iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

mRNA Expression
GEO	FFGED
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Protein 3D Structure
PDB	MMDB
Post-translational Modifications (PTMs)
CPLM	dbPAF	dbPTM	UniProt
BioGRID
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Beta-Prp	Beta-Prp	21070969

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	8.60e-32	106.3	183	221
UBD/Beta-Prp	1.30e-81	272.5	5	305

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf...sd.tllvsGsdDgtikvWDlrtgvll 36
           ++ +v+ +++   +d ++++++sdD tik+WD+ t  ++
   Q: 183  QERGVNYVDYyplPDkPYMITASDDLTIKIWDYQTKSCV 221
           56789999988**999****************9998886 PP

UBD/Beta-Prp

   S: 2    iktlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsf 102
           ik+ +++++++++ ++f+p +++++t+ ++g++++w+++t+  +rs++  e +v+a kf+ ++++++ gs+D  i+v++++tg+ v+ +++h d+++s+++
   Q: 5    IKKTFSNRSDRVKGIDFHPTEPWVLTTLYSGRVELWNYETQVEVRSIQVTETPVRAGKFIARKNWIIVGSDDFRIRVFNYNTGEKVVDFEAHPDYIRSIAV 105
           56778999********************************************************************************************* PP
   S: 103  spsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdg.nllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsng..kelvsgsl 200
           +p++ +++sGs+d t+++w++e+++ le+t++gh+++v+cv+++p++ + ++sG+lDrtv++W+l + +   tlt g+++ v+ +++ +    ++++++s+
   Q: 106  HPTKPYVLSGSDDLTVKLWNWENNWALEQTFEGHEHFVMCVAFNPKDpSTFASGCLDRTVKVWSLGQSTPNFTLTTGQERGVNYVDYYPLPdkPYMITASD 206
           **************************************************************************999*********7754344******** PP
   S: 201  dgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhnssvisvavlsfgdnvlvlgsedskvniwklkknep 299
           d t+k+wd+qt++cv tl+gh +nv+   f+p   +++sgs+Dg+++iW++ + ++ ktl+   ++++++a++  g++++++ ++d+ + +++l ++ep
   Q: 207  DLTIKIWDYQTKSCVATLEGHMSNVSFAVFHPTLPIIISGSEDGTLKIWNSSTYKVEKTLNVGLERSWCIATHPTGRKNYIASGFDNGFTVLSLGNDEP 305
           ************************************************************************8888999999999********999876 PP

Organism

Saccharomyces cerevisiae

Functional Description
(View)

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

Protein Sequence
(Fasta)

MKLDIKKTFS NRSDRVKGID FHPTEPWVLT TLYSGRVELW NYETQVEVRS IQVTETPVRA 60
GKFIARKNWI IVGSDDFRIR VFNYNTGEKV VDFEAHPDYI RSIAVHPTKP YVLSGSDDLT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAAGTTGG ATATAAAGGT ATGTTACCAG AGCGCGTTTT GCCAATGCAA TTGCGAACAA 60
GCTCCGACAA CTCCTATGAT TAGGAAATGA TCTCGTTCGC GAAGAATACA AAGCCTGCAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0903--Direct protein sequencing
KW-0931--ER-Golgi transport
KW-0333--Golgi apparatus
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0853--WD repeat

Interpro

IPR006692--Coatomer_WD-assoc_reg
IPR016453--COPB2
IPR020472--G-protein_beta_WD-40_rep
IPR011990--TPR-like_helical_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF04053--Coatomer_WDAD
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0030126--C:COPI vesicle coat
GO:0000139--C:Golgi membrane
GO:0005198--F:structural molecule activity
GO:0043130--F:ubiquitin binding
GO:0006888--P:ER to Golgi vesicle-mediated transport
GO:0006891--P:intra-Golgi vesicle-mediated transport
GO:0006886--P:intracellular protein transport
GO:0032511--P:late endosome to vacuole transport via multivesicular body sorting pathway
GO:0006890--P:retrograde vesicle-mediated transport, Golgi to ER

KEGG

sce:YGL137W

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000654	Aegilops tauschii	40.14	1.00e-173	601.00
IUUC-Aml-002154	Ailuropoda melanoleuca	47.30	0.00e+00	790.00
IUUC-Atr-003090	Amborella trichopoda	47.54	0.00e+00	746.00
IUUC-Apl-003976	Anas platyrhynchos	47.55	0.00e+00	786.00
IUUC-Aca-004301	Anolis carolinensis	47.43	0.00e+00	786.00
IUUC-Aly-005643	Arabidopsis lyrata	47.22	0.00e+00	726.00
IUUC-Ath-007630	Arabidopsis thaliana	47.61	0.00e+00	740.00
IUUC-Ago-007914	Ashbya gossypii	69.28	0.00e+00	1212.00
IUUC-Acl-008237	Aspergillus clavatus	50.61	0.00e+00	862.00
IUUC-Afl-008535	Aspergillus flavus	50.26	0.00e+00	818.00
IUUC-Afu-008845	Aspergillus fumigatus	50.97	0.00e+00	849.00
IUUC-Ani-009135	Aspergillus nidulans	50.74	0.00e+00	839.00
IUUC-Ang-009654	Aspergillus niger	54.68	0.00e+00	784.00
IUUC-Aor-009939	Aspergillus oryzae	50.67	0.00e+00	881.00
IUUC-Ate-010355	Aspergillus terreus	51.09	0.00e+00	843.00
IUUC-Ame-010922	Astyanax mexicanus	42.73	0.00e+00	676.00
IUUC-Bgr-012249	Blumeria graminis	51.30	0.00e+00	833.00
IUUC-Bta-013579	Bos taurus	46.77	0.00e+00	717.00
IUUC-Bci-013866	Botrytis cinerea	52.33	0.00e+00	824.00
IUUC-Bdi-015046	Brachypodium distachyon	45.52	0.00e+00	741.00
IUUC-Bol-016271	Brassica oleracea	47.36	0.00e+00	751.00
IUUC-Bra-017758	Brassica rapa	47.10	0.00e+00	748.00
IUUC-Cel-018387	Caenorhabditis elegans	44.06	0.00e+00	734.00
IUUC-Cja-019145	Callithrix jacchus	47.30	0.00e+00	791.00
IUUC-Cfa-020564	Canis familiaris	47.30	0.00e+00	791.00
IUUC-Cpo-022201	Cavia porcellus	47.04	0.00e+00	787.00
IUUC-Cre-022938	Chlamydomonas reinhardtii	46.15	0.00e+00	695.00
IUUC-Csa-023383	Chlorocebus sabaeus	50.00	0.00e+00	627.00
IUUC-Cho-024454	Choloepus hoffmanni	44.28	0.00e+00	685.00
IUUC-Cin-025681	Ciona intestinalis	46.98	0.00e+00	728.00
IUUC-Csv-026012	Ciona savignyi	47.11	0.00e+00	726.00
IUUC-Cgl-026649	Colletotrichum gloeosporioides	48.27	0.00e+00	744.00
IUUC-Cne-026986	Cryptococcus neoformans	47.77	0.00e+00	796.00
IUUC-Cme-027219	Cyanidioschyzon merolae	40.62	0.00e+00	667.00
IUUC-Dre-027846	Danio rerio	47.17	0.00e+00	786.00
IUUC-Dor-030462	Dipodomys ordii	44.46	0.00e+00	627.00
IUUC-Dse-031268	Dothistroma septosporum	49.82	0.00e+00	838.00
IUUC-Dme-031791	Drosophila melanogaster	45.09	0.00e+00	729.00
IUUC-Ete-033166	Echinops telfairi	45.09	1.00e-148	518.00
IUUC-Eca-034180	Equus caballus	46.23	0.00e+00	756.00
IUUC-Eeu-035086	Erinaceus europaeus	35.85	2.00e-72	265.00
IUUC-Fca-036265	Felis catus	47.30	0.00e+00	790.00
IUUC-Fal-037202	Ficedula albicollis	46.88	0.00e+00	743.00
IUUC-Fox-037711	Fusarium oxysporum	52.08	0.00e+00	785.00
IUUC-Fso-038268	Fusarium solani	52.07	0.00e+00	796.00
IUUC-Gmo-039046	Gadus morhua	47.30	0.00e+00	781.00
IUUC-Ggr-039863	Gaeumannomyces graminis	50.68	0.00e+00	797.00
IUUC-Gga-041112	Gallus gallus	46.92	0.00e+00	783.00
IUUC-Gac-041733	Gasterosteus aculeatus	47.17	0.00e+00	763.00
IUUC-Gma-042910	Glycine max	47.55	0.00e+00	756.00
IUUC-Ggo-044984	Gorilla gorilla	47.30	0.00e+00	791.00
IUUC-Hsa-046698	Homo sapiens	47.30	0.00e+00	790.00
IUUC-Hvu-047669	Hordeum vulgare	54.19	4.00e-120	422.00
IUUC-Itr-048212	Ictidomys tridecemlineatus	47.30	0.00e+00	790.00
IUUC-Kpa-049265	Komagataella pastoris	54.42	0.00e+00	967.00
IUUC-Lch-050473	Latimeria chalumnae	47.30	0.00e+00	786.00
IUUC-Lpe-051579	Leersia perrieri	46.98	0.00e+00	739.00
IUUC-Loc-052675	Lepisosteus oculatus	48.06	0.00e+00	791.00
IUUC-Lma-053218	Leptosphaeria maculans	51.60	0.00e+00	835.00
IUUC-Laf-053757	Loxodonta africana	47.43	0.00e+00	788.00
IUUC-Mcc-054859	Macaca mulatta	47.30	0.00e+00	791.00
IUUC-Meu-056174	Macropus eugenii	38.75	1.00e-64	239.00
IUUC-Mor-057264	Magnaporthe oryzae	52.31	0.00e+00	795.00
IUUC-Mpo-057538	Magnaporthe poae	51.29	0.00e+00	817.00
IUUC-Mtr-058310	Medicago truncatula	47.68	0.00e+00	760.00
IUUC-Mla-058937	Melampsora laricipopulina	49.38	0.00e+00	794.00
IUUC-Mga-059875	Meleagris gallopavo	47.18	0.00e+00	780.00
IUUC-Mvi-060240	Microbotryum violaceum	49.12	0.00e+00	779.00
IUUC-Mmr-061261	Microcebus murinus	47.30	0.00e+00	791.00
IUUC-Mdo-062076	Monodelphis domestica	47.17	0.00e+00	789.00
IUUC-Mmu-063324	Mus musculus	47.17	0.00e+00	790.00
IUUC-Mac-064636	Musa acuminata	46.23	0.00e+00	733.00
IUUC-Mpu-065961	Mustela putorius furo	47.30	0.00e+00	790.00
IUUC-Mlu-067059	Myotis lucifugus	46.73	0.00e+00	770.00
IUUC-Nfi-068277	Neosartorya fischeri	50.85	0.00e+00	842.00
IUUC-Ncr-068659	Neurospora crassa	52.55	0.00e+00	865.00
IUUC-Nle-069034	Nomascus leucogenys	47.30	0.00e+00	791.00
IUUC-Opr-070334	Ochotona princeps	47.74	0.00e+00	753.00
IUUC-Ont-071563	Oreochromis niloticus	47.04	0.00e+00	781.00
IUUC-Oan-073416	Ornithorhynchus anatinus	46.35	0.00e+00	741.00
IUUC-Ocu-074522	Oryctolagus cuniculus	47.30	0.00e+00	789.00
IUUC-Oba-075760	Oryza barthii	46.22	0.00e+00	724.00
IUUC-Obr-076163	Oryza brachyantha	47.61	0.00e+00	741.00
IUUC-Ogl-077450	Oryza glaberrima	46.98	0.00e+00	749.00
IUUC-Ogu-078994	Oryza glumaepatula	46.22	0.00e+00	723.00
IUUC-Oin-079856	Oryza indica	47.59	0.00e+00	737.00
IUUC-Olo-080731	Oryza longistaminata	46.68	0.00e+00	709.00
IUUC-Ome-081762	Oryza meridionalis	43.48	0.00e+00	655.00
IUUC-Oni-082324	Oryza nivara	46.22	0.00e+00	723.00
IUUC-Opu-083400	Oryza punctata	46.15	0.00e+00	724.00
IUUC-Oru-084829	Oryza rufipogon	46.22	0.00e+00	724.00
IUUC-Osa-086026	Oryza sativa	47.10	0.00e+00	752.00
IUUC-Ola-087245	Oryzias latipes	46.67	0.00e+00	778.00
IUUC-Olu-087655	Ostreococcus lucimarinus	48.24	0.00e+00	760.00
IUUC-Oga-088163	Otolemur garnettii	45.90	0.00e+00	754.00
IUUC-Oar-089842	Ovis aries	47.04	0.00e+00	788.00
IUUC-Ptr-090501	Pan troglodytes	47.30	0.00e+00	791.00
IUUC-Pan-092011	Papio anubis	47.30	0.00e+00	790.00
IUUC-Psi-093308	Pelodiscus sinensis	47.55	0.00e+00	786.00
IUUC-Pma-094695	Petromyzon marinus	45.05	0.00e+00	714.00
IUUC-Pno-094785	Phaeosphaeria nodorum	57.24	3.00e-100	357.00
IUUC-Ppa-095638	Physcomitrella patens	48.61	0.00e+00	762.00
IUUC-Pfo-096587	Poecilia formosa	47.04	0.00e+00	782.00
IUUC-Pab-097926	Pongo abelii	46.62	0.00e+00	730.00
IUUC-Pop-099634	Populus trichocarpa	46.85	0.00e+00	750.00
IUUC-Pca-100965	Procavia capensis	46.67	0.00e+00	761.00
IUUC-Ppe-101470	Prunus persica	47.61	0.00e+00	756.00
IUUC-Pva-102451	Pteropus vampyrus	45.07	0.00e+00	627.00
IUUC-Pgr-103453	Puccinia graminis	48.77	0.00e+00	795.00
IUUC-Ptt-103868	Puccinia triticina	49.08	0.00e+00	798.00
IUUC-Pte-104274	Pyrenophora teres	51.87	0.00e+00	868.00
IUUC-Pyt-104794	Pyrenophora triticirepentis	49.76	0.00e+00	814.00
IUUC-Rno-105979	Rattus norvegicus	40.08	8.00e-172	595.00
IUUC-Sha-106905	Sarcophilus harrisii	47.17	0.00e+00	789.00
IUUC-Sja-107838	Schizosaccharomyces japonicus	46.77	0.00e+00	748.00
IUUC-Spo-108299	Schizosaccharomyces pombe	46.16	0.00e+00	766.00
IUUC-Smo-108695	Selaginella moellendorffii	46.81	0.00e+00	723.00
IUUC-Sit-110239	Setaria italica	47.04	0.00e+00	750.00
IUUC-Sly-111775	Solanum lycopersicum	46.62	0.00e+00	752.00
IUUC-Stu-112906	Solanum tuberosum	46.71	0.00e+00	671.00
IUUC-Sar-113472	Sorex araneus	43.65	3.00e-161	560.00
IUUC-Sbi-114052	Sorghum bicolor	46.85	0.00e+00	753.00
IUUC-Sre-115040	Sporisorium reilianum	49.25	0.00e+00	764.00
IUUC-Ssc-115593	Sus scrofa	47.17	0.00e+00	789.00
IUUC-Tgu-117239	Taeniopygia guttata	47.43	0.00e+00	786.00
IUUC-Tru-118025	Takifugu rubripes	47.04	0.00e+00	786.00
IUUC-Tsy-118824	Tarsius syrichta	44.24	1.00e-166	577.00
IUUC-Tni-120142	Tetraodon nigroviridis	46.92	0.00e+00	776.00
IUUC-Tca-121613	Theobroma cacao	46.85	0.00e+00	748.00
IUUC-Tre-122072	Trichoderma reesei	51.23	0.00e+00	830.00
IUUC-Tvi-122546	Trichoderma virens	51.60	0.00e+00	833.00
IUUC-Tae-125488	Triticum aestivum	46.68	0.00e+00	741.00
IUUC-Tur-126283	Triticum urartu	40.55	1.00e-173	601.00
IUUC-Tme-127041	Tuber melanosporum	53.12	0.00e+00	870.00
IUUC-Tbe-127770	Tupaia belangeri	47.04	0.00e+00	665.00
IUUC-Ttr-129294	Tursiops truncatus	47.17	0.00e+00	787.00
IUUC-Uma-129351	Ustilago maydis	46.87	0.00e+00	759.00
IUUC-Vda-129716	Verticillium dahliae	52.85	0.00e+00	865.00
IUUC-Vpa-130037	Vicugna pacos	37.94	3.00e-84	304.00
IUUC-Vvi-131689	Vitis vinifera	47.10	0.00e+00	748.00
IUUC-Xtr-132633	Xenopus tropicalis	45.42	0.00e+00	777.00
IUUC-Xma-133347	Xiphophorus maculatus	47.17	0.00e+00	783.00
IUUC-Yli-134455	Yarrowia lipolytica	52.29	0.00e+00	847.00
IUUC-Zma-135867	Zea mays	47.10	0.00e+00	754.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence