iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

mRNA Expression
GEO	FFGED
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Post-translational Modifications (PTMs)
dbPAF	dbPTM	UniProt	PHOSIDA
BioGRID
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	29.67	1.40e-01	28.90	IUUC-Ots-000003

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Saccharomyces cerevisiae

Functional Description
(View)

Involved together with the closely related MLP1 in the structural and functional organization of perinuclear chromatin. MLP1/MLP2 associate with the nuclear pore complex and form filamentous structures along the nuclear periphery. According to PubMed:11862215 some telomeres are tethered to the nuclear periphery through MLP1/MLP2, probably mediated by YKU70/YKU80 (HDF1/HDF2) heterodimer and show perinuclear location dependent silencing. According to PubMed:12490156 MLP1 and MLP2 are involved in telomere length regulation but not silencing or telomere anchoring. MLP2 plays a role in the incorporation of components into the spindle pole body. MLP2 is also involved in double-strand break repair, probably also mediated by the YKU70/YKU80 (HDF1/HDF2) heterodimer.

Protein Sequence
(Fasta)

MEDKISEFLN VPFESLQGVT YPVLRKLYKK IAKFERSEEE VTKLNVLVDE IKSQYYSRIS 60
KLKQLLDESS EQKNTAKEEL NGLKDQLNEE RSRYRREIDA LKKQLHVSHE AMREVNDEKR 120

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Nucleotide Sequence
(Fasta)

ATGGAGGACA AAATATCTGA GTTTTTAAAT GTTCCATTCG AATCACTTCA AGGTGTTACC 60
TATCCTGTCT TAAGAAAGTT ATACAAGAAA ATAGCCAAGT TTGAACGTTC TGAAGAGGAA 120

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Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome

Interpro

IPR028933--Lebercilin_dom

Pfam

PF15619--Lebercilin

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005635--C:nuclear envelope
GO:0044615--C:nuclear pore nuclear basket
GO:0005654--C:nucleoplasm
GO:0005816--C:spindle pole body
GO:0005487--F:nucleocytoplasmic transporter activity
GO:0043021--F:ribonucleoprotein complex binding
GO:0007094--P:mitotic spindle assembly checkpoint
GO:1901925--P:negative regulation of protein import into nucleus during spindle assembly checkpoint
GO:0016973--P:poly(A)+ mRNA export from nucleus
GO:0000973--P:posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery
GO:0006355--P:regulation of transcription, DNA-templated
GO:0051300--P:spindle pole body organization
GO:0034398--P:telomere tethering at nuclear periphery
GO:0000972--P:transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery

KEGG

sce:YIL149C

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aly-006299	Arabidopsis lyrata	28.57	5.30e-02	29.60
IUUC-Ath-007197	Arabidopsis thaliana	28.57	3.10e-02	30.40
IUUC-Bgr-012100	Blumeria graminis	21.23	1.10e+00	26.90
IUUC-Bol-015347	Brassica oleracea	28.74	5.20e-02	29.60
IUUC-Csa-023809	Chlorocebus sabaeus	23.89	9.00e-03	32.70
IUUC-Lch-050570	Latimeria chalumnae	32.22	1.90e-01	29.30
IUUC-Mor-057252	Magnaporthe oryzae	38.10	8.80e-02	30.40
IUUC-Mtr-058494	Medicago truncatula	43.24	4.30e-02	32.30
IUUC-Ptt-104003	Puccinia triticina	21.43	2.30e-01	28.50
IUUC-Ssl-108390	Sclerotinia sclerotiorum	28.77	4.70e-01	28.10
IUUC-Stu-112887	Solanum tuberosum	36.17	5.20e-02	28.90
IUUC-Ttr-128663	Tursiops truncatus	20.87	1.60e-02	32.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence