iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

mRNA Expression
GEO	FFGED
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Protein 3D Structure
PDB	MMDB
Post-translational Modifications (PTMs)
CPLM	dbPAF	dbPTM	UniProt
PHOSIDA	BioGRID
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Beta-Prp	Beta-Prp	21070969

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.50e-41	136.4	604	638
UBD/Beta-Prp	2.50e-82	274.8	390	713

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclafsd.tllvsGsdDgtikvWDlrtgvl 35
           gHtd +t+l+f d   lv+Gs+D t+++WDlrtg l
   Q: 604  GHTDAITSLKF-DsACLVTGSYDRTVRIWDLRTGLL 638
           8**********.43679****************975 PP

UBD/Beta-Prp

   S: 2    iktlkghhksvitcvkf.spdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdls................... 82
           i +++++h++++tc++f +p+++l+++g+ d+t+k+wd+++++++ +l gh a+++++++++d+ +lvtg++D+++k+w+l+                   
   Q: 390  IGSIMSTHDDFLTCLDFdAPFGTLCTAGYLDHTVKIWDLSKQNKIGELAGHLATINCMQINRDYGTLVTGGRDAALKLWNLNlaqqlyqetqnltsptnhi 490
           67899**************************************************************************99999***************** PP
   S: 83   tgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqclee.....................tlsghdgvvncvvvhpdgnllvsGslDrtvr 162
           +++cvht+++h+d+v++ls++p  ++lvsGs+drtir wdl++g+cl++                     +l+++++  ++ ++++++  l++G++D++vr
   Q: 491  DSPCVHTFEAHTDEVTALSLDP--SFLVSGSQDRTIRQWDLRSGKCLQTidlsfanvlttstnvdlskstLLTQRNERPSIGALQSFDAALATGTKDGVVR 589
           **********************..***************************************************************************** PP
   S: 163  lWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlh 263
           lWdl++gk++rtl+g htd+++sl+fds   +lv+gs+d+tv++wdl+tg  ++++++++++v+s++++ +++  v++++++s++i+d+++++ ++++++ 
   Q: 590  LWDLRSGKVIRTLKG-HTDAITSLKFDS--ACLVTGSYDRTVRIWDLRTGL-LNKFHAYSAPVLSLDLF-QENAAVVVADEPSVQIYDSEKDESWSCVEQG 685
           **************9.************..9*******************5.*****************.99999999**********************5 PP
   S: 264  nssvisvavlsfgdnvlvlgsedskvniwk 293
           n   +sv+++++++n++v+g+e+++vniw+
   Q: 686  N--ETSVSTVKYKENYMVEGRENGDVNIWA 713
           5..888999999*****************8 PP

Organism

Saccharomyces cerevisiae

Functional Description
(View)

Involved in mitochondrial fission. Has a partially redundant function to CAF4 in acting as an adapter protein, binding to FIS1 on the mitochondrial outer membrane and recruiting the dynamin-like GTPase DNM1 to form mitochondrial fission complexes. Formation of these complexes is required to promote constriction and fission of the mitochondrial compartment at a late step in mitochondrial division.

Protein Sequence
(Fasta)

MSVNDQITHI GKTLSTTASA FLNYQKSNSN TQDVLTNNGP YKNLLSNTVN NASSTSYFYK 60
RTEHGRFVKN ASNTFEDIYS KTRRGDVFRN KFTDNKTCFR MLTYISDDLL NEIPTKEGLK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTCAGTGA ACGACCAAAT AACTCATATA GGAAAAACAT TGTCCACAAC GGCTTCCGCT 60
TTTTTAAACT ACCAAAAATC GAACAGCAAC ACTCAAGATG TACTGACCAA TAATGGGCCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0472--Membrane
KW-0496--Mitochondrion
KW-1000--Mitochondrion outer membrane
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR021061--Mt_division_protein_1
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF11542--Mdv1
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005741--C:mitochondrial outer membrane
GO:0043130--F:ubiquitin binding
GO:0000266--P:mitochondrial fission
GO:0000002--P:mitochondrial genome maintenance
GO:0016559--P:peroxisome fission
GO:0090141--P:positive regulation of mitochondrial fission

KEGG

sce:YJL112W

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ago-007941	Ashbya gossypii	41.19	1.00e-146	511.00
IUUC-Acl-008165	Aspergillus clavatus	34.44	3.00e-70	257.00
IUUC-Afu-009086	Aspergillus fumigatus	39.57	1.00e-69	254.00
IUUC-Ani-009192	Aspergillus nidulans	33.53	2.00e-72	265.00
IUUC-Ang-009540	Aspergillus niger	33.78	1.00e-75	275.00
IUUC-Aor-010128	Aspergillus oryzae	34.03	3.00e-69	254.00
IUUC-Ate-010579	Aspergillus terreus	35.17	1.00e-78	285.00
IUUC-Bgr-012212	Blumeria graminis	33.48	4.00e-82	296.00
IUUC-Bci-013867	Botrytis cinerea	35.54	1.00e-85	308.00
IUUC-Cgl-026600	Colletotrichum gloeosporioides	33.03	1.00e-86	312.00
IUUC-Cne-027030	Cryptococcus neoformans	31.07	6.00e-53	200.00
IUUC-Dse-031481	Dothistroma septosporum	37.59	1.00e-69	255.00
IUUC-Fox-037725	Fusarium oxysporum	30.92	9.00e-87	312.00
IUUC-Fso-038270	Fusarium solani	32.15	2.00e-80	292.00
IUUC-Ggr-039837	Gaeumannomyces graminis	30.03	5.00e-78	283.00
IUUC-Kpa-049115	Komagataella pastoris	32.58	2.00e-96	344.00
IUUC-Lma-053086	Leptosphaeria maculans	31.77	4.00e-79	286.00
IUUC-Mor-056934	Magnaporthe oryzae	31.91	9.00e-80	289.00
IUUC-Mpo-057367	Magnaporthe poae	32.08	6.00e-81	293.00
IUUC-Nfi-068414	Neosartorya fischeri	34.66	3.00e-75	274.00
IUUC-Ncr-068861	Neurospora crassa	32.68	4.00e-89	320.00
IUUC-Pno-095117	Phaeosphaeria nodorum	30.35	1.00e-76	278.00
IUUC-Ptt-103881	Puccinia triticina	32.51	3.00e-54	204.00
IUUC-Pte-104262	Pyrenophora teres	27.07	5.00e-50	190.00
IUUC-Pyt-104679	Pyrenophora triticirepentis	40.16	6.00e-70	255.00
IUUC-Sja-107810	Schizosaccharomyces japonicus	30.44	6.00e-56	209.00
IUUC-Spo-108016	Schizosaccharomyces pombe	30.98	3.00e-64	237.00
IUUC-Ssl-108498	Sclerotinia sclerotiorum	31.46	6.00e-82	296.00
IUUC-Tre-122068	Trichoderma reesei	32.36	8.00e-76	276.00
IUUC-Tvi-122485	Trichoderma virens	32.14	6.00e-78	284.00
IUUC-Tme-127188	Tuber melanosporum	33.49	2.00e-84	304.00
IUUC-Vda-130011	Verticillium dahliae	32.12	5.00e-85	306.00
IUUC-Yli-134598	Yarrowia lipolytica	36.03	6.00e-76	276.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence