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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Sce-106305
UUCD1 version UUC-SaC-00050
Ensembl Protein ID YMR247C
UniProt Accession Q04781; D6W074; Q04029; LTN1_YEAST
Genbank Protein ID CAA88574.1; CAA88657.1; DAA10148.1
Protein Name E3 ubiquitin-protein ligase listerin; RING domain mutant killed by rtf1 deletion protein 1; RING-type E3 ubiquitin transferase listerin
Genbank Nucleotide ID Z48639; Z48756; BK006946
Gene Name RKR1; LTN1; YMR247C; YM9408.09C; YM9920.01C
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
YMR247C YMR247C YMR247C
Annotation
mRNA Expression
GEOFFGED
Protein-protein Interaction
IIDiRefIndexHINTMentha
Post-translational Modifications (PTMs)
CPLMdbPAFBioGRID
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 20835226; 17283062
Classification
Family E-value Score Start End
E3 activity/RING/RING 0.00012 21.0 1508 1555
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledf...kdgplvlp......CgHvfhadClqkwpglknssskefrCPlCr 46
           CaiC++ +   +   + lp      C+  fh  Cl+kw      ss++ +CPlCr
   Q: 1508 CAICYSILhavD---RKLPsktcptCKNKFHGACLYKW----FRSSGNNTCPLCR 1555
           ******995551...3444444457*************....99**********8 PP
   
Organism Saccharomyces cerevisiae
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation (PubMed:23178123). Mediates ubiquitination of proteins derived from mRNAs lacking stop codons (non-stop proteins) and other translation arrest products induced by poly-lysine sequences and tandem rare codons. Ubiquitination leads to CDC48 recruitment for extraction and degradation of the incomplete translation product (PubMed:20835226, PubMed:23825054, PubMed:24261871). May indirectly play a role in chromatin function and transcription (PubMed:17283062).
 E3 ubiquitin-protein ligase component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation (PubMed:23178123). Mediates ubiquitination of proteins derived from mRNAs lacking stop codons (non-stop proteins) and other translation arrest products induced by poly-lysine sequences and tandem rare codons. Ubiquitination leads to CDC48 recruitment for extraction and degradation of the incomplete translation product (PubMed:20835226, PubMed:23825054, PubMed:24261871). May indirectly play a role in chromatin function and transcription (PubMed:17283062).
Protein Sequence
(Fasta)
MSFGGINTFQ QYNTDLGLGH NGVRISLNYF DGLPDPSLLN SLYSNELKLI FKSLLKRDET 60
TKEKALMDLS NLISDFNQNE YFFNDIFLLC WSQIYAKLII SDYKVIRLQS HQITIMLVKS 120
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Protein Fasta Sequence


>IUUC-Sce-106305|E3,RING|Saccharomyces cerevisiae
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Nucleotide Sequence
(Fasta)
ATGTCGTTTG GTGGAATCAA TACATTTCAA CAGTATAACA CAGATTTAGG GCTCGGCCAT 60
AATGGTGTTA GAATATCCTT AAACTACTTT GATGGTTTGC CGGATCCAAG TCTTTTAAAC 120
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Nucleotide Fasta Sequence


>IUUC-Sce-106305|E3,RING|Saccharomyces cerevisiae
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Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR001841--Znf_RING
IPR011016--Znf_RING-CH
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50089--ZF_RING_2
Pfam

PF13639--zf-RING_2
SMART

SM00744--RINGv
Gene Ontology

GO:0000781--C:chromosome, telomeric region
GO:0005634--C:nucleus
GO:1990112--C:RQC complex
GO:0043023--F:ribosomal large subunit binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006325--P:chromatin organization
GO:0006348--P:chromatin silencing at telomere
GO:0010498--P:proteasomal protein catabolic process
GO:0030163--P:protein catabolic process
GO:0016567--P:protein ubiquitination
GO:0072344--P:rescue of stalled ribosome
GO:1990116--P:ribosome-associated ubiquitin-dependent protein catabolic process
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG sce:YMR247C
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000717 Aegilops tauschii 33.91 2.00e-41 163.00
IUUC-Aml-002311 Ailuropoda melanoleuca 31.89 7.00e-46 178.00
IUUC-Atr-002905 Amborella trichopoda 34.88 6.00e-40 158.00
IUUC-Apl-003323 Anas platyrhynchos 37.56 6.00e-40 158.00
IUUC-Aca-004616 Anolis carolinensis 38.27 3.00e-43 169.00
IUUC-Aly-006145 Arabidopsis lyrata 36.36 8.00e-40 157.00
IUUC-Ath-006844 Arabidopsis thaliana 37.97 2.00e-41 163.00
IUUC-Ago-007750 Ashbya gossypii 37.94 0.00e+00 983.00
IUUC-Acl-008369 Aspergillus clavatus 30.95 3.00e-48 185.00
IUUC-Afl-008540 Aspergillus flavus 34.25 5.00e-48 185.00
IUUC-Afu-009089 Aspergillus fumigatus 29.21 4.00e-50 192.00
IUUC-Ani-009292 Aspergillus nidulans 31.79 8.00e-50 191.00
IUUC-Ang-009715 Aspergillus niger 29.46 2.00e-38 153.00
IUUC-Aor-009887 Aspergillus oryzae 34.25 4.00e-48 185.00
IUUC-Ate-010308 Aspergillus terreus 31.62 8.00e-36 144.00
IUUC-Ame-011345 Astyanax mexicanus 37.85 8.00e-46 177.00
IUUC-Bgr-012196 Blumeria graminis 30.94 3.00e-23 102.00
IUUC-Bta-012535 Bos taurus 31.56 1.00e-42 167.00
IUUC-Bci-013630 Botrytis cinerea 30.32 1.00e-46 180.00
IUUC-Bdi-014142 Brachypodium distachyon 32.62 5.00e-40 158.00
IUUC-Bol-015595 Brassica oleracea 37.43 3.00e-41 162.00
IUUC-Bra-018018 Brassica rapa 38.55 1.00e-09 54.70
IUUC-Cel-018254 Caenorhabditis elegans 31.36 7.00e-29 121.00
IUUC-Cja-019469 Callithrix jacchus 31.86 3.00e-46 179.00
IUUC-Cfa-020640 Canis familiaris 31.79 7.00e-45 174.00
IUUC-Cpo-021322 Cavia porcellus 31.68 2.00e-45 176.00
IUUC-Cre-022677 Chlamydomonas reinhardtii 40.16 1.00e-27 116.00
IUUC-Csa-024234 Chlorocebus sabaeus 31.86 2.00e-46 179.00
IUUC-Cho-024709 Choloepus hoffmanni 31.74 2.00e-44 172.00
IUUC-Cin-025371 Ciona intestinalis 41.38 9.00e-07 45.10
IUUC-Csv-026100 Ciona savignyi 34.39 3.00e-37 149.00
IUUC-Cgl-026598 Colletotrichum gloeosporioides 55.84 5.00e-25 103.00
IUUC-Cne-026789 Cryptococcus neoformans 32.48 4.00e-45 175.00
IUUC-Cme-027135 Cyanidioschyzon merolae 52.73 7.00e-15 75.50
IUUC-Dre-027405 Danio rerio 32.88 8.00e-46 177.00
IUUC-Dno-029874 Dasypus novemcinctus 26.82 2.00e-27 116.00
IUUC-Dor-030589 Dipodomys ordii 31.19 1.00e-43 170.00
IUUC-Dse-031427 Dothistroma septosporum 32.54 1.00e-55 210.00
IUUC-Dme-031827 Drosophila melanogaster 30.69 5.00e-25 108.00
IUUC-Ete-032459 Echinops telfairi 31.40 2.00e-45 176.00
IUUC-Eca-033218 Equus caballus 31.89 7.00e-46 177.00
IUUC-Eeu-035299 Erinaceus europaeus 17.19 9.00e-04 38.50
IUUC-Fca-036081 Felis catus 31.86 2.00e-46 180.00
IUUC-Fal-037561 Ficedula albicollis 31.58 1.00e-42 167.00
IUUC-Fox-037930 Fusarium oxysporum 32.00 2.00e-53 203.00
IUUC-Fso-038413 Fusarium solani 27.16 4.00e-53 202.00
IUUC-Gmo-039359 Gadus morhua 37.69 7.00e-46 177.00
IUUC-Ggr-039744 Gaeumannomyces graminis 31.88 7.00e-47 181.00
IUUC-Gga-041175 Gallus gallus 37.56 2.00e-40 159.00
IUUC-Gac-041943 Gasterosteus aculeatus 31.63 2.00e-45 176.00
IUUC-Gma-043888 Glycine max 37.17 7.00e-40 158.00
IUUC-Ggo-044912 Gorilla gorilla 22.58 3.00e-11 62.40
IUUC-Hsa-047016 Homo sapiens 31.86 2.00e-46 179.00
IUUC-Hvu-047059 Hordeum vulgare 33.48 7.00e-41 161.00
IUUC-Itr-048789 Ictidomys tridecemlineatus 32.08 4.00e-46 177.00
IUUC-Kpa-049133 Komagataella pastoris 30.46 3.00e-72 265.00
IUUC-Lch-049879 Latimeria chalumnae 31.16 2.00e-25 110.00
IUUC-Lpe-051455 Leersia perrieri 37.17 2.00e-40 160.00
IUUC-Loc-052799 Lepisosteus oculatus 31.97 2.00e-47 182.00
IUUC-Lma-052972 Leptosphaeria maculans 35.79 1.00e-53 204.00
IUUC-Laf-053479 Loxodonta africana 32.33 4.00e-46 179.00
IUUC-Mcc-055120 Macaca mulatta 31.86 2.00e-46 180.00
IUUC-Meu-055932 Macropus eugenii 31.53 6.00e-45 175.00
IUUC-Mor-057209 Magnaporthe oryzae 34.18 8.00e-49 187.00
IUUC-Mpo-057581 Magnaporthe poae 30.79 2.00e-41 163.00
IUUC-Mtr-058499 Medicago truncatula 37.70 8.00e-41 161.00
IUUC-Mla-059169 Melampsora laricipopulina 50.38 8.00e-45 170.00
IUUC-Mga-059800 Meleagris gallopavo 37.56 3.00e-40 159.00
IUUC-Mvi-060350 Microbotryum violaceum 26.55 8.00e-56 211.00
IUUC-Mmr-061548 Microcebus murinus 32.34 4.00e-46 179.00
IUUC-Mdo-062405 Monodelphis domestica 32.08 9.00e-46 177.00
IUUC-Mmu-064389 Mus musculus 31.53 1.00e-46 180.00
IUUC-Mac-064596 Musa acuminata 28.53 4.00e-39 155.00
IUUC-Mpu-065687 Mustela putorius furo 32.00 5.00e-46 178.00
IUUC-Mlu-067591 Myotis lucifugus 30.92 8.00e-44 171.00
IUUC-Nfi-068298 Neosartorya fischeri 29.34 3.00e-49 189.00
IUUC-Ncr-068876 Neurospora crassa 32.66 5.00e-50 191.00
IUUC-Nle-069799 Nomascus leucogenys 31.86 1.00e-46 180.00
IUUC-Opr-071155 Ochotona princeps 31.65 3.00e-46 179.00
IUUC-Ont-071290 Oreochromis niloticus 32.65 2.00e-51 196.00
IUUC-Oan-073161 Ornithorhynchus anatinus 34.94 9.00e-06 42.40
IUUC-Ocu-074947 Oryctolagus cuniculus 32.01 5.00e-46 178.00
IUUC-Oba-075986 Oryza barthii 37.70 9.00e-41 160.00
IUUC-Obr-076304 Oryza brachyantha 37.70 6.00e-41 161.00
IUUC-Ogl-077600 Oryza glaberrima 37.70 1.00e-40 160.00
IUUC-Ogu-078079 Oryza glumaepatula 37.70 9.00e-41 161.00
IUUC-Oin-079935 Oryza indica 37.70 1.00e-40 160.00
IUUC-Olo-080897 Oryza longistaminata 37.70 1.00e-40 160.00
IUUC-Ome-081777 Oryza meridionalis 37.70 9.00e-41 161.00
IUUC-Oni-082298 Oryza nivara 37.70 8.00e-41 161.00
IUUC-Opu-083156 Oryza punctata 31.75 5.00e-41 162.00
IUUC-Oru-085243 Oryza rufipogon 37.70 9.00e-41 160.00
IUUC-Osa-086219 Oryza sativa 37.70 1.00e-40 160.00
IUUC-Ola-087202 Oryzias latipes 31.97 1.00e-47 183.00
IUUC-Olu-087800 Ostreococcus lucimarinus 36.41 7.00e-37 148.00
IUUC-Oga-088962 Otolemur garnettii 31.86 9.00e-47 181.00
IUUC-Oar-089858 Ovis aries 31.23 4.00e-46 179.00
IUUC-Ptr-090958 Pan troglodytes 31.86 2.00e-46 179.00
IUUC-Pan-092712 Papio anubis 31.86 3.00e-46 179.00
IUUC-Psi-093557 Pelodiscus sinensis 31.05 4.00e-47 182.00
IUUC-Pma-094199 Petromyzon marinus 29.45 1.00e-16 77.00
IUUC-Pno-094947 Phaeosphaeria nodorum 32.93 3.00e-53 202.00
IUUC-Ppa-095258 Physcomitrella patens 39.21 4.00e-44 172.00
IUUC-Pfo-097035 Poecilia formosa 39.20 6.00e-47 181.00
IUUC-Pab-097897 Pongo abelii 31.86 2.00e-46 179.00
IUUC-Pop-099487 Populus trichocarpa 37.70 5.00e-41 162.00
IUUC-Pca-100688 Procavia capensis 44.85 4.00e-34 139.00
IUUC-Ppe-101821 Prunus persica 39.27 2.00e-40 160.00
IUUC-Pva-102632 Pteropus vampyrus 31.74 2.00e-45 176.00
IUUC-Pgr-103311 Puccinia graminis 28.42 1.00e-58 220.00
IUUC-Ptt-103825 Puccinia triticina 31.15 7.00e-47 181.00
IUUC-Pte-104036 Pyrenophora teres 34.85 1.00e-54 207.00
IUUC-Pyt-104460 Pyrenophora triticirepentis 34.55 2.00e-54 206.00
IUUC-Rno-104852 Rattus norvegicus 32.20 5.00e-47 182.00
IUUC-Sha-107023 Sarcophilus harrisii 36.54 7.00e-06 43.10
IUUC-Sja-107896 Schizosaccharomyces japonicus 35.78 1.00e-59 223.00
IUUC-Spo-108267 Schizosaccharomyces pombe 30.64 4.00e-58 218.00
IUUC-Ssl-108449 Sclerotinia sclerotiorum 40.32 5.00e-06 42.70
IUUC-Smo-109180 Selaginella moellendorffii 26.67 1.00e-37 150.00
IUUC-Sit-110615 Setaria italica 31.89 9.00e-41 161.00
IUUC-Sly-111861 Solanum lycopersicum 38.22 5.00e-41 162.00
IUUC-Stu-112373 Solanum tuberosum 38.22 5.00e-41 161.00
IUUC-Sar-113666 Sorex araneus 32.20 9.00e-46 177.00
IUUC-Sbi-114597 Sorghum bicolor 33.19 2.00e-40 160.00
IUUC-Sre-114965 Sporisorium reilianum 32.92 1.00e-59 224.00
IUUC-Ssc-115866 Sus scrofa 32.23 2.00e-46 179.00
IUUC-Tgu-117521 Taeniopygia guttata 31.25 2.00e-42 166.00
IUUC-Tru-117803 Takifugu rubripes 38.76 4.00e-47 182.00
IUUC-Tsy-119135 Tarsius syrichta 30.98 2.00e-41 163.00
IUUC-Tni-119807 Tetraodon nigroviridis 32.88 6.00e-45 175.00
IUUC-Tca-121036 Theobroma cacao 37.82 1.00e-40 160.00
IUUC-Tre-121942 Trichoderma reesei 31.67 1.00e-48 187.00
IUUC-Tvi-122453 Trichoderma virens 32.67 5.00e-46 178.00
IUUC-Tae-123061 Triticum aestivum 33.91 1.00e-41 164.00
IUUC-Tur-126021 Triticum urartu 33.48 7.00e-41 161.00
IUUC-Tme-126889 Tuber melanosporum 27.11 1.00e-56 213.00
IUUC-Tbe-127297 Tupaia belangeri 32.54 5.00e-25 108.00
IUUC-Ttr-128745 Tursiops truncatus 31.56 2.00e-46 179.00
IUUC-Uma-129552 Ustilago maydis 27.53 1.00e-59 224.00
IUUC-Vda-129838 Verticillium dahliae 26.26 1.00e-52 200.00
IUUC-Vpa-130567 Vicugna pacos 32.00 4.00e-46 179.00
IUUC-Vvi-131418 Vitis vinifera 37.70 1.00e-41 164.00
IUUC-Xtr-132926 Xenopus tropicalis 29.85 2.00e-43 169.00
IUUC-Xma-134278 Xiphophorus maculatus 39.20 7.00e-47 181.00
IUUC-Yli-134476 Yarrowia lipolytica 28.20 2.00e-69 256.00
IUUC-Zma-135611 Zea mays 33.19 3.00e-40 159.00
Created Date 25-Jun-2017

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