iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

mRNA Expression
GEO	FFGED
DNA & RNA Element
TRANSFAC
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Post-translational Modifications (PTMs)
dbPAF	dbPTM	BioGRID
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	3.90e-08	31.8	241	262

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 9    laf.sdtllvsGsdDgtikvWD 29
           ++f ++ +++++sdDg i+ W 
   Q: 241  IKFlNNQIFATCSDDGIIRFWG 262
           67877799*************7 PP

Organism

Saccharomyces cerevisiae

Functional Description
(View)

Catalytic component of the RPD3 histone deacetylase complexes RPD3C(L) and RPD3C(S) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.

Protein Sequence
(Fasta)

MSTLDIAEDN KIKNEEFKIW KKSIPSLYQH ISSLKPIFGS GVDESPSTLR SIVFTNDSSC 60
NKSKGVLSVP LLYSQGSEIF EVDCIVPLGL HYKKPESISE PLVQPDYTME SQKVEQTVLI 120

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Nucleotide Sequence
(Fasta)

ATGAGCACTT TAGATATTGC AGAAGACAAC AAAATAAAAA ATGAAGAATT CAAAATTTGG 60
AAAAAATCAA TACCCTCATT ATACCAACAT ATTTCAAGTT TGAAGCCTAT CTTTGGCTCA 120

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Sequence Source

Ensembl

Keyword

KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0469--Meiosis
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0853--WD repeat

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

SMART

SM00320--WD40

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0033698--C:Rpd3L complex
GO:0032221--C:Rpd3S complex
GO:0003714--F:transcription corepressor activity
GO:0016569--P:covalent chromatin modification
GO:0051321--P:meiotic cell cycle
GO:0031939--P:negative regulation of chromatin silencing at telomere
GO:0016479--P:negative regulation of transcription from RNA polymerase I promoter
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0040020--P:regulation of meiotic nuclear division
GO:0006351--P:transcription, DNA-templated

KEGG

sce:YPL139C

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ago-007881	Ashbya gossypii	36.36	9.00e-75	271.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence