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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Spo-108066
UUCD1 version UUC-ScP-00002
Ensembl Protein ID SPBC947.10.1:pep
UniProt Accession O43085; DSC1_SCHPO
Genbank Protein ID CAA17038.2
Protein Name DSC E3 ubiquitin ligase complex subunit 1; Defective for SREBP cleavage protein 1; RING-type E3 ubiquitin transferase DSC1
Genbank Nucleotide ID CU329671
Gene Name dsc1; SPBC947.10
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
SPBC947.10 SPBC947.10.1 SPBC947.10.1:pep
Annotation
mRNA Expression
GEO
Protein-protein Interaction
iRefIndexHINTMentha
Protein Expression/Proteomics
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 23760507
Classification
Family E-value Score Start End
E3 activity/RING/RING 8.90e-10 37.1 634 689
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledf................kdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iC++++                ++ ++++pC H++h++Cl +w        ++ +CP+Cr
   Q: 634  CPICMQPIelvstgstlnpasmmvRRNYMLTPCHHLYHRQCLLQW------METRSICPVCR 689
           ********9999999988888888555999***************......**********8 PP
   
Organism Schizosaccharomyces pombe
Functional Description
(View)

Functional Description


     Catalytic component of the DSC E3 ubiquitin ligase complex which is required for the sre1 transcriptional activator proteolytic cleavage to release the soluble transcription factor from the membrane in low oxygen or sterol conditions. The complex plays also an important role in the multivesicular body (MVB) pathway and functions in a post-endoplasmic reticulum pathway for protein degradation.
 Catalytic component of the DSC E3 ubiquitin ligase complex which is required for the sre1 transcriptional activator proteolytic cleavage to release the soluble transcription factor from the membrane in low oxygen or sterol conditions. The complex plays also an important role in the multivesicular body (MVB) pathway and functions in a post-endoplasmic reticulum pathway for protein degradation.
Protein Sequence
(Fasta)
MDRRRWVPST PVVTLLLLFM LFAPAPRLPS RNGESSEKSI KAEKRAFSEI KNATFLNIPE 60
RVEHSLTFPT EIWETRDGLF EEPVGKGDSH LNHTSVMTGN WNILPYPSFG KVSPNVTWHT 120
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Protein Fasta Sequence


>IUUC-Spo-108066|E3,RING|Schizosaccharomyces pombe
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Nucleotide Sequence
(Fasta)
TTTAAATTCG TTAAATAATT TAAGCTCTTA AGTTTGTAGA TCCCTATACA AAAGCGAGAC 60
TCAATAACCA ACTAGGGCAA ATTCAATTCA CCAAGAACCT TAAACACTGT GATCATTGAG 120
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Nucleotide Fasta Sequence


>IUUC-Spo-108066|E3,RING|Schizosaccharomyces pombe
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Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0333--Golgi apparatus
KW-0472--Membrane
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0732--Signal
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR024766--Znf_RING_H2
PROSITE

PS50089--ZF_RING_2
Pfam

PF12678--zf-rbx1
SMART

SM00184--RING
Gene Ontology

GO:0005783--C:endoplasmic reticulum
GO:0005789--C:endoplasmic reticulum membrane
GO:0005794--C:Golgi apparatus
GO:0000139--C:Golgi membrane
GO:0016021--C:integral component of membrane
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:1900039--P:positive regulation of cellular response to hypoxia
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0034067--P:protein localization to Golgi apparatus
GO:0000209--P:protein polyubiquitination
GO:0016485--P:protein processing
GO:0016567--P:protein ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0035103--P:sterol regulatory element binding protein cleavage
GO:0043162--P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
KEGG spo:SPBC947.10
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000147 Aegilops tauschii 33.52 2.00e-24 104.00
IUUC-Atr-003038 Amborella trichopoda 33.70 7.00e-23 99.80
IUUC-Aly-006241 Arabidopsis lyrata 25.71 1.00e-29 122.00
IUUC-Ath-007133 Arabidopsis thaliana 25.71 3.00e-31 127.00
IUUC-Ago-007897 Ashbya gossypii 27.35 1.00e-35 142.00
IUUC-Acl-008354 Aspergillus clavatus 27.75 1.00e-51 196.00
IUUC-Afl-008715 Aspergillus flavus 27.81 2.00e-49 188.00
IUUC-Afu-008993 Aspergillus fumigatus 28.89 6.00e-52 197.00
IUUC-Ani-009159 Aspergillus nidulans 28.31 4.00e-50 191.00
IUUC-Ang-009736 Aspergillus niger 27.77 1.00e-48 186.00
IUUC-Aor-010205 Aspergillus oryzae 27.64 3.00e-49 187.00
IUUC-Ate-010380 Aspergillus terreus 29.07 1.00e-50 192.00
IUUC-Bgr-012261 Blumeria graminis 29.66 6.00e-25 107.00
IUUC-Bci-013822 Botrytis cinerea 33.04 3.00e-29 122.00
IUUC-Bdi-014178 Brachypodium distachyon 32.04 4.00e-25 107.00
IUUC-Bol-016426 Brassica oleracea 25.94 2.00e-30 125.00
IUUC-Bra-017095 Brassica rapa 25.64 5.00e-31 127.00
IUUC-Cre-022642 Chlamydomonas reinhardtii 28.07 4.00e-11 59.70
IUUC-Cin-025407 Ciona intestinalis 27.06 3.00e-09 52.40
IUUC-Csv-026249 Ciona savignyi 28.24 6.00e-09 51.20
IUUC-Cgl-026705 Colletotrichum gloeosporioides 33.74 3.00e-30 124.00
IUUC-Cne-027078 Cryptococcus neoformans 31.82 4.00e-23 101.00
IUUC-Cme-027308 Cyanidioschyzon merolae 25.31 1.00e-28 119.00
IUUC-Dse-031227 Dothistroma septosporum 32.63 8.00e-32 130.00
IUUC-Fox-037716 Fusarium oxysporum 29.13 6.00e-24 103.00
IUUC-Fso-038434 Fusarium solani 34.69 4.00e-21 94.70
IUUC-Ggr-039796 Gaeumannomyces graminis 32.31 2.00e-28 119.00
IUUC-Gma-044142 Glycine max 27.36 2.00e-31 128.00
IUUC-Hvu-047407 Hordeum vulgare 32.54 2.00e-21 95.10
IUUC-Kpa-049246 Komagataella pastoris 31.70 6.00e-60 223.00
IUUC-Lpe-050804 Leersia perrieri 34.07 3.00e-25 107.00
IUUC-Lma-052994 Leptosphaeria maculans 28.41 3.00e-27 114.00
IUUC-Mor-057007 Magnaporthe oryzae 30.62 1.00e-31 130.00
IUUC-Mpo-057296 Magnaporthe poae 33.48 3.00e-29 121.00
IUUC-Mtr-057662 Medicago truncatula 29.21 9.00e-31 126.00
IUUC-Mvi-060396 Microbotryum violaceum 33.04 4.00e-29 121.00
IUUC-Mmu-064377 Mus musculus 30.26 9.00e-09 53.50
IUUC-Mac-065213 Musa acuminata 29.73 3.00e-17 81.30
IUUC-Nfi-068252 Neosartorya fischeri 28.49 6.00e-53 200.00
IUUC-Ncr-068860 Neurospora crassa 35.09 7.00e-23 100.00
IUUC-Oba-075543 Oryza barthii 32.12 8.00e-15 73.20
IUUC-Obr-076427 Oryza brachyantha 32.97 5.00e-25 107.00
IUUC-Ogl-077281 Oryza glaberrima 32.97 5.00e-25 107.00
IUUC-Ogu-078135 Oryza glumaepatula 32.12 1.00e-14 72.80
IUUC-Oin-079565 Oryza indica 31.55 4.00e-25 107.00
IUUC-Olo-080765 Oryza longistaminata 32.97 8.00e-25 106.00
IUUC-Ome-081704 Oryza meridionalis 32.12 9.00e-15 73.20
IUUC-Oni-082520 Oryza nivara 32.12 9.00e-15 72.00
IUUC-Opu-083443 Oryza punctata 32.85 5.00e-15 73.60
IUUC-Oru-085261 Oryza rufipogon 32.12 1.00e-14 72.80
IUUC-Osa-085322 Oryza sativa 46.94 9.00e-08 49.70
IUUC-Olu-087584 Ostreococcus lucimarinus 29.41 1.00e-23 101.00
IUUC-Pno-095138 Phaeosphaeria nodorum 30.08 5.00e-29 122.00
IUUC-Ppa-095903 Physcomitrella patens 30.43 2.00e-21 95.50
IUUC-Pop-098898 Populus trichocarpa 27.63 3.00e-29 121.00
IUUC-Ppe-102081 Prunus persica 26.84 2.00e-29 121.00
IUUC-Pgr-103658 Puccinia graminis 26.50 8.00e-18 84.00
IUUC-Ptt-103835 Puccinia triticina 26.52 1.00e-21 96.30
IUUC-Pte-104066 Pyrenophora teres 31.13 4.00e-15 75.90
IUUC-Pyt-104574 Pyrenophora triticirepentis 29.23 2.00e-24 105.00
IUUC-Sce-106438 Saccharomyces cerevisiae 28.31 6.00e-38 150.00
IUUC-Sja-107916 Schizosaccharomyces japonicus 37.92 2.00e-76 277.00
IUUC-Ssl-108517 Sclerotinia sclerotiorum 24.48 2.00e-20 92.00
IUUC-Smo-109376 Selaginella moellendorffii 26.72 9.00e-24 103.00
IUUC-Sit-109719 Setaria italica 32.97 2.00e-24 105.00
IUUC-Sly-111742 Solanum lycopersicum 27.66 8.00e-28 116.00
IUUC-Stu-112706 Solanum tuberosum 27.90 2.00e-27 115.00
IUUC-Sar-113430 Sorex araneus 50.00 1.00e-07 47.00
IUUC-Sbi-114347 Sorghum bicolor 34.07 2.00e-25 108.00
IUUC-Sre-114925 Sporisorium reilianum 32.00 4.00e-15 75.10
IUUC-Tca-121160 Theobroma cacao 27.36 1.00e-26 112.00
IUUC-Tre-121878 Trichoderma reesei 32.66 2.00e-32 132.00
IUUC-Tvi-122299 Trichoderma virens 32.39 9.00e-32 130.00
IUUC-Tae-125507 Triticum aestivum 32.04 1.00e-24 105.00
IUUC-Tur-126740 Triticum urartu 30.28 6.00e-14 70.50
IUUC-Tme-126915 Tuber melanosporum 31.80 5.00e-61 227.00
IUUC-Uma-129430 Ustilago maydis 26.55 4.00e-26 111.00
IUUC-Vda-129918 Verticillium dahliae 35.02 1.00e-29 123.00
IUUC-Vvi-131478 Vitis vinifera 26.89 8.00e-30 123.00
IUUC-Yli-134449 Yarrowia lipolytica 28.63 3.00e-51 194.00
IUUC-Zma-135016 Zea mays 31.08 4.00e-15 73.90
Created Date 25-Jun-2017

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