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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-064009
Ensembl Protein ID ENSMUSP00000071519.5
UniProt Accession P97868; P70287; Q3TTR9; Q3TUM7; Q3UMP7; Q4U217; Q7TT06; Q8BNY8; Q8R399; RBBP6_MOUSE
Genbank Protein ID BAC32441.1; BAC37553.1; BAC38179.1; BAE26051.1; BAE35944.1; BAE36255.1; AAH25874.1; AAC72432.1; AAB49620.1
Protein Name E3 ubiquitin-protein ligase RBBP6; Proliferation potential-related protein; Protein P2P-R; RING-type E3 ubiquitin transferase RBBP6; Retinoblastoma-binding protein 6; p53-associated cellular protein of testis
Genbank Nucleotide ID AK045635; AK079129; AK081261; AK144758; AK160656; AK161231; AC125221; U83913; U28789
Gene Name Rbbp6; P2pr; Pact
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000030779.15 ENSMUST00000052135.13 ENSMUSP00000049528.7
ENSMUSG00000030779.15 ENSMUST00000098062.8 ENSMUSP00000095670.2
ENSMUSG00000030779.15 ENSMUST00000071590.5 ENSMUSP00000071519.5
ENSMUSG00000030779.15 ENSMUST00000205495.1 ENSMUSP00000145759.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarmiRNAMapRAID2
Protein-protein Interaction
IIDHINTMentha
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
Phospho.ELMUniProtPHOSIDA
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
ULD/UDP/UFD/DWNN DWNN 16396680
Classification
Family E-value Score Start End
E3 activity/RING/U-box 1.60e-09 38.8 254 327
E3 activity/RING/RING 0.057 15.1 260 300
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/U-box
   S: 2    vpeeflCpIslelMrdPvvlp.sGitydrssIekwl.asggktcPvtrqpl.teedlvPnltlrrliqawceen 72
           +p+e+lC I +++M+d vv+p +G +y  ++I+  l +s+++tcP+++q   +++ l+ n++lr+ ++++ +e 
   Q: 254  IPDELLCLICKDIMTDAVVIPcCGNSYCDECIRTALlESDEHTCPTCHQNDvSPDALIANKFLRQAVNNFKNET 327
           8********************************998677777*****9975599999*********99998765 PP
   

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlp.CgHvfhadClqkwpglknssskefrCPlC 45
           C+iC++ + d  +v p Cg  ++ +C+        ++s e +CP+C
   Q: 260  CLICKDIMTD-AVVIPcCGNSYCDECIRTA----LLESDEHTCPTC 300
           ********99.55566589********544....57********** PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome (By similarity). May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth retardation (PubMed:17470788). Regulates DNA-replication and common fragile sites (CFS) stability in a ZBTB38- and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359).
 E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome (By similarity). May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth retardation (PubMed:17470788). Regulates DNA-replication and common fragile sites (CFS) stability in a ZBTB38- and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359).
Protein Sequence
(Fasta)
MSCVHYKFSS KLNYDTVTFD GLHISLCDLK KQIMGREKLK AADSDLQITN AQTKEEYTDD 60
NALIPKNSSV IVRRIPIGGV KSTSKTYVIS RTEPVMGTTK AIDDASASIS LAQLTKTANL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-064009|ULD,DWNN;E3,U-box;E3,RING|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGAGCTTACT TCTTTGGGAT TCCAGCTTTT ACTGAAGACC AGCTGAGACA TTGAGCCTCA 60
TGGACTGAGC AACGTTGGAT TCTTGAACTT TCCATTCATA GTCAGACATG ACTGGATTAT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-064009|ULD,DWNN;E3,U-box;E3,RING|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0227--DNA damage
KW-0235--DNA replication
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR014891--DWNN_domain
IPR033489--RBBP6
IPR003613--Ubox_domain
IPR025829--Zn_knuckle_CX2CX3GHX4C
IPR001878--Znf_CCHC
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS51282--DWNN
PS50158--ZF_CCHC
PS50089--ZF_RING_2
Pfam

PF08783--DWNN
PF04564--U-box
PF13696--zf-CCHC_2
SMART

SM01180--DWNN
SM00184--RING
SM00343--ZnF_C2HC
Gene Ontology

GO:0005694--C:chromosome
GO:0005737--C:cytoplasm
GO:0005815--C:microtubule organizing center
GO:0005730--C:nucleolus
GO:0003723--F:RNA binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:0006260--P:DNA replication
GO:0048568--P:embryonic organ development
GO:0001701--P:in utero embryonic development
GO:0006397--P:mRNA processing
GO:0035264--P:multicellular organism growth
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0006275--P:regulation of DNA replication
GO:0061053--P:somite development
KEGG mmu:19647
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000195 Aegilops tauschii 35.71 4.00e-16 80.50
IUUC-Aml-001655 Ailuropoda melanoleuca 79.54 0.00e+00 1061.00
IUUC-Atr-002768 Amborella trichopoda 38.69 9.00e-18 85.50
IUUC-Apl-004100 Anas platyrhynchos 65.36 0.00e+00 834.00
IUUC-Aca-004345 Anolis carolinensis 66.67 2.00e-113 403.00
IUUC-Aly-006036 Arabidopsis lyrata 30.54 2.00e-34 141.00
IUUC-Ath-006684 Arabidopsis thaliana 31.13 2.00e-34 141.00
IUUC-Ago-007949 Ashbya gossypii 29.13 6.00e-35 141.00
IUUC-Acl-008118 Aspergillus clavatus 31.01 2.00e-26 114.00
IUUC-Afl-008408 Aspergillus flavus 32.08 6.00e-16 79.00
IUUC-Afu-008777 Aspergillus fumigatus 31.88 1.00e-34 141.00
IUUC-Ani-009426 Aspergillus nidulans 30.83 3.00e-35 143.00
IUUC-Ang-009735 Aspergillus niger 30.08 3.00e-32 133.00
IUUC-Aor-010213 Aspergillus oryzae 31.53 4.00e-34 139.00
IUUC-Ate-010474 Aspergillus terreus 30.64 1.00e-31 131.00
IUUC-Ame-010679 Astyanax mexicanus 82.69 1.00e-164 575.00
IUUC-Bgr-012229 Blumeria graminis 32.84 5.00e-38 152.00
IUUC-Bta-012672 Bos taurus 80.48 0.00e+00 1161.00
IUUC-Bci-013880 Botrytis cinerea 31.41 9.00e-35 141.00
IUUC-Bdi-014250 Brachypodium distachyon 28.00 2.00e-35 144.00
IUUC-Bol-015602 Brassica oleracea 31.28 3.00e-39 157.00
IUUC-Bra-016670 Brassica rapa 31.28 5.00e-39 156.00
IUUC-Cel-018532 Caenorhabditis elegans 36.15 2.00e-54 207.00
IUUC-Cja-018843 Callithrix jacchus 80.37 0.00e+00 1213.00
IUUC-Cfa-021107 Canis familiaris 80.09 0.00e+00 1162.00
IUUC-Cre-022712 Chlamydomonas reinhardtii 40.00 7.00e-11 62.00
IUUC-Csa-023397 Chlorocebus sabaeus 79.93 0.00e+00 1220.00
IUUC-Cho-024327 Choloepus hoffmanni 96.15 0.00e+00 946.00
IUUC-Cin-025439 Ciona intestinalis 47.01 1.00e-47 182.00
IUUC-Csv-026162 Ciona savignyi 54.98 1.00e-55 209.00
IUUC-Cgl-026629 Colletotrichum gloeosporioides 30.40 3.00e-28 120.00
IUUC-Cne-026921 Cryptococcus neoformans 28.46 5.00e-39 155.00
IUUC-Cme-027244 Cyanidioschyzon merolae 45.05 6.00e-18 86.70
IUUC-Dre-028023 Danio rerio 83.04 2.00e-161 564.00
IUUC-Dno-029430 Dasypus novemcinctus 79.52 0.00e+00 1142.00
IUUC-Dor-030406 Dipodomys ordii 80.87 0.00e+00 1155.00
IUUC-Dse-031312 Dothistroma septosporum 30.61 6.00e-38 152.00
IUUC-Dme-032133 Drosophila melanogaster 43.07 2.00e-74 274.00
IUUC-Ete-032466 Echinops telfairi 77.02 0.00e+00 1065.00
IUUC-Eca-034174 Equus caballus 80.71 0.00e+00 941.00
IUUC-Eeu-034677 Erinaceus europaeus 94.04 0.00e+00 827.00
IUUC-Fca-035439 Felis catus 79.76 0.00e+00 1120.00
IUUC-Fal-037230 Ficedula albicollis 64.17 0.00e+00 724.00
IUUC-Fox-037976 Fusarium oxysporum 30.32 9.00e-35 141.00
IUUC-Fso-038202 Fusarium solani 28.89 4.00e-34 139.00
IUUC-Gmo-038618 Gadus morhua 67.15 2.00e-74 272.00
IUUC-Ggr-040035 Gaeumannomyces graminis 27.88 3.00e-31 130.00
IUUC-Gga-040908 Gallus gallus 65.58 0.00e+00 729.00
IUUC-Gac-041718 Gasterosteus aculeatus 70.72 6.00e-86 310.00
IUUC-Gma-044229 Glycine max 31.71 3.00e-40 160.00
IUUC-Ggo-044567 Gorilla gorilla 79.93 0.00e+00 1171.00
IUUC-Hsa-046849 Homo sapiens 80.37 0.00e+00 1178.00
IUUC-Hvu-047050 Hordeum vulgare 25.49 3.00e-23 103.00
IUUC-Itr-048832 Ictidomys tridecemlineatus 81.10 0.00e+00 1110.00
IUUC-Kpa-049323 Komagataella pastoris 30.91 2.00e-34 140.00
IUUC-Lch-050524 Latimeria chalumnae 67.28 0.00e+00 700.00
IUUC-Lpe-050947 Leersia perrieri 29.57 1.00e-29 125.00
IUUC-Loc-052709 Lepisosteus oculatus 82.54 6.00e-167 582.00
IUUC-Lma-053186 Leptosphaeria maculans 33.93 8.00e-36 145.00
IUUC-Laf-054472 Loxodonta africana 78.98 0.00e+00 1134.00
IUUC-Mcc-055743 Macaca mulatta 78.08 0.00e+00 1220.00
IUUC-Meu-056399 Macropus eugenii 77.02 0.00e+00 731.00
IUUC-Mor-057073 Magnaporthe oryzae 30.06 6.00e-32 132.00
IUUC-Mpo-057378 Magnaporthe poae 27.58 1.00e-30 128.00
IUUC-Mtr-058761 Medicago truncatula 31.37 1.00e-32 135.00
IUUC-Mla-058840 Melampsora laricipopulina 36.73 1.00e-24 108.00
IUUC-Mga-060129 Meleagris gallopavo 64.64 0.00e+00 795.00
IUUC-Mvi-060424 Microbotryum violaceum 35.85 1.00e-24 108.00
IUUC-Mmr-061295 Microcebus murinus 80.87 0.00e+00 1177.00
IUUC-Mdo-062295 Monodelphis domestica 69.99 0.00e+00 978.00
IUUC-Mac-065479 Musa acuminata 35.63 4.00e-24 107.00
IUUC-Mpu-065875 Mustela putorius furo 81.37 0.00e+00 1171.00
IUUC-Mlu-066941 Myotis lucifugus 79.19 0.00e+00 1067.00
IUUC-Nfi-068518 Neosartorya fischeri 32.17 1.00e-35 144.00
IUUC-Ncr-068886 Neurospora crassa 28.61 1.00e-31 131.00
IUUC-Nle-069717 Nomascus leucogenys 96.73 0.00e+00 973.00
IUUC-Opr-070280 Ochotona princeps 94.38 0.00e+00 689.00
IUUC-Ont-071462 Oreochromis niloticus 66.31 8.00e-140 492.00
IUUC-Oan-073300 Ornithorhynchus anatinus 69.56 0.00e+00 895.00
IUUC-Ocu-074124 Oryctolagus cuniculus 80.11 0.00e+00 1221.00
IUUC-Oba-075756 Oryza barthii 30.75 3.00e-30 127.00
IUUC-Obr-076580 Oryza brachyantha 29.87 2.00e-28 121.00
IUUC-Ogl-077759 Oryza glaberrima 32.35 2.00e-36 147.00
IUUC-Ogu-078657 Oryza glumaepatula 31.10 6.00e-30 126.00
IUUC-Oin-079481 Oryza indica 32.47 2.00e-31 131.00
IUUC-Olo-081062 Oryza longistaminata 36.31 1.00e-22 102.00
IUUC-Ome-081813 Oryza meridionalis 30.83 1.00e-29 125.00
IUUC-Oni-083007 Oryza nivara 30.83 1.00e-29 125.00
IUUC-Opu-083385 Oryza punctata 29.84 2.00e-29 124.00
IUUC-Oru-084861 Oryza rufipogon 30.83 1.00e-29 125.00
IUUC-Osa-085896 Oryza sativa 32.18 4.00e-36 145.00
IUUC-Ola-086693 Oryzias latipes 62.67 5.00e-126 445.00
IUUC-Olu-087631 Ostreococcus lucimarinus 47.30 2.00e-14 70.10
IUUC-Oga-088262 Otolemur garnettii 80.22 0.00e+00 1158.00
IUUC-Oar-089658 Ovis aries 79.28 0.00e+00 1221.00
IUUC-Ptr-091311 Pan troglodytes 80.26 0.00e+00 1182.00
IUUC-Pan-091925 Papio anubis 80.04 0.00e+00 1221.00
IUUC-Psi-093605 Pelodiscus sinensis 65.36 0.00e+00 809.00
IUUC-Pma-094163 Petromyzon marinus 72.81 3.00e-98 350.00
IUUC-Pno-094790 Phaeosphaeria nodorum 29.79 1.00e-24 108.00
IUUC-Ppa-095943 Physcomitrella patens 30.41 7.00e-45 176.00
IUUC-Pfo-096581 Poecilia formosa 69.41 7.00e-134 472.00
IUUC-Pab-098229 Pongo abelii 79.61 0.00e+00 1172.00
IUUC-Pop-099160 Populus trichocarpa 30.40 1.00e-39 158.00
IUUC-Pca-100875 Procavia capensis 75.08 0.00e+00 749.00
IUUC-Ppe-101658 Prunus persica 36.47 3.00e-17 84.30
IUUC-Pva-102343 Pteropus vampyrus 91.91 0.00e+00 926.00
IUUC-Pgr-103275 Puccinia graminis 36.24 5.00e-18 87.00
IUUC-Ptt-104004 Puccinia triticina 40.00 3.00e-10 60.50
IUUC-Pte-104161 Pyrenophora teres 31.99 7.00e-30 125.00
IUUC-Pyt-104576 Pyrenophora triticirepentis 32.41 2.00e-30 127.00
IUUC-Rno-105264 Rattus norvegicus 92.46 0.00e+00 1287.00
IUUC-Sce-106138 Saccharomyces cerevisiae 31.20 2.00e-38 153.00
IUUC-Sha-107497 Sarcophilus harrisii 69.57 0.00e+00 1000.00
IUUC-Sja-107991 Schizosaccharomyces japonicus 34.03 6.00e-44 171.00
IUUC-Spo-108257 Schizosaccharomyces pombe 34.12 2.00e-46 179.00
IUUC-Ssl-108581 Sclerotinia sclerotiorum 29.74 3.00e-37 149.00
IUUC-Smo-109358 Selaginella moellendorffii 29.95 3.00e-34 139.00
IUUC-Sit-109920 Setaria italica 31.99 7.00e-37 149.00
IUUC-Sly-111616 Solanum lycopersicum 38.10 1.00e-26 115.00
IUUC-Stu-112648 Solanum tuberosum 32.37 3.00e-11 63.20
IUUC-Sar-113120 Sorex araneus 75.39 0.00e+00 1016.00
IUUC-Sbi-113881 Sorghum bicolor 30.87 4.00e-38 153.00
IUUC-Sre-115127 Sporisorium reilianum 30.46 3.00e-47 183.00
IUUC-Ssc-116147 Sus scrofa 80.96 0.00e+00 1161.00
IUUC-Tgu-117215 Taeniopygia guttata 64.07 0.00e+00 714.00
IUUC-Tru-118525 Takifugu rubripes 63.83 2.00e-132 465.00
IUUC-Tsy-119160 Tarsius syrichta 81.84 0.00e+00 1198.00
IUUC-Tni-119816 Tetraodon nigroviridis 68.52 4.00e-82 297.00
IUUC-Tca-121727 Theobroma cacao 30.83 2.00e-32 134.00
IUUC-Tre-122181 Trichoderma reesei 28.92 2.00e-35 144.00
IUUC-Tvi-122316 Trichoderma virens 28.27 2.00e-35 143.00
IUUC-Tae-125227 Triticum aestivum 36.31 3.00e-17 84.00
IUUC-Tur-126827 Triticum urartu 36.31 2.00e-16 81.30
IUUC-Tme-126984 Tuber melanosporum 30.46 1.00e-44 174.00
IUUC-Tbe-127263 Tupaia belangeri 76.35 0.00e+00 874.00
IUUC-Ttr-128498 Tursiops truncatus 78.04 0.00e+00 1196.00
IUUC-Uma-129457 Ustilago maydis 30.63 7.00e-45 175.00
IUUC-Vda-129986 Verticillium dahliae 28.95 1.00e-34 141.00
IUUC-Vpa-130795 Vicugna pacos 89.78 0.00e+00 760.00
IUUC-Vvi-131146 Vitis vinifera 36.31 7.00e-17 82.80
IUUC-Xtr-132789 Xenopus tropicalis 65.35 0.00e+00 647.00
IUUC-Xma-133011 Xiphophorus maculatus 68.71 3.00e-132 465.00
IUUC-Yli-134516 Yarrowia lipolytica 32.49 1.00e-39 157.00
IUUC-Zma-134699 Zea mays 30.00 1.00e-36 148.00
Created Date 25-Jun-2017

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