iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Yli-134660

Ensembl Protein ID

CAG78731

UniProt Accession

Q6C093; UBC2_YARLI

Genbank Protein ID

CAG78731.1

Protein Name

Ubiquitin-conjugating enzyme E2 2; E2 ubiquitin-conjugating enzyme 2; Ubiquitin carrier protein UBC2; Ubiquitin-protein ligase UBC2

Genbank Nucleotide ID

CR382132

Gene Name

UBC2; YALI0F26697g

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
YALI0_F26697g	CAG78731	CAG78731

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E2/UBC	1.40e-51	172.4	8	142

Active Site

Position(s)	Description	Evidence
88	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00388, ECO:0000255\|PROSITE-ProRule:PRU10133}

Domain Profile

E2/UBC

   S: 1    RlkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilkeeekWspalsvesv 101
           Rl++++k++++dpp+g+sa+pv + ++ +w+++i+Gp++tp+e+g+F++ ++f+e+YP kPP vkf++++fhPnvy++G++Cl+il+  ++Wsp+++v+ +
   Q: 8    RLMRDFKRMQQDPPQGVSASPVAD-NVLTWNAVIIGPAETPFEDGTFRMVLQFDEQYPNKPPAVKFVSQMFHPNVYSSGELCLDILQ--NRWSPTYDVAAI 105
           9***********************.9************************************************************9..************ PP
   S: 102  llsiqsllaepnpesplneeaaellkknreeykkkvr 138
           l+s+qsll++pn++sp+n+ea+ l+k++r++y+k+vr
   Q: 106  LTSVQSLLNDPNTSSPANVEASMLYKDHRQQYEKRVR 142
           ***********************************98 PP

Organism

Yarrowia lipolytica

Functional Description
(View)

Catalyzes the covalent attachment of ubiquitin to other proteins. Plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation. Also involved in postreplication repair of UV-damaged DNA, in N-end rule-dependent protein degradation and in sporulation.

Protein Sequence
(Fasta)

MSTTARRRLM RDFKRMQQDP PQGVSASPVA DNVLTWNAVI IGPAETPFED GTFRMVLQFD 60
EQYPNKPPAV KFVSQMFHPN VYSSGELCLD ILQNRWSPTY DVAAILTSVQ SLLNDPNTSS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTCCACTA CAGCTCGAAG ACGTCTCATG CGAGACTTCA AGCGCATGCA ACAGGATCCT 60
CCCCAGGGAG TCAGTGCATC TCCTGTGGCT GATAACGTGC TGACATGGAA CGCCGTGATC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0227--DNA damage
KW-0234--DNA repair
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0749--Sporulation
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0000781--C:chromosome, telomeric region
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0033503--C:HULC complex
GO:1990304--C:MUB1-RAD6-UBR2 ubiquitin ligase complex
GO:0000790--C:nuclear chromatin
GO:0000502--C:proteasome complex
GO:0097505--C:Rad6-Rad18 complex
GO:0005524--F:ATP binding
GO:0003697--F:single-stranded DNA binding
GO:0043142--F:single-stranded DNA-dependent ATPase activity
GO:0061631--F:ubiquitin conjugating enzyme activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0071455--P:cellular response to hyperoxia
GO:0031497--P:chromatin assembly
GO:0006348--P:chromatin silencing at telomere
GO:0006281--P:DNA repair
GO:0006353--P:DNA-templated transcription, termination
GO:0000724--P:double-strand break repair via homologous recombination
GO:0042275--P:error-free postreplication DNA repair
GO:0070987--P:error-free translesion synthesis
GO:0042276--P:error-prone translesion synthesis
GO:0071894--P:histone H2B conserved C-terminal lysine ubiquitination
GO:0010390--P:histone monoubiquitination
GO:0016574--P:histone ubiquitination
GO:0042138--P:meiotic DNA double-strand break formation
GO:0031571--P:mitotic G1 DNA damage checkpoint
GO:0061186--P:negative regulation of chromatin silencing at silent mating-type cassette
GO:0031939--P:negative regulation of chromatin silencing at telomere
GO:1901487--P:negative regulation of SREBP signaling pathway by positive regulation of transcription factor catabolic process in response to increased oxygen levels
GO:0010620--P:negative regulation of transcription by transcription factor catabolism
GO:1990920--P:proteasome localization to nuclear periphery
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0070534--P:protein K63-linked ubiquitination
GO:0000209--P:protein polyubiquitination
GO:1901044--P:protein polyubiquitination involved in nucleus-associated proteasomal ubiquitin-dependent protein catabolic process
GO:0090089--P:regulation of dipeptide transport
GO:0051569--P:regulation of histone H3-K4 methylation
GO:0030435--P:sporulation resulting in formation of a cellular spore
GO:0000722--P:telomere maintenance via recombination
GO:0006366--P:transcription from RNA polymerase II promoter
GO:0071629--P:ubiquitin-dependent catabolism of misfolded proteins by cytoplasm-associated proteasome
GO:0030433--P:ubiquitin-dependent ERAD pathway
GO:0071596--P:ubiquitin-dependent protein catabolic process via the N-end rule pathway

KEGG

yli:YALI0F26697g

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001001	Aegilops tauschii	60.67	3.00e-59	218.00
IUUC-Aml-002120	Ailuropoda melanoleuca	66.23	2.00e-63	232.00
IUUC-Atr-002623	Amborella trichopoda	64.00	3.00e-60	221.00
IUUC-Apl-004063	Anas platyrhynchos	58.78	4.00e-53	197.00
IUUC-Aca-005001	Anolis carolinensis	65.56	2.00e-63	232.00
IUUC-Aly-005584	Arabidopsis lyrata	65.33	4.00e-61	224.00
IUUC-Ath-007149	Arabidopsis thaliana	65.33	4.00e-61	224.00
IUUC-Ago-007745	Ashbya gossypii	75.17	3.00e-70	255.00
IUUC-Acl-008139	Aspergillus clavatus	85.43	4.00e-78	280.00
IUUC-Afl-008551	Aspergillus flavus	85.43	4.00e-78	281.00
IUUC-Afu-008980	Aspergillus fumigatus	85.43	4.00e-78	281.00
IUUC-Ang-009554	Aspergillus niger	85.43	4.00e-78	281.00
IUUC-Aor-010242	Aspergillus oryzae	85.43	4.00e-78	281.00
IUUC-Ate-010390	Aspergillus terreus	85.43	4.00e-78	281.00
IUUC-Ame-010743	Astyanax mexicanus	66.23	6.00e-64	234.00
IUUC-Bgr-012039	Blumeria graminis	84.56	1.00e-69	252.00
IUUC-Bta-012840	Bos taurus	66.23	2.00e-63	232.00
IUUC-Bci-013919	Botrytis cinerea	84.11	4.00e-77	277.00
IUUC-Bdi-014475	Brachypodium distachyon	63.33	1.00e-59	219.00
IUUC-Bol-015726	Brassica oleracea	65.33	8.00e-61	226.00
IUUC-Bra-016809	Brassica rapa	65.33	4.00e-61	225.00
IUUC-Cel-018244	Caenorhabditis elegans	68.46	9.00e-65	237.00
IUUC-Cja-019737	Callithrix jacchus	66.23	2.00e-63	232.00
IUUC-Cfa-020244	Canis familiaris	66.23	2.00e-63	232.00
IUUC-Cpo-022192	Cavia porcellus	66.23	2.00e-63	232.00
IUUC-Cre-022822	Chlamydomonas reinhardtii	62.25	1.00e-51	193.00
IUUC-Csa-023430	Chlorocebus sabaeus	66.23	2.00e-63	232.00
IUUC-Cho-024773	Choloepus hoffmanni	52.32	2.00e-43	166.00
IUUC-Cin-025537	Ciona intestinalis	66.23	3.00e-53	198.00
IUUC-Csv-025846	Ciona savignyi	65.77	3.00e-56	208.00
IUUC-Cgl-026381	Colletotrichum gloeosporioides	84.77	7.00e-78	280.00
IUUC-Cne-026864	Cryptococcus neoformans	69.13	1.00e-64	236.00
IUUC-Cme-027284	Cyanidioschyzon merolae	60.67	8.00e-49	184.00
IUUC-Dre-027775	Danio rerio	66.89	3.00e-64	234.00
IUUC-Dno-029661	Dasypus novemcinctus	66.23	2.00e-63	232.00
IUUC-Dor-030452	Dipodomys ordii	63.24	5.00e-55	204.00
IUUC-Dse-031487	Dothistroma septosporum	84.11	1.00e-77	279.00
IUUC-Dme-031863	Drosophila melanogaster	67.55	9.00e-64	233.00
IUUC-Ete-032595	Echinops telfairi	64.90	2.00e-62	228.00
IUUC-Eca-033377	Equus caballus	66.23	2.00e-63	232.00
IUUC-Eeu-035191	Erinaceus europaeus	52.29	1.00e-42	163.00
IUUC-Fca-036336	Felis catus	66.23	2.00e-63	232.00
IUUC-Fal-037474	Ficedula albicollis	65.25	3.00e-48	181.00
IUUC-Fox-037808	Fusarium oxysporum	84.11	3.00e-77	278.00
IUUC-Fso-038232	Fusarium solani	83.44	7.00e-77	276.00
IUUC-Gmo-038517	Gadus morhua	66.23	2.00e-63	231.00
IUUC-Ggr-039875	Gaeumannomyces graminis	83.89	3.00e-76	274.00
IUUC-Gga-040494	Gallus gallus	66.23	2.00e-63	232.00
IUUC-Gac-042471	Gasterosteus aculeatus	66.23	1.00e-63	233.00
IUUC-Gma-043688	Glycine max	65.33	6.00e-61	223.00
IUUC-Ggo-044896	Gorilla gorilla	66.23	2.00e-63	231.00
IUUC-Hsa-046239	Homo sapiens	66.23	2.00e-63	232.00
IUUC-Hvu-047054	Hordeum vulgare	60.67	3.00e-59	218.00
IUUC-Itr-048960	Ictidomys tridecemlineatus	66.23	2.00e-63	232.00
IUUC-Kpa-049225	Komagataella pastoris	81.33	1.00e-74	269.00
IUUC-Lch-050283	Latimeria chalumnae	66.23	9.00e-64	233.00
IUUC-Lpe-051301	Leersia perrieri	64.00	2.00e-60	221.00
IUUC-Loc-051962	Lepisosteus oculatus	66.23	6.00e-64	233.00
IUUC-Laf-053380	Loxodonta africana	66.23	2.00e-63	232.00
IUUC-Mcc-054819	Macaca mulatta	66.23	1.00e-63	233.00
IUUC-Meu-056231	Macropus eugenii	66.23	2.00e-63	231.00
IUUC-Mor-057087	Magnaporthe oryzae	82.84	3.00e-67	244.00
IUUC-Mpo-057498	Magnaporthe poae	83.89	3.00e-76	275.00
IUUC-Mtr-058305	Medicago truncatula	64.00	2.00e-60	222.00
IUUC-Mla-058876	Melampsora laricipopulina	72.85	3.00e-62	228.00
IUUC-Mga-059863	Meleagris gallopavo	62.59	9.00e-56	206.00
IUUC-Mvi-060330	Microbotryum violaceum	76.16	2.00e-62	228.00
IUUC-Mmr-060630	Microcebus murinus	66.23	2.00e-63	232.00
IUUC-Mdo-062676	Monodelphis domestica	66.23	2.00e-63	232.00
IUUC-Mmu-063491	Mus musculus	66.23	2.00e-63	232.00
IUUC-Mac-064774	Musa acuminata	65.33	8.00e-61	223.00
IUUC-Mpu-065803	Mustela putorius furo	66.23	2.00e-63	232.00
IUUC-Mlu-067147	Myotis lucifugus	66.23	2.00e-63	232.00
IUUC-Nfi-068580	Neosartorya fischeri	85.43	4.00e-78	281.00
IUUC-Ncr-068913	Neurospora crassa	82.78	9.00e-77	276.00
IUUC-Nle-070105	Nomascus leucogenys	66.23	2.00e-63	232.00
IUUC-Opr-070935	Ochotona princeps	66.23	2.00e-63	232.00
IUUC-Ont-071335	Oreochromis niloticus	66.23	1.00e-63	233.00
IUUC-Oan-072706	Ornithorhynchus anatinus	60.96	2.00e-56	209.00
IUUC-Ocu-074130	Oryctolagus cuniculus	66.23	2.00e-63	232.00
IUUC-Oba-075896	Oryza barthii	64.00	2.00e-60	221.00
IUUC-Obr-076770	Oryza brachyantha	64.67	1.00e-60	223.00
IUUC-Ogl-077116	Oryza glaberrima	64.00	2.00e-60	221.00
IUUC-Ogu-078696	Oryza glumaepatula	64.00	2.00e-60	221.00
IUUC-Oin-079099	Oryza indica	64.00	2.00e-60	221.00
IUUC-Olo-081018	Oryza longistaminata	53.94	2.00e-50	189.00
IUUC-Ome-081285	Oryza meridionalis	64.00	2.00e-60	221.00
IUUC-Oni-082088	Oryza nivara	64.00	2.00e-60	221.00
IUUC-Opu-083310	Oryza punctata	64.00	2.00e-60	221.00
IUUC-Oru-084449	Oryza rufipogon	64.00	2.00e-60	221.00
IUUC-Osa-085923	Oryza sativa	64.00	2.00e-60	221.00
IUUC-Ola-087160	Oryzias latipes	66.23	1.00e-63	233.00
IUUC-Olu-087830	Ostreococcus lucimarinus	63.09	4.00e-52	194.00
IUUC-Oga-088836	Otolemur garnettii	66.23	2.00e-63	232.00
IUUC-Oar-090141	Ovis aries	66.23	2.00e-63	232.00
IUUC-Ptr-091453	Pan troglodytes	66.23	2.00e-63	232.00
IUUC-Pan-092511	Papio anubis	66.23	2.00e-63	232.00
IUUC-Psi-093968	Pelodiscus sinensis	65.56	2.00e-63	232.00
IUUC-Pma-094376	Petromyzon marinus	66.89	4.00e-63	231.00
IUUC-Pno-094935	Phaeosphaeria nodorum	82.12	4.00e-76	274.00
IUUC-Ppa-095689	Physcomitrella patens	64.00	2.00e-52	195.00
IUUC-Pfo-096784	Poecilia formosa	66.23	1.00e-63	233.00
IUUC-Pab-098121	Pongo abelii	66.23	2.00e-63	232.00
IUUC-Pop-099517	Populus trichocarpa	64.00	2.00e-60	222.00
IUUC-Pca-100906	Procavia capensis	60.93	1.00e-56	209.00
IUUC-Ppe-101594	Prunus persica	64.00	2.00e-60	222.00
IUUC-Pva-102380	Pteropus vampyrus	65.56	2.00e-61	225.00
IUUC-Pgr-103611	Puccinia graminis	72.85	2.00e-62	229.00
IUUC-Ptt-103971	Puccinia triticina	76.27	2.00e-48	182.00
IUUC-Pte-104378	Pyrenophora teres	83.44	5.00e-77	277.00
IUUC-Pyt-104757	Pyrenophora triticirepentis	83.44	5.00e-77	277.00
IUUC-Rno-105772	Rattus norvegicus	66.23	1.00e-63	233.00
IUUC-Sce-106283	Saccharomyces cerevisiae	75.17	2.00e-70	255.00
IUUC-Sha-107650	Sarcophilus harrisii	65.56	3.00e-62	228.00
IUUC-Sja-107790	Schizosaccharomyces japonicus	80.54	3.00e-65	238.00
IUUC-Spo-108073	Schizosaccharomyces pombe	80.54	3.00e-65	238.00
IUUC-Ssl-108432	Sclerotinia sclerotiorum	84.11	4.00e-77	277.00
IUUC-Smo-109036	Selaginella moellendorffii	64.67	6.00e-61	223.00
IUUC-Sit-110731	Setaria italica	64.00	2.00e-60	221.00
IUUC-Sly-111506	Solanum lycopersicum	64.00	2.00e-60	222.00
IUUC-Stu-112518	Solanum tuberosum	63.33	2.00e-60	223.00
IUUC-Sar-113429	Sorex araneus	66.23	2.00e-63	232.00
IUUC-Sbi-114289	Sorghum bicolor	64.00	2.00e-60	221.00
IUUC-Sre-115106	Sporisorium reilianum	70.20	1.00e-60	223.00
IUUC-Ssc-116265	Sus scrofa	66.23	2.00e-63	231.00
IUUC-Tgu-117383	Taeniopygia guttata	66.23	2.00e-63	231.00
IUUC-Tru-118576	Takifugu rubripes	66.23	1.00e-63	233.00
IUUC-Tsy-119000	Tarsius syrichta	66.23	2.00e-63	232.00
IUUC-Tni-119745	Tetraodon nigroviridis	66.23	1.00e-63	233.00
IUUC-Tca-121827	Theobroma cacao	63.33	3.00e-60	221.00
IUUC-Tre-122002	Trichoderma reesei	83.44	7.00e-77	276.00
IUUC-Tvi-122331	Trichoderma virens	83.44	7.00e-77	276.00
IUUC-Tae-124461	Triticum aestivum	64.00	2.00e-60	223.00
IUUC-Tur-126866	Triticum urartu	62.00	3.00e-59	218.00
IUUC-Tme-127148	Tuber melanosporum	83.22	2.00e-76	275.00
IUUC-Tbe-127921	Tupaia belangeri	64.24	4.00e-59	218.00
IUUC-Ttr-129121	Tursiops truncatus	66.23	2.00e-63	232.00
IUUC-Uma-129561	Ustilago maydis	70.20	9.00e-61	223.00
IUUC-Vda-129711	Verticillium dahliae	84.77	7.00e-78	280.00
IUUC-Vpa-130570	Vicugna pacos	58.09	3.00e-49	184.00
IUUC-Vvi-131108	Vitis vinifera	64.00	8.00e-61	223.00
IUUC-Xtr-131824	Xenopus tropicalis	66.89	5.00e-64	234.00
IUUC-Xma-133667	Xiphophorus maculatus	66.23	1.00e-63	233.00
IUUC-Zma-135584	Zea mays	62.67	7.00e-60	220.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence