iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

mRNA Expression
GEO	FFGED
DNA & RNA Element
TRANSFAC
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Post-translational Modifications (PTMs)
CPLM	dbPAF	dbPTM	UniProt
PHOSIDA	BioGRID
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	7.40e-08	31.0	228	256

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 8    claf.sdtllvsGsdDgtikvWDlrtgvl 35
            ++f ++++++s+sdD+ ++ WD+rt ++
   Q: 228  TVRFfDNHIFASCSDDNILRFWDTRTSDK 256
           4787555889**************99876 PP

Organism

Saccharomyces cerevisiae

Functional Description
(View)

Transcriptional modulator with roles in meiotic regulation and silencing. Acts either as an adapter to facilitate nuclear import by KAP122 of the RNR2-RNR4 herodimer, also called beta-beta' subunit, which corresponds to the small subunit of the ribonucleotide reductase (RNR); or as an anchor to retain RNR2-RNR4 in the nucleus.

Protein Sequence
(Fasta)

MPKKVWKSST PSTYEHISSL RPKFVSRVDN VLHQRKSLTF SNVVVPDKKN NTLTSSVIYS 60
QGSDIYEIDF AVPLQEAASE PVKDYGDAFE GIENTSLSPK FVYQGETVSK MAYLDKTGET 120

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Nucleotide Sequence
(Fasta)

ATGCCAAAAA AGGTTTGGAA ATCATCTACG CCTTCCACTT ATGAACATAT CTCCAGCTTA 60
AGACCAAAAT TTGTGTCTCG TGTGGACAAT GTTCTGCACC AAAGGAAGTC CTTGACGTTC 120

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Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0469--Meiosis
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0853--WD repeat

Interpro

IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

PROSITE

PS50294--WD_REPEATS_REGION

SMART

SM00320--WD40

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0003714--F:transcription corepressor activity
GO:0051457--P:maintenance of protein location in nucleus
GO:0061186--P:negative regulation of chromatin silencing at silent mating-type cassette
GO:0031939--P:negative regulation of chromatin silencing at telomere
GO:0010674--P:negative regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0006606--P:protein import into nucleus
GO:0006351--P:transcription, DNA-templated

KEGG

sce:YOR230W

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence