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Tag Content
UUCD2 ID IUUC-Dre-027536
UUCD1 version UUC-DaR-01185
Ensembl Protein ID ENSDARP00000033992.5
UniProt Accession Q5RHI5; Q7ZU24; Q8JHI4; DTL_DANRE
Genbank Protein ID AAM34656.1; CAI20732.1; CAI20732.1; CAI20792.1; CAI20792.1; AAH45316.1
Protein Name Denticleless protein homolog
Genbank Nucleotide ID AF506212; BX511163; BX510324; BX510324; BX511163; BC045316
Gene Name dtl; cdt2; si:dkey-18c8.4
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSDARG00000023002.5 ENSDART00000034098.5 ENSDARP00000033992.5
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 2.20e-34 116.9 353 385
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf..sd.tllvsGsdDgtikvWDl 30
           gH+ +vt++a+  +d t ++s+sdD+t+++W+l
   Q: 353  GHSQEVTSVAWcpTDfTKIASCSDDNTVRIWRL 385
           8***********888****************97 PP
   
Organism Danio rerio
Functional Description
(View)

Functional Description


     Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1, CDKN1A/p21(CIP1) and KMT5A. CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication. CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing. KMT5A degradation is also important for a proper regulation of mechanisms such as TGF-beta signaling, cell cycle progression, DNA repair and cell migration. Most substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis (By similarity).
 Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1, CDKN1A/p21(CIP1) and KMT5A. CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication. CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing. KMT5A degradation is also important for a proper regulation of mechanisms such as TGF-beta signaling, cell cycle progression, DNA repair and cell migration. Most substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis (By similarity).
Protein Sequence
(Fasta)
MTLFHHVVDR GAKKRGRNGE QRLFPLSSLL DGYECARRDE HISYGASAAA VPPFGCTFSS 60
AHGQQNCLAV ANEEGFVTIF NTGEKQSSVL KEWQAHDNAV FDIAWVPGTN CLVTASGDQT 120
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Protein Fasta Sequence


>IUUC-Dre-027536|E3,WD_repeat|Danio rerio
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Nucleotide Sequence
(Fasta)
AAACTTACCA CTTCTGAACG CGACTTGCAT CCTGCAGCGA TGACTCTTTT TCACCATGTT 60
GTTGATCGAG GGGCTAAAAA AAGAGGACGA AATGGTGAGT TTGCTGAATA TACGTTAACC 120
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Nucleotide Fasta Sequence


>IUUC-Dre-027536|E3,WD_repeat|Danio rerio
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Sequence Source Ensembl
Keyword

KW-0158--Chromosome
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0227--DNA damage
KW-0235--DNA replication
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat
Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00400--WD40
PRINTS

PR00320--GPROTEINBRPT
SMART

SM00320--WD40
Gene Ontology

GO:0005813--C:centrosome
GO:0005694--C:chromosome
GO:0031464--C:Cul4A-RING E3 ubiquitin ligase complex
GO:0031465--C:Cul4B-RING E3 ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0006974--P:cellular response to DNA damage stimulus
GO:0006260--P:DNA replication
GO:0031572--P:G2 DNA damage checkpoint
GO:0007095--P:mitotic G2 DNA damage checkpoint
GO:0006513--P:protein monoubiquitination
GO:0000209--P:protein polyubiquitination
GO:0051726--P:regulation of cell cycle
GO:0009411--P:response to UV
GO:0019985--P:translesion synthesis
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG dre:192314
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002111 Ailuropoda melanoleuca 45.79 9.00e-164 570.00
IUUC-Atr-003097 Amborella trichopoda 36.06 3.00e-64 239.00
IUUC-Apl-004088 Anas platyrhynchos 47.52 9.00e-173 600.00
IUUC-Aca-004732 Anolis carolinensis 45.83 2.00e-159 556.00
IUUC-Aly-005686 Arabidopsis lyrata 34.35 5.00e-59 222.00
IUUC-Ath-006970 Arabidopsis thaliana 33.61 2.00e-56 213.00
IUUC-Acl-008219 Aspergillus clavatus 24.52 1.00e-23 105.00
IUUC-Afu-008784 Aspergillus fumigatus 24.94 4.00e-23 103.00
IUUC-Ani-009304 Aspergillus nidulans 24.67 2.00e-20 94.40
IUUC-Ang-009842 Aspergillus niger 23.61 7.00e-23 102.00
IUUC-Aor-009883 Aspergillus oryzae 23.93 2.00e-22 101.00
IUUC-Ame-010949 Astyanax mexicanus 62.09 0.00e+00 782.00
IUUC-Bta-012333 Bos taurus 46.86 8.00e-164 570.00
IUUC-Bdi-014494 Brachypodium distachyon 34.17 2.00e-56 213.00
IUUC-Bol-015301 Brassica oleracea 33.33 1.00e-57 217.00
IUUC-Bra-017384 Brassica rapa 36.26 3.00e-61 229.00
IUUC-Cel-018498 Caenorhabditis elegans 28.78 4.00e-36 146.00
IUUC-Cja-019534 Callithrix jacchus 45.97 2.00e-162 566.00
IUUC-Cfa-020847 Canis familiaris 46.00 5.00e-164 571.00
IUUC-Cpo-021695 Cavia porcellus 46.49 3.00e-165 575.00
IUUC-Cre-022762 Chlamydomonas reinhardtii 30.40 4.00e-47 184.00
IUUC-Csa-023748 Chlorocebus sabaeus 46.38 3.00e-163 568.00
IUUC-Cho-024445 Choloepus hoffmanni 63.07 2.00e-110 393.00
IUUC-Cne-027008 Cryptococcus neoformans 24.40 5.00e-12 67.80
IUUC-Dno-030035 Dasypus novemcinctus 62.98 1.00e-155 543.00
IUUC-Dor-030814 Dipodomys ordii 50.94 6.00e-50 192.00
IUUC-Dse-031354 Dothistroma septosporum 25.48 2.00e-24 107.00
IUUC-Dme-031691 Drosophila melanogaster 41.28 2.00e-74 273.00
IUUC-Ete-032814 Echinops telfairi 42.44 7.00e-103 368.00
IUUC-Eca-033332 Equus caballus 59.24 1.00e-157 550.00
IUUC-Fca-035571 Felis catus 46.21 2.00e-163 569.00
IUUC-Fal-037421 Ficedula albicollis 47.82 4.00e-169 588.00
IUUC-Fox-038069 Fusarium oxysporum 24.67 1.00e-18 88.20
IUUC-Fso-038192 Fusarium solani 25.43 6.00e-19 89.70
IUUC-Gmo-039365 Gadus morhua 64.08 5.00e-177 614.00
IUUC-Gga-041153 Gallus gallus 47.49 5.00e-169 588.00
IUUC-Gac-041984 Gasterosteus aculeatus 57.84 0.00e+00 695.00
IUUC-Gma-043734 Glycine max 35.92 1.00e-55 210.00
IUUC-Ggo-044419 Gorilla gorilla 46.57 3.00e-164 572.00
IUUC-Hsa-045862 Homo sapiens 46.63 3.00e-165 575.00
IUUC-Hvu-047728 Hordeum vulgare 35.65 2.00e-59 223.00
IUUC-Itr-048786 Ictidomys tridecemlineatus 46.48 3.00e-166 578.00
IUUC-Lch-050616 Latimeria chalumnae 45.23 8.00e-156 544.00
IUUC-Lpe-051222 Leersia perrieri 34.10 1.00e-58 221.00
IUUC-Loc-052564 Lepisosteus oculatus 56.83 0.00e+00 682.00
IUUC-Lma-053098 Leptosphaeria maculans 23.92 5.00e-23 102.00
IUUC-Laf-053892 Loxodonta africana 45.82 2.00e-160 559.00
IUUC-Mcc-055854 Macaca mulatta 46.38 2.00e-163 569.00
IUUC-Mtr-058510 Medicago truncatula 32.95 1.00e-52 201.00
IUUC-Mla-058823 Melampsora laricipopulina 28.49 5.00e-26 112.00
IUUC-Mga-060128 Meleagris gallopavo 47.97 2.00e-169 589.00
IUUC-Mvi-060475 Microbotryum violaceum 34.66 1.00e-43 171.00
IUUC-Mmr-061331 Microcebus murinus 46.21 2.00e-162 566.00
IUUC-Mdo-063020 Monodelphis domestica 46.01 1.00e-165 577.00
IUUC-Mmu-063713 Mus musculus 62.97 6.00e-157 548.00
IUUC-Mac-064653 Musa acuminata 33.61 2.00e-56 213.00
IUUC-Mpu-066490 Mustela putorius furo 47.09 6.00e-165 574.00
IUUC-Mlu-067900 Myotis lucifugus 45.16 1.00e-158 553.00
IUUC-Nfi-068433 Neosartorya fischeri 24.94 2.00e-23 103.00
IUUC-Ncr-068776 Neurospora crassa 27.04 2.00e-26 114.00
IUUC-Nle-069675 Nomascus leucogenys 44.72 4.00e-148 518.00
IUUC-Opr-070769 Ochotona princeps 45.70 3.00e-51 197.00
IUUC-Ont-071441 Oreochromis niloticus 54.75 0.00e+00 644.00
IUUC-Oan-072757 Ornithorhynchus anatinus 45.26 2.00e-155 542.00
IUUC-Ocu-074670 Oryctolagus cuniculus 47.50 6.00e-165 574.00
IUUC-Oba-075844 Oryza barthii 33.24 3.00e-56 213.00
IUUC-Obr-076625 Oryza brachyantha 36.39 5.00e-62 232.00
IUUC-Ogl-077771 Oryza glaberrima 33.24 3.00e-56 213.00
IUUC-Ogu-078475 Oryza glumaepatula 31.14 3.00e-47 182.00
IUUC-Oin-079958 Oryza indica 33.24 2.00e-56 213.00
IUUC-Olo-080311 Oryza longistaminata 33.89 2.00e-50 193.00
IUUC-Ome-081985 Oryza meridionalis 32.66 3.00e-55 209.00
IUUC-Oni-082921 Oryza nivara 33.24 2.00e-56 213.00
IUUC-Opu-083174 Oryza punctata 32.02 6.00e-55 208.00
IUUC-Oru-084338 Oryza rufipogon 33.24 3.00e-56 213.00
IUUC-Osa-085609 Oryza sativa 44.83 6.00e-22 97.40
IUUC-Olu-087907 Ostreococcus lucimarinus 30.38 1.00e-31 130.00
IUUC-Oga-088358 Otolemur garnettii 45.92 5.00e-164 571.00
IUUC-Oar-089994 Ovis aries 47.48 1.00e-162 566.00
IUUC-Ptr-091338 Pan troglodytes 46.77 9.00e-166 577.00
IUUC-Pan-091759 Papio anubis 46.32 6.00e-162 564.00
IUUC-Psi-093211 Pelodiscus sinensis 46.97 1.00e-152 533.00
IUUC-Pma-094588 Petromyzon marinus 56.21 2.00e-94 338.00
IUUC-Pno-094964 Phaeosphaeria nodorum 25.30 5.00e-26 112.00
IUUC-Ppa-095159 Physcomitrella patens 35.05 3.00e-66 246.00
IUUC-Pfo-096592 Poecilia formosa 51.39 1.00e-167 583.00
IUUC-Pab-098597 Pongo abelii 37.67 6.00e-102 365.00
IUUC-Pop-099255 Populus trichocarpa 36.39 1.00e-60 227.00
IUUC-Pca-100593 Procavia capensis 56.37 2.00e-116 413.00
IUUC-Ppe-101333 Prunus persica 34.58 3.00e-57 216.00
IUUC-Pva-102283 Pteropus vampyrus 43.65 8.00e-150 524.00
IUUC-Pgr-103383 Puccinia graminis 30.40 5.00e-21 96.30
IUUC-Ptt-103974 Puccinia triticina 30.91 2.00e-19 90.50
IUUC-Pte-104329 Pyrenophora teres 25.00 2.00e-21 97.80
IUUC-Pyt-104424 Pyrenophora triticirepentis 26.90 6.00e-21 96.30
IUUC-Rno-105720 Rattus norvegicus 46.41 8.00e-159 554.00
IUUC-Sha-106891 Sarcophilus harrisii 45.05 8.00e-150 524.00
IUUC-Sja-107723 Schizosaccharomyces japonicus 29.22 1.00e-32 134.00
IUUC-Spo-108060 Schizosaccharomyces pombe 27.73 6.00e-22 99.00
IUUC-Ssl-108481 Sclerotinia sclerotiorum 27.60 5.00e-19 89.70
IUUC-Sit-109862 Setaria italica 32.96 9.00e-58 218.00
IUUC-Sly-111468 Solanum lycopersicum 34.19 2.00e-61 230.00
IUUC-Stu-112346 Solanum tuberosum 33.77 2.00e-57 216.00
IUUC-Sar-113734 Sorex araneus 57.87 3.00e-66 246.00
IUUC-Sbi-114076 Sorghum bicolor 33.43 3.00e-60 226.00
IUUC-Sre-114918 Sporisorium reilianum 24.04 1.00e-17 85.50
IUUC-Ssc-115561 Sus scrofa 45.84 2.00e-159 556.00
IUUC-Tgu-117011 Taeniopygia guttata 48.74 1.00e-177 616.00
IUUC-Tru-118411 Takifugu rubripes 55.62 0.00e+00 662.00
IUUC-Tsy-119367 Tarsius syrichta 40.30 4.00e-125 442.00
IUUC-Tni-120301 Tetraodon nigroviridis 56.82 0.00e+00 656.00
IUUC-Tca-121265 Theobroma cacao 34.81 2.00e-59 223.00
IUUC-Tre-121997 Trichoderma reesei 25.00 1.00e-16 81.60
IUUC-Tae-125188 Triticum aestivum 35.10 2.00e-58 220.00
IUUC-Tur-126794 Triticum urartu 34.95 2.00e-46 180.00
IUUC-Tme-127090 Tuber melanosporum 27.80 1.00e-20 94.40
IUUC-Tbe-127646 Tupaia belangeri 58.01 3.00e-138 485.00
IUUC-Ttr-128171 Tursiops truncatus 46.93 2.00e-164 573.00
IUUC-Uma-129525 Ustilago maydis 23.36 4.00e-19 90.50
IUUC-Vda-129871 Verticillium dahliae 23.51 5.00e-19 89.70
IUUC-Vpa-130554 Vicugna pacos 58.96 7.00e-68 252.00
IUUC-Vvi-131698 Vitis vinifera 36.26 8.00e-62 231.00
IUUC-Xtr-131962 Xenopus tropicalis 46.70 2.00e-166 579.00
IUUC-Xma-133803 Xiphophorus maculatus 52.43 1.00e-178 619.00
IUUC-Zma-135693 Zea mays 31.62 9.00e-55 207.00
Created Date 25-Jun-2017

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