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Tag Content
UUCD2 ID IUUC-Gga-040935
UUCD1 version UUC-GaG-00535
Ensembl Protein ID ENSGALP00000014300.4
UniProt Accession Q5ZKU1; DCNL1_CHICK
Genbank Protein ID CAG31652.1
Protein Name DCN1-like protein 1; DCUN1 domain-containing protein 1; Defective in cullin neddylation protein 1-like protein 1
Genbank Nucleotide ID AJ719993
Gene Name DCUN1D1; DCUN1L1; RCJMB04_9c8
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSGALG00000008807.4 ENSGALT00000066444.1 ENSGALP00000057752.1
ENSGALG00000008807.4 ENSGALT00000014316.4 ENSGALP00000014300.4
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/DCUN1 1.60e-90 302.6 61 247
UBD/Alpha-Helix/UBA 3.30e-07 30.6 7 45
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/DCUN1
   S: 2    skkkleelferYkdpqed.ligieglekfcedlgvdpediavLvlawkleaatlcefsreefldgltalgcdsieklqeklktleselk 89
           ++kkle+l++rYkdpq++ +igi+g+++fc+dl++dp++i+vL++awk++aat+cefs+ ef+dg+t+lgcdsiekl+++++++e+elk
   Q: 61   DRKKLEQLYNRYKDPQDEnKIGIDGIQQFCDDLALDPASITVLIIAWKFRAATQCEFSKLEFMDGMTELGCDSIEKLKAQIPKMEQELK 149
           78**************999********************************************************************** PP
   S: 90   deqkfkdiYrfafnfakdkgqksldldtaialwkLllaerefklldawlkfLeeekkksiskDtWnllLefskviakdlsnYdeegaWP 178
           +  +fkd+Y+f+fnfak++gqk+ldl++aia+w+L+l++r fk+ld+w+kfL e++k+si+kDtWnllL+fs++ia+d+snYdeegaWP
   Q: 150  EPGRFKDFYQFTFNFAKNPGQKGLDLEMAIAYWNLVLNGR-FKFLDLWNKFLLEHHKRSIPKDTWNLLLDFSTMIADDMSNYDEEGAWP 237
           ***************************************9.************************************************ PP
   S: 179  vliDefveyl 188
           vliD+fve++
   Q: 238  VLIDDFVEFA 247
           ********97 PP
   

   UBD/Alpha-Helix/UBA
   S: 2    ededkleqlve.MGFdreealqaLraannnleaAveyLl 39
           +++dk++q++  +  ++++a+ +L ++++ l++A+++++
   Q: 7    SQKDKVRQFMVfTQSSEKTAVSCLSQNDWKLDVATDNFF 45
           699********9999999*******************99 PP
   
Organism Gallus gallus
Functional Description
(View)

Functional Description


     Part of an E3 ubiquitin ligase complex for neddylation. Promotes neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes. Acts by binding to cullin-RBX1 complexes in the cytoplasm and promoting their nuclear translocation, enhancing recruitment of E2-NEDD8 (UBE2M-NEDD8) thioester to the complex, and optimizing the orientation of proteins in the complex to allow efficient transfer of NEDD8 from the E2 to the cullin substrates.
 Part of an E3 ubiquitin ligase complex for neddylation. Promotes neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes. Acts by binding to cullin-RBX1 complexes in the cytoplasm and promoting their nuclear translocation, enhancing recruitment of E2-NEDD8 (UBE2M-NEDD8) thioester to the complex, and optimizing the orientation of proteins in the complex to allow efficient transfer of NEDD8 from the E2 to the cullin substrates.
Protein Sequence
(Fasta)
MNKLKSSQKD KVRQFMVFTQ SSEKTAVSCL SQNDWKLDVA TDNFFQNPEL YIRESVKGSL 60
DRKKLEQLYN RYKDPQDENK IGIDGIQQFC DDLALDPASI TVLIIAWKFR AATQCEFSKL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Gga-040935|E3,DCUN1;UBD,UBA|Gallus gallus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGCCCGTGAG GAGCCGGAGC CGCCGCCGCC GGAGGAAGAC GTTGACCGCC GCCGCCGCCC 60
TCAGCGTCCG TCCGAACGGC GAGGGAAGCA GGCCCGCGCA GCCCTCACCA TGGTGAGCGT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Gga-040935|E3,DCUN1;UBD,UBA|Gallus gallus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
Interpro

IPR014764--DCN-prot
IPR005176--PONY_dom
IPR009060--UBA-like
PROSITE

PS51229--DCUN1
Pfam

PF03556--Cullin_binding
Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0000151--C:ubiquitin ligase complex
GO:0097602--F:cullin family protein binding
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0032182--F:ubiquitin-like protein binding
GO:0051443--P:positive regulation of ubiquitin-protein transferase activity
GO:0045116--P:protein neddylation
KEGG gga:424963
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000561 Aegilops tauschii 42.91 1.00e-60 225.00
IUUC-Aml-001879 Ailuropoda melanoleuca 98.45 1.00e-151 528.00
IUUC-Atr-002662 Amborella trichopoda 38.69 5.00e-25 107.00
IUUC-Apl-003451 Anas platyrhynchos 98.85 1.00e-151 528.00
IUUC-Aca-005269 Anolis carolinensis 95.37 3.00e-149 520.00
IUUC-Aly-006285 Arabidopsis lyrata 37.25 3.00e-44 171.00
IUUC-Ath-007531 Arabidopsis thaliana 43.72 4.00e-58 217.00
IUUC-Ago-007806 Ashbya gossypii 23.74 2.00e-20 92.40
IUUC-Acl-008172 Aspergillus clavatus 27.04 9.00e-23 100.00
IUUC-Afl-008569 Aspergillus flavus 29.34 3.00e-29 121.00
IUUC-Ani-009241 Aspergillus nidulans 26.94 4.00e-25 108.00
IUUC-Ang-009664 Aspergillus niger 28.40 2.00e-23 102.00
IUUC-Ate-010414 Aspergillus terreus 30.04 2.00e-30 125.00
IUUC-Ame-011763 Astyanax mexicanus 87.64 6.00e-136 476.00
IUUC-Bgr-011991 Blumeria graminis 32.23 2.00e-25 108.00
IUUC-Bta-013561 Bos taurus 98.36 1.00e-143 501.00
IUUC-Bci-013824 Botrytis cinerea 32.68 1.00e-30 125.00
IUUC-Bdi-014138 Brachypodium distachyon 43.32 1.00e-61 229.00
IUUC-Bol-016110 Brassica oleracea 43.72 7.00e-58 216.00
IUUC-Bra-017111 Brassica rapa 43.72 1.00e-57 216.00
IUUC-Cel-018441 Caenorhabditis elegans 36.73 3.00e-51 195.00
IUUC-Cja-019502 Callithrix jacchus 98.45 2.00e-151 527.00
IUUC-Cfa-020523 Canis familiaris 98.77 4.00e-144 503.00
IUUC-Cpo-022196 Cavia porcellus 97.67 2.00e-150 524.00
IUUC-Cre-022620 Chlamydomonas reinhardtii 36.36 4.00e-50 191.00
IUUC-Csa-023551 Chlorocebus sabaeus 98.84 1.00e-152 531.00
IUUC-Cho-024373 Choloepus hoffmanni 97.29 3.00e-145 506.00
IUUC-Cin-025269 Ciona intestinalis 61.24 8.00e-100 355.00
IUUC-Dre-028247 Danio rerio 87.64 2.00e-136 477.00
IUUC-Dno-028974 Dasypus novemcinctus 98.84 1.00e-152 531.00
IUUC-Dor-030696 Dipodomys ordii 87.98 2.00e-131 460.00
IUUC-Dme-032197 Drosophila melanogaster 63.45 2.00e-92 331.00
IUUC-Ete-032371 Echinops telfairi 98.45 2.00e-151 527.00
IUUC-Eca-033242 Equus caballus 98.84 5.00e-152 529.00
IUUC-Eeu-035317 Erinaceus europaeus 98.45 1.00e-151 528.00
IUUC-Fca-036061 Felis catus 98.46 3.00e-152 530.00
IUUC-Fal-037372 Ficedula albicollis 98.85 9.00e-152 528.00
IUUC-Gmo-038885 Gadus morhua 87.26 5.00e-136 476.00
IUUC-Gac-041937 Gasterosteus aculeatus 87.64 4.00e-136 476.00
IUUC-Gma-043545 Glycine max 42.91 1.00e-58 218.00
IUUC-Ggo-044468 Gorilla gorilla 97.69 9.00e-150 521.00
IUUC-Hsa-046089 Homo sapiens 98.84 1.00e-152 531.00
IUUC-Lch-050600 Latimeria chalumnae 93.82 4.00e-147 513.00
IUUC-Lpe-051540 Leersia perrieri 43.90 4.00e-61 227.00
IUUC-Loc-052509 Lepisosteus oculatus 93.44 2.00e-144 504.00
IUUC-Laf-053527 Loxodonta africana 98.06 2.00e-151 527.00
IUUC-Mcc-055699 Macaca mulatta 88.89 3.00e-146 510.00
IUUC-Meu-056626 Macropus eugenii 77.13 5.00e-111 393.00
IUUC-Mor-056909 Magnaporthe oryzae 28.72 8.00e-25 107.00
IUUC-Mpo-057299 Magnaporthe poae 25.00 3.00e-17 82.00
IUUC-Mtr-057964 Medicago truncatula 42.11 5.00e-58 217.00
IUUC-Mla-058990 Melampsora laricipopulina 28.27 1.00e-18 87.40
IUUC-Mga-059379 Meleagris gallopavo 100.00 9.00e-138 481.00
IUUC-Mvi-060312 Microbotryum violaceum 34.09 2.00e-42 165.00
IUUC-Mmr-060851 Microcebus murinus 98.84 1.00e-151 528.00
IUUC-Mdo-063074 Monodelphis domestica 98.45 3.00e-154 539.00
IUUC-Mmu-063954 Mus musculus 98.07 7.00e-152 528.00
IUUC-Mpu-066870 Mustela putorius furo 98.77 4.00e-144 503.00
IUUC-Mlu-067701 Myotis lucifugus 98.45 5.00e-151 526.00
IUUC-Nle-069291 Nomascus leucogenys 98.84 1.00e-152 531.00
IUUC-Opr-070265 Ochotona princeps 71.71 2.00e-94 338.00
IUUC-Ont-071408 Oreochromis niloticus 87.60 2.00e-134 471.00
IUUC-Oan-073031 Ornithorhynchus anatinus 98.45 1.00e-151 528.00
IUUC-Ocu-074648 Oryctolagus cuniculus 98.84 5.00e-152 529.00
IUUC-Oba-074993 Oryza barthii 44.13 8.00e-62 229.00
IUUC-Obr-076341 Oryza brachyantha 43.72 4.00e-62 230.00
IUUC-Ogl-077099 Oryza glaberrima 44.13 8.00e-62 229.00
IUUC-Ogu-078285 Oryza glumaepatula 43.72 1.00e-60 225.00
IUUC-Oin-079441 Oryza indica 44.13 8.00e-62 229.00
IUUC-Olo-081037 Oryza longistaminata 44.13 8.00e-62 229.00
IUUC-Ome-081357 Oryza meridionalis 44.13 8.00e-62 229.00
IUUC-Oni-082632 Oryza nivara 43.72 8.00e-62 229.00
IUUC-Oru-084306 Oryza rufipogon 44.13 8.00e-62 229.00
IUUC-Osa-085307 Oryza sativa 44.13 8.00e-62 229.00
IUUC-Olu-087646 Ostreococcus lucimarinus 36.84 2.00e-44 172.00
IUUC-Oga-089015 Otolemur garnettii 98.45 2.00e-151 527.00
IUUC-Oar-090405 Ovis aries 98.45 2.00e-151 527.00
IUUC-Ptr-090735 Pan troglodytes 98.84 5.00e-152 529.00
IUUC-Pan-092186 Papio anubis 98.08 2.00e-149 520.00
IUUC-Psi-093110 Pelodiscus sinensis 98.77 5.00e-144 502.00
IUUC-Ppa-095306 Physcomitrella patens 42.97 4.00e-58 217.00
IUUC-Pca-100218 Procavia capensis 94.96 1.00e-148 518.00
IUUC-Ppe-102032 Prunus persica 43.78 5.00e-61 226.00
IUUC-Pva-102983 Pteropus vampyrus 93.02 8.00e-138 482.00
IUUC-Pgr-103633 Puccinia graminis 27.53 1.00e-24 106.00
IUUC-Ptt-103979 Puccinia triticina 38.81 2.00e-04 40.00
IUUC-Rno-105554 Rattus norvegicus 97.30 7.00e-152 528.00
IUUC-Sha-106888 Sarcophilus harrisii 98.45 8.00e-152 528.00
IUUC-Sja-107938 Schizosaccharomyces japonicus 30.65 1.00e-22 99.80
IUUC-Ssl-108410 Sclerotinia sclerotiorum 33.33 4.00e-32 131.00
IUUC-Smo-108750 Selaginella moellendorffii 42.11 4.00e-50 191.00
IUUC-Sit-110052 Setaria italica 43.37 7.00e-62 229.00
IUUC-Sly-111489 Solanum lycopersicum 44.31 9.00e-60 223.00
IUUC-Stu-112517 Solanum tuberosum 43.55 1.00e-59 222.00
IUUC-Sar-113509 Sorex araneus 74.42 2.00e-105 374.00
IUUC-Sbi-114113 Sorghum bicolor 42.97 7.00e-62 229.00
IUUC-Sre-115221 Sporisorium reilianum 27.74 7.00e-26 110.00
IUUC-Ssc-115547 Sus scrofa 98.84 1.00e-152 531.00
IUUC-Tgu-117147 Taeniopygia guttata 100.00 3.00e-153 533.00
IUUC-Tru-117740 Takifugu rubripes 84.88 4.00e-132 463.00
IUUC-Tsy-119599 Tarsius syrichta 98.45 2.00e-151 527.00
IUUC-Tca-121033 Theobroma cacao 43.72 4.00e-59 220.00
IUUC-Tae-125740 Triticum aestivum 36.81 1.00e-54 206.00
IUUC-Tur-126375 Triticum urartu 34.07 3.00e-50 192.00
IUUC-Ttr-129086 Tursiops truncatus 87.98 2.00e-131 460.00
IUUC-Uma-129364 Ustilago maydis 29.70 5.00e-34 137.00
IUUC-Vpa-130048 Vicugna pacos 85.66 1.00e-126 445.00
IUUC-Vvi-130834 Vitis vinifera 44.13 6.00e-60 223.00
IUUC-Xtr-131888 Xenopus tropicalis 97.29 2.00e-150 523.00
IUUC-Yli-134595 Yarrowia lipolytica 31.95 3.00e-36 144.00
Created Date 25-Jun-2017

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