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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Sce-106251
UUCD1 version UUC-SaC-00141
Ensembl Protein ID YMR146C
UniProt Accession P40217; D6VZW8; EIF3I_YEAST
Genbank Protein ID AAC49616.1; CAA87361.1; AAS56742.1; DAA10042.1
Protein Name Eukaryotic translation initiation factor 3 subunit I; Eukaryotic translation initiation factor 3 39 kDa subunit
Genbank Nucleotide ID U56937; Z47071; AY558416; BK006946
Gene Name TIF34; YMR146C; YM9375.16C
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
YMR146C YMR146C YMR146C
Annotation
mRNA Expression
GEOFFGED
Protein-protein Interaction
IIDiRefIndexHINTMentha
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
CPLMdbPAFdbPTMUniProt
BioGRID
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 2.70e-16 57.5 50 87
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf..sdtllvsGsdDgtikvWDlrtgvll 36
           gHt+ +++++    +++ v+Gs D +ik+WD++ g ++
   Q: 50   GHTGTIWSIDVdcFTKYCVTGSADYSIKLWDVSNGQCV 87
           8*******98855349*****************99997 PP
   
Organism Saccharomyces cerevisiae
Functional Description
(View)

Functional Description


     Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
 Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Protein Sequence
(Fasta)
MKAIKLTGHE RPLTQVKYNK EGDLLFSCSK DSSASVWYSL NGERLGTLDG HTGTIWSIDV 60
DCFTKYCVTG SADYSIKLWD VSNGQCVATW KSPVPVKRVE FSPCGNYFLA ILDNVMKNPG 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Sce-106251|E3,WD_repeat|Saccharomyces cerevisiae
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGAAGGCTA TCAAATTAAC AGGTCATGAA CGTCCATTAA CTCAAGTGAA GTACAACAAA 60
GAAGGTGATT TACTATTTTC ATGTTCGAAA GATAGCTCGG CCAGTGTTTG GTATTCGTTG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Sce-106251|E3,WD_repeat|Saccharomyces cerevisiae
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0396--Initiation factor
KW-0597--Phosphoprotein
KW-0648--Protein biosynthesis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR027525--eIF3i
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00400--WD40
SMART

SM00320--WD40
Gene Ontology

GO:0010494--C:cytoplasmic stress granule
GO:0005852--C:eukaryotic translation initiation factor 3 complex
GO:0043614--C:multi-eIF complex
GO:0003743--F:translation initiation factor activity
GO:0002183--P:cytoplasmic translational initiation
GO:0002188--P:translation reinitiation
GO:0006413--P:translational initiation
KEGG sce:YMR146C
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000115 Aegilops tauschii 47.79 2.00e-28 117.00
IUUC-Aml-001321 Ailuropoda melanoleuca 45.18 3.00e-83 299.00
IUUC-Atr-002468 Amborella trichopoda 45.40 9.00e-43 164.00
IUUC-Apl-003841 Anas platyrhynchos 45.78 2.00e-85 306.00
IUUC-Aca-005123 Anolis carolinensis 46.55 5.00e-86 308.00
IUUC-Aly-005473 Arabidopsis lyrata 39.46 2.00e-70 256.00
IUUC-Ath-007094 Arabidopsis thaliana 39.52 2.00e-71 260.00
IUUC-Ago-008000 Ashbya gossypii 61.10 3.00e-129 452.00
IUUC-Acl-008098 Aspergillus clavatus 54.44 1.00e-106 377.00
IUUC-Afl-008494 Aspergillus flavus 54.60 3.00e-108 382.00
IUUC-Afu-009080 Aspergillus fumigatus 53.85 4.00e-106 375.00
IUUC-Ani-009230 Aspergillus nidulans 54.60 8.00e-109 384.00
IUUC-Aor-010114 Aspergillus oryzae 54.60 3.00e-108 382.00
IUUC-Ate-010285 Aspergillus terreus 54.01 5.00e-108 382.00
IUUC-Ame-011534 Astyanax mexicanus 45.95 3.00e-85 306.00
IUUC-Bgr-012121 Blumeria graminis 51.32 2.00e-98 350.00
IUUC-Bta-013143 Bos taurus 45.05 1.00e-83 301.00
IUUC-Bci-013950 Botrytis cinerea 52.34 1.00e-103 367.00
IUUC-Bdi-015019 Brachypodium distachyon 41.44 1.00e-72 264.00
IUUC-Bol-015709 Brassica oleracea 39.88 3.00e-70 257.00
IUUC-Bra-017760 Brassica rapa 40.18 9.00e-71 259.00
IUUC-Cel-018226 Caenorhabditis elegans 40.24 3.00e-74 269.00
IUUC-Cja-019741 Callithrix jacchus 45.05 1.00e-83 301.00
IUUC-Cfa-021204 Canis familiaris 44.58 2.00e-82 296.00
IUUC-Cpo-021661 Cavia porcellus 44.88 6.00e-83 298.00
IUUC-Cre-022952 Chlamydomonas reinhardtii 40.79 2.00e-77 280.00
IUUC-Csa-024038 Chlorocebus sabaeus 45.05 1.00e-83 301.00
IUUC-Cin-025597 Ciona intestinalis 45.48 2.00e-92 329.00
IUUC-Csv-026287 Ciona savignyi 26.99 6.00e-27 112.00
IUUC-Cgl-026583 Colletotrichum gloeosporioides 50.88 2.00e-99 353.00
IUUC-Cne-026838 Cryptococcus neoformans 50.30 7.00e-96 341.00
IUUC-Cme-027304 Cyanidioschyzon merolae 40.12 5.00e-66 242.00
IUUC-Dre-028567 Danio rerio 45.65 6.00e-84 301.00
IUUC-Dno-029171 Dasypus novemcinctus 45.18 1.00e-82 298.00
IUUC-Dor-030257 Dipodomys ordii 35.56 1.00e-25 108.00
IUUC-Dse-031191 Dothistroma septosporum 51.18 7.00e-97 345.00
IUUC-Dme-031879 Drosophila melanogaster 45.12 1.00e-83 300.00
IUUC-Ete-032336 Echinops telfairi 39.27 7.00e-40 154.00
IUUC-Eca-033259 Equus caballus 44.88 7.00e-83 298.00
IUUC-Eeu-035153 Erinaceus europaeus 36.05 2.00e-25 107.00
IUUC-Fca-036489 Felis catus 44.88 7.00e-83 298.00
IUUC-Fal-037485 Ficedula albicollis 45.48 4.00e-85 305.00
IUUC-Fox-037860 Fusarium oxysporum 52.23 6.00e-103 365.00
IUUC-Fso-038188 Fusarium solani 51.73 1.00e-100 357.00
IUUC-Gmo-039311 Gadus morhua 43.92 2.00e-82 297.00
IUUC-Ggr-040045 Gaeumannomyces graminis 52.74 4.00e-106 375.00
IUUC-Gga-040645 Gallus gallus 44.87 4.00e-84 302.00
IUUC-Gac-042086 Gasterosteus aculeatus 43.88 4.00e-80 289.00
IUUC-Gma-043246 Glycine max 41.02 4.00e-73 266.00
IUUC-Ggo-045578 Gorilla gorilla 45.05 1.00e-83 301.00
IUUC-Hsa-046734 Homo sapiens 45.05 1.00e-83 301.00
IUUC-Hvu-047553 Hordeum vulgare 41.27 1.00e-72 264.00
IUUC-Itr-048467 Ictidomys tridecemlineatus 44.58 2.00e-82 296.00
IUUC-Kpa-049325 Komagataella pastoris 55.30 2.00e-114 402.00
IUUC-Lch-049620 Latimeria chalumnae 45.25 4.00e-75 272.00
IUUC-Lpe-051338 Leersia perrieri 41.10 6.00e-70 255.00
IUUC-Loc-052094 Lepisosteus oculatus 39.88 4.00e-70 256.00
IUUC-Lma-053047 Leptosphaeria maculans 52.23 2.00e-102 363.00
IUUC-Laf-053801 Loxodonta africana 44.58 5.00e-82 295.00
IUUC-Mcc-055498 Macaca mulatta 38.14 3.00e-63 233.00
IUUC-Meu-056729 Macropus eugenii 42.22 6.00e-75 271.00
IUUC-Mor-057025 Magnaporthe oryzae 52.72 3.00e-105 372.00
IUUC-Mpo-057511 Magnaporthe poae 54.01 4.00e-105 372.00
IUUC-Mtr-058051 Medicago truncatula 41.02 4.00e-71 259.00
IUUC-Mla-059061 Melampsora laricipopulina 46.22 2.00e-88 316.00
IUUC-Mga-059229 Meleagris gallopavo 45.21 6.00e-83 298.00
IUUC-Mvi-060399 Microbotryum violaceum 45.88 9.00e-87 311.00
IUUC-Mmr-060764 Microcebus murinus 45.35 3.00e-84 303.00
IUUC-Mdo-062088 Monodelphis domestica 45.65 1.00e-83 300.00
IUUC-Mmu-064304 Mus musculus 45.05 7.00e-84 301.00
IUUC-Mac-065520 Musa acuminata 41.46 1.00e-73 267.00
IUUC-Mpu-066340 Mustela putorius furo 44.88 7.00e-83 298.00
IUUC-Mlu-067111 Myotis lucifugus 45.18 2.00e-83 300.00
IUUC-Nfi-068478 Neosartorya fischeri 54.14 7.00e-107 378.00
IUUC-Ncr-068820 Neurospora crassa 53.80 8.00e-105 371.00
IUUC-Nle-069903 Nomascus leucogenys 44.88 4.00e-83 299.00
IUUC-Opr-070221 Ochotona princeps 44.14 4.00e-81 292.00
IUUC-Ont-071765 Oreochromis niloticus 44.18 6.00e-83 298.00
IUUC-Oan-073660 Ornithorhynchus anatinus 43.14 2.00e-70 256.00
IUUC-Ocu-074039 Oryctolagus cuniculus 44.88 6.00e-83 298.00
IUUC-Oba-075395 Oryza barthii 36.45 5.00e-59 219.00
IUUC-Obr-076334 Oryza brachyantha 39.76 9.00e-70 254.00
IUUC-Ogl-077060 Oryza glaberrima 40.96 1.00e-72 264.00
IUUC-Ogu-078207 Oryza glumaepatula 41.27 6.00e-74 268.00
IUUC-Oin-079878 Oryza indica 41.27 9.00e-74 268.00
IUUC-Olo-080677 Oryza longistaminata 36.01 2.00e-66 243.00
IUUC-Ome-081228 Oryza meridionalis 32.50 1.00e-30 124.00
IUUC-Oni-082411 Oryza nivara 35.84 1.00e-57 214.00
IUUC-Opu-083136 Oryza punctata 40.96 2.00e-74 270.00
IUUC-Oru-084916 Oryza rufipogon 39.88 2.00e-72 263.00
IUUC-Osa-085776 Oryza sativa 41.27 8.00e-75 271.00
IUUC-Ola-087053 Oryzias latipes 45.65 3.00e-85 306.00
IUUC-Olu-087602 Ostreococcus lucimarinus 41.57 3.00e-76 276.00
IUUC-Oga-088154 Otolemur garnettii 44.88 5.00e-83 298.00
IUUC-Oar-089915 Ovis aries 44.88 5.00e-83 298.00
IUUC-Ptr-091124 Pan troglodytes 40.43 1.00e-60 224.00
IUUC-Pan-092035 Papio anubis 45.05 1.00e-83 301.00
IUUC-Psi-094096 Pelodiscus sinensis 45.88 8.00e-50 187.00
IUUC-Pma-094255 Petromyzon marinus 28.04 2.00e-21 94.40
IUUC-Pno-094988 Phaeosphaeria nodorum 48.83 1.00e-90 324.00
IUUC-Ppa-095536 Physcomitrella patens 43.07 1.00e-75 274.00
IUUC-Pfo-096101 Poecilia formosa 45.65 6.00e-84 301.00
IUUC-Pab-097726 Pongo abelii 45.05 1.00e-83 301.00
IUUC-Pop-099617 Populus trichocarpa 41.57 2.00e-71 260.00
IUUC-Pca-101014 Procavia capensis 45.35 5.00e-84 302.00
IUUC-Ppe-101320 Prunus persica 40.60 2.00e-71 260.00
IUUC-Pva-102789 Pteropus vampyrus 40.84 6.00e-73 265.00
IUUC-Pgr-103479 Puccinia graminis 45.62 7.00e-89 318.00
IUUC-Ptt-103981 Puccinia triticina 45.92 1.00e-88 317.00
IUUC-Pte-104278 Pyrenophora teres 51.04 1.00e-98 350.00
IUUC-Pyt-104492 Pyrenophora triticirepentis 51.04 1.00e-98 350.00
IUUC-Rno-105867 Rattus norvegicus 40.06 2.00e-70 256.00
IUUC-Sha-107039 Sarcophilus harrisii 45.54 3.00e-84 302.00
IUUC-Sja-107758 Schizosaccharomyces japonicus 52.24 2.00e-106 377.00
IUUC-Spo-108314 Schizosaccharomyces pombe 52.08 8.00e-105 371.00
IUUC-Ssl-108478 Sclerotinia sclerotiorum 52.63 2.00e-103 366.00
IUUC-Smo-108728 Selaginella moellendorffii 41.27 1.00e-74 271.00
IUUC-Sit-110801 Setaria italica 41.87 1.00e-74 271.00
IUUC-Sly-111326 Solanum lycopersicum 41.44 2.00e-72 263.00
IUUC-Stu-112458 Solanum tuberosum 41.44 4.00e-72 262.00
IUUC-Sbi-114063 Sorghum bicolor 40.36 1.00e-72 264.00
IUUC-Sre-115096 Sporisorium reilianum 48.14 4.00e-87 312.00
IUUC-Ssc-116080 Sus scrofa 45.35 6.00e-84 301.00
IUUC-Tgu-116988 Taeniopygia guttata 45.48 4.00e-85 305.00
IUUC-Tru-118766 Takifugu rubripes 44.67 2.00e-84 303.00
IUUC-Tsy-119522 Tarsius syrichta 26.93 2.00e-17 80.90
IUUC-Tni-120197 Tetraodon nigroviridis 44.18 9.00e-84 301.00
IUUC-Tca-121316 Theobroma cacao 41.62 5.00e-73 265.00
IUUC-Tre-122097 Trichoderma reesei 53.41 9.00e-105 370.00
IUUC-Tvi-122442 Trichoderma virens 53.12 7.00e-105 371.00
IUUC-Tae-125800 Triticum aestivum 41.27 2.00e-72 264.00
IUUC-Tur-126334 Triticum urartu 35.54 2.00e-54 203.00
IUUC-Tme-127038 Tuber melanosporum 54.30 3.00e-108 382.00
IUUC-Ttr-128659 Tursiops truncatus 42.04 8.00e-65 238.00
IUUC-Uma-129464 Ustilago maydis 48.42 1.00e-86 310.00
IUUC-Vda-129841 Verticillium dahliae 52.52 5.00e-103 365.00
IUUC-Vpa-130382 Vicugna pacos 27.47 1.00e-20 91.70
IUUC-Vvi-131076 Vitis vinifera 40.42 4.00e-72 262.00
IUUC-Xtr-132395 Xenopus tropicalis 46.08 7.00e-85 305.00
IUUC-Xma-133383 Xiphophorus maculatus 45.65 8.00e-84 301.00
IUUC-Yli-134586 Yarrowia lipolytica 54.65 8.00e-99 351.00
IUUC-Zma-135904 Zea mays 41.27 4.00e-74 269.00
Created Date 25-Jun-2017

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