iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	RAID2
Protein-protein Interaction
IID	HINT
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
UniProt	PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	2.90e-24	85.9	223	277

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
           +ek  v+y+y+a ++de++l++G vv+v+  +++ egW+k     +gk+G  P+ + +k
   Q: 223  EEKYTVIYPYTARDQDEMNLERGAVVEVV--QKNLEGWWKI--RYQGKEGWAPASYLKK 277
           67889************************..8899****88..9**********99886 PP

Organism

Mus musculus

Functional Description
(View)

Adapter protein involved in invadopodia and podosome formation and extracellular matrix degradation. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. Plays a role in mitotic clonal expansion during the immediate early stage of adipocyte differentiation.

Protein Sequence
(Fasta)

MPPRRSIVEV KVLDVQKRRV PNKHYVYIIR VTWSSGATEA IYRRYSKFFD LQMQMLDKFP 60
MEGGQKDPKQ RIIPFLPGKI LFRRSHIRDV AVKRLIPIDE YCKALIQLPP YISQCDEVLQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGCGGCAAGT GCTCGGCGGC AAGGATCGCT TTGGCCCGGC CCGGCCCGCA CGGCGCTGGG 60
CGCGGAGAAC GGCCATGCCG CCGCGGCGCA GTATCGTGGA GGTGAAGGTG CTGGACGTGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0965--Cell junction
KW-0966--Cell projection
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0221--Differentiation
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0728--SH3 domain

Interpro

IPR001683--Phox
IPR011511--SH3_2
IPR001452--SH3_domain
IPR030512--SH3PXD2B

PROSITE

PS50195--PX
PS50002--SH3

Pfam

PF00787--PX
PF00018--SH3_1
PF07653--SH3_2

SMART

SM00312--PX
SM00326--SH3

Gene Ontology

GO:0030054--C:cell junction
GO:0042995--C:cell projection
GO:0005737--C:cytoplasm
GO:0002102--C:podosome
GO:0080025--F:phosphatidylinositol-3,5-bisphosphate binding
GO:0032266--F:phosphatidylinositol-3-phosphate binding
GO:0070273--F:phosphatidylinositol-4-phosphate binding
GO:0010314--F:phosphatidylinositol-5-phosphate binding
GO:0042169--F:SH2 domain binding
GO:0016176--F:superoxide-generating NADPH oxidase activator activity
GO:0060612--P:adipose tissue development
GO:0060348--P:bone development
GO:1904888--P:cranial skeletal system development
GO:0022617--P:extracellular matrix disassembly
GO:0001654--P:eye development
GO:0007507--P:heart development
GO:0002051--P:osteoblast fate commitment
GO:0055114--P:oxidation-reduction process
GO:0071800--P:podosome assembly
GO:1904179--P:positive regulation of adipose tissue development
GO:0045600--P:positive regulation of fat cell differentiation
GO:0010628--P:positive regulation of gene expression
GO:0040018--P:positive regulation of multicellular organism growth
GO:0051496--P:positive regulation of stress fiber assembly
GO:0072657--P:protein localization to membrane
GO:0060378--P:regulation of brood size
GO:0001501--P:skeletal system development
GO:0048705--P:skeletal system morphogenesis
GO:0006801--P:superoxide metabolic process

KEGG

mmu:268396

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001572	Ailuropoda melanoleuca	85.78	0.00e+00	1498.00
IUUC-Apl-003349	Anas platyrhynchos	65.87	0.00e+00	1050.00
IUUC-Aca-004769	Anolis carolinensis	66.03	0.00e+00	1079.00
IUUC-Ame-011734	Astyanax mexicanus	47.89	4.00e-136	479.00
IUUC-Bta-012847	Bos taurus	83.24	0.00e+00	1439.00
IUUC-Bci-013600	Botrytis cinerea	32.81	2.00e-14	74.30
IUUC-Cja-019338	Callithrix jacchus	85.43	0.00e+00	1439.00
IUUC-Cfa-020751	Canis familiaris	84.95	0.00e+00	1461.00
IUUC-Cpo-021623	Cavia porcellus	84.23	0.00e+00	1405.00
IUUC-Csa-023399	Chlorocebus sabaeus	86.86	0.00e+00	1463.00
IUUC-Cho-024720	Choloepus hoffmanni	84.45	4.00e-102	365.00
IUUC-Cin-025592	Ciona intestinalis	38.67	9.00e-88	317.00
IUUC-Csv-026038	Ciona savignyi	38.27	3.00e-85	308.00
IUUC-Cgl-026496	Colletotrichum gloeosporioides	31.54	2.00e-14	73.90
IUUC-Cne-026892	Cryptococcus neoformans	27.94	4.00e-09	57.00
IUUC-Dno-029443	Dasypus novemcinctus	80.55	0.00e+00	1192.00
IUUC-Dor-030546	Dipodomys ordii	79.59	0.00e+00	1358.00
IUUC-Ete-032485	Echinops telfairi	71.83	0.00e+00	1127.00
IUUC-Eca-033780	Equus caballus	83.99	0.00e+00	1380.00
IUUC-Fca-036365	Felis catus	83.59	0.00e+00	1415.00
IUUC-Fal-036632	Ficedula albicollis	70.93	0.00e+00	848.00
IUUC-Fox-037760	Fusarium oxysporum	32.69	1.00e-13	71.20
IUUC-Fso-038453	Fusarium solani	33.65	2.00e-13	71.20
IUUC-Gmo-039101	Gadus morhua	69.80	2.00e-145	510.00
IUUC-Ggr-039899	Gaeumannomyces graminis	31.06	4.00e-14	73.20
IUUC-Gga-041167	Gallus gallus	63.89	0.00e+00	1040.00
IUUC-Gac-041676	Gasterosteus aculeatus	56.01	0.00e+00	670.00
IUUC-Ggo-045275	Gorilla gorilla	84.14	0.00e+00	1413.00
IUUC-Hsa-046483	Homo sapiens	85.79	0.00e+00	1453.00
IUUC-Itr-048237	Ictidomys tridecemlineatus	81.96	0.00e+00	1309.00
IUUC-Kpa-049363	Komagataella pastoris	31.09	3.00e-15	76.60
IUUC-Lch-049474	Latimeria chalumnae	58.99	0.00e+00	937.00
IUUC-Loc-052659	Lepisosteus oculatus	59.79	0.00e+00	801.00
IUUC-Laf-054220	Loxodonta africana	84.68	0.00e+00	1419.00
IUUC-Mcc-055001	Macaca mulatta	85.29	0.00e+00	1430.00
IUUC-Meu-056086	Macropus eugenii	69.91	0.00e+00	1127.00
IUUC-Mor-057190	Magnaporthe oryzae	33.65	1.00e-13	71.60
IUUC-Mpo-057398	Magnaporthe poae	33.65	8.00e-14	72.40
IUUC-Mga-059772	Meleagris gallopavo	64.49	0.00e+00	1014.00
IUUC-Mmr-061321	Microcebus murinus	77.50	0.00e+00	1293.00
IUUC-Mdo-061943	Monodelphis domestica	72.52	0.00e+00	1259.00
IUUC-Mpu-065848	Mustela putorius furo	83.76	0.00e+00	1514.00
IUUC-Mlu-067413	Myotis lucifugus	81.76	0.00e+00	1293.00
IUUC-Nle-069834	Nomascus leucogenys	90.33	0.00e+00	1056.00
IUUC-Opr-070355	Ochotona princeps	76.98	0.00e+00	1135.00
IUUC-Ont-071453	Oreochromis niloticus	50.51	2.00e-127	450.00
IUUC-Oan-073473	Ornithorhynchus anatinus	73.52	0.00e+00	835.00
IUUC-Ocu-073822	Oryctolagus cuniculus	79.95	0.00e+00	1316.00
IUUC-Oga-088006	Otolemur garnettii	86.39	0.00e+00	1473.00
IUUC-Oar-090176	Ovis aries	82.00	0.00e+00	1406.00
IUUC-Ptr-090730	Pan troglodytes	83.62	0.00e+00	1409.00
IUUC-Pan-092549	Papio anubis	84.38	0.00e+00	1143.00
IUUC-Pfo-096582	Poecilia formosa	57.12	0.00e+00	679.00
IUUC-Pab-097634	Pongo abelii	86.01	0.00e+00	1459.00
IUUC-Pca-101110	Procavia capensis	75.70	0.00e+00	1098.00
IUUC-Pva-103256	Pteropus vampyrus	79.83	0.00e+00	827.00
IUUC-Rno-106109	Rattus norvegicus	94.41	0.00e+00	1417.00
IUUC-Sce-106380	Saccharomyces cerevisiae	31.86	6.00e-11	62.40
IUUC-Spo-108303	Schizosaccharomyces pombe	28.44	2.00e-10	60.80
IUUC-Ssl-108480	Sclerotinia sclerotiorum	31.90	2.00e-12	67.80
IUUC-Sre-114971	Sporisorium reilianum	34.04	2.00e-10	61.20
IUUC-Ssc-115251	Sus scrofa	81.93	0.00e+00	1316.00
IUUC-Tgu-116480	Taeniopygia guttata	63.32	0.00e+00	944.00
IUUC-Tru-117751	Takifugu rubripes	67.85	3.00e-175	609.00
IUUC-Tni-120253	Tetraodon nigroviridis	53.78	4.00e-175	608.00
IUUC-Tre-121970	Trichoderma reesei	35.24	3.00e-14	73.60
IUUC-Tvi-122571	Trichoderma virens	34.29	8.00e-14	72.00
IUUC-Tme-127033	Tuber melanosporum	33.33	2.00e-13	70.90
IUUC-Tbe-127871	Tupaia belangeri	78.98	0.00e+00	1004.00
IUUC-Ttr-128955	Tursiops truncatus	84.57	0.00e+00	1479.00
IUUC-Uma-129402	Ustilago maydis	34.04	2.00e-10	61.20
IUUC-Vda-129885	Verticillium dahliae	33.65	1.00e-13	71.60
IUUC-Xtr-132258	Xenopus tropicalis	58.87	0.00e+00	897.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence