iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Xtr-131953

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AAMC01112390

Gene Name

usp5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXETG00000023925.3	ENSXETT00000051604.3	ENSXETP00000051604.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	3.70e-62	210.6	325	852
UBD/Alpha-Helix/UBA	1.40e-22	79.2	720	758

Active Site

Position(s)	Description	Evidence
334	Nucleophile	{ECO:0000256\|PIRSR:PIRSR016308-1}
815	Proton acceptor	{ECO:0000256\|PIRSR:PIRSR016308-1}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeel...................wkskkkavsp 70
           tG++NlgN+CY+NS++Q++++ip +++ + e   e++ +++p +p++++ ++++kl + +                    k+ +  ++p
   Q: 325  TGIQNLGNSCYLNSTMQVIFSIPAFQRKYVE-RMEQIFQKSPADPTQDFNTQVAKLGNGMlsgeyskpavekdndtapeHKGLQDGIAP 412
           7******************************.66666667789*****************7776666666666554443366666**** PP
   S: 71   rellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclec 159
           r++++ ++k ++efs+++qqDaqEf+ ++++ +e+++                             +++s  +++F++ ++++ikcl  
   Q: 413  RMFKALVGKGHPEFSTNRQQDAQEFFLHFINMVERNC-----------------------------RSSSNPNEVFRFLVEEKIKCLVS 472
           *************************************.............................788999***************** PP
   S: 160  dnvssreepfldlslpvpgkeetkke...........................slqdcLesftkeeelegenkyycekckkkqeaekkl 221
           ++v+ ++   + l+lpvp++   +k                             +++cLe+f+++e+l++   +++   ++k++a k+ 
   Q: 473  QKVKYTQRVEYILQLPVPMEAALNKDelsayeqcrlqaerehrpppelvrariPFTSCLEAFAAPEQLDE---FWSAALQAKSNALKTS 558
           ******************9998877799****************************************96...**************** PP
   S: 222  klkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts........................................... 267
           ++ ++P++L++++k+f+f  + ++++k++ ++++p+eLdls+f                                              
   Q: 559  RFASFPDYLVIQIKKFTFGLD-WVPKKLDVSIDVPDELDLSEFRGGglqggeeelpdvapplvtpdepkgslgfyglddddsycsphfs 646
           ******************997.**********************998888888888888888888888888888888888888888888 PP
   S: 268  .......................................................................................pe 269
                                                                                                  + 
   Q: 647  sptspvldesvvtqlvemgfpaeacrkavyytgnsgaeaamtwvmshmddpdfalplsgasapssvttggdppseehvatiismgfsQ- 734
           8888888887777777777777777777777777777777777777777777777776666666666666666555555555555551. PP
   S: 270  ekqke...........................................................kkkYeLiavvvHsG.slssGHYvay 298
               e                                                             +YeL+a ++H+G s+ +GHYv++
   Q: 735  ----EqavkalratnnnleravdwifshiddldaeaamdlsegrsaaesvseslpaagprvrdgAGRYELFAFISHMGtSTMCGHYVCH 819
           ....055555666666666777777777777777777777778888888888899999999999************************* PP
   S: 299  vknekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
           +k+ +g+W+ ++D+kV ++  e+  +   + +Y++fY+r
   Q: 820  IKK-EGRWVIYNDQKVCAS--EKPPK---DLGYIYFYQR 852
           ***.9***********999..78888...89******98 PP

UBD/Alpha-Helix/UBA

   S: 3    dedkleqlveMGFdreealqaLraannnleaAveyLldg 41
           +e+ ++ +++MGF++e+a++aLra+nnnle+Av++++++
   Q: 720  SEEHVATIISMGFSQEQAVKALRATNNNLERAVDWIFSH 758
           68899********************************97 PP

Organism

Xenopus tropicalis

Protein Sequence
(Fasta)

MGDVKDALLS VLPTIRLPRA GDRVHKDECA YTFHTPETDS GLYICMNTFL GFGRPYVERQ 60
YNKTGQRAFL HLKRTAKMKS EESNSGTGDP PRKKPTRLAI GMEGGFDMSE EQCEYEEVVK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCGGCATCTC ATAGCTGTCC AGGAACCGCA GTCATGGGTG ATGTGAAAGA TGCTCTGCTC 60
TCTGTGCTAC CGACCATTCG GCTACCTCGG GCTGGGGACC GAGTGCACAA GGATGAGTGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1015--Disulfide bond
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR016652--Ubiquitinyl_hydrolase
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS50030--UBA
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP

SMART

SM00165--UBA
SM00290--ZnF_UBP

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0009953--P:dorsal/ventral pattern formation
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000394	Aegilops tauschii	43.33	0.00e+00	639.00
IUUC-Aml-002104	Ailuropoda melanoleuca	79.53	0.00e+00	1380.00
IUUC-Atr-002580	Amborella trichopoda	44.55	0.00e+00	704.00
IUUC-Apl-003774	Anas platyrhynchos	80.54	0.00e+00	1378.00
IUUC-Aca-005368	Anolis carolinensis	77.83	0.00e+00	1385.00
IUUC-Aly-005727	Arabidopsis lyrata	46.61	0.00e+00	725.00
IUUC-Ath-006974	Arabidopsis thaliana	46.50	0.00e+00	722.00
IUUC-Ago-007890	Ashbya gossypii	28.73	2.00e-75	276.00
IUUC-Acl-008057	Aspergillus clavatus	33.10	1.00e-116	414.00
IUUC-Afl-008547	Aspergillus flavus	35.00	9.00e-113	400.00
IUUC-Afu-008805	Aspergillus fumigatus	32.64	2.00e-107	382.00
IUUC-Ani-009441	Aspergillus nidulans	31.81	6.00e-95	341.00
IUUC-Ang-009720	Aspergillus niger	32.33	1.00e-109	390.00
IUUC-Aor-010111	Aspergillus oryzae	32.21	6.00e-118	418.00
IUUC-Ate-010531	Aspergillus terreus	31.16	1.00e-97	350.00
IUUC-Ame-011893	Astyanax mexicanus	63.66	0.00e+00	956.00
IUUC-Bgr-012183	Blumeria graminis	33.53	3.00e-120	426.00
IUUC-Bta-013179	Bos taurus	79.83	0.00e+00	1387.00
IUUC-Bci-013858	Botrytis cinerea	34.23	3.00e-126	446.00
IUUC-Bdi-014904	Brachypodium distachyon	45.92	0.00e+00	691.00
IUUC-Bol-015296	Brassica oleracea	47.02	0.00e+00	735.00
IUUC-Bra-017939	Brassica rapa	47.37	0.00e+00	739.00
IUUC-Cel-018625	Caenorhabditis elegans	34.63	2.00e-129	456.00
IUUC-Cja-019063	Callithrix jacchus	77.91	0.00e+00	1355.00
IUUC-Cfa-020976	Canis familiaris	77.95	0.00e+00	1342.00
IUUC-Cpo-022265	Cavia porcellus	77.39	0.00e+00	1329.00
IUUC-Cre-022640	Chlamydomonas reinhardtii	40.26	2.00e-117	416.00
IUUC-Csa-024177	Chlorocebus sabaeus	76.30	0.00e+00	1208.00
IUUC-Cho-024702	Choloepus hoffmanni	75.13	0.00e+00	840.00
IUUC-Cin-025411	Ciona intestinalis	50.48	0.00e+00	812.00
IUUC-Csv-026347	Ciona savignyi	45.05	0.00e+00	776.00
IUUC-Cgl-026667	Colletotrichum gloeosporioides	33.56	3.00e-109	389.00
IUUC-Cne-026831	Cryptococcus neoformans	34.98	2.00e-123	436.00
IUUC-Dre-027982	Danio rerio	66.01	0.00e+00	1077.00
IUUC-Dno-029034	Dasypus novemcinctus	80.31	0.00e+00	1402.00
IUUC-Dor-030479	Dipodomys ordii	78.43	5.00e-174	604.00
IUUC-Dse-031467	Dothistroma septosporum	34.07	2.00e-120	426.00
IUUC-Dme-032075	Drosophila melanogaster	47.83	0.00e+00	775.00
IUUC-Ete-032865	Echinops telfairi	73.04	0.00e+00	1246.00
IUUC-Eca-034059	Equus caballus	79.74	0.00e+00	1392.00
IUUC-Eeu-035304	Erinaceus europaeus	76.06	0.00e+00	1273.00
IUUC-Fca-035515	Felis catus	79.95	0.00e+00	1391.00
IUUC-Fal-037271	Ficedula albicollis	77.83	0.00e+00	1309.00
IUUC-Fox-037745	Fusarium oxysporum	34.08	2.00e-121	429.00
IUUC-Fso-038158	Fusarium solani	33.99	2.00e-118	420.00
IUUC-Gmo-039071	Gadus morhua	64.61	0.00e+00	1051.00
IUUC-Ggr-040098	Gaeumannomyces graminis	33.57	2.00e-87	317.00
IUUC-Gga-040635	Gallus gallus	80.05	0.00e+00	1441.00
IUUC-Gac-042528	Gasterosteus aculeatus	63.07	0.00e+00	1052.00
IUUC-Gma-043614	Glycine max	45.29	0.00e+00	697.00
IUUC-Ggo-044602	Gorilla gorilla	79.60	0.00e+00	1380.00
IUUC-Hsa-045959	Homo sapiens	79.60	0.00e+00	1380.00
IUUC-Hvu-047563	Hordeum vulgare	46.49	2.00e-164	572.00
IUUC-Itr-048712	Ictidomys tridecemlineatus	79.15	0.00e+00	1384.00
IUUC-Kpa-049156	Komagataella pastoris	32.38	4.00e-107	382.00
IUUC-Lch-049648	Latimeria chalumnae	76.89	0.00e+00	1291.00
IUUC-Lpe-051523	Leersia perrieri	44.57	0.00e+00	687.00
IUUC-Loc-052520	Lepisosteus oculatus	61.69	0.00e+00	998.00
IUUC-Lma-053216	Leptosphaeria maculans	33.22	6.00e-107	383.00
IUUC-Laf-054327	Loxodonta africana	79.95	0.00e+00	1394.00
IUUC-Mcc-055443	Macaca mulatta	79.83	0.00e+00	1388.00
IUUC-Meu-056298	Macropus eugenii	80.03	0.00e+00	944.00
IUUC-Mor-057106	Magnaporthe oryzae	34.06	6.00e-120	424.00
IUUC-Mpo-057589	Magnaporthe poae	32.49	1.00e-114	407.00
IUUC-Mtr-058680	Medicago truncatula	45.81	0.00e+00	711.00
IUUC-Mla-058903	Melampsora laricipopulina	32.19	8.00e-113	401.00
IUUC-Mga-059669	Meleagris gallopavo	79.88	0.00e+00	1367.00
IUUC-Mvi-060476	Microbotryum violaceum	33.89	2.00e-115	409.00
IUUC-Mmr-060575	Microcebus murinus	79.36	0.00e+00	1384.00
IUUC-Mdo-062183	Monodelphis domestica	78.42	0.00e+00	1339.00
IUUC-Mmu-063592	Mus musculus	79.83	0.00e+00	1391.00
IUUC-Mac-065446	Musa acuminata	41.25	0.00e+00	640.00
IUUC-Mpu-066082	Mustela putorius furo	77.48	0.00e+00	1334.00
IUUC-Mlu-067345	Myotis lucifugus	78.73	0.00e+00	1373.00
IUUC-Nfi-068558	Neosartorya fischeri	33.99	1.00e-120	427.00
IUUC-Ncr-068960	Neurospora crassa	33.83	3.00e-108	385.00
IUUC-Nle-070173	Nomascus leucogenys	77.24	0.00e+00	1326.00
IUUC-Opr-070556	Ochotona princeps	80.07	0.00e+00	1403.00
IUUC-Ont-071502	Oreochromis niloticus	64.30	0.00e+00	1052.00
IUUC-Ocu-074861	Oryctolagus cuniculus	77.59	0.00e+00	1347.00
IUUC-Oba-075109	Oryza barthii	44.81	0.00e+00	700.00
IUUC-Obr-076292	Oryza brachyantha	46.50	0.00e+00	701.00
IUUC-Ogl-077065	Oryza glaberrima	45.87	0.00e+00	727.00
IUUC-Ogu-078776	Oryza glumaepatula	44.92	0.00e+00	713.00
IUUC-Oin-080048	Oryza indica	46.10	0.00e+00	722.00
IUUC-Olo-080711	Oryza longistaminata	43.65	0.00e+00	649.00
IUUC-Ome-081506	Oryza meridionalis	44.55	0.00e+00	659.00
IUUC-Oni-082320	Oryza nivara	44.06	0.00e+00	698.00
IUUC-Opu-083801	Oryza punctata	44.92	0.00e+00	684.00
IUUC-Oru-085139	Oryza rufipogon	45.13	0.00e+00	701.00
IUUC-Osa-085713	Oryza sativa	45.98	0.00e+00	731.00
IUUC-Ola-086951	Oryzias latipes	64.61	0.00e+00	1071.00
IUUC-Olu-087822	Ostreococcus lucimarinus	39.31	1.00e-166	580.00
IUUC-Oga-088625	Otolemur garnettii	78.68	0.00e+00	1373.00
IUUC-Oar-089995	Ovis aries	77.79	0.00e+00	1362.00
IUUC-Ptr-090640	Pan troglodytes	78.42	0.00e+00	1380.00
IUUC-Pan-091974	Papio anubis	78.73	0.00e+00	1370.00
IUUC-Psi-093957	Pelodiscus sinensis	79.63	0.00e+00	1448.00
IUUC-Pma-094242	Petromyzon marinus	69.57	6.00e-160	556.00
IUUC-Pno-094835	Phaeosphaeria nodorum	34.04	1.00e-97	350.00
IUUC-Ppa-095901	Physcomitrella patens	47.70	0.00e+00	769.00
IUUC-Pfo-097148	Poecilia formosa	64.92	0.00e+00	1070.00
IUUC-Pab-098068	Pongo abelii	73.38	0.00e+00	1220.00
IUUC-Pop-098943	Populus trichocarpa	46.62	0.00e+00	713.00
IUUC-Pca-100738	Procavia capensis	80.56	0.00e+00	974.00
IUUC-Ppe-101315	Prunus persica	46.34	0.00e+00	738.00
IUUC-Pva-102154	Pteropus vampyrus	78.72	0.00e+00	1362.00
IUUC-Pgr-103343	Puccinia graminis	33.89	2.00e-102	366.00
IUUC-Ptt-103928	Puccinia triticina	30.80	4.00e-99	355.00
IUUC-Pte-104306	Pyrenophora teres	32.37	1.00e-100	360.00
IUUC-Pyt-104696	Pyrenophora triticirepentis	33.06	1.00e-101	363.00
IUUC-Rno-105801	Rattus norvegicus	79.95	0.00e+00	1390.00
IUUC-Sce-106304	Saccharomyces cerevisiae	29.38	1.00e-69	258.00
IUUC-Sha-107635	Sarcophilus harrisii	78.30	0.00e+00	1345.00
IUUC-Sja-107678	Schizosaccharomyces japonicus	29.59	3.00e-96	346.00
IUUC-Spo-108144	Schizosaccharomyces pombe	32.28	3.00e-110	392.00
IUUC-Smo-108848	Selaginella moellendorffii	46.47	0.00e+00	739.00
IUUC-Sit-110728	Setaria italica	46.62	0.00e+00	749.00
IUUC-Sly-111523	Solanum lycopersicum	46.97	0.00e+00	763.00
IUUC-Sbi-114419	Sorghum bicolor	45.57	0.00e+00	743.00
IUUC-Sre-115225	Sporisorium reilianum	33.22	4.00e-114	405.00
IUUC-Ssc-115686	Sus scrofa	78.68	0.00e+00	1377.00
IUUC-Tgu-117346	Taeniopygia guttata	79.72	0.00e+00	1432.00
IUUC-Tru-118350	Takifugu rubripes	62.66	0.00e+00	1075.00
IUUC-Tni-120658	Tetraodon nigroviridis	63.60	0.00e+00	1053.00
IUUC-Tca-121585	Theobroma cacao	46.92	0.00e+00	726.00
IUUC-Tre-122043	Trichoderma reesei	33.95	1.00e-110	394.00
IUUC-Tvi-122303	Trichoderma virens	32.59	6.00e-110	391.00
IUUC-Tae-123798	Triticum aestivum	45.69	0.00e+00	713.00
IUUC-Tur-126732	Triticum urartu	43.53	0.00e+00	671.00
IUUC-Tme-126909	Tuber melanosporum	34.07	9.00e-116	410.00
IUUC-Tbe-127261	Tupaia belangeri	73.92	0.00e+00	860.00
IUUC-Uma-129599	Ustilago maydis	33.08	3.00e-119	422.00
IUUC-Vda-129688	Verticillium dahliae	33.14	3.00e-113	402.00
IUUC-Vvi-131116	Vitis vinifera	46.88	0.00e+00	700.00
IUUC-Xma-133837	Xiphophorus maculatus	65.15	0.00e+00	1074.00
IUUC-Yli-134510	Yarrowia lipolytica	37.22	2.00e-96	346.00
IUUC-Zma-135786	Zea mays	45.80	0.00e+00	717.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence