iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Xma-133299

Ensembl Protein ID

ENSXMAP00000016345.1

UniProt Accession

M4APF0; M4APF0_XIPMA

Genbank Protein ID

ENSXMAP00000016345

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AGAJ01016924

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXMAG00000016297.1	ENSXMAT00000016369.1	ENSXMAP00000016345.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.50e-102	342.7	496	819

Active Site

Position(s)	Description	Evidence
791	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           +sdlkk+l+vef++E+g+d gGv++ef++l+++e++n d+g+f+y+++ k  ++ n++s     e++  ++++G++lg+a++++ +ld+
   Q: 496  PSDLKKQLYVEFEDEQGVDEGGVSKEFFQLVLEEIFNLDIGMFTYDNDTKLFWF-NSSSL----ENEAQYTLIGIVLGLAIYNNCILDV 579
           799****************************************99998888877.55555....67999******************** PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfs.vseeilgetkeeeLkpgGenipVtneNkeeYvklvv 178
           +++ ++y++l+gkk ++ dl++ +p ly+slke++e+   ++e +++ ltf+  +++++g+   ++Lk++G++ipVt+eN++e+v+l++
   Q: 580  HFPMVVYRKLMGKKGTFLDLSDSHPVLYQSLKEVLEYS-GSLE-EDMMLTFQiSHTDLFGNPILYDLKEKGDQIPVTKENRQEFVHLYA 666
           *************************************4.4444.469999994456679****************************** PP
   S: 179  eyrlkegikeqveafreGfneviple.llslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLq 266
           +y+l++++++q++af++Gf  v +++ l  lF++ee+ellicG++++d+e+l+k+t+y+ggyt+ds+ i+ Fwe++++f +e+++ fLq
   Q: 667  DYILNKSVESQFKAFKKGFLMVTNESpLKYLFRPEEVELLICGSRKLDFEALEKTTEYDGGYTKDSQIIKDFWETIHSFGEEQKRLFLQ 755
           ***********************99934558********************************************************** PP
   S: 267  FvTgssrlPlgGfaelkprlfvirkdasd.drlPssnTCfnyLkLPeYsskeilkekLlyAieetkg 332
           F+Tg++r+P+gG+ +lk   ++i k++sd drlP+s+TCfn L LPeYssk++lke+Ll Ai+++kg
   Q: 756  FTTGTDRAPVGGLGKLK---MIIAKNGSDsDRLPTSHTCFNALLLPEYSSKDKLKERLLKAITYAKG 819
           *****************...8999988888*********************************9876 PP

Organism

Xiphophorus maculatus

Protein Sequence
(Fasta)

MNRATAKRLI ERYFRQLTEG CGNSNCTNEF CASCSTCQPL GNNAAAAKAL ELFKVNAKLC 60
DYYPSVESRS DENSRLRREM STEEFSDVHY LTEHTVCRIL SACEEEGNYS ALVRVIGRIF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCGATATTAA GTGCTGCCAG GTTCGTCTTA CTAAAAGACA GGTTTGTACT TCTATTTTTT 60
TTTTTTTTTG TCATTTGTTT TTCTACTTTC TTGATCAGAA AAATATCCGT AGTGCATTCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR032353--AZUL
IPR000569--HECT_dom

PROSITE

PS50237--HECT

Pfam

PF16558--AZUL
PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Atr-003144	Amborella trichopoda	44.62	8.00e-94	337.00
IUUC-Gmo-038840	Gadus morhua	69.30	0.00e+00	1159.00
IUUC-Gac-042293	Gasterosteus aculeatus	75.94	0.00e+00	1266.00
IUUC-Ont-072087	Oreochromis niloticus	83.91	0.00e+00	1396.00
IUUC-Ola-086833	Oryzias latipes	81.01	0.00e+00	1305.00
IUUC-Pfo-096868	Poecilia formosa	94.39	0.00e+00	1531.00
IUUC-Sce-106306	Saccharomyces cerevisiae	37.70	5.00e-64	239.00
IUUC-Tru-117763	Takifugu rubripes	74.15	0.00e+00	1244.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence