iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
TRANSFAC	RAID2
Protein-protein Interaction
IID
Drug and target
GRAC
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.40e-16	59.6	992	1021

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclafsd..tllvsGsdDgtikvWD 29
           H++ v+ ++ sd   l++++s+Dgt+k+W+
   Q: 992  HKSAVNRIRVSDehLLFATCSNDGTVKIWN 1021
           99999999995545668************9 PP

Organism

Rattus norvegicus

Functional Description
(View)

Regulatory subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (By similarity).

Protein Sequence
(Fasta)

MGNQLAGIAP SQILSVESYF SDIHDFEYDK SLGSTRFFKV ARAKHREGLV VVKVFAIQDP 60
TLPLTSYKQE LEELKIRLHS AQNCLPFQKA AEKASEKAAM LFRQYVRDNL YDRISTRPFL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTGAAGTCAA CCCAGCGGCT TTCCCGGGAG TTCAGCGTTC GCCGCAGGTG AAGTAGTCTT 60
CCTGGACGGG TGCTGGCACT GTCCCCCGTC CAGGGCTGGC GCAAAGGCCC GGGGATCCGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0968--Cytoplasmic vesicle
KW-0967--Endosome
KW-0418--Kinase
KW-0449--Lipoprotein
KW-0472--Membrane
KW-0519--Myristate
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase
KW-0853--WD repeat

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR021133--HEAT_type_2
IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR008271--Ser/Thr_kinase_AS
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50077--HEAT_REPEAT
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00069--Pkinase
PF00400--WD40

SMART

SM00220--S_TKc
SM00320--WD40

Gene Ontology

GO:0005776--C:autophagosome
GO:0005930--C:axoneme
GO:0005770--C:late endosome
GO:0015630--C:microtubule cytoskeleton
GO:0005643--C:nuclear pore
GO:0071561--C:nucleus-vacuole junction
GO:0035032--C:phosphatidylinositol 3-kinase complex, class III
GO:0034271--C:phosphatidylinositol 3-kinase complex, class III, type I
GO:0034272--C:phosphatidylinositol 3-kinase complex, class III, type II
GO:0005524--F:ATP binding
GO:0004674--F:protein serine/threonine kinase activity
GO:0042149--P:cellular response to glucose starvation
GO:0045324--P:late endosome to vacuole transport
GO:0016236--P:macroautophagy
GO:0030242--P:pexophagy
GO:0043552--P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0006468--P:protein phosphorylation
GO:0006623--P:protein targeting to vacuole
GO:0032801--P:receptor catabolic process
GO:0032465--P:regulation of cytokinesis

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000213	Aegilops tauschii	31.82	3.00e-44	174.00
IUUC-Aml-001659	Ailuropoda melanoleuca	95.14	0.00e+00	2625.00
IUUC-Atr-002968	Amborella trichopoda	45.60	5.00e-45	177.00
IUUC-Apl-003418	Anas platyrhynchos	89.59	0.00e+00	2543.00
IUUC-Aca-004344	Anolis carolinensis	88.70	0.00e+00	2261.00
IUUC-Aly-006107	Arabidopsis lyrata	45.76	3.00e-68	254.00
IUUC-Ath-007260	Arabidopsis thaliana	46.06	7.00e-69	256.00
IUUC-Ago-007721	Ashbya gossypii	24.70	6.00e-56	213.00
IUUC-Acl-008378	Aspergillus clavatus	35.19	6.00e-146	512.00
IUUC-Afl-008632	Aspergillus flavus	36.30	9.00e-141	495.00
IUUC-Afu-009020	Aspergillus fumigatus	36.44	2.00e-139	490.00
IUUC-Ani-009204	Aspergillus nidulans	35.74	3.00e-130	460.00
IUUC-Ang-009811	Aspergillus niger	34.80	2.00e-136	481.00
IUUC-Aor-010168	Aspergillus oryzae	36.30	9.00e-141	495.00
IUUC-Ate-010556	Aspergillus terreus	35.51	7.00e-137	482.00
IUUC-Ame-011955	Astyanax mexicanus	79.34	0.00e+00	1790.00
IUUC-Bgr-012050	Blumeria graminis	35.95	2.00e-137	484.00
IUUC-Bta-012432	Bos taurus	94.33	0.00e+00	2658.00
IUUC-Bci-013846	Botrytis cinerea	34.35	3.00e-140	493.00
IUUC-Bdi-015072	Brachypodium distachyon	42.41	7.00e-65	243.00
IUUC-Bol-015314	Brassica oleracea	26.28	1.00e-91	332.00
IUUC-Bra-017476	Brassica rapa	46.06	6.00e-69	256.00
IUUC-Cel-018550	Caenorhabditis elegans	31.85	2.00e-84	307.00
IUUC-Cja-019538	Callithrix jacchus	95.14	0.00e+00	2678.00
IUUC-Cfa-020483	Canis familiaris	94.99	0.00e+00	2634.00
IUUC-Cpo-021392	Cavia porcellus	95.07	0.00e+00	2661.00
IUUC-Csa-024112	Chlorocebus sabaeus	95.66	0.00e+00	2690.00
IUUC-Cho-025015	Choloepus hoffmanni	87.88	0.00e+00	925.00
IUUC-Cin-025209	Ciona intestinalis	40.80	0.00e+00	1069.00
IUUC-Csv-026334	Ciona savignyi	41.67	0.00e+00	890.00
IUUC-Cgl-026447	Colletotrichum gloeosporioides	35.49	3.00e-139	490.00
IUUC-Cne-026999	Cryptococcus neoformans	35.95	1.00e-112	401.00
IUUC-Dre-028662	Danio rerio	80.35	0.00e+00	2271.00
IUUC-Dno-029545	Dasypus novemcinctus	93.37	0.00e+00	2593.00
IUUC-Dor-030941	Dipodomys ordii	65.75	0.00e+00	723.00
IUUC-Dse-031455	Dothistroma septosporum	36.48	1.00e-134	474.00
IUUC-Dme-031726	Drosophila melanogaster	39.52	0.00e+00	972.00
IUUC-Ete-033147	Echinops telfairi	91.46	0.00e+00	991.00
IUUC-Eca-034025	Equus caballus	95.21	0.00e+00	2674.00
IUUC-Eeu-034480	Erinaceus europaeus	87.91	0.00e+00	1485.00
IUUC-Fca-035741	Felis catus	94.55	0.00e+00	2638.00
IUUC-Fal-037666	Ficedula albicollis	88.63	0.00e+00	2517.00
IUUC-Fox-037818	Fusarium oxysporum	33.49	2.00e-123	437.00
IUUC-Fso-038086	Fusarium solani	33.92	4.00e-126	446.00
IUUC-Gmo-038804	Gadus morhua	79.81	0.00e+00	730.00
IUUC-Ggr-039800	Gaeumannomyces graminis	35.12	2.00e-130	460.00
IUUC-Gga-041251	Gallus gallus	87.66	0.00e+00	1966.00
IUUC-Gac-042376	Gasterosteus aculeatus	77.81	0.00e+00	2200.00
IUUC-Gma-044095	Glycine max	45.03	1.00e-70	262.00
IUUC-Ggo-044506	Gorilla gorilla	95.14	0.00e+00	2674.00
IUUC-Hsa-045871	Homo sapiens	95.73	0.00e+00	2687.00
IUUC-Hvu-047648	Hordeum vulgare	31.58	6.00e-46	179.00
IUUC-Itr-048082	Ictidomys tridecemlineatus	96.35	0.00e+00	1184.00
IUUC-Kpa-049390	Komagataella pastoris	32.00	3.00e-123	436.00
IUUC-Lch-050284	Latimeria chalumnae	84.00	0.00e+00	2303.00
IUUC-Lpe-050880	Leersia perrieri	41.19	9.00e-63	236.00
IUUC-Loc-052815	Lepisosteus oculatus	80.62	0.00e+00	2285.00
IUUC-Lma-053324	Leptosphaeria maculans	32.20	6.00e-171	595.00
IUUC-Laf-054204	Loxodonta africana	83.24	0.00e+00	2256.00
IUUC-Mcc-054612	Macaca mulatta	95.73	0.00e+00	2689.00
IUUC-Meu-056227	Macropus eugenii	84.74	0.00e+00	835.00
IUUC-Mor-057094	Magnaporthe oryzae	35.99	6.00e-131	462.00
IUUC-Mtr-058550	Medicago truncatula	43.09	9.00e-70	259.00
IUUC-Mla-058893	Melampsora laricipopulina	35.04	1.00e-126	448.00
IUUC-Mga-059474	Meleagris gallopavo	88.21	0.00e+00	2377.00
IUUC-Mvi-060227	Microbotryum violaceum	45.30	1.00e-82	302.00
IUUC-Mmr-061543	Microcebus murinus	88.37	0.00e+00	2393.00
IUUC-Mdo-062129	Monodelphis domestica	91.79	0.00e+00	2486.00
IUUC-Mmu-064381	Mus musculus	98.82	0.00e+00	2760.00
IUUC-Mac-064455	Musa acuminata	38.09	2.00e-122	433.00
IUUC-Mpu-066151	Mustela putorius furo	96.48	0.00e+00	948.00
IUUC-Mlu-067824	Myotis lucifugus	95.43	0.00e+00	2675.00
IUUC-Nfi-068241	Neosartorya fischeri	37.32	2.00e-143	504.00
IUUC-Ncr-068964	Neurospora crassa	35.77	6.00e-136	479.00
IUUC-Nle-069152	Nomascus leucogenys	95.80	0.00e+00	2690.00
IUUC-Opr-070870	Ochotona princeps	84.12	0.00e+00	1404.00
IUUC-Ont-071293	Oreochromis niloticus	79.23	0.00e+00	2252.00
IUUC-Oan-072852	Ornithorhynchus anatinus	86.15	0.00e+00	2389.00
IUUC-Ocu-074727	Oryctolagus cuniculus	95.36	0.00e+00	2645.00
IUUC-Oba-075932	Oryza barthii	39.18	2.00e-62	234.00
IUUC-Obr-076424	Oryza brachyantha	46.89	2.00e-60	228.00
IUUC-Ogl-077491	Oryza glaberrima	39.18	2.00e-62	234.00
IUUC-Ogu-078933	Oryza glumaepatula	44.89	8.00e-66	246.00
IUUC-Oin-079604	Oryza indica	43.55	7.00e-68	252.00
IUUC-Olo-080850	Oryza longistaminata	35.22	3.00e-115	410.00
IUUC-Ome-081860	Oryza meridionalis	43.55	6.00e-68	253.00
IUUC-Oni-082895	Oryza nivara	39.18	4.00e-62	234.00
IUUC-Opu-083741	Oryza punctata	40.90	1.00e-66	248.00
IUUC-Oru-084616	Oryza rufipogon	38.87	8.00e-62	233.00
IUUC-Osa-085941	Oryza sativa	28.50	5.00e-36	145.00
IUUC-Ola-087357	Oryzias latipes	84.94	3.00e-156	543.00
IUUC-Olu-087659	Ostreococcus lucimarinus	30.19	3.00e-85	310.00
IUUC-Oga-088555	Otolemur garnettii	96.02	0.00e+00	2666.00
IUUC-Oar-089304	Ovis aries	92.64	0.00e+00	1297.00
IUUC-Ptr-091140	Pan troglodytes	95.80	0.00e+00	2690.00
IUUC-Pan-092413	Papio anubis	95.35	0.00e+00	2576.00
IUUC-Psi-093210	Pelodiscus sinensis	89.42	0.00e+00	2540.00
IUUC-Pma-094674	Petromyzon marinus	55.61	0.00e+00	721.00
IUUC-Pno-094969	Phaeosphaeria nodorum	30.99	4.00e-146	513.00
IUUC-Ppa-096017	Physcomitrella patens	43.01	1.00e-74	276.00
IUUC-Pfo-096077	Poecilia formosa	79.09	0.00e+00	2199.00
IUUC-Pab-098269	Pongo abelii	94.92	0.00e+00	2668.00
IUUC-Pop-100052	Populus trichocarpa	43.40	1.00e-61	232.00
IUUC-Pca-100377	Procavia capensis	89.41	0.00e+00	2392.00
IUUC-Ppe-101445	Prunus persica	46.39	3.00e-71	264.00
IUUC-Pva-102198	Pteropus vampyrus	95.59	0.00e+00	1763.00
IUUC-Pgr-103544	Puccinia graminis	46.86	2.00e-78	288.00
IUUC-Ptt-103964	Puccinia triticina	46.23	1.00e-74	275.00
IUUC-Pte-104196	Pyrenophora teres	36.63	1.00e-136	481.00
IUUC-Pyt-104544	Pyrenophora triticirepentis	31.03	1.00e-171	597.00
IUUC-Sce-106295	Saccharomyces cerevisiae	32.92	1.00e-111	398.00
IUUC-Sha-107597	Sarcophilus harrisii	91.05	0.00e+00	2520.00
IUUC-Sja-107781	Schizosaccharomyces japonicus	33.85	2.00e-110	394.00
IUUC-Spo-108031	Schizosaccharomyces pombe	44.44	1.00e-72	269.00
IUUC-Ssl-108579	Sclerotinia sclerotiorum	35.26	3.00e-132	466.00
IUUC-Smo-108679	Selaginella moellendorffii	44.01	2.00e-75	278.00
IUUC-Sit-110765	Setaria italica	40.69	2.00e-61	231.00
IUUC-Sly-111527	Solanum lycopersicum	43.37	1.00e-70	262.00
IUUC-Stu-112899	Solanum tuberosum	43.09	2.00e-70	261.00
IUUC-Sar-112986	Sorex araneus	94.48	0.00e+00	2645.00
IUUC-Sbi-114604	Sorghum bicolor	40.21	1.00e-64	242.00
IUUC-Sre-115191	Sporisorium reilianum	43.08	2.00e-63	238.00
IUUC-Ssc-115440	Sus scrofa	93.82	0.00e+00	2615.00
IUUC-Tgu-116633	Taeniopygia guttata	88.85	0.00e+00	2524.00
IUUC-Tru-118439	Takifugu rubripes	77.93	0.00e+00	2216.00
IUUC-Tsy-119472	Tarsius syrichta	86.79	0.00e+00	1382.00
IUUC-Tni-119808	Tetraodon nigroviridis	73.79	0.00e+00	2016.00
IUUC-Tca-121648	Theobroma cacao	46.69	1.00e-71	265.00
IUUC-Tre-122161	Trichoderma reesei	33.82	5.00e-119	422.00
IUUC-Tvi-122575	Trichoderma virens	32.51	1.00e-110	395.00
IUUC-Tae-123381	Triticum aestivum	45.98	3.00e-65	244.00
IUUC-Tur-126291	Triticum urartu	43.55	6.00e-66	246.00
IUUC-Tme-126979	Tuber melanosporum	37.20	1.00e-145	511.00
IUUC-Tbe-127576	Tupaia belangeri	78.96	0.00e+00	905.00
IUUC-Ttr-129106	Tursiops truncatus	96.21	0.00e+00	1291.00
IUUC-Uma-129633	Ustilago maydis	42.24	4.00e-72	267.00
IUUC-Vda-130001	Verticillium dahliae	34.36	2.00e-124	441.00
IUUC-Vpa-130733	Vicugna pacos	86.34	0.00e+00	1269.00
IUUC-Vvi-131318	Vitis vinifera	43.75	1.00e-68	255.00
IUUC-Xtr-131908	Xenopus tropicalis	84.63	0.00e+00	2417.00
IUUC-Xma-133331	Xiphophorus maculatus	78.94	0.00e+00	2214.00
IUUC-Yli-134651	Yarrowia lipolytica	36.75	2.00e-117	417.00
IUUC-Zma-135850	Zea mays	39.95	2.00e-65	245.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence