryza longistaminata 26.04 8.00e-25 108.00
IUUC-Ome-081646 Oryza meridionalis 24.74 1.00e-23 104.00
IUUC-Oni-082914 Oryza nivara 29.57 3.00e-46 179.00
IUUC-Oru-084878 Oryza rufipogon 29.57 4.00e-46 179.00
IUUC-Osa-085822 Oryza sativa 30.93 5.00e-50 192.00
IUUC-Ola-086931 Oryzias latipes 70.35 0.00e+00 667.00
IUUC-Oga-088443 Otolemur garnettii 92.30 0.00e+00 1440.00
IUUC-Oar-089325 Ovis aries 84.49 0.00e+00 1184.00
IUUC-Ptr-091584 Pan troglodytes 96.62 0.00e+00 1475.00
IUUC-Pan-092551 Papio anubis 96.12 0.00e+00 1483.00
IUUC-Psi-093366 Pelodiscus sinensis 74.62 0.00e+00 695.00
IUUC-Pno-095136 Phaeosphaeria nodorum 35.23 8.00e-52 199.00
IUUC-Ppa-095574 Physcomitrella patens 36.22 3.00e-59 223.00
IUUC-Pfo-097462 Poecilia formosa 77.25 0.00e+00 695.00
IUUC-Pab-098547 Pongo abelii 99.25 0.00e+00 1536.00
IUUC-Pop-099529 Populus trichocarpa 36.29 5.00e-61 228.00
IUUC-Pca-101066 Procavia capensis 78.97 0.00e+00 1177.00
IUUC-Ppe-102110 Prunus persica 35.88 7.00e-59 221.00
IUUC-Pva-103015 Pteropus vampyrus 83.23 0.00e+00 1254.00
IUUC-Ptt-103998 Puccinia triticina 32.59 6.00e-53 202.00
IUUC-Pte-104417 Pyrenophora teres 33.92 1.00e-54 208.00
IUUC-Pyt-104820 Pyrenophora triticirepentis 35.20 7.00e-55 209.00
IUUC-Rno-105533 Rattus norvegicus 84.12 0.00e+00 1280.00
IUUC-Sce-106160 Saccharomyces cerevisiae 27.84 1.00e-36 148.00
IUUC-Sha-106590 Sarcophilus harrisii 80.85 0.00e+00 1208.00
IUUC-Sja-107669 Schizosaccharomyces japonicus 35.61 4.00e-57 215.00
IUUC-Spo-108353 Schizosaccharomyces pombe 36.75 5.00e-64 238.00
IUUC-Ssl-108599 Sclerotinia sclerotiorum 36.22 8.00e-58 218.00
IUUC-Smo-108842 Selaginella moellendorffii 35.84 4.00e-37 147.00
IUUC-Sit-110781 Setaria italica 31.75 1.00e-55 211.00
IUUC-Sly-111797 Solanum lycopersicum 33.76 8.00e-55 207.00
IUUC-Stu-112188 Solanum tuberosum 34.77 2.00e-55 210.00
IUUC-Sbi-114862 Sorghum bicolor 33.06 1.00e-45 177.00
IUUC-Sre-115162 Sporisorium reilianum 34.79 3.00e-66 247.00
IUUC-Ssc-115505 Sus scrofa 95.79 1.00e-165 575.00
IUUC-Tgu-116535 Taeniopygia guttata 76.17 0.00e+00 1104.00
IUUC-Tru-117542 Takifugu rubripes 57.41 0.00e+00 811.00
IUUC-Tni-120200 Tetraodon nigroviridis 58.00 0.00e+00 805.00
IUUC-Tca-121548 Theobroma cacao 34.60 2.00e-43 170.00
IUUC-Tre-122124 Trichoderma reesei 33.67 2.00e-61 231.00
IUUC-Tvi-122457 Trichoderma virens 34.85 6.00e-54 206.00
IUUC-Tae-125646 Triticum aestivum 34.18 2.00e-55 210.00
IUUC-Tme-127180 Tuber melanosporum 39.35 3.00e-69 256.00
IUUC-Tbe-127530 Tupaia belangeri 75.35 0.00e+00 1053.00
IUUC-Ttr-128549 Tursiops truncatus 80.08 0.00e+00 1189.00
IUUC-Uma-129381 Ustilago maydis 33.41 1.00e-64 241.00
IUUC-Vda-129889 Verticillium dahliae 32.11 2.00e-52 201.00
IUUC-Vpa-130100 Vicugna pacos 81.61 0.00e+00 1209.00
IUUC-Vvi-131366 Vitis vinifera 35.11 2.00e-62 233.00
IUUC-Xtr-132048 Xenopus tropicalis 63.37 0.00e+00 903.00
IUUC-Xma-133593 Xiphophorus maculatus 77.73 0.00e+00 692.00
IUUC-Yli-134338 Yarrowia lipolytica 30.92 5.00e-33 136.00
IUUC-Zma-135586 Zea mays 31.21 2.00e-48 186.00
Created Date 25-Jun-2017

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