iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Sce-106255

UUCD1 version

UUC-SaC-00095

Ensembl Protein ID

YLR148W

UniProt Accession

P27801; D6VYE3; PEP3_YEAST

Genbank Protein ID

AAA34852.1; CAA97720.1; AAB82382.1; DAA09459.1

Protein Name

Vacuolar membrane protein PEP3; Carboxypeptidase Y-deficient protein 3; Vacuolar morphogenesis protein 8; Vacuolar protein sorting-associated protein 18; Vacuolar protein-targeting protein 18

Genbank Nucleotide ID

M65144; Z73320; U53879; BK006945

Gene Name

PEP3; VAM8; VPS18; VPT18; YLR148W; L9634.2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
YLR148W	YLR148W	YLR148W

Annotation

mRNA Expression
GEO	FFGED
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Protein 3D Structure
PDB	MMDB
Post-translational Modifications (PTMs)
CPLM	dbPAF	dbPTM	UniProt
BioGRID
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	23.18	9.00e-43	173.00	IUUC-Hsa-046635

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Saccharomyces cerevisiae

Functional Description
(View)

Required for vacuolar biogenesis and for trafficking of hydrolase precursors to the vacuole. Mediates transport at the vacuolar membrane where it may be responsible for tethering transport vesicles on the target membranes. Acts as component of the HOPS complex that acts during the docking stage of vacuole fusion. HOPS is an effector for the vacuolar Rab GTPase YPT7 and is required for vacuolar SNARE complex assembly. It remains bound to SNARE complexes after vacuole fusion.

Protein Sequence
(Fasta)

MIKTRIEEVQ LQFLTGNTEL THLKVSNDQL IVTTQRTIYR INLQDPAIVN HFDCPLSKEL 60
ETIMNVHVSP MGSVILIRTN FGRYMLLKDG EFTQLNKIKN LDLSSLHWIN ETTFLMGIKK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGATAAAAA CACGTATAGA GGAAGTTCAG TTACAATTCC TCACAGGGAA TACCGAACTT 60
ACGCATTTGA AAGTCTCCAA TGATCAACTT ATAGTAACGA CACAACGGAC AATTTACAGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0472--Membrane
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0926--Vacuole
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000547--Clathrin_H-chain/VPS_repeat
IPR007810--Pep3_Vps18
IPR011990--TPR-like_helical_dom
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50236--CHCR

Pfam

PF00637--Clathrin
PF05131--Pep3_Vps18

SMART

SM00299--CLH

Gene Ontology

GO:0033263--C:CORVET complex
GO:0005829--C:cytosol
GO:0000306--C:extrinsic component of vacuolar membrane
GO:0000329--C:fungal-type vacuole membrane
GO:0030897--C:HOPS complex
GO:0046872--F:metal ion binding
GO:0030674--F:protein binding, bridging
GO:0007032--P:endosome organization
GO:0006895--P:Golgi to endosome transport
GO:0006886--P:intracellular protein transport
GO:0045324--P:late endosome to vacuole transport
GO:0007040--P:lysosome organization
GO:0035542--P:regulation of SNARE complex assembly
GO:0032889--P:regulation of vacuole fusion, non-autophagic
GO:0042144--P:vacuole fusion, non-autophagic
GO:0006904--P:vesicle docking involved in exocytosis
GO:0099022--P:vesicle tethering

KEGG

sce:YLR148W

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000419	Aegilops tauschii	22.90	8.00e-44	170.00
IUUC-Aml-001240	Ailuropoda melanoleuca	22.99	1.00e-47	182.00
IUUC-Atr-003125	Amborella trichopoda	21.79	2.00e-46	179.00
IUUC-Apl-004181	Anas platyrhynchos	25.10	1.00e-49	189.00
IUUC-Aca-004437	Anolis carolinensis	25.00	4.00e-55	207.00
IUUC-Aly-006046	Arabidopsis lyrata	23.37	7.00e-54	203.00
IUUC-Ath-006932	Arabidopsis thaliana	23.17	3.00e-54	205.00
IUUC-Ago-007800	Ashbya gossypii	37.31	3.00e-159	553.00
IUUC-Acl-008035	Aspergillus clavatus	25.03	6.00e-72	263.00
IUUC-Afl-008714	Aspergillus flavus	26.29	4.00e-73	267.00
IUUC-Afu-009063	Aspergillus fumigatus	24.67	6.00e-73	267.00
IUUC-Ani-009384	Aspergillus nidulans	25.87	4.00e-77	281.00
IUUC-Ang-009507	Aspergillus niger	27.02	4.00e-72	264.00
IUUC-Aor-010094	Aspergillus oryzae	26.29	1.00e-72	266.00
IUUC-Ate-010421	Aspergillus terreus	26.92	1.00e-65	243.00
IUUC-Ame-011797	Astyanax mexicanus	24.67	7.00e-55	207.00
IUUC-Bgr-012107	Blumeria graminis	24.37	1.00e-63	236.00
IUUC-Bta-012339	Bos taurus	23.73	5.00e-52	197.00
IUUC-Bci-013895	Botrytis cinerea	26.02	2.00e-70	258.00
IUUC-Bdi-014554	Brachypodium distachyon	23.53	9.00e-56	209.00
IUUC-Bol-015270	Brassica oleracea	23.41	6.00e-57	213.00
IUUC-Bra-017424	Brassica rapa	23.28	1.00e-53	202.00
IUUC-Cel-018455	Caenorhabditis elegans	21.07	1.00e-30	126.00
IUUC-Cja-019629	Callithrix jacchus	23.66	3.00e-49	188.00
IUUC-Cfa-020425	Canis familiaris	23.06	2.00e-46	178.00
IUUC-Cpo-021349	Cavia porcellus	23.33	3.00e-47	182.00
IUUC-Cre-022799	Chlamydomonas reinhardtii	23.58	5.00e-10	58.20
IUUC-Csa-023559	Chlorocebus sabaeus	23.45	5.00e-49	187.00
IUUC-Cho-024862	Choloepus hoffmanni	22.29	7.00e-12	63.90
IUUC-Cin-025599	Ciona intestinalis	24.09	1.00e-51	196.00
IUUC-Csv-026152	Ciona savignyi	25.00	2.00e-52	198.00
IUUC-Cgl-026551	Colletotrichum gloeosporioides	26.69	7.00e-67	246.00
IUUC-Cne-026907	Cryptococcus neoformans	27.66	8.00e-58	217.00
IUUC-Dre-027747	Danio rerio	24.74	2.00e-55	208.00
IUUC-Dno-029668	Dasypus novemcinctus	23.06	3.00e-48	184.00
IUUC-Dor-030404	Dipodomys ordii	23.09	2.00e-48	185.00
IUUC-Dse-031345	Dothistroma septosporum	26.45	2.00e-73	268.00
IUUC-Dme-031711	Drosophila melanogaster	22.05	2.00e-36	145.00
IUUC-Ete-032308	Echinops telfairi	22.03	4.00e-37	148.00
IUUC-Eca-033637	Equus caballus	22.98	2.00e-47	182.00
IUUC-Eeu-035151	Erinaceus europaeus	23.03	3.00e-47	181.00
IUUC-Fca-035585	Felis catus	23.06	7.00e-48	183.00
IUUC-Fal-037122	Ficedula albicollis	25.71	1.00e-48	186.00
IUUC-Fox-038030	Fusarium oxysporum	26.19	4.00e-67	247.00
IUUC-Fso-038426	Fusarium solani	24.62	1.00e-75	276.00
IUUC-Gmo-038784	Gadus morhua	24.61	1.00e-53	202.00
IUUC-Ggr-039973	Gaeumannomyces graminis	24.66	2.00e-73	268.00
IUUC-Gga-040692	Gallus gallus	24.87	5.00e-50	191.00
IUUC-Gac-041868	Gasterosteus aculeatus	24.67	1.00e-52	199.00
IUUC-Gma-044274	Glycine max	24.13	1.00e-56	213.00
IUUC-Ggo-045053	Gorilla gorilla	23.05	3.00e-48	184.00
IUUC-Hsa-046635	Homo sapiens	23.18	2.00e-48	186.00
IUUC-Hvu-047361	Hordeum vulgare	23.34	2.00e-54	205.00
IUUC-Itr-048868	Ictidomys tridecemlineatus	22.98	3.00e-46	178.00
IUUC-Kpa-049270	Komagataella pastoris	29.51	6.00e-69	253.00
IUUC-Lch-050188	Latimeria chalumnae	25.96	2.00e-53	202.00
IUUC-Lpe-051026	Leersia perrieri	23.70	7.00e-60	223.00
IUUC-Loc-051821	Lepisosteus oculatus	24.83	1.00e-53	202.00
IUUC-Lma-053178	Leptosphaeria maculans	25.82	3.00e-65	241.00
IUUC-Laf-053552	Loxodonta africana	22.98	3.00e-49	188.00
IUUC-Mcc-054667	Macaca mulatta	23.18	7.00e-49	187.00
IUUC-Meu-056422	Macropus eugenii	23.20	2.00e-37	149.00
IUUC-Mor-056981	Magnaporthe oryzae	26.80	4.00e-73	267.00
IUUC-Mtr-058703	Medicago truncatula	23.56	4.00e-52	197.00
IUUC-Mla-059088	Melampsora laricipopulina	25.29	5.00e-59	220.00
IUUC-Mga-059798	Meleagris gallopavo	24.87	2.00e-50	192.00
IUUC-Mvi-060404	Microbotryum violaceum	23.59	3.00e-53	202.00
IUUC-Mmr-061630	Microcebus murinus	22.98	8.00e-48	183.00
IUUC-Mdo-062354	Monodelphis domestica	23.09	1.00e-52	199.00
IUUC-Mmu-063199	Mus musculus	22.98	4.00e-47	181.00
IUUC-Mac-065595	Musa acuminata	24.44	2.00e-57	215.00
IUUC-Mpu-066596	Mustela putorius furo	23.26	3.00e-47	181.00
IUUC-Mlu-067455	Myotis lucifugus	23.12	5.00e-46	177.00
IUUC-Nfi-068565	Neosartorya fischeri	24.80	5.00e-75	273.00
IUUC-Ncr-068748	Neurospora crassa	25.91	6.00e-72	263.00
IUUC-Nle-068979	Nomascus leucogenys	23.58	8.00e-41	160.00
IUUC-Opr-070711	Ochotona princeps	22.59	1.00e-47	183.00
IUUC-Ont-072603	Oreochromis niloticus	24.74	5.00e-55	207.00
IUUC-Oan-073136	Ornithorhynchus anatinus	23.85	2.00e-39	154.00
IUUC-Ocu-074496	Oryctolagus cuniculus	23.19	4.00e-48	184.00
IUUC-Oba-075933	Oryza barthii	23.91	3.00e-53	201.00
IUUC-Obr-076290	Oryza brachyantha	23.12	7.00e-58	217.00
IUUC-Ogu-078728	Oryza glumaepatula	23.91	4.00e-53	201.00
IUUC-Oin-079954	Oryza indica	23.71	1.00e-53	202.00
IUUC-Olo-081033	Oryza longistaminata	21.68	2.00e-41	162.00
IUUC-Ome-081797	Oryza meridionalis	24.20	2.00e-54	205.00
IUUC-Oni-082802	Oryza nivara	23.91	4.00e-53	201.00
IUUC-Opu-083595	Oryza punctata	24.03	2.00e-60	225.00
IUUC-Oru-084199	Oryza rufipogon	23.91	4.00e-53	201.00
IUUC-Osa-085349	Oryza sativa	24.04	8.00e-61	226.00
IUUC-Ola-087482	Oryzias latipes	24.27	4.00e-53	201.00
IUUC-Olu-087797	Ostreococcus lucimarinus	18.99	9.00e-25	107.00
IUUC-Oga-088817	Otolemur garnettii	23.12	4.00e-47	181.00
IUUC-Oar-090350	Ovis aries	23.63	4.00e-32	131.00
IUUC-Ptr-090999	Pan troglodytes	23.05	1.00e-48	186.00
IUUC-Pan-092704	Papio anubis	23.18	7.00e-49	187.00
IUUC-Psi-093529	Pelodiscus sinensis	24.07	7.00e-51	194.00
IUUC-Pma-094400	Petromyzon marinus	26.03	4.00e-65	241.00
IUUC-Pno-094875	Phaeosphaeria nodorum	25.31	1.00e-69	255.00
IUUC-Ppa-095231	Physcomitrella patens	22.63	2.00e-54	206.00
IUUC-Pfo-096967	Poecilia formosa	24.47	4.00e-53	201.00
IUUC-Pab-098300	Pongo abelii	23.18	1.00e-48	186.00
IUUC-Pop-098966	Populus trichocarpa	23.82	3.00e-59	221.00
IUUC-Pca-100643	Procavia capensis	24.18	5.00e-47	181.00
IUUC-Ppe-101589	Prunus persica	23.01	1.00e-57	216.00
IUUC-Pva-102766	Pteropus vampyrus	22.82	4.00e-41	161.00
IUUC-Pgr-103330	Puccinia graminis	24.29	2.00e-56	212.00
IUUC-Ptt-103809	Puccinia triticina	23.34	3.00e-53	201.00
IUUC-Pte-104319	Pyrenophora teres	26.62	1.00e-70	259.00
IUUC-Pyt-104798	Pyrenophora triticirepentis	24.24	2.00e-59	222.00
IUUC-Rno-105817	Rattus norvegicus	23.25	2.00e-46	178.00
IUUC-Sha-107479	Sarcophilus harrisii	23.09	1.00e-51	196.00
IUUC-Sja-107976	Schizosaccharomyces japonicus	23.61	4.00e-53	201.00
IUUC-Spo-108146	Schizosaccharomyces pombe	24.04	1.00e-45	176.00
IUUC-Ssl-108663	Sclerotinia sclerotiorum	26.47	4.00e-61	228.00
IUUC-Smo-109585	Selaginella moellendorffii	24.71	1.00e-51	196.00
IUUC-Sit-110275	Setaria italica	23.81	8.00e-59	220.00
IUUC-Sly-111073	Solanum lycopersicum	23.38	2.00e-59	222.00
IUUC-Sar-113718	Sorex araneus	21.88	1.00e-40	159.00
IUUC-Sbi-114080	Sorghum bicolor	24.17	1.00e-62	233.00
IUUC-Sre-115160	Sporisorium reilianum	25.33	1.00e-61	229.00
IUUC-Ssc-115997	Sus scrofa	22.98	3.00e-47	181.00
IUUC-Tgu-116904	Taeniopygia guttata	25.17	2.00e-51	195.00
IUUC-Tru-117946	Takifugu rubripes	25.00	2.00e-54	205.00
IUUC-Tni-119692	Tetraodon nigroviridis	24.80	5.00e-53	201.00
IUUC-Tca-121455	Theobroma cacao	23.67	1.00e-58	219.00
IUUC-Tre-122128	Trichoderma reesei	24.35	7.00e-70	256.00
IUUC-Tvi-122657	Trichoderma virens	24.30	2.00e-73	268.00
IUUC-Tae-125953	Triticum aestivum	23.52	3.00e-54	204.00
IUUC-Tur-126110	Triticum urartu	22.53	4.00e-36	144.00
IUUC-Tme-127173	Tuber melanosporum	24.51	3.00e-65	241.00
IUUC-Ttr-128420	Tursiops truncatus	23.46	4.00e-51	194.00
IUUC-Uma-129580	Ustilago maydis	24.39	6.00e-61	227.00
IUUC-Vda-129790	Verticillium dahliae	23.23	2.00e-66	245.00
IUUC-Vvi-131095	Vitis vinifera	23.37	2.00e-56	212.00
IUUC-Xtr-131906	Xenopus tropicalis	25.00	1.00e-54	206.00
IUUC-Xma-134197	Xiphophorus maculatus	24.34	1.00e-53	202.00
IUUC-Yli-134617	Yarrowia lipolytica	23.90	3.00e-65	241.00
IUUC-Zma-134979	Zea mays	22.54	9.00e-24	103.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence