iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ani-009488

Ensembl Protein ID

CADANIAP00000127

UniProt Accession

Q02398; C8VCP5; Q00178; Q00183; Q5AWM1; RAD18_EMENI

Genbank Protein ID

AAB35098.1; CAA90033.1; CAA89995.1; EAA61360.1; CBF78646.1

Protein Name

Postreplication repair E3 ubiquitin-protein ligase rad18; RING-type E3 ubiquitin transferase rad18

Genbank Nucleotide ID

S79392; Z49875; Z49834; AACD01000127; BN001304

Gene Name

ANIA_07309; uvsH; nuvA; rad18; AN7309

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
CADANIAG00000127	CADANIAT00000127	CADANIAP00000127

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	1.10e-06	27.7	27	91
E3 activity/RING/RING	7.70e-06	25.5	30	68

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 5    eflCpIslelMrdPvvlpsGitydrssIekwlasggktcPvtrqplteedlvPnltlrrliqawce 70
            ++C + ++ + +Pv++++ +t+   +I+++l++ gk cP++r++ +e +l  n ++++l++ + +
   Q: 27   SLRCQVCKDFFDNPVITSCSHTFCSLCIRRCLSTEGK-CPTCRSSDQELKLRRNWVVQELVEGFKN 91
           579**********************************.******9999999999999999988765 PP

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C +C++ f++ p++++C H+f+  C+ +        s+e +CP+Cr
   Q: 30   CQVCKDFFDN-PVITSCSHTFCSLCIRRC------LSTEGKCPTCR 68
           99****9999.999************999......9*********8 PP

Organism

Aspergillus nidulans

Functional Description
(View)

E3 RING-finger protein, member of the UBC2/RAD6 epistasis group. Associates to the E2 ubiquitin conjugating enzyme UBC2/RAD6 to form the UBC2-RAD18 ubiquitin ligase complex involved in postreplicative repair (PRR) of damaged DNA.

Protein Sequence
(Fasta)

MEPTFDIPDS TDWLDTPLTL LAPFETSLRC QVCKDFFDNP VITSCSHTFC SLCIRRCLST 60
EGKCPTCRSS DQELKLRRNW VVQELVEGFK NARPSILQLA RMAQTGTDDS GDLAAEEPAS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCGAGATATA AGCAAGAGCT TCGCGGAGAA GTCTACCTGG AAGGCGGCTA CCATCGCGTT 60
TGTACTGATG GAGCCGACAT TTGACATCCC GGACTCGACC GATTGGCTCG ACACGCCGTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR004580--Rad18
IPR003034--SAP_dom
IPR006642--Znf_Rad18_put
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50800--SAP
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF02037--SAP

SMART

SM00184--RING
SM00513--SAP
SM00734--ZnF_Rad18

Gene Ontology

GO:0005634--C:nucleus
GO:0097505--C:Rad6-Rad18 complex
GO:0003684--F:damaged DNA binding
GO:0043142--F:single-stranded DNA-dependent ATPase activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0006281--P:DNA repair
GO:0006312--P:mitotic recombination
GO:0006301--P:postreplication repair
GO:0006513--P:protein monoubiquitination
GO:0009411--P:response to UV

KEGG

ani:AN7309.2

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000858	Aegilops tauschii	32.31	7.00e-09	52.40
IUUC-Aml-002086	Ailuropoda melanoleuca	28.07	3.00e-24	105.00
IUUC-Apl-003657	Anas platyrhynchos	28.00	5.00e-31	127.00
IUUC-Aca-005369	Anolis carolinensis	33.87	2.00e-17	79.30
IUUC-Aly-006055	Arabidopsis lyrata	41.18	4.00e-07	48.50
IUUC-Ath-007462	Arabidopsis thaliana	41.18	4.00e-07	48.90
IUUC-Ago-007876	Ashbya gossypii	27.48	4.00e-28	117.00
IUUC-Acl-008246	Aspergillus clavatus	64.65	1.00e-134	471.00
IUUC-Afl-008666	Aspergillus flavus	58.73	2.00e-135	473.00
IUUC-Afu-009052	Aspergillus fumigatus	65.37	9.00e-135	471.00
IUUC-Ang-009681	Aspergillus niger	67.80	8.00e-142	494.00
IUUC-Aor-010037	Aspergillus oryzae	62.60	1.00e-138	484.00
IUUC-Ate-010516	Aspergillus terreus	64.41	3.00e-64	236.00
IUUC-Ame-010630	Astyanax mexicanus	26.42	2.00e-29	121.00
IUUC-Bgr-012178	Blumeria graminis	40.17	5.00e-67	246.00
IUUC-Bta-012976	Bos taurus	26.59	5.00e-23	100.00
IUUC-Bci-013680	Botrytis cinerea	44.90	2.00e-77	281.00
IUUC-Bdi-014145	Brachypodium distachyon	33.82	5.00e-09	52.40
IUUC-Bol-015858	Brassica oleracea	41.18	8.00e-08	51.20
IUUC-Bra-017176	Brassica rapa	28.57	2.00e-07	49.70
IUUC-Cel-018356	Caenorhabditis elegans	47.50	3.00e-08	49.30
IUUC-Cja-019453	Callithrix jacchus	27.15	3.00e-26	111.00
IUUC-Cfa-020856	Canis familiaris	26.32	1.00e-25	108.00
IUUC-Cpo-021950	Cavia porcellus	26.45	2.00e-27	114.00
IUUC-Csa-023997	Chlorocebus sabaeus	25.89	3.00e-25	107.00
IUUC-Cho-024771	Choloepus hoffmanni	27.86	1.00e-16	79.70
IUUC-Cin-025118	Ciona intestinalis	31.11	1.00e-08	53.50
IUUC-Cgl-026668	Colletotrichum gloeosporioides	45.25	2.00e-79	287.00
IUUC-Cme-027202	Cyanidioschyzon merolae	35.11	8.00e-16	76.60
IUUC-Dre-028479	Danio rerio	27.47	3.00e-27	114.00
IUUC-Dno-028943	Dasypus novemcinctus	25.70	3.00e-25	107.00
IUUC-Dor-031046	Dipodomys ordii	28.32	8.00e-11	60.10
IUUC-Dse-031235	Dothistroma septosporum	38.78	9.00e-48	182.00
IUUC-Ete-032503	Echinops telfairi	29.21	2.00e-14	72.00
IUUC-Eca-033725	Equus caballus	24.54	7.00e-24	103.00
IUUC-Eeu-034573	Erinaceus europaeus	27.88	7.00e-21	93.20
IUUC-Fca-036495	Felis catus	27.47	1.00e-27	115.00
IUUC-Fal-036791	Ficedula albicollis	29.77	3.00e-23	101.00
IUUC-Fox-037868	Fusarium oxysporum	44.19	7.00e-75	272.00
IUUC-Fso-038144	Fusarium solani	48.85	2.00e-82	297.00
IUUC-Gmo-039152	Gadus morhua	28.99	2.00e-24	105.00
IUUC-Ggr-039737	Gaeumannomyces graminis	45.99	8.00e-35	139.00
IUUC-Gga-040788	Gallus gallus	27.72	4.00e-26	110.00
IUUC-Gac-041993	Gasterosteus aculeatus	25.71	1.00e-28	118.00
IUUC-Ggo-044889	Gorilla gorilla	25.55	3.00e-25	107.00
IUUC-Hsa-045957	Homo sapiens	26.87	5.00e-26	110.00
IUUC-Itr-048998	Ictidomys tridecemlineatus	25.61	1.00e-17	82.80
IUUC-Kpa-049300	Komagataella pastoris	25.71	8.00e-27	112.00
IUUC-Lch-050172	Latimeria chalumnae	27.33	3.00e-25	107.00
IUUC-Loc-052609	Lepisosteus oculatus	27.75	8.00e-24	103.00
IUUC-Lma-053037	Leptosphaeria maculans	42.74	2.00e-71	261.00
IUUC-Laf-053889	Loxodonta africana	27.83	3.00e-25	108.00
IUUC-Mcc-055853	Macaca mulatta	25.61	3.00e-25	107.00
IUUC-Meu-056866	Macropus eugenii	27.72	9.00e-16	76.30
IUUC-Mor-057071	Magnaporthe oryzae	45.05	8.00e-77	278.00
IUUC-Mpo-057628	Magnaporthe poae	35.48	3.00e-37	147.00
IUUC-Mla-058953	Melampsora laricipopulina	25.07	2.00e-20	92.00
IUUC-Mga-059687	Meleagris gallopavo	26.85	2.00e-26	111.00
IUUC-Mvi-060412	Microbotryum violaceum	27.20	6.00e-27	114.00
IUUC-Mmr-061563	Microcebus murinus	26.32	3.00e-25	107.00
IUUC-Mdo-062655	Monodelphis domestica	27.27	3.00e-24	104.00
IUUC-Mmu-063647	Mus musculus	27.08	3.00e-26	111.00
IUUC-Mpu-065778	Mustela putorius furo	27.70	5.00e-27	114.00
IUUC-Mlu-068205	Myotis lucifugus	25.27	3.00e-23	101.00
IUUC-Nfi-068501	Neosartorya fischeri	65.89	2.00e-135	474.00
IUUC-Ncr-068917	Neurospora crassa	42.97	2.00e-75	275.00
IUUC-Nle-068990	Nomascus leucogenys	26.32	3.00e-25	108.00
IUUC-Opr-071146	Ochotona princeps	27.69	1.00e-25	108.00
IUUC-Ont-071835	Oreochromis niloticus	26.42	2.00e-25	108.00
IUUC-Oan-072827	Ornithorhynchus anatinus	42.86	1.00e-16	77.80
IUUC-Ocu-073986	Oryctolagus cuniculus	28.09	1.00e-25	109.00
IUUC-Obr-076406	Oryza brachyantha	38.33	5.00e-09	53.10
IUUC-Oin-079762	Oryza indica	41.27	9.00e-11	59.70
IUUC-Olo-081000	Oryza longistaminata	41.27	7.00e-11	58.90
IUUC-Ome-081927	Oryza meridionalis	41.27	8.00e-11	59.30
IUUC-Opu-083381	Oryza punctata	41.27	2.00e-10	56.60
IUUC-Osa-085470	Oryza sativa	39.13	4.00e-10	56.20
IUUC-Ola-086997	Oryzias latipes	24.62	1.00e-22	98.20
IUUC-Olu-087771	Ostreococcus lucimarinus	27.55	5.00e-19	87.00
IUUC-Oga-088092	Otolemur garnettii	26.10	3.00e-26	111.00
IUUC-Oar-089651	Ovis aries	26.61	7.00e-23	100.00
IUUC-Ptr-091103	Pan troglodytes	26.59	1.00e-25	109.00
IUUC-Pan-092478	Papio anubis	25.89	4.00e-26	110.00
IUUC-Psi-093356	Pelodiscus sinensis	30.03	1.00e-30	125.00
IUUC-Ppa-095332	Physcomitrella patens	48.89	2.00e-07	50.10
IUUC-Pfo-096663	Poecilia formosa	28.18	8.00e-16	76.60
IUUC-Pab-098515	Pongo abelii	26.59	2.00e-25	108.00
IUUC-Ppe-102065	Prunus persica	39.22	2.00e-06	46.60
IUUC-Pva-102377	Pteropus vampyrus	26.59	1.00e-23	102.00
IUUC-Pgr-103556	Puccinia graminis	24.01	5.00e-21	94.00
IUUC-Pte-104362	Pyrenophora teres	39.62	1.00e-71	261.00
IUUC-Pyt-104823	Pyrenophora triticirepentis	40.62	2.00e-69	254.00
IUUC-Rno-105866	Rattus norvegicus	26.04	2.00e-24	105.00
IUUC-Sce-106454	Saccharomyces cerevisiae	25.18	2.00e-27	115.00
IUUC-Sha-107515	Sarcophilus harrisii	45.95	6.00e-15	73.60
IUUC-Sja-107689	Schizosaccharomyces japonicus	35.00	6.00e-29	120.00
IUUC-Spo-108248	Schizosaccharomyces pombe	28.07	3.00e-43	167.00
IUUC-Ssl-108430	Sclerotinia sclerotiorum	41.19	6.00e-79	286.00
IUUC-Smo-109416	Selaginella moellendorffii	43.48	3.00e-06	45.80
IUUC-Sly-111863	Solanum lycopersicum	28.57	7.00e-08	51.60
IUUC-Stu-112154	Solanum tuberosum	27.84	3.00e-07	49.30
IUUC-Sar-113591	Sorex araneus	47.27	3.00e-09	56.20
IUUC-Sre-115123	Sporisorium reilianum	29.65	2.00e-13	68.90
IUUC-Ssc-115992	Sus scrofa	23.58	2.00e-16	78.20
IUUC-Tgu-117286	Taeniopygia guttata	44.16	6.00e-15	73.60
IUUC-Tru-117959	Takifugu rubripes	27.22	5.00e-14	70.10
IUUC-Tni-120570	Tetraodon nigroviridis	27.48	3.00e-26	110.00
IUUC-Tre-121893	Trichoderma reesei	47.35	2.00e-82	297.00
IUUC-Tvi-122405	Trichoderma virens	47.40	5.00e-86	309.00
IUUC-Tur-126363	Triticum urartu	38.10	8.00e-09	52.80
IUUC-Tbe-127758	Tupaia belangeri	43.24	6.00e-13	67.00
IUUC-Ttr-128841	Tursiops truncatus	27.86	1.00e-24	105.00
IUUC-Uma-129563	Ustilago maydis	30.68	3.00e-12	64.70
IUUC-Vda-130021	Verticillium dahliae	47.01	8.00e-30	122.00
IUUC-Vpa-130169	Vicugna pacos	28.67	1.00e-18	86.30
IUUC-Xtr-132308	Xenopus tropicalis	27.39	8.00e-31	125.00
IUUC-Xma-133868	Xiphophorus maculatus	27.65	2.00e-26	111.00
IUUC-Yli-134474	Yarrowia lipolytica	31.38	5.00e-35	139.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence