iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Kpa-049231

Ensembl Protein ID

CAY67689

UniProt Accession

C4QWR6; C4QWR6_KOMPG

Genbank Protein ID

CAY67689.1

Protein Name

Cullin, structural protein of SCF complexes, involved in ubiquination

Genbank Nucleotide ID

FN392319

Gene Name

PAS_chr1-1_0312

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
PAS_chr1-1_0312	CAY67689	CAY67689

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/Cullin	6.80e-164	545.0	33	681

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/Cullin

   S: 14   sv.kkeyeelytavynlclsk......................vgaklYkklkevleefikqvkkkveesedeqlLktynreWekfreqlkvlrkifayld 91
           +v  k y+++yta+yn+c++k                      vg ++Y kl+++l e+i+q++kk ees    +L++y+r W +f++++ +l+++f+y++
   Q: 33   TVtPKMYMNVYTAIYNYCINKsrtptqdssygsgsnsttnaslVGGEIYLKLQQYLIEYIQQLEKKPEES----FLQFYVRRWVRFTIGAGYLNNVFDYMN 129
           455789***********************************************************99999....*************************** PP
   S: 92   rtyvkk.....skkvsevrkLaldlwrkeivedikkrllelllklieaeRkgeavdrrllsgvveslveLslnk.......laiykesFEakfleatqefy 180
           r++vkk     ++++++v++L l +wr+ +++++ + lle +l+ +e +R  ++  +  +s +++s+v+L+ +        l++y ++FE+++l+at +fy
   Q: 130  RYWVKKersngRRDIYDVNTLCLLTWRDFMFRPNLEILLEEILTQVELQRLHKIELNMEISFAIKSFVSLGFDIndlkkqnLSVYITDFEKAYLDATLKFY 230
           ******988888888**************************************999999************99999************************* PP
   S: 181  kaesaeflqenevdeYlkkvearlneeeeraaryleestetkLlevvekeliakhlesllaelvallrdkktedlsrmykLlsrvlngleellkeleshik 281
           ++es+efl+ n+v eY+kkv++rl ee++ra+ +l e t+ +L+ v++++li+ h+e +++e+++ll++k+ted+ rmy+Ll+rv+++le+ll ++e+++k
   Q: 231  TEESDEFLETNGVVEYMKKVDTRLAEENSRANIILIEHTKRPLADVLNNALIERHVEVMYEEFNNLLDQKQTEDIYRMYSLLQRVPPTLEPLLIKFEAYVK 331
           ***************************************************************************************************** PP
   S: 282  eqgkaaltaeekek................dpkkyVerllelknklqklvseaFnndakFlkaldkafetfvnknsvlka.............akspEllA 353
           +qg++a+++ ++++                 pk y+++ll+++++++++v +aF+n++ F+k+ld+a+++ +n+ns++               +k+pEllA
   Q: 332  QQGLKAVAELKQSQaaaesmgaaskkyqalLPKLYIKTLLQVYERFNEVVYMAFGNNPLFVKSLDNACRDYINNNSIAMPgidnngptvfkgnSKTPELLA 432
           ********77777777899*********9999*******************************************99999********************* PP
   S: 354  ryiDqlLrksskglteeeleaqldkvllvfkyisekdvFekyYkkhLakRLlsgksasseaEesviekLkeecgaeftskLerMfqdlkvSedlnrqFkee 454
           ry D lL+k +k   ++  ++  d+++ +fk+i++kd Fe +Y+++La+RL++g+++s+e Ees+i+kLke +++e+t k+++Mf d+k+S+dl   Fk  
   Q: 433  RYGDTLLKKKAKD-SDATADMSADELMNIFKFIADKDAFETHYRRLLARRLINGNMVSEEEEESIIQKLKEFNSLEYTTKMSNMFADMKASKDLRYWFK-- 530
           **********776.57889********************************************************************************.. PP
   S: 455  kenteesesvelsvlvLsagaWptasetekvsLPaelektiekfeefYlekhsgRkLqWqhtlgraelkaelkkg...kyelqVstfQmavLLafnnsekv 552
             ++ees + +l++ vLs+ aWp+ + ++ ++LP el  t e+fe+ Y+ekhsgR+L+W+++l+r+e+ka+l+     +++l+V  fQm +LL fn++e++
   Q: 531  --EQEESDNTDLNIFVLSQTAWPFPQFKQPFTLPDELLGTKEQFEKLYSEKHSGRRLKWLWNLCRGEMKANLARPgkpPFILTVNLFQMSILLPFNKRETY 629
           ..778899****************977777****************************************996545779********************** PP
   S: 553  sveelkkatelpeeeLrrtlqsLvsskkqvlkkepeske..ieeedlfsvNqef 604
           s+eel+++t+l +e L+ ++ +Lv+ k  +l ++pe++e   ++ ++f+v +e+
   Q: 630  SFEELHEITNLTPEHLESCITPLVKYK--LLIQSPEGSEntGKSSTKFTVVKEY 681
           *************************98..9999999977556677888887776 PP

Organism

Komagataella pastoris

Protein Sequence
(Fasta)

MAEKLPKSDD LKATWSFVEP GLQLILGSDS VATVTPKMYM NVYTAIYNYC INKSRTPTQD 60
SSYGSGSNST TNASLVGGEI YLKLQQYLIE YIQQLEKKPE ESFLQFYVRR WVRFTIGAGY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCTGAGA AACTACCCAA ATCTGATGAT CTAAAAGCTA CATGGTCTTT TGTAGAACCT 60
GGACTCCAAT TGATTCTTGG AAGCGACTCA GTGGCCACGG TTACTCCCAA AATGTACATG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR016157--Cullin_CS
IPR016158--Cullin_homology
IPR001373--Cullin_N
IPR019559--Cullin_neddylation_domain
IPR016159--Cullin_repeat-like_dom
IPR011991--WHTH_DNA-bd_dom

PROSITE

PS01256--CULLIN_1
PS50069--CULLIN_2

Pfam

PF00888--Cullin
PF10557--Cullin_Nedd8

SMART

SM00182--CULLIN
SM00884--Cullin_Nedd8

Gene Ontology

GO:0005829--C:cytosol
GO:0043224--C:nuclear SCF ubiquitin ligase complex
GO:0003688--F:DNA replication origin binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0000082--P:G1/S transition of mitotic cell cycle
GO:0000086--P:G2/M transition of mitotic cell cycle
GO:1903467--P:negative regulation of mitotic DNA replication initiation
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

KEGG

ppa:PAS_chr1-1_0312

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002277	Ailuropoda melanoleuca	38.61	2.00e-141	493.00
IUUC-Apl-003503	Anas platyrhynchos	37.08	2.00e-109	387.00
IUUC-Aca-004534	Anolis carolinensis	28.61	8.00e-93	332.00
IUUC-Ago-007977	Ashbya gossypii	48.32	0.00e+00	709.00
IUUC-Acl-008190	Aspergillus clavatus	39.22	3.00e-150	523.00
IUUC-Afl-008542	Aspergillus flavus	38.22	4.00e-116	410.00
IUUC-Afu-009007	Aspergillus fumigatus	40.58	1.00e-143	501.00
IUUC-Ani-009290	Aspergillus nidulans	38.40	1.00e-154	537.00
IUUC-Ang-009600	Aspergillus niger	41.35	5.00e-150	522.00
IUUC-Aor-009978	Aspergillus oryzae	39.71	7.00e-130	455.00
IUUC-Ate-010584	Aspergillus terreus	38.84	9.00e-154	535.00
IUUC-Ame-011861	Astyanax mexicanus	38.43	1.00e-136	478.00
IUUC-Bgr-012209	Blumeria graminis	40.05	4.00e-145	506.00
IUUC-Bta-012878	Bos taurus	38.61	3.00e-141	493.00
IUUC-Bci-013941	Botrytis cinerea	40.05	6.00e-160	555.00
IUUC-Cel-018294	Caenorhabditis elegans	34.63	2.00e-121	427.00
IUUC-Cja-018965	Callithrix jacchus	37.78	7.00e-134	469.00
IUUC-Cfa-020671	Canis familiaris	38.61	3.00e-141	493.00
IUUC-Cpo-021762	Cavia porcellus	38.61	2.00e-141	493.00
IUUC-Csa-023873	Chlorocebus sabaeus	38.61	2.00e-141	493.00
IUUC-Cin-025547	Ciona intestinalis	36.74	7.00e-129	452.00
IUUC-Csv-026083	Ciona savignyi	36.40	2.00e-137	481.00
IUUC-Cgl-026452	Colletotrichum gloeosporioides	38.42	1.00e-154	538.00
IUUC-Cne-026919	Cryptococcus neoformans	36.18	3.00e-133	466.00
IUUC-Dre-027875	Danio rerio	37.41	9.00e-137	478.00
IUUC-Dno-028931	Dasypus novemcinctus	38.61	4.00e-140	489.00
IUUC-Dor-030846	Dipodomys ordii	40.00	2.00e-96	344.00
IUUC-Dse-031472	Dothistroma septosporum	39.64	2.00e-154	537.00
IUUC-Dme-031793	Drosophila melanogaster	35.96	2.00e-133	467.00
IUUC-Ete-033112	Echinops telfairi	42.25	3.00e-50	191.00
IUUC-Eca-034309	Equus caballus	38.61	3.00e-141	493.00
IUUC-Fca-036330	Felis catus	37.39	6.00e-133	466.00
IUUC-Fal-036899	Ficedula albicollis	36.90	5.00e-113	399.00
IUUC-Fox-037705	Fusarium oxysporum	36.56	6.00e-147	512.00
IUUC-Fso-038367	Fusarium solani	36.94	3.00e-150	523.00
IUUC-Gmo-038708	Gadus morhua	37.96	3.00e-136	477.00
IUUC-Ggr-039917	Gaeumannomyces graminis	37.34	5.00e-149	519.00
IUUC-Gga-041038	Gallus gallus	38.61	3.00e-141	493.00
IUUC-Gac-041820	Gasterosteus aculeatus	38.35	1.00e-142	498.00
IUUC-Ggo-045235	Gorilla gorilla	30.55	3.00e-90	323.00
IUUC-Hsa-046034	Homo sapiens	38.61	2.00e-141	493.00
IUUC-Itr-048285	Ictidomys tridecemlineatus	38.61	3.00e-141	493.00
IUUC-Lch-049673	Latimeria chalumnae	38.48	5.00e-140	489.00
IUUC-Loc-052490	Lepisosteus oculatus	38.81	8.00e-138	482.00
IUUC-Lma-053191	Leptosphaeria maculans	38.80	2.00e-147	513.00
IUUC-Laf-054582	Loxodonta africana	38.48	1.00e-140	491.00
IUUC-Mcc-055162	Macaca mulatta	38.10	3.00e-136	477.00
IUUC-Meu-055904	Macropus eugenii	37.13	3.00e-47	181.00
IUUC-Mor-057035	Magnaporthe oryzae	36.15	1.00e-138	484.00
IUUC-Mpo-057555	Magnaporthe poae	37.34	7.00e-149	518.00
IUUC-Mla-059021	Melampsora laricipopulina	37.05	3.00e-137	480.00
IUUC-Mga-060078	Meleagris gallopavo	38.61	3.00e-141	493.00
IUUC-Mvi-060519	Microbotryum violaceum	37.47	1.00e-141	495.00
IUUC-Mmr-061312	Microcebus murinus	38.61	2.00e-141	493.00
IUUC-Mdo-062867	Monodelphis domestica	38.35	3.00e-140	489.00
IUUC-Mmu-063336	Mus musculus	38.61	3.00e-141	493.00
IUUC-Mpu-066400	Mustela putorius furo	36.90	6.00e-113	399.00
IUUC-Mlu-067800	Myotis lucifugus	38.61	2.00e-141	494.00
IUUC-Nfi-068384	Neosartorya fischeri	37.64	3.00e-146	510.00
IUUC-Ncr-068965	Neurospora crassa	38.85	2.00e-152	530.00
IUUC-Nle-069729	Nomascus leucogenys	38.61	2.00e-141	493.00
IUUC-Opr-071197	Ochotona princeps	28.85	1.00e-70	258.00
IUUC-Ont-071729	Oreochromis niloticus	38.74	3.00e-140	489.00
IUUC-Oan-073309	Ornithorhynchus anatinus	38.61	2.00e-141	494.00
IUUC-Ocu-074661	Oryctolagus cuniculus	38.48	7.00e-140	489.00
IUUC-Ola-087422	Oryzias latipes	38.66	1.00e-139	488.00
IUUC-Oga-088130	Otolemur garnettii	38.61	2.00e-141	493.00
IUUC-Oar-089510	Ovis aries	36.92	1.00e-127	448.00
IUUC-Ptr-090665	Pan troglodytes	38.61	2.00e-141	493.00
IUUC-Pan-092218	Papio anubis	38.61	2.00e-141	493.00
IUUC-Psi-093175	Pelodiscus sinensis	38.61	4.00e-141	493.00
IUUC-Pma-094502	Petromyzon marinus	38.69	1.00e-140	491.00
IUUC-Pno-095067	Phaeosphaeria nodorum	38.92	6.00e-157	545.00
IUUC-Pfo-096705	Poecilia formosa	38.49	8.00e-143	498.00
IUUC-Pab-097578	Pongo abelii	38.61	2.00e-141	493.00
IUUC-Pca-100242	Procavia capensis	39.33	3.00e-97	347.00
IUUC-Pva-102155	Pteropus vampyrus	33.16	1.00e-106	379.00
IUUC-Pgr-103297	Puccinia graminis	35.58	1.00e-134	471.00
IUUC-Ptt-103706	Puccinia triticina	32.13	2.00e-66	245.00
IUUC-Pte-104257	Pyrenophora teres	39.02	4.00e-157	546.00
IUUC-Pyt-104795	Pyrenophora triticirepentis	39.14	1.00e-157	547.00
IUUC-Rno-105939	Rattus norvegicus	38.61	3.00e-141	493.00
IUUC-Sce-106293	Saccharomyces cerevisiae	43.81	0.00e+00	652.00
IUUC-Sha-106949	Sarcophilus harrisii	38.61	2.00e-141	493.00
IUUC-Sja-107737	Schizosaccharomyces japonicus	37.55	4.00e-140	489.00
IUUC-Spo-108280	Schizosaccharomyces pombe	36.31	5.00e-136	476.00
IUUC-Sar-113138	Sorex araneus	31.82	1.00e-92	332.00
IUUC-Sre-114984	Sporisorium reilianum	36.57	3.00e-130	456.00
IUUC-Ssc-115829	Sus scrofa	38.01	7.00e-138	482.00
IUUC-Tgu-116950	Taeniopygia guttata	38.61	3.00e-141	493.00
IUUC-Tru-118558	Takifugu rubripes	38.28	4.00e-142	496.00
IUUC-Tsy-119621	Tarsius syrichta	32.16	7.00e-69	253.00
IUUC-Tni-120460	Tetraodon nigroviridis	38.35	9.00e-143	498.00
IUUC-Tre-122223	Trichoderma reesei	37.32	2.00e-140	490.00
IUUC-Tvi-122539	Trichoderma virens	36.68	2.00e-136	477.00
IUUC-Tme-126926	Tuber melanosporum	39.02	1.00e-153	535.00
IUUC-Tbe-127369	Tupaia belangeri	40.64	6.00e-57	213.00
IUUC-Ttr-129022	Tursiops truncatus	37.60	6.00e-104	369.00
IUUC-Uma-129341	Ustilago maydis	37.32	2.00e-128	451.00
IUUC-Vda-129857	Verticillium dahliae	36.66	2.00e-141	493.00
IUUC-Vpa-130166	Vicugna pacos	34.73	2.00e-101	360.00
IUUC-Xtr-131818	Xenopus tropicalis	38.43	3.00e-141	493.00
IUUC-Xma-134206	Xiphophorus maculatus	38.48	1.00e-138	484.00
IUUC-Yli-134486	Yarrowia lipolytica	37.31	3.00e-148	516.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence