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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Sce-106295
Ensembl Protein ID YBR097W
UniProt Accession P22219; D6VQ98; VPS15_YEAST
Genbank Protein ID AAA35214.1; CAA55602.1; CAA85050.1; DAA07218.2
Protein Name Serine/threonine-protein kinase VPS15; Golgi-retention defective mutant protein 8; Vacuolar protein sorting-associated protein 15
Genbank Nucleotide ID M59835; X78993; Z35966; BK006936
Gene Name VPS15; GRD8; VAC4; VPL19; YBR097W; YBR0825
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
YBR097W YBR097W YBR097W
Annotation
mRNA Expression
GEOFFGED
Protein-protein Interaction
IIDiRefIndexHINTMentha
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
CPLMdbPAFdbPTMBioGRID
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/Beta-Prp Beta-Prp 21070969
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 1.70e-06 26.7 1083 1110
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 6    vtclaf.sd..tllvsGsdDgtikvWDl 30
           +t+ a  ++  ++l++Gsd g+ik+W+l
   Q: 1083 ITSSAVsPGetPYLITGSDQGVIKIWNL 1110
           555555533359***************8 PP
   
Organism Saccharomyces cerevisiae
Functional Description
(View)

Functional Description


     Serine/threonine-protein kinase required for cytoplasm to vacuole transport (Cvt) and autophagy as a part of the autophagy-specific VPS34 PI3-kinase complex I. This complex is essential to recruit the ATG8-phosphatidylinositol conjugate and the ATG12-ATG5 conjugate to the pre-autophagosomal structure. Is also involved in endosome-to-Golgi retrograde transport as part of the VPS34 PI3-kinase complex II. This second complex is required for the endosome-to-Golgi retrieval of PEP1 and KEX2, and the recruitment of VPS5 and VPS7, two components of the retromer complex, to endosomal membranes (probably through the synthesis of a specific pool of phosphatidylinositol 3-phosphate recruiting the retromer to the endosomes). By regulating VPS34 kinase activity, VPS15 appears to be essential for the efficient delivery of soluble hydrolases to the yeast vacuole.
 Serine/threonine-protein kinase required for cytoplasm to vacuole transport (Cvt) and autophagy as a part of the autophagy-specific VPS34 PI3-kinase complex I. This complex is essential to recruit the ATG8-phosphatidylinositol conjugate and the ATG12-ATG5 conjugate to the pre-autophagosomal structure. Is also involved in endosome-to-Golgi retrograde transport as part of the VPS34 PI3-kinase complex II. This second complex is required for the endosome-to-Golgi retrieval of PEP1 and KEX2, and the recruitment of VPS5 and VPS7, two components of the retromer complex, to endosomal membranes (probably through the synthesis of a specific pool of phosphatidylinositol 3-phosphate recruiting the retromer to the endosomes). By regulating VPS34 kinase activity, VPS15 appears to be essential for the efficient delivery of soluble hydrolases to the yeast vacuole.
Protein Sequence
(Fasta)
MGAQLSLVVQ ASPSIAIFSY IDVLEEVHYV SQLNSSRFLK TCKALDPNGE IVIKVFIKPK 60
DQYSLRPFLQ RIRAQSFKLG QLPHVLNYSK LIETNRAGYM IRQHLKNNLY DRLSLRPYLQ 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Sce-106295|UBD,Beta-Prp;E3,WD_repeat|Saccharomyces cerevisiae
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGGGGGCAC AATTATCACT AGTGGTCCAA GCATCACCTT CCATAGCCAT TTTTTCATAT 60
ATCGATGTCT TAGAGGAAGT ACACTACGTT TCACAGTTAA ACTCATCAAG ATTCTTAAAA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Sce-106295|UBD,Beta-Prp;E3,WD_repeat|Saccharomyces cerevisiae
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0067--ATP-binding
KW-0072--Autophagy
KW-0181--Complete proteome
KW-0967--Endosome
KW-0333--Golgi apparatus
KW-0418--Kinase
KW-0449--Lipoprotein
KW-0472--Membrane
KW-0519--Myristate
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0677--Repeat
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase
KW-0813--Transport
KW-0853--WD repeat
Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR021133--HEAT_type_2
IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR008271--Ser/Thr_kinase_AS
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom
PROSITE

PS50077--HEAT_REPEAT
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00069--Pkinase
SMART

SM00220--S_TKc
SM00320--WD40
Gene Ontology

GO:0010008--C:endosome membrane
GO:0005794--C:Golgi apparatus
GO:0005770--C:late endosome
GO:0071561--C:nucleus-vacuole junction
GO:0034271--C:phosphatidylinositol 3-kinase complex, class III, type I
GO:0034272--C:phosphatidylinositol 3-kinase complex, class III, type II
GO:0005524--F:ATP binding
GO:0004674--F:protein serine/threonine kinase activity
GO:0043130--F:ubiquitin binding
GO:0048017--P:inositol lipid-mediated signaling
GO:0045324--P:late endosome to vacuole transport
GO:0016236--P:macroautophagy
GO:0030242--P:pexophagy
GO:0032968--P:positive regulation of transcription elongation from RNA polymerase II promoter
GO:0006468--P:protein phosphorylation
GO:0045053--P:protein retention in Golgi apparatus
GO:0006623--P:protein targeting to vacuole
GO:0000011--P:vacuole inheritance
KEGG sce:YBR097W
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000213 Aegilops tauschii 27.57 6.00e-36 144.00
IUUC-Aml-001659 Ailuropoda melanoleuca 33.37 1.00e-116 412.00
IUUC-Atr-002968 Amborella trichopoda 42.31 3.00e-39 155.00
IUUC-Apl-003418 Anas platyrhynchos 32.84 4.00e-115 407.00
IUUC-Aca-004344 Anolis carolinensis 32.63 5.00e-114 404.00
IUUC-Aly-006107 Arabidopsis lyrata 30.18 2.00e-98 352.00
IUUC-Ath-007260 Arabidopsis thaliana 43.24 6.00e-63 234.00
IUUC-Ago-007721 Ashbya gossypii 46.45 0.00e+00 1247.00
IUUC-Acl-008378 Aspergillus clavatus 33.87 2.00e-154 538.00
IUUC-Afl-008632 Aspergillus flavus 33.80 3.00e-148 518.00
IUUC-Afu-009020 Aspergillus fumigatus 33.47 3.00e-151 528.00
IUUC-Ani-009204 Aspergillus nidulans 33.76 3.00e-145 508.00
IUUC-Ang-009811 Aspergillus niger 33.78 7.00e-155 540.00
IUUC-Aor-010168 Aspergillus oryzae 33.80 3.00e-148 518.00
IUUC-Ate-010556 Aspergillus terreus 33.96 1.00e-150 526.00
IUUC-Ame-011955 Astyanax mexicanus 33.29 4.00e-123 434.00
IUUC-Bgr-012050 Blumeria graminis 34.69 5.00e-150 523.00
IUUC-Bta-012432 Bos taurus 33.00 3.00e-112 398.00
IUUC-Bci-013846 Botrytis cinerea 33.02 1.00e-152 532.00
IUUC-Bdi-015072 Brachypodium distachyon 40.74 5.00e-65 241.00
IUUC-Bol-015314 Brassica oleracea 30.53 4.00e-95 341.00
IUUC-Bra-017476 Brassica rapa 43.58 4.00e-62 231.00
IUUC-Cel-018550 Caenorhabditis elegans 35.69 4.00e-40 158.00
IUUC-Cja-019538 Callithrix jacchus 32.75 7.00e-111 393.00
IUUC-Cfa-020483 Canis familiaris 33.25 1.00e-116 412.00
IUUC-Cpo-021392 Cavia porcellus 33.42 5.00e-113 400.00
IUUC-Cre-022568 Chlamydomonas reinhardtii 27.12 2.00e-08 52.80
IUUC-Csa-024112 Chlorocebus sabaeus 33.25 4.00e-113 400.00
IUUC-Cho-025015 Choloepus hoffmanni 28.98 2.00e-62 232.00
IUUC-Cin-025209 Ciona intestinalis 42.22 3.00e-73 268.00
IUUC-Csv-026334 Ciona savignyi 42.27 7.00e-74 270.00
IUUC-Cgl-026447 Colletotrichum gloeosporioides 33.05 3.00e-153 534.00
IUUC-Cne-026999 Cryptococcus neoformans 36.27 6.00e-114 404.00
IUUC-Dre-028662 Danio rerio 32.29 2.00e-116 412.00
IUUC-Dno-029545 Dasypus novemcinctus 33.04 3.00e-111 395.00
IUUC-Dor-030941 Dipodomys ordii 25.82 2.00e-22 99.80
IUUC-Dse-031455 Dothistroma septosporum 33.37 2.00e-134 472.00
IUUC-Dme-031726 Drosophila melanogaster 31.46 6.00e-108 384.00
IUUC-Ete-033147 Echinops telfairi 31.63 9.00e-43 167.00
IUUC-Eca-034025 Equus caballus 40.41 9.00e-68 250.00
IUUC-Eeu-034480 Erinaceus europaeus 32.89 7.00e-89 320.00
IUUC-Fca-035741 Felis catus 33.13 7.00e-113 400.00
IUUC-Fal-037666 Ficedula albicollis 39.94 5.00e-71 261.00
IUUC-Fox-037818 Fusarium oxysporum 32.52 9.00e-137 479.00
IUUC-Fso-038086 Fusarium solani 31.78 6.00e-135 473.00
IUUC-Gmo-038804 Gadus morhua 39.52 5.00e-69 254.00
IUUC-Ggr-039800 Gaeumannomyces graminis 34.53 3.00e-149 521.00
IUUC-Gga-041251 Gallus gallus 28.49 8.00e-48 183.00
IUUC-Gac-042376 Gasterosteus aculeatus 40.72 7.00e-73 267.00
IUUC-Gma-044095 Glycine max 41.25 4.00e-60 225.00
IUUC-Ggo-044506 Gorilla gorilla 33.04 8.00e-113 400.00
IUUC-Hsa-045871 Homo sapiens 33.25 9.00e-113 399.00
IUUC-Hvu-047648 Hordeum vulgare 28.03 1.00e-35 143.00
IUUC-Itr-048082 Ictidomys tridecemlineatus 33.53 4.00e-90 323.00
IUUC-Kpa-049390 Komagataella pastoris 39.14 0.00e+00 642.00
IUUC-Lch-050284 Latimeria chalumnae 32.06 3.00e-108 384.00
IUUC-Lpe-050880 Leersia perrieri 43.75 2.00e-63 236.00
IUUC-Loc-052815 Lepisosteus oculatus 41.32 7.00e-75 274.00
IUUC-Lma-053324 Leptosphaeria maculans 34.49 1.00e-146 513.00
IUUC-Laf-054204 Loxodonta africana 30.03 8.00e-62 230.00
IUUC-Mcc-054612 Macaca mulatta 33.25 5.00e-113 400.00
IUUC-Meu-056227 Macropus eugenii 31.82 3.00e-15 75.90
IUUC-Mor-057094 Magnaporthe oryzae 29.16 1.00e-170 592.00
IUUC-Mtr-058550 Medicago truncatula 40.43 1.00e-60 227.00
IUUC-Mla-058893 Melampsora laricipopulina 32.93 9.00e-132 463.00
IUUC-Mga-059474 Meleagris gallopavo 33.20 6.00e-107 380.00
IUUC-Mvi-060227 Microbotryum violaceum 30.87 3.00e-123 434.00
IUUC-Mmr-061543 Microcebus murinus 32.84 3.00e-112 398.00
IUUC-Mdo-062129 Monodelphis domestica 32.59 1.00e-109 389.00
IUUC-Mmu-064381 Mus musculus 32.88 2.00e-112 398.00
IUUC-Mac-064455 Musa acuminata 32.09 5.00e-101 360.00
IUUC-Mpu-066151 Mustela putorius furo 33.21 1.00e-77 281.00
IUUC-Mlu-067824 Myotis lucifugus 33.00 1.00e-112 399.00
IUUC-Nfi-068241 Neosartorya fischeri 34.22 7.00e-155 540.00
IUUC-Ncr-068964 Neurospora crassa 29.94 1.00e-174 605.00
IUUC-Nle-069152 Nomascus leucogenys 33.25 4.00e-113 401.00
IUUC-Opr-070870 Ochotona princeps 29.80 1.00e-91 329.00
IUUC-Ont-071293 Oreochromis niloticus 32.88 2.00e-119 422.00
IUUC-Oan-072852 Ornithorhynchus anatinus 30.22 2.00e-97 348.00
IUUC-Ocu-074727 Oryctolagus cuniculus 32.96 2.00e-112 398.00
IUUC-Oba-075932 Oryza barthii 38.72 2.00e-63 236.00
IUUC-Obr-076424 Oryza brachyantha 45.00 1.00e-62 233.00
IUUC-Ogl-077491 Oryza glaberrima 38.72 2.00e-63 236.00
IUUC-Ogu-078933 Oryza glumaepatula 30.33 1.00e-95 343.00
IUUC-Oin-079604 Oryza indica 42.24 1.00e-66 246.00
IUUC-Olo-080850 Oryza longistaminata 31.08 5.00e-100 357.00
IUUC-Ome-081860 Oryza meridionalis 39.24 1.00e-66 246.00
IUUC-Oni-082895 Oryza nivara 36.76 1.00e-62 233.00
IUUC-Opu-083741 Oryza punctata 39.78 9.00e-67 247.00
IUUC-Oru-084616 Oryza rufipogon 38.12 3.00e-62 232.00
IUUC-Osa-085941 Oryza sativa 25.29 2.00e-11 62.00
IUUC-Ola-087357 Oryzias latipes 39.48 1.00e-66 244.00
IUUC-Olu-087659 Ostreococcus lucimarinus 38.29 8.00e-53 201.00
IUUC-Oga-088555 Otolemur garnettii 33.00 4.00e-112 397.00
IUUC-Oar-089304 Ovis aries 33.15 3.00e-98 350.00
IUUC-Ptr-091140 Pan troglodytes 33.25 8.00e-113 400.00
IUUC-Pan-092413 Papio anubis 32.75 1.00e-112 399.00
IUUC-Psi-093210 Pelodiscus sinensis 32.75 6.00e-115 407.00
IUUC-Pma-094449 Petromyzon marinus 42.72 5.00e-63 232.00
IUUC-Pno-094969 Phaeosphaeria nodorum 29.34 2.00e-154 538.00
IUUC-Ppa-095655 Physcomitrella patens 42.20 5.00e-73 268.00
IUUC-Pfo-096077 Poecilia formosa 41.32 3.00e-72 265.00
IUUC-Pab-098269 Pongo abelii 33.13 1.00e-112 399.00
IUUC-Pop-100052 Populus trichocarpa 41.69 2.00e-54 206.00
IUUC-Pca-100377 Procavia capensis 31.76 1.00e-110 392.00
IUUC-Ppe-101445 Prunus persica 30.79 1.00e-103 370.00
IUUC-Pva-102198 Pteropus vampyrus 33.00 3.00e-112 398.00
IUUC-Pgr-103544 Puccinia graminis 34.90 4.00e-131 461.00
IUUC-Ptt-103964 Puccinia triticina 33.91 1.00e-125 442.00
IUUC-Pte-104196 Pyrenophora teres 29.74 5.00e-172 597.00
IUUC-Pyt-104544 Pyrenophora triticirepentis 31.16 1.00e-178 619.00
IUUC-Rno-105256 Rattus norvegicus 32.88 1.00e-112 399.00
IUUC-Sha-107597 Sarcophilus harrisii 32.30 3.00e-114 404.00
IUUC-Sja-107781 Schizosaccharomyces japonicus 28.11 7.00e-129 453.00
IUUC-Spo-108031 Schizosaccharomyces pombe 31.63 7.00e-127 447.00
IUUC-Ssl-108579 Sclerotinia sclerotiorum 33.92 5.00e-150 523.00
IUUC-Smo-108679 Selaginella moellendorffii 31.34 2.00e-102 365.00
IUUC-Sit-110765 Setaria italica 39.63 3.00e-61 228.00
IUUC-Sly-111527 Solanum lycopersicum 43.03 1.00e-64 240.00
IUUC-Stu-112899 Solanum tuberosum 42.72 2.00e-64 239.00
IUUC-Sar-112986 Sorex araneus 32.42 5.00e-111 394.00
IUUC-Sbi-114604 Sorghum bicolor 40.34 7.00e-66 244.00
IUUC-Sre-115191 Sporisorium reilianum 30.70 1.00e-119 423.00
IUUC-Ssc-115440 Sus scrofa 32.58 5.00e-113 400.00
IUUC-Tgu-116633 Taeniopygia guttata 32.84 1.00e-113 402.00
IUUC-Tru-118439 Takifugu rubripes 32.92 1.00e-119 422.00
IUUC-Tsy-119472 Tarsius syrichta 29.14 5.00e-46 177.00
IUUC-Tni-119808 Tetraodon nigroviridis 32.29 3.00e-110 391.00
IUUC-Tca-121648 Theobroma cacao 43.92 2.00e-65 242.00
IUUC-Tre-122161 Trichoderma reesei 33.44 5.00e-141 494.00
IUUC-Tvi-122575 Trichoderma virens 32.67 6.00e-134 470.00
IUUC-Tae-123381 Triticum aestivum 44.18 2.00e-65 242.00
IUUC-Tur-126291 Triticum urartu 41.16 1.00e-65 243.00
IUUC-Tme-126979 Tuber melanosporum 50.00 2.00e-84 306.00
IUUC-Tbe-127576 Tupaia belangeri 45.49 1.00e-63 236.00
IUUC-Ttr-129106 Tursiops truncatus 32.83 1.00e-99 356.00
IUUC-Uma-129633 Ustilago maydis 31.22 1.00e-131 463.00
IUUC-Vda-130001 Verticillium dahliae 28.81 2.00e-154 538.00
IUUC-Vpa-130733 Vicugna pacos 28.24 3.00e-50 191.00
IUUC-Vvi-131318 Vitis vinifera 42.17 2.00e-65 243.00
IUUC-Xtr-131908 Xenopus tropicalis 33.13 6.00e-118 417.00
IUUC-Xma-133331 Xiphophorus maculatus 42.39 1.00e-72 266.00
IUUC-Yli-134651 Yarrowia lipolytica 35.54 2.00e-145 508.00
IUUC-Zma-135850 Zea mays 38.94 1.00e-63 236.00
Created Date 25-Jun-2017

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