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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-046804
Ensembl Protein ID ENSP00000295050.7
UniProt Accession Q9H040; B1AKT0; B5MEF7; Q5TE78; Q6UWW6; Q96BC5; Q96KA0; SPRTN_HUMAN
Genbank Protein ID AAQ88974.1; BAB55232.1; BAB55037.1; CAC21670.1; EAW69956.1; AAH15740.1; AAH68478.1
Protein Name SprT-like domain-containing protein Spartan; DNA damage protein targeting VCP; Protein with SprT-like domain at the N terminus
Genbank Nucleotide ID AY358611; AK027613; AK027317; AL512744; AL117352; BC015740; BC068478
Gene Name SPRTN; C1orf124; DVC1; UNQ1880/PRO4323
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000010072.15 ENST00000391858.8 ENSP00000375731.4
ENSG00000010072.15 ENST00000295050.11 ENSP00000295050.7
ENSG00000010072.15 ENST00000008440.9 ENSP00000008440.9
ENSG00000010072.15 ENST00000366644.3 ENSP00000355604.3
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
AREsiteCircNetmiRTarBasemicroRNA
TRANSFACTargetScanRepTarSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDPINAHINTMentha
InWeb_IM
Protein 3D Structure
PDB
Disease-associated Information
ClinVarGWAS CentralOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDUniProtBioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/ZnF/UBZ UBZ 23042607; 22894931
Classification
Family E-value Score Start End
UBD/ZnF/UBZ 1.90e-07 32.8 454 476
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/ZnF/UBZ
   S: 2    lvCPvCqkmvdqtdfeeHlDeCl 24
           + CPvCq +v +++++eHlD+Cl
   Q: 454  VNCPVCQNEVLESQINEHLDWCL 476
           89********************8 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Regulator of UV-induced DNA damage response: acts as a 'reader' of ubiquitinated PCNA that enhances RAD18-mediated PCNA ubiquitination and translesion DNA synthesis (TLS). Recruited to sites of UV damage and interacts with ubiquitinated PCNA and RAD18, the E3 ubiquitin ligase that monoubiquitinates PCNA. Facilitates chromatin association of RAD18 and is required for efficient PCNA monoubiquitination, promoting a feed-forward loop to enhance PCNA ubiquitination and translesion DNA synthesis. Acts as a regulator of TLS by recruiting VCP/p97 to sites of DNA damage, possibly leading to extraction of DNA polymerase eta (POLH) by VCP/p97 to prevent excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage.
 Regulator of UV-induced DNA damage response: acts as a 'reader' of ubiquitinated PCNA that enhances RAD18-mediated PCNA ubiquitination and translesion DNA synthesis (TLS). Recruited to sites of UV damage and interacts with ubiquitinated PCNA and RAD18, the E3 ubiquitin ligase that monoubiquitinates PCNA. Facilitates chromatin association of RAD18 and is required for efficient PCNA monoubiquitination, promoting a feed-forward loop to enhance PCNA ubiquitination and translesion DNA synthesis. Acts as a regulator of TLS by recruiting VCP/p97 to sites of DNA damage, possibly leading to extraction of DNA polymerase eta (POLH) by VCP/p97 to prevent excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage.
Protein Sequence
(Fasta)
MDDDLMLALR LQEEWNLQEA ERDHAQESLS LVDASWELVD PTPDLQALFV QFNDQFFWGQ 60
LEAVEVKWSV RMTLCAGICS YEGKGGMCSI RLSEPLLKLR PRKDLVETLL HEMIHAYLFV 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046804|UBD,UBZ|Homo sapiens
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Nucleotide Sequence
(Fasta)
CACCAACAAG CAATCGTTCA TGAGAAAGCC GTGCACCCGC TGCAGTTGGG CCATGTGGTC 60
CGCATCGTAT TCCACTAGGT CCCCATTGTA CACCAAGTAC TGTCCCGGCG TCTCCAGCAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046804|UBD,UBZ|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0225--Disease mutation
KW-0227--DNA damage
KW-0234--DNA repair
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR006640--SprT-like_domain
IPR006642--Znf_Rad18_put
PROSITE

PS00142--ZINC_PROTEASE
Pfam

PF10263--SprT-like
SMART

SM00731--SprT
SM00734--ZnF_Rad18
Gene Ontology

GO:0005694--C:chromosome
GO:0016607--C:nuclear speck
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0070530--F:K63-linked polyubiquitin binding
GO:0046872--F:metal ion binding
GO:0043130--F:ubiquitin binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:0070987--P:error-free translesion synthesis
GO:0031398--P:positive regulation of protein ubiquitination
GO:0009411--P:response to UV
GO:0019985--P:translesion synthesis
KEGG hsa:83932
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-001028 Aegilops tauschii 35.56 3.00e-16 79.70
IUUC-Aml-001352 Ailuropoda melanoleuca 80.86 0.00e+00 772.00
IUUC-Atr-002445 Amborella trichopoda 46.38 9.00e-44 171.00
IUUC-Apl-003724 Anas platyrhynchos 44.47 5.00e-67 248.00
IUUC-Aca-005382 Anolis carolinensis 53.20 3.00e-133 468.00
IUUC-Ame-011053 Astyanax mexicanus 47.72 5.00e-100 358.00
IUUC-Bgr-012304 Blumeria graminis 23.78 3.50e-01 29.30
IUUC-Bta-012578 Bos taurus 76.64 0.00e+00 721.00
IUUC-Bci-013808 Botrytis cinerea 50.00 2.80e-02 33.10
IUUC-Cel-018317 Caenorhabditis elegans 64.77 6.00e-80 291.00
IUUC-Cja-019824 Callithrix jacchus 89.41 0.00e+00 812.00
IUUC-Cfa-020307 Canis familiaris 82.58 0.00e+00 786.00
IUUC-Cpo-022142 Cavia porcellus 71.75 3.00e-174 604.00
IUUC-Cre-022820 Chlamydomonas reinhardtii 38.68 4.00e-30 125.00
IUUC-Csa-024002 Chlorocebus sabaeus 95.70 0.00e+00 866.00
IUUC-Cho-024371 Choloepus hoffmanni 76.18 4.00e-132 464.00
IUUC-Cin-025503 Ciona intestinalis 56.23 6.00e-90 323.00
IUUC-Csv-025903 Ciona savignyi 73.12 1.00e-89 322.00
IUUC-Cgl-026737 Colletotrichum gloeosporioides 25.14 6.00e-06 45.80
IUUC-Dre-027871 Danio rerio 56.62 5.00e-104 371.00
IUUC-Dno-029800 Dasypus novemcinctus 72.80 0.00e+00 661.00
IUUC-Dor-030856 Dipodomys ordii 59.02 4.00e-125 441.00
IUUC-Dme-031958 Drosophila melanogaster 51.53 3.00e-69 256.00
IUUC-Ete-032321 Echinops telfairi 84.52 2.00e-119 422.00
IUUC-Eca-033610 Equus caballus 83.40 0.00e+00 792.00
IUUC-Eeu-034608 Erinaceus europaeus 68.28 1.00e-169 589.00
IUUC-Fca-035456 Felis catus 75.41 0.00e+00 707.00
IUUC-Fal-036725 Ficedula albicollis 44.98 7.00e-91 327.00
IUUC-Fso-038353 Fusarium solani 30.68 6.00e-05 42.40
IUUC-Gmo-039428 Gadus morhua 59.83 6.00e-90 324.00
IUUC-Ggr-039914 Gaeumannomyces graminis 28.03 1.00e-04 41.20
IUUC-Gga-041138 Gallus gallus 51.42 3.00e-123 435.00
IUUC-Gac-041946 Gasterosteus aculeatus 58.54 6.00e-89 321.00
IUUC-Ggo-044909 Gorilla gorilla 98.98 0.00e+00 906.00
IUUC-Hvu-047629 Hordeum vulgare 30.15 3.00e-17 83.20
IUUC-Itr-048136 Ictidomys tridecemlineatus 76.29 0.00e+00 644.00
IUUC-Lch-050399 Latimeria chalumnae 46.40 2.00e-102 366.00
IUUC-Lpe-050694 Leersia perrieri 33.33 2.00e-17 84.70
IUUC-Loc-052526 Lepisosteus oculatus 53.26 4.00e-102 365.00
IUUC-Lma-053205 Leptosphaeria maculans 44.00 1.00e-50 193.00
IUUC-Laf-054101 Loxodonta africana 82.52 0.00e+00 785.00
IUUC-Mcc-055889 Macaca mulatta 95.70 0.00e+00 864.00
IUUC-Meu-056236 Macropus eugenii 67.57 5.00e-24 105.00
IUUC-Mor-057257 Magnaporthe oryzae 28.48 5.00e-08 52.40
IUUC-Mpo-057531 Magnaporthe poae 28.03 2.00e-04 40.80
IUUC-Mga-059774 Meleagris gallopavo 48.50 4.00e-102 365.00
IUUC-Mmr-061635 Microcebus murinus 82.45 0.00e+00 761.00
IUUC-Mdo-062699 Monodelphis domestica 66.57 1.00e-120 426.00
IUUC-Mmu-063270 Mus musculus 69.15 0.00e+00 646.00
IUUC-Mac-065121 Musa acuminata 33.17 4.00e-19 89.00
IUUC-Mpu-065833 Mustela putorius furo 79.51 0.00e+00 780.00
IUUC-Mlu-067479 Myotis lucifugus 69.40 4.00e-146 510.00
IUUC-Ncr-068774 Neurospora crassa 30.08 7.00e-06 45.40
IUUC-Nle-069224 Nomascus leucogenys 95.05 0.00e+00 878.00
IUUC-Opr-070699 Ochotona princeps 61.40 4.00e-146 511.00
IUUC-Ont-072423 Oreochromis niloticus 55.38 7.00e-101 361.00
IUUC-Oan-073554 Ornithorhynchus anatinus 71.01 7.00e-32 128.00
IUUC-Ocu-074946 Oryctolagus cuniculus 89.39 4.00e-129 453.00
IUUC-Oba-075090 Oryza barthii 33.01 1.00e-18 88.20
IUUC-Obr-076066 Oryza brachyantha 32.84 4.00e-17 83.60
IUUC-Ogl-077154 Oryza glaberrima 33.01 1.00e-18 88.20
IUUC-Ogu-077955 Oryza glumaepatula 33.01 1.00e-18 88.60
IUUC-Oin-079055 Oryza indica 33.01 2.00e-18 88.20
IUUC-Olo-080733 Oryza longistaminata 38.60 2.00e-14 74.30
IUUC-Ome-081338 Oryza meridionalis 33.01 1.00e-18 88.60
IUUC-Oni-082257 Oryza nivara 33.01 2.00e-18 88.20
IUUC-Opu-083290 Oryza punctata 33.49 3.00e-18 87.00
IUUC-Oru-084633 Oryza rufipogon 31.58 1.00e-17 85.10
IUUC-Osa-086222 Oryza sativa 33.01 1.00e-18 88.60
IUUC-Ola-087333 Oryzias latipes 46.28 1.00e-106 380.00
IUUC-Olu-087722 Ostreococcus lucimarinus 31.17 3.00e-04 42.00
IUUC-Oga-088956 Otolemur garnettii 80.79 0.00e+00 734.00
IUUC-Oar-090014 Ovis aries 78.69 0.00e+00 724.00
IUUC-Ptr-091565 Pan troglodytes 99.80 0.00e+00 909.00
IUUC-Pan-092756 Papio anubis 95.29 0.00e+00 868.00
IUUC-Psi-093051 Pelodiscus sinensis 50.74 2.00e-99 356.00
IUUC-Pma-094409 Petromyzon marinus 71.43 1.00e-56 211.00
IUUC-Pno-094926 Phaeosphaeria nodorum 45.77 3.00e-48 185.00
IUUC-Pfo-096555 Poecilia formosa 54.02 1.00e-98 353.00
IUUC-Pab-098754 Pongo abelii 95.32 0.00e+00 659.00
IUUC-Pca-100166 Procavia capensis 74.49 0.00e+00 719.00
IUUC-Pva-102910 Pteropus vampyrus 66.73 2.00e-173 601.00
IUUC-Pte-104222 Pyrenophora teres 45.10 3.00e-49 189.00
IUUC-Pyt-104688 Pyrenophora triticirepentis 44.83 9.00e-48 184.00
IUUC-Rno-105616 Rattus norvegicus 60.89 3.00e-155 541.00
IUUC-Sha-106669 Sarcophilus harrisii 72.13 3.00e-129 455.00
IUUC-Smo-108867 Selaginella moellendorffii 47.34 2.00e-43 169.00
IUUC-Sit-110221 Setaria italica 27.14 2.00e-16 80.10
IUUC-Sar-113141 Sorex araneus 69.12 2.00e-176 612.00
IUUC-Sbi-114252 Sorghum bicolor 27.62 4.00e-16 79.70
IUUC-Ssc-115883 Sus scrofa 78.07 0.00e+00 727.00
IUUC-Tgu-116997 Taeniopygia guttata 45.10 8.00e-104 370.00
IUUC-Tru-117785 Takifugu rubripes 50.42 8.00e-97 347.00
IUUC-Tsy-119449 Tarsius syrichta 77.98 6.00e-157 546.00
IUUC-Tni-120379 Tetraodon nigroviridis 47.48 7.00e-112 397.00
IUUC-Tre-121886 Trichoderma reesei 41.94 2.00e-04 40.40
IUUC-Tvi-122337 Trichoderma virens 50.00 7.00e-03 35.40
IUUC-Tae-124356 Triticum aestivum 32.37 3.00e-18 87.80
IUUC-Tur-126257 Triticum urartu 30.50 1.00e-19 90.90
IUUC-Tbe-128156 Tupaia belangeri 70.17 0.00e+00 648.00
IUUC-Ttr-128748 Tursiops truncatus 78.79 5.00e-178 617.00
IUUC-Vda-129771 Verticillium dahliae 29.85 1.00e-04 41.60
IUUC-Vpa-130454 Vicugna pacos 77.47 7.00e-82 297.00
IUUC-Xtr-132163 Xenopus tropicalis 45.86 1.00e-104 373.00
IUUC-Xma-134184 Xiphophorus maculatus 61.62 5.00e-104 371.00
IUUC-Zma-134864 Zea mays 28.64 3.00e-17 83.20
Created Date 25-Jun-2017

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