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Tag Content
iUUCD ID IUUC-Mor-057276
Ensembl Protein ID MGG_01062T0
UniProt Accession Q51MW4; A4RD89; G4NCJ6; ATG8_MAGO7
Genbank Protein ID EHA48293.1
Protein Name Autophagy-related protein 8; Autophagy-related ubiquitin-like modifier ATG8
Genbank Nucleotide ID CM001235
Gene Name ATG8; MGG_01062
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
MGG_01062 MGG_01062T0 MGG_01062T0
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
ULD/UBL/ATG8 80.17 1.00e-51 196.00 IUUC-Sce-106150
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Magnaporthe oryzae
Functional Description
(View)

Functional Description



     Ubiquitin-like modifier involved in autophagosomes formation. With ATG4, mediates the delivery of the autophagosomes to the vacuole via the microtubule cytoskeleton. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Participates also in membrane fusion events that take place in the early secretory pathway. Also involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress. The ATG8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy.
Ubiquitin-like modifier involved in autophagosomes formation. With ATG4, mediates the delivery of the autophagosomes to the vacuole via the microtubule cytoskeleton. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Participates also in membrane fusion events that take place in the early secretory pathway. Also involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress. The ATG8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy.
Protein Sequence
(Fasta)
MRSKFKDEHP FEKRKAEAER IRQKYTDRIP VICEKVEKSD IATIDKKKYL VPADLTVGQF 60
VYVIRKRIKL SPEKAIFIFV QDTLPPTAAL MSSIYELHKD EDGFLYITYS GENTFGDLFE 120
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Protein Fasta Sequence



>IUUC-Mor-057276|ULD,ATG8|Magnaporthe oryzae
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Nucleotide Sequence
(Fasta)
CGTTTTTGGT TGACCCAGTC CAGTCCCTTG TTCCCGCTTC TCACAAGGCG GCAACCACCT 60
GAGGAGCTAC GGTGCGTGCA GTGCCACAGC CGCCCATTTC AAGGTCTACG CAATCCCTCT 120
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Nucleotide Fasta Sequence



>IUUC-Mor-057276|ULD,ATG8|Magnaporthe oryzae
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0072--Autophagy
KW-0181--Complete proteome
KW-0968--Cytoplasmic vesicle
KW-0449--Lipoprotein
KW-0472--Membrane
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0833--Ubl conjugation pathway
KW-0926--Vacuole

Interpro

IPR004241--Atg8-like
IPR029071--Ubiquitin-rel_dom

Pfam

PF02991--Atg8

Gene Ontology

GO:0000421--C:autophagosome membrane
GO:0031410--C:cytoplasmic vesicle
GO:0048102--P:autophagic cell death
GO:0006914--P:autophagy
GO:0009405--P:pathogenesis
GO:0016239--P:positive regulation of macroautophagy
GO:0015031--P:protein transport

KEGG mgr:MGG_01062
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000059 Aegilops tauschii 77.39 3.00e-51 191.00
IUUC-Aml-001629 Ailuropoda melanoleuca 58.62 3.00e-38 148.00
IUUC-Atr-002791 Amborella trichopoda 80.34 3.00e-52 194.00
IUUC-Apl-003994 Anas platyrhynchos 56.03 2.00e-37 145.00
IUUC-Aca-005288 Anolis carolinensis 58.62 3.00e-38 148.00
IUUC-Aly-005987 Arabidopsis lyrata 78.63 3.00e-52 194.00
IUUC-Ath-006958 Arabidopsis thaliana 80.00 4.00e-43 164.00
IUUC-Ago-007898 Ashbya gossypii 73.68 9.00e-49 183.00
IUUC-Acl-008314 Aspergillus clavatus 94.92 3.00e-62 228.00
IUUC-Afl-008708 Aspergillus flavus 95.76 7.00e-63 230.00
IUUC-Afu-009097 Aspergillus fumigatus 94.92 3.00e-62 228.00
IUUC-Ani-009196 Aspergillus nidulans 94.07 2.00e-61 225.00
IUUC-Ang-009530 Aspergillus niger 94.92 3.00e-62 228.00
IUUC-Aor-009909 Aspergillus oryzae 95.76 7.00e-63 230.00
IUUC-Ate-010358 Aspergillus terreus 94.92 3.00e-62 228.00
IUUC-Ame-010751 Astyanax mexicanus 58.62 2.00e-38 148.00
IUUC-Bgr-012248 Blumeria graminis 90.83 5.00e-61 224.00
IUUC-Bta-012520 Bos taurus 58.62 4.00e-38 147.00
IUUC-Bci-013959 Botrytis cinerea 90.98 2.00e-62 228.00
IUUC-Bdi-014390 Brachypodium distachyon 81.36 8.00e-53 196.00
IUUC-Bol-016488 Brassica oleracea 80.00 4.00e-51 191.00
IUUC-Bra-016921 Brassica rapa 80.70 4.00e-52 194.00
IUUC-Cel-018200 Caenorhabditis elegans 54.47 5.00e-36 140.00
IUUC-Cja-019273 Callithrix jacchus 57.76 6.00e-38 147.00
IUUC-Cfa-020373 Canis familiaris 58.62 3.00e-38 148.00
IUUC-Cpo-021831 Cavia porcellus 58.62 3.00e-38 148.00
IUUC-Cre-022866 Chlamydomonas reinhardtii 83.93 3.00e-45 171.00
IUUC-Csa-024201 Chlorocebus sabaeus 58.62 3.00e-38 148.00
IUUC-Cho-025008 Choloepus hoffmanni 52.59 6.00e-35 137.00
IUUC-Cin-025297 Ciona intestinalis 56.03 1.00e-37 146.00
IUUC-Csv-026146 Ciona savignyi 36.75 1.00e-19 86.70
IUUC-Cgl-026691 Colletotrichum gloeosporioides 68.52 4.00e-55 205.00
IUUC-Cne-026889 Cryptococcus neoformans 88.14 2.00e-58 215.00
IUUC-Dre-027910 Danio rerio 56.56 3.00e-39 151.00
IUUC-Dno-029331 Dasypus novemcinctus 58.62 3.00e-38 148.00
IUUC-Dor-030453 Dipodomys ordii 58.62 3.00e-38 148.00
IUUC-Dse-031428 Dothistroma septosporum 94.87 5.00e-62 227.00
IUUC-Dme-031813 Drosophila melanogaster 59.48 1.00e-39 153.00
IUUC-Ete-032671 Echinops telfairi 57.76 3.00e-38 147.00
IUUC-Eca-034113 Equus caballus 58.62 5.00e-38 148.00
IUUC-Eeu-035131 Erinaceus europaeus 55.81 3.00e-25 104.00
IUUC-Fca-036385 Felis catus 58.62 3.00e-38 148.00
IUUC-Fal-036896 Ficedula albicollis 58.62 6.00e-38 147.00
IUUC-Fox-037846 Fusarium oxysporum 94.17 3.00e-63 231.00
IUUC-Fso-038134 Fusarium solani 95.73 2.00e-62 228.00
IUUC-Gmo-039671 Gadus morhua 57.26 3.00e-38 148.00
IUUC-Ggr-039770 Gaeumannomyces graminis 97.54 5.00e-67 244.00
IUUC-Gga-040257 Gallus gallus 59.48 2.00e-39 152.00
IUUC-Gac-041604 Gasterosteus aculeatus 59.48 2.00e-39 152.00
IUUC-Gma-044021 Glycine max 77.97 2.00e-52 195.00
IUUC-Ggo-044429 Gorilla gorilla 58.62 3.00e-38 148.00
IUUC-Hsa-046764 Homo sapiens 58.62 3.00e-38 148.00
IUUC-Hvu-047588 Hordeum vulgare 80.34 1.00e-52 196.00
IUUC-Itr-048405 Ictidomys tridecemlineatus 57.76 5.00e-38 147.00
IUUC-Kpa-049124 Komagataella pastoris 79.20 2.00e-54 202.00
IUUC-Lch-049542 Latimeria chalumnae 57.76 3.00e-38 148.00
IUUC-Lpe-051292 Leersia perrieri 81.36 2.00e-53 199.00
IUUC-Loc-052290 Lepisosteus oculatus 57.76 4.00e-38 148.00
IUUC-Laf-054203 Loxodonta africana 57.76 5.00e-38 147.00
IUUC-Mcc-055307 Macaca mulatta 57.76 5.00e-38 147.00
IUUC-Meu-056515 Macropus eugenii 58.62 3.00e-38 148.00
IUUC-Mpo-057469 Magnaporthe poae 96.69 1.00e-65 239.00
IUUC-Mtr-057664 Medicago truncatula 78.26 2.00e-45 172.00
IUUC-Mla-059098 Melampsora laricipopulina 87.93 3.00e-58 214.00
IUUC-Mga-060108 Meleagris gallopavo 54.92 2.00e-38 149.00
IUUC-Mvi-060496 Microbotryum violaceum 88.70 2.00e-56 208.00
IUUC-Mmr-061776 Microcebus murinus 57.76 5.00e-38 147.00
IUUC-Mdo-061915 Monodelphis domestica 58.62 4.00e-38 148.00
IUUC-Mmu-064152 Mus musculus 58.62 3.00e-38 148.00
IUUC-Mac-064739 Musa acuminata 77.78 4.00e-45 171.00
IUUC-Mpu-066760 Mustela putorius furo 58.62 3.00e-38 148.00
IUUC-Mlu-068211 Myotis lucifugus 58.62 3.00e-38 148.00
IUUC-Nfi-068367 Neosartorya fischeri 94.92 3.00e-62 228.00
IUUC-Ncr-068894 Neurospora crassa 94.92 1.00e-62 229.00
IUUC-Nle-069755 Nomascus leucogenys 58.62 3.00e-38 148.00
IUUC-Opr-070777 Ochotona princeps 57.76 5.00e-38 147.00
IUUC-Ont-072343 Oreochromis niloticus 58.62 3.00e-38 148.00
IUUC-Oan-073485 Ornithorhynchus anatinus 60.95 5.00e-35 137.00
IUUC-Ocu-073861 Oryctolagus cuniculus 58.62 3.00e-38 148.00
IUUC-Oba-075926 Oryza barthii 81.74 2.00e-52 195.00
IUUC-Obr-076830 Oryza brachyantha 81.74 3.00e-53 198.00
IUUC-Ogl-077457 Oryza glaberrima 81.74 2.00e-52 195.00
IUUC-Ogu-078078 Oryza glumaepatula 81.74 2.00e-52 195.00
IUUC-Oin-079771 Oryza indica 81.74 2.00e-52 195.00
IUUC-Olo-080412 Oryza longistaminata 81.74 2.00e-52 195.00
IUUC-Ome-081791 Oryza meridionalis 81.74 2.00e-52 195.00
IUUC-Oni-082774 Oryza nivara 81.74 2.00e-52 195.00
IUUC-Opu-083501 Oryza punctata 82.05 8.00e-54 199.00
IUUC-Oru-084425 Oryza rufipogon 79.49 5.00e-52 194.00
IUUC-Osa-085439 Oryza sativa 81.74 2.00e-52 195.00
IUUC-Ola-086310 Oryzias latipes 57.76 1.00e-37 145.00
IUUC-Olu-087892 Ostreococcus lucimarinus 79.46 2.00e-51 192.00
IUUC-Oga-088483 Otolemur garnettii 58.62 3.00e-38 148.00
IUUC-Oar-089989 Ovis aries 57.76 5.00e-38 147.00
IUUC-Ptr-091560 Pan troglodytes 58.62 3.00e-38 148.00
IUUC-Pan-092269 Papio anubis 58.62 3.00e-38 148.00
IUUC-Psi-093055 Pelodiscus sinensis 56.03 2.00e-37 145.00
IUUC-Pma-094337 Petromyzon marinus 57.76 1.00e-39 152.00
IUUC-Pno-095035 Phaeosphaeria nodorum 94.87 6.00e-62 226.00
IUUC-Ppa-095701 Physcomitrella patens 81.20 6.00e-47 177.00
IUUC-Pfo-096380 Poecilia formosa 57.76 5.00e-38 147.00
IUUC-Pab-098563 Pongo abelii 58.62 3.00e-38 148.00
IUUC-Pop-098791 Populus trichocarpa 79.13 2.00e-51 192.00
IUUC-Pca-100230 Procavia capensis 57.76 5.00e-38 147.00
IUUC-Ppe-101670 Prunus persica 79.13 1.00e-44 169.00
IUUC-Pva-103103 Pteropus vampyrus 56.03 2.00e-37 145.00
IUUC-Pte-104230 Pyrenophora teres 94.87 5.00e-62 227.00
IUUC-Rno-105111 Rattus norvegicus 58.62 3.00e-38 148.00
IUUC-Sce-106150 Saccharomyces cerevisiae 80.17 1.00e-52 196.00
IUUC-Sha-106656 Sarcophilus harrisii 57.76 5.00e-38 147.00
IUUC-Sja-107857 Schizosaccharomyces japonicus 85.34 1.00e-55 206.00
IUUC-Spo-108156 Schizosaccharomyces pombe 82.35 4.00e-47 177.00
IUUC-Ssl-108578 Sclerotinia sclerotiorum 90.98 2.00e-62 229.00
IUUC-Smo-109082 Selaginella moellendorffii 79.13 8.00e-51 190.00
IUUC-Sit-109732 Setaria italica 80.87 8.00e-52 193.00
IUUC-Sly-111488 Solanum lycopersicum 78.63 2.00e-45 172.00
IUUC-Stu-112612 Solanum tuberosum 80.34 3.00e-52 194.00
IUUC-Sar-113670 Sorex araneus 52.59 1.00e-33 132.00
IUUC-Sbi-114346 Sorghum bicolor 81.74 2.00e-52 195.00
IUUC-Sre-114964 Sporisorium reilianum 83.62 4.00e-55 204.00
IUUC-Ssc-115828 Sus scrofa 58.62 3.00e-38 148.00
IUUC-Tgu-117195 Taeniopygia guttata 58.62 3.00e-38 148.00
IUUC-Tru-118632 Takifugu rubripes 55.74 2.00e-38 149.00
IUUC-Tsy-118919 Tarsius syrichta 56.03 2.00e-37 145.00
IUUC-Tni-120706 Tetraodon nigroviridis 57.76 1.00e-37 146.00
IUUC-Tca-121335 Theobroma cacao 75.83 4.00e-45 172.00
IUUC-Tre-122077 Trichoderma reesei 95.69 6.00e-62 227.00
IUUC-Tvi-122400 Trichoderma virens 95.69 6.00e-62 227.00
IUUC-Tae-124455 Triticum aestivum 80.34 4.00e-52 194.00
IUUC-Tur-126158 Triticum urartu 76.52 2.00e-50 188.00
IUUC-Tme-126955 Tuber melanosporum 92.62 1.00e-60 223.00
IUUC-Tbe-127765 Tupaia belangeri 62.79 3.00e-29 117.00
IUUC-Ttr-128205 Tursiops truncatus 58.62 3.00e-38 148.00
IUUC-Uma-129435 Ustilago maydis 83.05 1.00e-55 206.00
IUUC-Vda-129807 Verticillium dahliae 94.92 1.00e-62 229.00
IUUC-Vpa-130804 Vicugna pacos 57.76 1.00e-38 149.00
IUUC-Vvi-130830 Vitis vinifera 79.49 3.00e-45 171.00
IUUC-Xtr-132685 Xenopus tropicalis 58.62 2.00e-38 148.00
IUUC-Xma-133400 Xiphophorus maculatus 55.74 3.00e-38 148.00
IUUC-Yli-134327 Yarrowia lipolytica 89.83 7.00e-52 193.00
IUUC-Zma-135270 Zea mays 82.05 4.00e-53 197.00
Created Date 25-Jun-2017

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