iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ncr-068636

Ensembl Protein ID

EAA29969

UniProt Accession

Q872C6; Q1K6F8; ATG5_NEUCR

Genbank Protein ID

CAD70807.1; EAA29969.3

Protein Name

Autophagy-related protein 5

Genbank Nucleotide ID

BX294013; CM002240

Gene Name

apg-4; atg5; NCU04662; X4G11.040

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
NCU04662	EAA29969	EAA29969

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 adaptor/Cullin RING/Other	34.09	1.40e-02	35.40	IUUC-Sce-106216

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Neurospora crassa

Functional Description
(View)

Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy). Also required for mitophagy, which eliminates defective or superfluous mitochondria in order to fulfill cellular energy requirements and prevent excess ROS production. Conjugation with atg12, through a ubiquitin-like conjugating system involving apg-5/atg7 as an E1-like activating enzyme and atg10 as an E2-like conjugating enzyme, is essential for its function. The atg12-apg-4/atg5 conjugate acts as an E3-like enzyme which is required for lipidation of apg-6/atg8 and apg-6/atg8 association to the vesicle membranes (By similarity).

Protein Sequence
(Fasta)

MASPNPYSYS PQLPQREESP YQEDQYQSSP SFRSTPFRSS RGTGAGTGIG LGLSSGFTSS 60
LRGGAGGPSE PRSGDGSHDD LPQRSSSSST VIPSLPPKPK PSSIPETLWS LQIPLHITHQ 120

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Nucleotide Sequence
(Fasta)

GCGGACACAC CTAAGCTCCG AAACACCACA GACTTGCTAC GCAGTATTAC ATGAACCAAG 60
GAAAATTGAA TCATTATTTT GTCGCTAGAT ACCTCTATGA CTTGCCGCAA TACGTGTGTA 120

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Sequence Source

Ensembl

Keyword

KW-0072--Autophagy
KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-0472--Membrane
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0832--Ubl conjugation

Interpro

IPR007239--Atg5

Pfam

PF04106--APG5

Gene Ontology

GO:0034274--C:Atg12-Atg5-Atg16 complex
GO:0034045--C:pre-autophagosomal structure membrane
GO:0000045--P:autophagosome assembly
GO:0006501--P:C-terminal protein lipidation
GO:0006995--P:cellular response to nitrogen starvation
GO:0000422--P:mitophagy
GO:0044804--P:nucleophagy
GO:0015031--P:protein transport

KEGG

ncr:NCU04662

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000583	Aegilops tauschii	29.08	4.00e-10	58.50
IUUC-Aml-002403	Ailuropoda melanoleuca	25.94	2.00e-11	61.20
IUUC-Atr-002645	Amborella trichopoda	28.96	8.00e-13	65.90
IUUC-Apl-003611	Anas platyrhynchos	25.00	2.00e-13	67.80
IUUC-Aca-004411	Anolis carolinensis	25.57	3.00e-13	67.00
IUUC-Aly-005636	Arabidopsis lyrata	32.98	7.00e-09	52.80
IUUC-Ath-006959	Arabidopsis thaliana	32.98	8.00e-09	52.80
IUUC-Ago-007978	Ashbya gossypii	27.63	1.00e-05	42.00
IUUC-Acl-008328	Aspergillus clavatus	42.51	3.00e-37	146.00
IUUC-Afl-008638	Aspergillus flavus	37.90	3.00e-41	160.00
IUUC-Afu-009042	Aspergillus fumigatus	40.13	3.00e-43	167.00
IUUC-Ani-009364	Aspergillus nidulans	38.42	3.00e-26	110.00
IUUC-Aor-009889	Aspergillus oryzae	37.90	3.00e-41	160.00
IUUC-Ate-010511	Aspergillus terreus	36.47	3.00e-04	35.00
IUUC-Bgr-012153	Blumeria graminis	43.68	1.00e-48	184.00
IUUC-Bta-012360	Bos taurus	27.56	7.00e-03	31.60
IUUC-Bci-013723	Botrytis cinerea	53.41	2.00e-71	260.00
IUUC-Bdi-014520	Brachypodium distachyon	31.31	1.00e-08	52.00
IUUC-Bol-016053	Brassica oleracea	29.27	3.00e-09	54.30
IUUC-Bra-017072	Brassica rapa	28.66	2.00e-09	54.30
IUUC-Cel-018529	Caenorhabditis elegans	22.22	2.00e-09	54.70
IUUC-Cja-019569	Callithrix jacchus	25.00	7.00e-12	62.40
IUUC-Cfa-020473	Canis familiaris	25.00	4.00e-12	63.20
IUUC-Cpo-021421	Cavia porcellus	25.00	2.00e-11	61.20
IUUC-Cre-022862	Chlamydomonas reinhardtii	26.45	1.10e-02	31.60
IUUC-Csa-024197	Chlorocebus sabaeus	25.00	9.00e-12	62.00
IUUC-Cho-024521	Choloepus hoffmanni	23.53	3.00e-09	53.50
IUUC-Cin-025119	Ciona intestinalis	23.16	2.00e-09	53.90
IUUC-Csv-026192	Ciona savignyi	24.71	5.00e-13	66.20
IUUC-Cgl-026686	Colletotrichum gloeosporioides	60.29	5.00e-81	291.00
IUUC-Dre-028466	Danio rerio	27.31	3.00e-15	73.90
IUUC-Dse-031228	Dothistroma septosporum	37.06	1.00e-39	155.00
IUUC-Ete-032482	Echinops telfairi	23.94	2.00e-09	53.90
IUUC-Eca-034036	Equus caballus	24.62	1.00e-11	62.00
IUUC-Eeu-035235	Erinaceus europaeus	26.72	6.00e-03	32.70
IUUC-Fca-036263	Felis catus	25.00	5.00e-12	62.80
IUUC-Fal-037064	Ficedula albicollis	25.38	2.00e-13	67.80
IUUC-Fox-037813	Fusarium oxysporum	64.09	4.00e-94	335.00
IUUC-Fso-038139	Fusarium solani	64.86	5.00e-94	335.00
IUUC-Gmo-039509	Gadus morhua	25.58	2.00e-09	53.50
IUUC-Ggr-040111	Gaeumannomyces graminis	67.44	2.00e-88	317.00
IUUC-Gga-040517	Gallus gallus	25.77	6.00e-14	69.30
IUUC-Gac-042270	Gasterosteus aculeatus	24.31	1.00e-08	51.60
IUUC-Gma-044400	Glycine max	26.63	4.00e-09	53.10
IUUC-Ggo-045048	Gorilla gorilla	25.00	4.00e-12	63.20
IUUC-Hsa-046744	Homo sapiens	25.00	6.00e-12	62.80
IUUC-Hvu-047268	Hordeum vulgare	41.38	4.00e-01	25.00
IUUC-Kpa-049174	Komagataella pastoris	26.95	2.00e-09	54.70
IUUC-Lch-049475	Latimeria chalumnae	25.00	1.00e-13	68.60
IUUC-Lpe-051283	Leersia perrieri	30.00	3.00e-10	58.90
IUUC-Loc-052446	Lepisosteus oculatus	25.38	1.00e-15	75.10
IUUC-Lma-053278	Leptosphaeria maculans	35.37	1.00e-39	154.00
IUUC-Laf-054020	Loxodonta africana	25.94	2.00e-11	60.80
IUUC-Mcc-055176	Macaca mulatta	25.00	6.00e-12	62.80
IUUC-Mor-057164	Magnaporthe oryzae	62.98	3.00e-83	299.00
IUUC-Mpo-057428	Magnaporthe poae	67.18	3.00e-84	302.00
IUUC-Mtr-058424	Medicago truncatula	27.22	2.00e-09	53.90
IUUC-Mla-058872	Melampsora laricipopulina	25.42	2.00e-14	71.60
IUUC-Mga-059859	Meleagris gallopavo	25.77	6.00e-14	69.30
IUUC-Mmr-061482	Microcebus murinus	25.38	7.00e-12	62.40
IUUC-Mdo-062371	Monodelphis domestica	25.38	1.00e-13	68.20
IUUC-Mmu-063139	Mus musculus	25.00	6.00e-12	62.80
IUUC-Mac-065332	Musa acuminata	28.40	8.00e-10	56.20
IUUC-Mpu-066783	Mustela putorius furo	24.62	2.00e-11	61.20
IUUC-Mlu-068165	Myotis lucifugus	26.72	3.00e-12	63.50
IUUC-Nfi-068578	Neosartorya fischeri	40.13	2.00e-43	167.00
IUUC-Nle-069740	Nomascus leucogenys	25.00	6.00e-12	62.80
IUUC-Opr-070802	Ochotona princeps	26.72	5.00e-03	33.10
IUUC-Ont-072222	Oreochromis niloticus	25.48	4.00e-14	69.70
IUUC-Oan-072760	Ornithorhynchus anatinus	26.54	7.00e-09	52.40
IUUC-Ocu-074844	Oryctolagus cuniculus	25.44	3.00e-09	53.10
IUUC-Oba-075834	Oryza barthii	31.43	1.00e-11	62.40
IUUC-Obr-076230	Oryza brachyantha	32.32	2.00e-08	50.80
IUUC-Ogl-077554	Oryza glaberrima	31.43	1.00e-11	62.40
IUUC-Ogu-078687	Oryza glumaepatula	30.71	4.00e-11	60.50
IUUC-Oin-079677	Oryza indica	28.12	9.00e-13	65.90
IUUC-Olo-081078	Oryza longistaminata	31.21	8.00e-12	63.20
IUUC-Ome-081548	Oryza meridionalis	29.24	8.00e-12	63.90
IUUC-Oni-082050	Oryza nivara	30.71	4.00e-11	60.50
IUUC-Opu-083609	Oryza punctata	26.78	4.00e-12	63.90
IUUC-Oru-085057	Oryza rufipogon	30.71	2.00e-11	61.20
IUUC-Osa-085917	Oryza sativa	30.71	3.00e-11	61.20
IUUC-Ola-087032	Oryzias latipes	25.00	3.00e-13	67.00
IUUC-Oga-088468	Otolemur garnettii	26.34	1.00e-12	65.10
IUUC-Oar-089751	Ovis aries	25.38	9.00e-12	62.00
IUUC-Ptr-091064	Pan troglodytes	25.00	6.00e-12	62.80
IUUC-Pan-092505	Papio anubis	25.94	2.00e-11	60.50
IUUC-Psi-093086	Pelodiscus sinensis	26.44	5.00e-14	69.70
IUUC-Pno-094825	Phaeosphaeria nodorum	34.40	9.00e-36	141.00
IUUC-Ppa-095419	Physcomitrella patens	24.40	9.00e-10	56.20
IUUC-Pfo-096224	Poecilia formosa	24.32	1.00e-12	65.10
IUUC-Pab-098501	Pongo abelii	25.00	8.00e-12	62.40
IUUC-Pop-099243	Populus trichocarpa	28.69	3.00e-09	54.30
IUUC-Ppe-101255	Prunus persica	27.54	2.00e-08	51.60
IUUC-Pva-102828	Pteropus vampyrus	24.62	2.00e-11	60.80
IUUC-Pgr-103672	Puccinia graminis	26.24	2.00e-11	61.20
IUUC-Ptt-104013	Puccinia triticina	25.49	3.00e-09	53.90
IUUC-Pyt-104615	Pyrenophora triticirepentis	32.81	4.00e-36	143.00
IUUC-Rno-106089	Rattus norvegicus	24.62	3.00e-11	60.10
IUUC-Sce-106216	Saccharomyces cerevisiae	34.09	1.00e-03	35.40
IUUC-Sha-106484	Sarcophilus harrisii	25.38	2.00e-13	67.40
IUUC-Sja-107699	Schizosaccharomyces japonicus	25.89	6.00e-19	85.90
IUUC-Spo-108177	Schizosaccharomyces pombe	27.86	5.00e-21	92.80
IUUC-Ssl-108475	Sclerotinia sclerotiorum	54.55	1.00e-74	270.00
IUUC-Smo-109473	Selaginella moellendorffii	31.25	2.00e-04	37.70
IUUC-Sit-110736	Setaria italica	27.49	4.00e-12	63.90
IUUC-Sly-111657	Solanum lycopersicum	29.34	1.00e-12	65.90
IUUC-Stu-112261	Solanum tuberosum	29.17	4.20e-01	27.30
IUUC-Sbi-114258	Sorghum bicolor	30.50	2.00e-11	61.60
IUUC-Sre-114902	Sporisorium reilianum	37.65	1.00e-09	56.20
IUUC-Ssc-116166	Sus scrofa	24.23	1.00e-08	51.60
IUUC-Tgu-116814	Taeniopygia guttata	25.38	2.00e-13	67.80
IUUC-Tru-118172	Takifugu rubripes	24.71	1.00e-13	68.20
IUUC-Tsy-119010	Tarsius syrichta	26.54	1.00e-08	51.60
IUUC-Tni-120397	Tetraodon nigroviridis	24.68	3.00e-07	46.60
IUUC-Tca-121283	Theobroma cacao	27.54	2.00e-10	57.80
IUUC-Tvi-122545	Trichoderma virens	63.95	1.00e-91	327.00
IUUC-Tae-122685	Triticum aestivum	25.21	2.00e-10	58.20
IUUC-Tur-126407	Triticum urartu	29.08	7.00e-11	59.30
IUUC-Tme-126913	Tuber melanosporum	33.78	5.00e-34	135.00
IUUC-Tbe-127738	Tupaia belangeri	25.23	5.00e-10	55.80
IUUC-Ttr-128528	Tursiops truncatus	25.38	1.00e-11	62.00
IUUC-Uma-129625	Ustilago maydis	37.65	9.00e-10	56.60
IUUC-Vda-129906	Verticillium dahliae	61.60	6.00e-82	295.00
IUUC-Vpa-130223	Vicugna pacos	24.90	4.00e-10	56.60
IUUC-Vvi-131617	Vitis vinifera	31.68	4.00e-10	57.40
IUUC-Xtr-132288	Xenopus tropicalis	26.15	7.00e-17	79.00
IUUC-Xma-134214	Xiphophorus maculatus	24.20	2.00e-07	47.40
IUUC-Yli-134377	Yarrowia lipolytica	27.31	6.00e-15	72.40
IUUC-Zma-135108	Zea mays	30.50	9.00e-12	62.40

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence