iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046666

UUCD1 version

UUC-HoS-00051

Ensembl Protein ID

ENSP00000326731.5

UniProt Accession

O95628; B7Z6I4; E7ET38; F8VQP3; O95339; O95627; Q8IYM7; Q8NCL0; Q9NPQ1; Q9NZN6; CNOT4_HUMAN

Genbank Protein ID

AAD00179.1; AAD00180.1; AAF29829.1; CAB97536.1; BAC11125.1; BAH13270.1; AAH35590.1; AAC72963.1

Protein Name

CCR4-NOT transcription complex subunit 4; CCR4-associated factor 4; E3 ubiquitin-protein ligase CNOT4; Potential transcriptional repressor NOT4Hp; RING-type E3 ubiquitin transferase CNOT4

Genbank Nucleotide ID

U71267; U71268; AF180475; AL389980; AK074671; AK300365; AC083871; AF091094

Gene Name

CNOT4; NOT4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000080802.18	ENST00000451834.5	ENSP00000388491.1
ENSG00000080802.18	ENST00000423368.6	ENSP00000406777.2
ENSG00000080802.18	ENST00000361528.8	ENSP00000354673.4
ENSG00000080802.18	ENST00000414802.5	ENSP00000416532.1
ENSG00000080802.18	ENST00000428680.6	ENSP00000399108.2
ENSG00000080802.18	ENST00000541284.5	ENSP00000445508.1
ENSG00000080802.18	ENST00000315544.6	ENSP00000326731.5
ENSG00000080802.18	ENST00000356162.5	ENSP00000348485.5

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
miRWalk	RepTar	miRNAMap	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	HPRD
Phospho.ELM	UniProt	PHOSIDA	BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	19346402

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	0.93	11.7	14	57

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledf..kdgplvlp..CgHvfhadClqkwpglknssskefrCPlCr 46
           C++C+e++  +d   + p  Cg ++++ C++++      +  + +CP Cr
   Q: 14   CPLCMEPLeiDD-INFFPctCGYQICRFCWHRI-----RTDENGLCPACR 57
           ******997644.4444434999******9999.....5777778****8 PP

Organism

Homo sapiens

Functional Description
(View)

Has E3 ubiquitin ligase activity. Involved in activation of the JAK/STAT pathway.

Protein Sequence
(Fasta)

MSRSPDAKED PVECPLCMEP LEIDDINFFP CTCGYQICRF CWHRIRTDEN GLCPACRKPY 60
PEDPAVYKPL SQEELQRIKN EKKQKQNERK QKISENRKHL ASVRVVQKNL VFVVGLSQRL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGCGTGCGCC TGCGCACGGG AGGCCGGAGG AGTCTTACCC TAATGTAAGA TGGTGGCCCG 60
TCTGGCTGTG GAACCCACCG AAAGCTGAGA GTCTCTCTCT CAGCCGTAAA GGTCGGACTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0488--Methylation
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0694--RNA-binding
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR034261--CNOT4_RRM
IPR012677--Nucleotide-bd_a/b_plait
IPR000504--RRM_dom
IPR003954--RRM_dom_euk
IPR000571--Znf_CCCH
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50102--RRM
PS50103--ZF_C3H1
PS50089--ZF_RING_2

Pfam

PF00076--RRM_1

SMART

SM00361--RRM_1

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0000166--F:nucleotide binding
GO:0003723--F:RNA binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006977--P:DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0000289--P:nuclear-transcribed mRNA poly(A) tail shortening
GO:0051865--P:protein autoubiquitination

KEGG

hsa:4850

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000464	Aegilops tauschii	42.48	8.00e-54	206.00
IUUC-Aml-002384	Ailuropoda melanoleuca	99.45	0.00e+00	1048.00
IUUC-Atr-002462	Amborella trichopoda	46.64	4.00e-61	230.00
IUUC-Apl-003756	Anas platyrhynchos	87.48	0.00e+00	1004.00
IUUC-Aca-004643	Anolis carolinensis	87.48	0.00e+00	966.00
IUUC-Aly-006093	Arabidopsis lyrata	39.76	8.00e-55	209.00
IUUC-Ath-007371	Arabidopsis thaliana	41.73	2.00e-54	207.00
IUUC-Ago-007799	Ashbya gossypii	48.94	1.00e-56	214.00
IUUC-Acl-008077	Aspergillus clavatus	39.21	7.00e-41	163.00
IUUC-Afl-008720	Aspergillus flavus	40.09	3.00e-45	178.00
IUUC-Afu-008905	Aspergillus fumigatus	40.00	5.00e-42	167.00
IUUC-Ani-009264	Aspergillus nidulans	40.44	6.00e-27	116.00
IUUC-Ang-009537	Aspergillus niger	40.09	8.00e-45	176.00
IUUC-Aor-010123	Aspergillus oryzae	35.68	6.00e-28	120.00
IUUC-Ate-010409	Aspergillus terreus	40.97	3.00e-45	178.00
IUUC-Ame-011538	Astyanax mexicanus	96.05	2.00e-131	463.00
IUUC-Bgr-012062	Blumeria graminis	43.59	2.00e-54	208.00
IUUC-Bta-012419	Bos taurus	99.63	0.00e+00	1039.00
IUUC-Bci-013633	Botrytis cinerea	43.35	2.00e-53	205.00
IUUC-Bdi-014913	Brachypodium distachyon	43.81	5.00e-54	206.00
IUUC-Bol-016407	Brassica oleracea	44.80	5.00e-57	216.00
IUUC-Bra-017755	Brassica rapa	45.25	2.00e-57	217.00
IUUC-Cel-018123	Caenorhabditis elegans	59.66	4.00e-85	309.00
IUUC-Cja-019705	Callithrix jacchus	98.89	0.00e+00	1035.00
IUUC-Cfa-020440	Canis familiaris	98.89	0.00e+00	1038.00
IUUC-Cpo-022091	Cavia porcellus	94.26	0.00e+00	1066.00
IUUC-Cre-022872	Chlamydomonas reinhardtii	35.71	1.00e-11	64.70
IUUC-Csa-024202	Chlorocebus sabaeus	99.26	0.00e+00	1016.00
IUUC-Cho-024410	Choloepus hoffmanni	99.47	4.00e-100	359.00
IUUC-Cin-025558	Ciona intestinalis	70.04	2.00e-112	399.00
IUUC-Cgl-026687	Colletotrichum gloeosporioides	45.57	7.00e-56	212.00
IUUC-Cne-027084	Cryptococcus neoformans	37.75	2.00e-44	174.00
IUUC-Cme-027148	Cyanidioschyzon merolae	30.39	7.00e-22	99.00
IUUC-Dre-028377	Danio rerio	96.03	3.00e-130	459.00
IUUC-Dno-029100	Dasypus novemcinctus	98.71	0.00e+00	1068.00
IUUC-Dor-030310	Dipodomys ordii	85.08	0.00e+00	728.00
IUUC-Dse-031514	Dothistroma septosporum	42.51	1.00e-48	188.00
IUUC-Dme-031735	Drosophila melanogaster	73.47	4.00e-107	383.00
IUUC-Ete-033091	Echinops telfairi	95.76	0.00e+00	1004.00
IUUC-Eca-033506	Equus caballus	98.89	0.00e+00	1032.00
IUUC-Eeu-034506	Erinaceus europaeus	92.25	0.00e+00	984.00
IUUC-Fca-036033	Felis catus	98.78	0.00e+00	1100.00
IUUC-Fal-037540	Ficedula albicollis	88.16	0.00e+00	1024.00
IUUC-Fox-037944	Fusarium oxysporum	46.29	5.00e-58	219.00
IUUC-Fso-038172	Fusarium solani	42.55	4.00e-47	184.00
IUUC-Gmo-039211	Gadus morhua	58.92	5.00e-164	571.00
IUUC-Ggr-040096	Gaeumannomyces graminis	47.68	8.00e-61	229.00
IUUC-Gga-040487	Gallus gallus	88.16	0.00e+00	1021.00
IUUC-Gac-042294	Gasterosteus aculeatus	58.25	2.00e-159	556.00
IUUC-Gma-043229	Glycine max	45.11	6.00e-56	213.00
IUUC-Ggo-044950	Gorilla gorilla	99.59	0.00e+00	900.00
IUUC-Hvu-047405	Hordeum vulgare	42.92	8.00e-54	206.00
IUUC-Itr-047888	Ictidomys tridecemlineatus	100.00	3.00e-152	530.00
IUUC-Kpa-049260	Komagataella pastoris	47.03	1.00e-54	207.00
IUUC-Lch-050203	Latimeria chalumnae	83.81	0.00e+00	945.00
IUUC-Lpe-051195	Leersia perrieri	43.67	4.00e-53	203.00
IUUC-Loc-052886	Lepisosteus oculatus	78.89	0.00e+00	835.00
IUUC-Lma-053073	Leptosphaeria maculans	43.67	5.00e-52	199.00
IUUC-Laf-053490	Loxodonta africana	97.79	0.00e+00	1021.00
IUUC-Mcc-055724	Macaca mulatta	100.00	0.00e+00	1030.00
IUUC-Meu-056787	Macropus eugenii	82.47	0.00e+00	825.00
IUUC-Mor-056921	Magnaporthe oryzae	47.01	5.00e-59	222.00
IUUC-Mpo-057616	Magnaporthe poae	47.26	8.00e-60	225.00
IUUC-Mtr-058426	Medicago truncatula	43.35	9.00e-53	202.00
IUUC-Mla-059146	Melampsora laricipopulina	41.70	1.00e-45	178.00
IUUC-Mga-059372	Meleagris gallopavo	87.65	0.00e+00	1002.00
IUUC-Mvi-060479	Microbotryum violaceum	36.04	6.00e-31	130.00
IUUC-Mmr-061012	Microcebus murinus	99.63	0.00e+00	1052.00
IUUC-Mdo-062330	Monodelphis domestica	97.23	0.00e+00	1020.00
IUUC-Mmu-063894	Mus musculus	98.15	0.00e+00	1059.00
IUUC-Mac-064805	Musa acuminata	45.33	1.00e-57	217.00
IUUC-Mpu-066894	Mustela putorius furo	98.89	0.00e+00	1038.00
IUUC-Mlu-067321	Myotis lucifugus	99.63	0.00e+00	1038.00
IUUC-Nfi-068451	Neosartorya fischeri	39.65	5.00e-42	167.00
IUUC-Ncr-068667	Neurospora crassa	45.85	2.00e-52	202.00
IUUC-Nle-070058	Nomascus leucogenys	99.63	0.00e+00	994.00
IUUC-Opr-071108	Ochotona princeps	75.65	0.00e+00	793.00
IUUC-Ont-071541	Oreochromis niloticus	88.32	1.00e-129	457.00
IUUC-Oan-073232	Ornithorhynchus anatinus	95.96	0.00e+00	1002.00
IUUC-Ocu-074893	Oryctolagus cuniculus	98.89	0.00e+00	1009.00
IUUC-Oba-075623	Oryza barthii	39.38	2.00e-28	119.00
IUUC-Obr-076653	Oryza brachyantha	43.36	3.00e-55	210.00
IUUC-Ogl-077946	Oryza glaberrima	43.07	3.00e-43	168.00
IUUC-Ogu-078775	Oryza glumaepatula	44.05	2.00e-53	202.00
IUUC-Oin-079214	Oryza indica	44.05	3.00e-55	210.00
IUUC-Olo-080799	Oryza longistaminata	32.74	3.00e-28	118.00
IUUC-Ome-081843	Oryza meridionalis	40.83	2.00e-52	200.00
IUUC-Oni-082944	Oryza nivara	39.38	1.00e-28	119.00
IUUC-Opu-083668	Oryza punctata	43.61	4.00e-55	210.00
IUUC-Oru-084249	Oryza rufipogon	35.29	5.00e-35	143.00
IUUC-Osa-086233	Oryza sativa	44.05	2.00e-55	211.00
IUUC-Ola-087121	Oryzias latipes	66.40	0.00e+00	660.00
IUUC-Olu-087772	Ostreococcus lucimarinus	42.11	3.00e-41	161.00
IUUC-Oga-088556	Otolemur garnettii	99.63	0.00e+00	1052.00
IUUC-Oar-089768	Ovis aries	99.63	0.00e+00	1052.00
IUUC-Ptr-090585	Pan troglodytes	99.82	0.00e+00	1028.00
IUUC-Pan-092625	Papio anubis	99.08	0.00e+00	1014.00
IUUC-Psi-093462	Pelodiscus sinensis	86.49	0.00e+00	937.00
IUUC-Pma-094468	Petromyzon marinus	86.75	1.00e-124	440.00
IUUC-Pno-094812	Phaeosphaeria nodorum	40.45	6.00e-29	124.00
IUUC-Ppa-095589	Physcomitrella patens	51.79	8.00e-15	75.10
IUUC-Pfo-096762	Poecilia formosa	59.05	1.00e-157	550.00
IUUC-Pab-097890	Pongo abelii	99.26	0.00e+00	1015.00
IUUC-Pop-099764	Populus trichocarpa	45.50	1.00e-58	222.00
IUUC-Pca-101121	Procavia capensis	94.83	0.00e+00	891.00
IUUC-Ppe-102076	Prunus persica	42.75	9.00e-56	212.00
IUUC-Pva-102489	Pteropus vampyrus	99.08	0.00e+00	1045.00
IUUC-Pgr-103568	Puccinia graminis	41.70	3.00e-48	187.00
IUUC-Ptt-103721	Puccinia triticina	37.08	2.00e-29	124.00
IUUC-Pte-104118	Pyrenophora teres	42.98	5.00e-54	206.00
IUUC-Pyt-104612	Pyrenophora triticirepentis	42.98	3.00e-54	207.00
IUUC-Rno-105627	Rattus norvegicus	97.97	0.00e+00	1013.00
IUUC-Sce-106312	Saccharomyces cerevisiae	44.90	1.00e-54	207.00
IUUC-Sha-106619	Sarcophilus harrisii	97.23	0.00e+00	1021.00
IUUC-Sja-107765	Schizosaccharomyces japonicus	50.65	1.00e-56	214.00
IUUC-Spo-108328	Schizosaccharomyces pombe	51.29	4.00e-62	232.00
IUUC-Ssl-108577	Sclerotinia sclerotiorum	44.54	2.00e-50	194.00
IUUC-Smo-108760	Selaginella moellendorffii	44.21	9.00e-56	209.00
IUUC-Sit-109923	Setaria italica	40.68	4.00e-52	200.00
IUUC-Sly-110900	Solanum lycopersicum	39.15	2.00e-50	194.00
IUUC-Stu-112226	Solanum tuberosum	39.15	2.00e-50	194.00
IUUC-Sar-113620	Sorex araneus	99.47	0.00e+00	733.00
IUUC-Sbi-114318	Sorghum bicolor	40.95	8.00e-54	206.00
IUUC-Sre-114956	Sporisorium reilianum	47.74	7.00e-65	242.00
IUUC-Ssc-116116	Sus scrofa	100.00	1.00e-154	539.00
IUUC-Tgu-117357	Taeniopygia guttata	88.16	0.00e+00	1023.00
IUUC-Tru-118759	Takifugu rubripes	88.97	2.00e-134	473.00
IUUC-Tsy-119387	Tarsius syrichta	94.45	0.00e+00	980.00
IUUC-Tni-120536	Tetraodon nigroviridis	71.76	0.00e+00	712.00
IUUC-Tca-121035	Theobroma cacao	45.74	2.00e-57	217.00
IUUC-Tre-121996	Trichoderma reesei	42.98	4.00e-47	184.00
IUUC-Tvi-122371	Trichoderma virens	44.26	5.00e-54	207.00
IUUC-Tae-124373	Triticum aestivum	42.92	6.00e-54	206.00
IUUC-Tur-126324	Triticum urartu	42.92	5.00e-54	206.00
IUUC-Tme-127072	Tuber melanosporum	40.00	2.00e-42	168.00
IUUC-Tbe-128107	Tupaia belangeri	95.76	0.00e+00	1016.00
IUUC-Ttr-128846	Tursiops truncatus	98.16	0.00e+00	1023.00
IUUC-Uma-129607	Ustilago maydis	47.74	5.00e-65	243.00
IUUC-Vda-129971	Verticillium dahliae	42.86	6.00e-47	183.00
IUUC-Vpa-130298	Vicugna pacos	93.17	0.00e+00	964.00
IUUC-Vvi-131651	Vitis vinifera	45.74	3.00e-58	220.00
IUUC-Xtr-132728	Xenopus tropicalis	98.18	4.00e-153	535.00
IUUC-Xma-133789	Xiphophorus maculatus	65.44	0.00e+00	633.00
IUUC-Yli-134461	Yarrowia lipolytica	42.22	2.00e-47	183.00
IUUC-Zma-135031	Zea mays	42.37	3.00e-54	206.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence