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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-064355
UUCD1 version UUC-MuM-00644
Ensembl Protein ID ENSMUSP00000082419.6
UniProt Accession Q8BK06; Q8VDY6; Q9D349; Q9JJC5; FBX9_MOUSE
Genbank Protein ID BAA95068.1; BAC36897.1; BAB31231.1; AAH20074.1
Protein Name F-box only protein 9
Genbank Nucleotide ID AB041585; AK077607; AK018482; BC020074
Gene Name Fbxo9; MNCb-2471
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000001366.14 ENSMUST00000085311.12 ENSMUSP00000082419.6
ENSMUSG00000001366.14 ENSMUST00000001402.13 ENSMUSP00000001402.7
ENSMUSG00000001366.14 ENSMUST00000159099.7 ENSMUSP00000125381.1
ENSMUSG00000001366.14 ENSMUST00000162625.1 ENSMUSP00000123807.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarmiRNAMapRAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMUniProt
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 adaptor/Cullin RING/SCF/F-box 21.67 3.00e-14 74.30 IUUC-Sce-106426
E3 adaptor/Cullin RING/SCF/F-box 30.56 3.00e-19 90.90 IUUC-Spo-108193
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Mus musculus
Functional Description
(View)

Functional Description


     Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of TTI1 and TELO2 in a CK2-dependent manner, thereby directly regulating mTOR signaling. SCF(FBXO9) recognizes and binds mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, the SCF(FBXO9) does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is inactivated to restrain cell growth and protein translation, while mTORC2 is activated due to the relief of feedback inhibition by mTORC1 (By similarity).
 Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of TTI1 and TELO2 in a CK2-dependent manner, thereby directly regulating mTOR signaling. SCF(FBXO9) recognizes and binds mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, the SCF(FBXO9) does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is inactivated to restrain cell growth and protein translation, while mTORC2 is activated due to the relief of feedback inhibition by mTORC1 (By similarity).
Protein Sequence
(Fasta)
MAEAEEDCHS DADRVGDEGN ESPAERDLQA QLQMFRAQWM FELTPGVGSS HGETRPCRAG 60
RSSMLKAAAD TKGRQELAKE EKARELFLQA VEEEQNGALY EAIKFYRRAM QLVPDIEFKI 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-064355|E3,F-box|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GTGGGATCTG TAGTTCGACG TGACTTGCGT TGGCTGTTAC CACTCTCCGG CTGCACACAT 60
GAGCGTACGT TTTCTTCGGT TCAGAGTCTG TGGGGTTCAA TGATTGTTGA GTTTTCGCTC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-064355|E3,F-box|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0802--TPR repeat
KW-0833--Ubl conjugation pathway
Interpro

IPR001810--F-box_dom
IPR007330--MIT
IPR011990--TPR-like_helical_dom
PROSITE

PS50181--FBOX
Pfam

PF12937--F-box-like
Gene Ontology

GO:0005737--C:cytoplasm
GO:0019005--C:SCF ubiquitin ligase complex
GO:0004842--F:ubiquitin-protein transferase activity
GO:0045444--P:fat cell differentiation
GO:0045087--P:innate immune response
GO:0016567--P:protein ubiquitination
GO:0032006--P:regulation of TOR signaling
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
KEGG mmu:71538
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000378 Aegilops tauschii 34.71 9.00e-15 73.60
IUUC-Aml-001660 Ailuropoda melanoleuca 90.60 0.00e+00 829.00
IUUC-Atr-003042 Amborella trichopoda 33.90 1.00e-22 100.00
IUUC-Apl-004118 Anas platyrhynchos 82.38 0.00e+00 708.00
IUUC-Aca-005282 Anolis carolinensis 80.78 0.00e+00 715.00
IUUC-Aly-005616 Arabidopsis lyrata 31.25 2.00e-18 86.70
IUUC-Ath-007590 Arabidopsis thaliana 31.82 1.00e-18 87.40
IUUC-Acl-008135 Aspergillus clavatus 27.42 1.00e-16 81.60
IUUC-Afl-008699 Aspergillus flavus 28.43 2.00e-17 84.00
IUUC-Afu-008824 Aspergillus fumigatus 26.28 1.00e-16 81.60
IUUC-Ani-009388 Aspergillus nidulans 25.61 4.00e-17 82.80
IUUC-Ang-009815 Aspergillus niger 26.37 1.00e-16 81.30
IUUC-Aor-010113 Aspergillus oryzae 48.57 4.00e-05 41.60
IUUC-Ate-010365 Aspergillus terreus 30.86 3.00e-14 73.60
IUUC-Ame-011406 Astyanax mexicanus 70.73 6.00e-178 616.00
IUUC-Bgr-012145 Blumeria graminis 27.42 1.00e-17 84.30
IUUC-Bta-012354 Bos taurus 89.50 0.00e+00 820.00
IUUC-Bci-013686 Botrytis cinerea 25.13 3.00e-18 86.70
IUUC-Bdi-014609 Brachypodium distachyon 35.80 2.00e-24 106.00
IUUC-Bol-016149 Brassica oleracea 31.25 2.00e-19 89.70
IUUC-Bra-017126 Brassica rapa 31.25 2.00e-19 90.10
IUUC-Cfa-020387 Canis familiaris 90.60 0.00e+00 830.00
IUUC-Cpo-021298 Cavia porcellus 89.68 0.00e+00 795.00
IUUC-Cre-022803 Chlamydomonas reinhardtii 34.50 4.00e-20 92.00
IUUC-Csa-024074 Chlorocebus sabaeus 91.53 0.00e+00 816.00
IUUC-Cho-024705 Choloepus hoffmanni 93.00 4.00e-142 497.00
IUUC-Cin-025508 Ciona intestinalis 36.88 1.00e-65 243.00
IUUC-Csv-026173 Ciona savignyi 34.44 4.00e-60 225.00
IUUC-Cgl-026681 Colletotrichum gloeosporioides 25.75 5.00e-18 85.90
IUUC-Cne-026854 Cryptococcus neoformans 27.19 2.00e-23 104.00
IUUC-Cme-027201 Cyanidioschyzon merolae 36.09 6.00e-23 101.00
IUUC-Dre-027811 Danio rerio 66.21 2.00e-170 591.00
IUUC-Dno-029907 Dasypus novemcinctus 90.85 0.00e+00 832.00
IUUC-Dor-030126 Dipodomys ordii 88.28 0.00e+00 793.00
IUUC-Dse-031460 Dothistroma septosporum 43.75 4.00e-13 69.70
IUUC-Dme-031882 Drosophila melanogaster 36.38 5.00e-67 248.00
IUUC-Ete-032852 Echinops telfairi 78.46 0.00e+00 674.00
IUUC-Eca-033835 Equus caballus 90.64 0.00e+00 822.00
IUUC-Eeu-034960 Erinaceus europaeus 79.00 0.00e+00 684.00
IUUC-Fca-035547 Felis catus 90.37 0.00e+00 824.00
IUUC-Fal-037181 Ficedula albicollis 79.41 0.00e+00 663.00
IUUC-Fox-038043 Fusarium oxysporum 22.86 2.00e-15 77.40
IUUC-Fso-038242 Fusarium solani 27.84 3.00e-18 86.70
IUUC-Gmo-039658 Gadus morhua 61.82 2.00e-148 518.00
IUUC-Ggr-040039 Gaeumannomyces graminis 44.30 8.00e-14 72.00
IUUC-Gga-040387 Gallus gallus 81.46 0.00e+00 704.00
IUUC-Gac-042247 Gasterosteus aculeatus 64.91 4.00e-171 594.00
IUUC-Gma-043457 Glycine max 34.48 2.00e-22 100.00
IUUC-Ggo-045216 Gorilla gorilla 91.32 0.00e+00 814.00
IUUC-Hsa-046445 Homo sapiens 91.28 0.00e+00 814.00
IUUC-Hvu-047506 Hordeum vulgare 34.57 1.00e-23 103.00
IUUC-Itr-048990 Ictidomys tridecemlineatus 88.99 8.00e-111 392.00
IUUC-Kpa-049180 Komagataella pastoris 25.79 2.00e-18 86.30
IUUC-Lch-049659 Latimeria chalumnae 73.91 0.00e+00 683.00
IUUC-Lpe-051160 Leersia perrieri 34.62 5.00e-09 55.10
IUUC-Loc-051734 Lepisosteus oculatus 72.77 0.00e+00 642.00
IUUC-Lma-053018 Leptosphaeria maculans 24.16 4.00e-15 76.30
IUUC-Laf-053937 Loxodonta africana 90.39 0.00e+00 817.00
IUUC-Mcc-055178 Macaca mulatta 91.76 0.00e+00 822.00
IUUC-Mor-056938 Magnaporthe oryzae 44.00 8.00e-13 68.90
IUUC-Mpo-057448 Magnaporthe poae 44.30 3.00e-14 73.20
IUUC-Mtr-058008 Medicago truncatula 35.63 3.00e-24 105.00
IUUC-Mla-058994 Melampsora laricipopulina 29.02 6.00e-14 72.80
IUUC-Mga-059979 Meleagris gallopavo 81.42 0.00e+00 702.00
IUUC-Mvi-060524 Microbotryum violaceum 29.96 6.00e-21 95.90
IUUC-Mmr-061163 Microcebus murinus 72.25 9.00e-163 566.00
IUUC-Mdo-062767 Monodelphis domestica 86.31 0.00e+00 771.00
IUUC-Mac-064946 Musa acuminata 33.54 3.00e-21 95.90
IUUC-Mpu-066278 Mustela putorius furo 89.00 0.00e+00 760.00
IUUC-Mlu-068028 Myotis lucifugus 90.80 0.00e+00 831.00
IUUC-Nfi-068607 Neosartorya fischeri 25.91 3.00e-18 87.00
IUUC-Ncr-068733 Neurospora crassa 28.89 2.00e-13 71.20
IUUC-Nle-070061 Nomascus leucogenys 91.30 0.00e+00 818.00
IUUC-Opr-071040 Ochotona princeps 55.73 5.00e-125 441.00
IUUC-Ont-071715 Oreochromis niloticus 69.38 2.00e-174 605.00
IUUC-Oan-073385 Ornithorhynchus anatinus 84.86 0.00e+00 773.00
IUUC-Ocu-074608 Oryctolagus cuniculus 90.59 0.00e+00 813.00
IUUC-Oba-075531 Oryza barthii 31.33 6.00e-09 54.70
IUUC-Obr-076891 Oryza brachyantha 35.80 1.00e-23 103.00
IUUC-Ogl-077925 Oryza glaberrima 35.19 6.00e-24 104.00
IUUC-Ogu-078352 Oryza glumaepatula 31.33 6.00e-09 54.70
IUUC-Oin-080025 Oryza indica 35.19 5.00e-24 104.00
IUUC-Olo-080624 Oryza longistaminata 30.97 1.00e-15 77.40
IUUC-Ome-081745 Oryza meridionalis 35.19 6.00e-24 104.00
IUUC-Oni-082992 Oryza nivara 35.80 3.00e-24 105.00
IUUC-Opu-083594 Oryza punctata 30.67 1.00e-15 77.00
IUUC-Oru-084792 Oryza rufipogon 31.33 5.00e-09 55.10
IUUC-Osa-086272 Oryza sativa 37.21 3.00e-10 57.40
IUUC-Ola-086443 Oryzias latipes 67.15 1.00e-170 592.00
IUUC-Olu-087849 Ostreococcus lucimarinus 27.38 1.00e-14 73.90
IUUC-Oga-087973 Otolemur garnettii 82.46 0.00e+00 736.00
IUUC-Oar-089479 Ovis aries 89.27 0.00e+00 819.00
IUUC-Ptr-091217 Pan troglodytes 91.53 0.00e+00 820.00
IUUC-Pan-092809 Papio anubis 91.76 0.00e+00 822.00
IUUC-Psi-093838 Pelodiscus sinensis 82.61 0.00e+00 756.00
IUUC-Pma-094194 Petromyzon marinus 49.53 5.00e-110 391.00
IUUC-Pno-094974 Phaeosphaeria nodorum 29.38 5.00e-14 72.80
IUUC-Ppa-095612 Physcomitrella patens 36.90 2.00e-21 96.30
IUUC-Pfo-097152 Poecilia formosa 64.27 4.00e-169 587.00
IUUC-Pab-098181 Pongo abelii 91.53 0.00e+00 820.00
IUUC-Pop-098903 Populus trichocarpa 37.27 1.00e-21 96.70
IUUC-Pca-100097 Procavia capensis 84.21 0.00e+00 749.00
IUUC-Ppe-101770 Prunus persica 36.02 3.00e-22 99.00
IUUC-Pva-103016 Pteropus vampyrus 91.06 0.00e+00 830.00
IUUC-Pgr-103565 Puccinia graminis 47.06 9.00e-13 68.90
IUUC-Ptt-103963 Puccinia triticina 26.97 4.00e-03 36.20
IUUC-Pte-104397 Pyrenophora teres 28.16 3.00e-13 70.10
IUUC-Pyt-104618 Pyrenophora triticirepentis 55.56 9.00e-03 35.00
IUUC-Rno-104872 Rattus norvegicus 95.64 0.00e+00 874.00
IUUC-Sce-106426 Saccharomyces cerevisiae 24.07 5.00e-14 72.00
IUUC-Sha-106487 Sarcophilus harrisii 86.20 6.00e-176 609.00
IUUC-Sja-107695 Schizosaccharomyces japonicus 30.40 1.00e-19 90.10
IUUC-Spo-108193 Schizosaccharomyces pombe 30.56 9.00e-20 90.90
IUUC-Ssl-108468 Sclerotinia sclerotiorum 27.52 2.00e-18 87.40
IUUC-Smo-109062 Selaginella moellendorffii 35.71 1.00e-20 94.00
IUUC-Sit-110175 Setaria italica 35.80 3.00e-25 109.00
IUUC-Sly-111632 Solanum lycopersicum 32.23 1.00e-22 100.00
IUUC-Stu-112393 Solanum tuberosum 33.65 7.00e-23 101.00
IUUC-Sar-113758 Sorex araneus 87.10 0.00e+00 750.00
IUUC-Sbi-114191 Sorghum bicolor 35.80 3.00e-24 105.00
IUUC-Sre-115169 Sporisorium reilianum 28.85 2.00e-15 78.20
IUUC-Ssc-116249 Sus scrofa 89.98 0.00e+00 813.00
IUUC-Tgu-117421 Taeniopygia guttata 78.90 0.00e+00 659.00
IUUC-Tru-118114 Takifugu rubripes 65.32 2.00e-161 561.00
IUUC-Tsy-119305 Tarsius syrichta 78.21 0.00e+00 679.00
IUUC-Tni-120491 Tetraodon nigroviridis 63.16 4.00e-161 560.00
IUUC-Tca-120948 Theobroma cacao 37.27 4.00e-22 99.00
IUUC-Tre-121934 Trichoderma reesei 28.66 1.00e-18 87.80
IUUC-Tvi-122432 Trichoderma virens 26.23 1.00e-18 87.80
IUUC-Tae-123129 Triticum aestivum 35.19 1.00e-23 103.00
IUUC-Tur-126459 Triticum urartu 34.62 2.00e-09 55.50
IUUC-Tme-127190 Tuber melanosporum 26.09 7.00e-16 79.00
IUUC-Tbe-127313 Tupaia belangeri 66.98 3.00e-120 424.00
IUUC-Ttr-128471 Tursiops truncatus 89.91 0.00e+00 810.00
IUUC-Uma-129486 Ustilago maydis 29.30 9.00e-14 72.40
IUUC-Vda-129897 Verticillium dahliae 25.40 1.00e-19 91.30
IUUC-Vpa-130277 Vicugna pacos 65.51 1.00e-120 426.00
IUUC-Vvi-130912 Vitis vinifera 34.48 3.00e-22 99.00
IUUC-Xtr-132405 Xenopus tropicalis 75.29 0.00e+00 655.00
IUUC-Xma-133338 Xiphophorus maculatus 64.73 1.00e-170 592.00
IUUC-Yli-134647 Yarrowia lipolytica 30.91 9.00e-14 71.60
IUUC-Zma-135447 Zea mays 36.42 8.00e-25 107.00
Created Date 25-Jun-2017

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