iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Pab-098048

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitin carboxyl-terminal hydrolase

Genbank Nucleotide ID

ABGA01004326

Gene Name

UCHL1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPPYG00000014691.2	ENSPPYT00000017082.2	ENSPPYP00000016413.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/UCH	1.80e-65	221.6	2	222

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/UCH

   S: 7    ewleLesdPglftllvedfgvkrdiqveelysLdpenlglyqepvegllllFkinekressrksqvtsndlevvdediiktiffakqvi 95
           ++ ++e +P++++++++++gv +++++ ++ +L++e+lg+++ p ++llllF+++ ++e++rk+q++    e +++++  +++f+kq+i
   Q: 2    QLKPMEINPEMLNKVLSRLGVAGQWRFVDVLGLEEESLGSVPAPACALLLLFPLTAQHENFRKKQIE----ELKGQEVSPKVYFMKQTI 86
           5789*************************************************************99....99**************** PP
   S: 96   gNsCatyAllsvllncedkl.ldlGttlsrlkestkaespenkalalgnqqvlecihnslariesrseperqdedneqytkeafhfvsy 183
           gNsC+t++l+++++n++dkl ++ G+ l++++++t+++spe++a++++++++++++h+++a++++++ +          +k +fhf+++
   Q: 87   GNSCGTIGLIHAVANNQDKLgFEDGSVLKQFLSETEKMSPEDRAKCFEKNEAIQAAHDAVAQEGQCRVD----------DKVNFHFILF 165
           *******************************************************************99..........5679****** PP
   S: 184  vningrlyeldglkpfPldlgkkketeelkdklkvvraflerikllesdeirfnllaivad 244
            n++g+lyeldg++pfP+++g+++e++ lkd++kv+r+f+er    e++e+rf+++a++++
   Q: 166  NNVDGHLYELDGRMPFPVNHGASSEDTLLKDAAKVCREFTER----EQGEVRFSAVALCKA 222
           ******************************************....************987 PP

Organism

Pongo abelii

Protein Sequence
(Fasta)

MQLKPMEINP EMLNKVLSRL GVAGQWRFVD VLGLEEESLG SVPAPACALL LLFPLTAQHE 60
NFRKKQIEEL KGQEVSPKVY FMKQTIGNSC GTIGLIHAVA NNQDKLGFED GSVLKQFLSE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAAAATTAAA GACTCCATCA AAAGGACTGC TCCATACACT CAAGGAACAC CCACCAACAA 60
ATCCCGTCTC CACAACCACC AGATTATCTC ACCCGCGAGT GAGACTGCAA GGTTTGGGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001578--Peptidase_C12_UCH
IPR030297--UCHL1

PROSITE

PS00140--UCH_1

Pfam

PF01088--Peptidase_C12

PRINTS

PR00707--UBCTHYDRLASE

Gene Ontology

GO:1904115--C:axon cytoplasm
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0043209--C:myelin sheath
GO:0044306--C:neuron projection terminus
GO:0043025--C:neuronal cell body
GO:0005654--C:nucleoplasm
GO:0005886--C:plasma membrane
GO:0004197--F:cysteine-type endopeptidase activity
GO:0016874--F:ligase activity
GO:0008242--F:omega peptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0007628--P:adult walking behavior
GO:0007412--P:axon target recognition
GO:0019896--P:axonal transport of mitochondrion
GO:0008283--P:cell proliferation
GO:0042755--P:eating behavior
GO:0048747--P:muscle fiber development
GO:0043407--P:negative regulation of MAP kinase activity
GO:0050905--P:neuromuscular process
GO:0016579--P:protein deubiquitination
GO:0002931--P:response to ischemia
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

pon:100440914

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000360	Aegilops tauschii	38.86	2.00e-44	172.00
IUUC-Aml-001376	Ailuropoda melanoleuca	80.08	1.00e-112	398.00
IUUC-Atr-002931	Amborella trichopoda	44.28	4.00e-40	157.00
IUUC-Apl-003693	Anas platyrhynchos	69.64	2.00e-91	327.00
IUUC-Aca-004716	Anolis carolinensis	77.68	4.00e-103	366.00
IUUC-Aly-005939	Arabidopsis lyrata	42.66	3.00e-47	181.00
IUUC-Ath-006827	Arabidopsis thaliana	43.58	6.00e-49	186.00
IUUC-Acl-008305	Aspergillus clavatus	35.43	7.00e-30	124.00
IUUC-Afl-008611	Aspergillus flavus	36.96	2.00e-32	132.00
IUUC-Afu-008945	Aspergillus fumigatus	36.52	2.00e-31	129.00
IUUC-Ani-009339	Aspergillus nidulans	35.65	2.00e-31	129.00
IUUC-Ang-009691	Aspergillus niger	35.22	2.00e-31	128.00
IUUC-Aor-009961	Aspergillus oryzae	36.96	2.00e-32	132.00
IUUC-Ate-010316	Aspergillus terreus	36.09	7.00e-33	133.00
IUUC-Ame-011806	Astyanax mexicanus	68.16	6.00e-86	309.00
IUUC-Bgr-012125	Blumeria graminis	34.89	6.00e-31	127.00
IUUC-Bta-013521	Bos taurus	81.75	1.00e-114	405.00
IUUC-Bci-013734	Botrytis cinerea	35.78	5.00e-34	137.00
IUUC-Bdi-014330	Brachypodium distachyon	42.27	5.00e-47	181.00
IUUC-Bol-015214	Brassica oleracea	43.12	5.00e-49	187.00
IUUC-Bra-017721	Brassica rapa	43.58	2.00e-49	188.00
IUUC-Cel-018302	Caenorhabditis elegans	37.67	9.00e-35	139.00
IUUC-Cja-018752	Callithrix jacchus	98.66	7.00e-120	422.00
IUUC-Cfa-020442	Canis familiaris	95.54	2.00e-116	411.00
IUUC-Cpo-021723	Cavia porcellus	96.99	3.00e-94	337.00
IUUC-Cre-022599	Chlamydomonas reinhardtii	40.76	4.00e-34	137.00
IUUC-Csa-023626	Chlorocebus sabaeus	99.10	9.00e-121	425.00
IUUC-Cho-024548	Choloepus hoffmanni	85.19	3.00e-40	157.00
IUUC-Cin-025545	Ciona intestinalis	48.00	1.00e-57	215.00
IUUC-Cgl-026409	Colletotrichum gloeosporioides	32.77	8.00e-27	113.00
IUUC-Cne-026914	Cryptococcus neoformans	33.19	1.00e-23	102.00
IUUC-Cme-027216	Cyanidioschyzon merolae	33.33	8.00e-20	90.10
IUUC-Dre-027854	Danio rerio	66.07	1.00e-84	305.00
IUUC-Dno-029325	Dasypus novemcinctus	95.96	4.00e-118	416.00
IUUC-Dor-030114	Dipodomys ordii	94.62	1.00e-126	444.00
IUUC-Dse-031461	Dothistroma septosporum	33.48	1.00e-27	116.00
IUUC-Dme-032146	Drosophila melanogaster	45.13	8.00e-54	203.00
IUUC-Ete-033092	Echinops telfairi	77.58	4.00e-97	347.00
IUUC-Eca-033854	Equus caballus	96.48	3.00e-79	286.00
IUUC-Eeu-034493	Erinaceus europaeus	93.27	1.00e-113	401.00
IUUC-Fal-036693	Ficedula albicollis	74.29	1.00e-92	332.00
IUUC-Fox-037830	Fusarium oxysporum	36.12	1.00e-32	133.00
IUUC-Fso-038259	Fusarium solani	33.92	2.00e-30	127.00
IUUC-Gmo-038848	Gadus morhua	61.32	1.00e-74	272.00
IUUC-Ggr-039832	Gaeumannomyces graminis	34.93	6.00e-27	114.00
IUUC-Gga-041078	Gallus gallus	75.00	1.00e-101	362.00
IUUC-Gac-042064	Gasterosteus aculeatus	62.27	6.00e-78	283.00
IUUC-Gma-043057	Glycine max	43.64	3.00e-43	168.00
IUUC-Ggo-044827	Gorilla gorilla	100.00	4.00e-122	429.00
IUUC-Hsa-045820	Homo sapiens	100.00	4.00e-122	429.00
IUUC-Hvu-047176	Hordeum vulgare	34.38	2.00e-36	145.00
IUUC-Itr-048496	Ictidomys tridecemlineatus	95.96	2.00e-117	414.00
IUUC-Kpa-049123	Komagataella pastoris	30.05	2.00e-21	95.10
IUUC-Lch-050121	Latimeria chalumnae	74.32	2.00e-98	351.00
IUUC-Lpe-051377	Leersia perrieri	43.08	9.00e-41	159.00
IUUC-Loc-052342	Lepisosteus oculatus	70.35	2.00e-92	331.00
IUUC-Lma-053316	Leptosphaeria maculans	36.36	5.00e-34	137.00
IUUC-Laf-053916	Loxodonta africana	94.22	9.00e-116	409.00
IUUC-Mcc-054838	Macaca mulatta	99.10	9.00e-121	425.00
IUUC-Meu-056478	Macropus eugenii	89.24	2.00e-121	427.00
IUUC-Mor-057271	Magnaporthe oryzae	34.93	2.00e-32	132.00
IUUC-Mpo-057343	Magnaporthe poae	32.05	4.00e-19	87.40
IUUC-Mtr-057713	Medicago truncatula	42.27	8.00e-44	169.00
IUUC-Mla-058942	Melampsora laricipopulina	35.34	6.00e-36	143.00
IUUC-Mga-059878	Meleagris gallopavo	73.73	2.00e-95	341.00
IUUC-Mvi-060249	Microbotryum violaceum	36.84	3.00e-26	111.00
IUUC-Mmr-061284	Microcebus murinus	55.03	6.00e-46	177.00
IUUC-Mdo-062544	Monodelphis domestica	87.89	5.00e-110	389.00
IUUC-Mmu-063300	Mus musculus	95.52	2.00e-127	447.00
IUUC-Mac-065075	Musa acuminata	40.72	2.00e-43	168.00
IUUC-Mpu-066128	Mustela putorius furo	95.00	3.00e-103	367.00
IUUC-Mlu-067778	Myotis lucifugus	94.17	1.00e-125	441.00
IUUC-Nfi-068320	Neosartorya fischeri	36.52	1.00e-31	129.00
IUUC-Ncr-068673	Neurospora crassa	34.06	6.00e-33	134.00
IUUC-Nle-069686	Nomascus leucogenys	99.55	9.00e-122	428.00
IUUC-Opr-070535	Ochotona princeps	78.48	3.00e-99	353.00
IUUC-Ont-071510	Oreochromis niloticus	62.61	7.00e-80	289.00
IUUC-Oan-073247	Ornithorhynchus anatinus	54.72	4.00e-29	119.00
IUUC-Ocu-074590	Oryctolagus cuniculus	96.41	2.00e-118	417.00
IUUC-Oba-075098	Oryza barthii	38.25	1.00e-43	169.00
IUUC-Obr-076041	Oryza brachyantha	41.18	9.00e-46	176.00
IUUC-Ogl-076980	Oryza glaberrima	41.63	2.00e-45	175.00
IUUC-Ogu-078978	Oryza glumaepatula	36.18	9.00e-42	163.00
IUUC-Oin-079285	Oryza indica	37.79	4.00e-43	167.00
IUUC-Olo-080671	Oryza longistaminata	37.79	2.00e-42	165.00
IUUC-Ome-081428	Oryza meridionalis	36.87	5.00e-41	160.00
IUUC-Oni-082406	Oryza nivara	38.25	1.00e-43	169.00
IUUC-Opu-083305	Oryza punctata	36.87	5.00e-42	163.00
IUUC-Oru-084969	Oryza rufipogon	38.25	1.00e-43	169.00
IUUC-Osa-085830	Oryza sativa	41.63	2.00e-45	175.00
IUUC-Ola-087552	Oryzias latipes	59.21	2.00e-74	271.00
IUUC-Olu-087858	Ostreococcus lucimarinus	35.91	6.00e-37	147.00
IUUC-Oga-089013	Otolemur garnettii	82.14	8.00e-114	402.00
IUUC-Oar-089861	Ovis aries	81.75	1.00e-114	405.00
IUUC-Ptr-091536	Pan troglodytes	98.21	1.00e-119	421.00
IUUC-Pan-092909	Papio anubis	99.10	9.00e-121	425.00
IUUC-Psi-093818	Pelodiscus sinensis	79.91	8.00e-105	372.00
IUUC-Pma-094412	Petromyzon marinus	51.33	3.00e-41	160.00
IUUC-Pno-094997	Phaeosphaeria nodorum	33.73	3.00e-25	108.00
IUUC-Ppa-095519	Physcomitrella patens	42.15	3.00e-46	178.00
IUUC-Pfo-097335	Poecilia formosa	60.44	3.00e-79	287.00
IUUC-Pop-099282	Populus trichocarpa	42.73	2.00e-44	171.00
IUUC-Pca-100818	Procavia capensis	72.31	2.00e-66	244.00
IUUC-Ppe-101332	Prunus persica	42.20	7.00e-46	176.00
IUUC-Pva-102954	Pteropus vampyrus	95.07	6.00e-113	399.00
IUUC-Pgr-103430	Puccinia graminis	38.02	6.00e-36	144.00
IUUC-Ptt-103955	Puccinia triticina	39.83	2.00e-36	145.00
IUUC-Pte-104414	Pyrenophora teres	33.19	4.00e-30	124.00
IUUC-Pyt-104587	Pyrenophora triticirepentis	37.50	5.00e-31	127.00
IUUC-Rno-105966	Rattus norvegicus	95.52	2.00e-127	447.00
IUUC-Sce-106412	Saccharomyces cerevisiae	29.89	5.00e-19	87.80
IUUC-Sha-107111	Sarcophilus harrisii	87.27	2.00e-87	313.00
IUUC-Sja-107753	Schizosaccharomyces japonicus	29.60	4.00e-18	84.70
IUUC-Spo-108322	Schizosaccharomyces pombe	33.19	8.00e-24	103.00
IUUC-Ssl-108641	Sclerotinia sclerotiorum	35.32	9.00e-32	130.00
IUUC-Smo-109283	Selaginella moellendorffii	40.79	1.00e-41	162.00
IUUC-Sit-110163	Setaria italica	40.72	6.00e-46	177.00
IUUC-Sly-111832	Solanum lycopersicum	45.41	2.00e-49	188.00
IUUC-Stu-112526	Solanum tuberosum	45.41	1.00e-49	189.00
IUUC-Sar-113190	Sorex araneus	74.56	2.00e-38	150.00
IUUC-Sbi-114545	Sorghum bicolor	40.99	4.00e-44	170.00
IUUC-Sre-114961	Sporisorium reilianum	32.03	2.00e-23	102.00
IUUC-Ssc-115908	Sus scrofa	78.22	4.00e-99	353.00
IUUC-Tgu-117465	Taeniopygia guttata	70.14	2.00e-86	311.00
IUUC-Tru-118565	Takifugu rubripes	60.78	5.00e-70	256.00
IUUC-Tsy-119561	Tarsius syrichta	77.58	1.00e-96	345.00
IUUC-Tni-120042	Tetraodon nigroviridis	52.54	7.00e-51	195.00
IUUC-Tca-120976	Theobroma cacao	43.12	8.00e-47	179.00
IUUC-Tre-122149	Trichoderma reesei	37.89	2.00e-35	142.00
IUUC-Tvi-122450	Trichoderma virens	37.00	2.00e-35	142.00
IUUC-Tae-122693	Triticum aestivum	40.27	5.00e-46	177.00
IUUC-Tur-126250	Triticum urartu	38.86	4.00e-44	171.00
IUUC-Tme-126961	Tuber melanosporum	37.77	1.00e-31	129.00
IUUC-Tbe-128048	Tupaia belangeri	95.15	2.00e-92	330.00
IUUC-Ttr-128494	Tursiops truncatus	95.05	2.00e-114	404.00
IUUC-Uma-129382	Ustilago maydis	32.62	6.00e-29	120.00
IUUC-Vda-129850	Verticillium dahliae	34.20	7.00e-29	120.00
IUUC-Vvi-131661	Vitis vinifera	40.37	9.00e-46	176.00
IUUC-Xtr-132286	Xenopus tropicalis	69.96	9.00e-93	332.00
IUUC-Xma-133019	Xiphophorus maculatus	60.54	5.00e-79	286.00
IUUC-Yli-134570	Yarrowia lipolytica	34.20	4.00e-30	124.00
IUUC-Zma-134740	Zea mays	40.99	1.00e-44	172.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence