iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
TRANSFAC
Protein-protein Interaction
PINA	HINT
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	1.10e-08	36.1	148	210

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 6    vvggeeffahkivLaasSsvFyalflmeleesksklmveik.d.vqpevfrallkFlYtgklde 67
           vv  +e +    +Laa S++Fy+lf+++++es+ +  v+++    + +++ +ll+F+Y+++l+ 
   Q: 148  VVRVKELHISSPILAAKSPFFYKLFSNGMRESE-QRHVTLRiSaQEEGALMELLNFMYSNSLSV 210
           5555666777779*******************8.99*****756999************99875 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Protein Sequence
(Fasta)

MRGSNNTDLF DPKTEMDSNF SRHGSSSEGD FGFAFNDSNF SDRLLRIEIL GGPSDSRSDA 60
EGCTSIADWA RHRKRRREDN KKDNGVAISD IVACAEEQIL TDNNQPDMDD APGGDNLDDE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCAAATTTGA CGCTTTCCAA CTAAATACAC TCCTAATTTT GCCTATTACC TTTTTCCTCC 60
TCTAATTAAG TAAATGCTAA ATTTCCCCCA AATACTAAAA ATCGAATCCG ATAAGTCAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR011705--BACK
IPR000210--BTB/POZ_dom
IPR011333--SKP1/BTB/POZ
IPR008974--TRAF-like

PROSITE

PS50097--BTB

Pfam

PF07707--BACK
PF00651--BTB

SMART

SM00875--BACK
SM00225--BTB

Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0005634--C:nucleus
GO:0046982--F:protein heterodimerization activity
GO:0042803--F:protein homodimerization activity
GO:0016567--P:protein ubiquitination
GO:0010114--P:response to red light

KEGG

ath:AT2G46260

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aly-006217	Arabidopsis lyrata	98.04	0.00e+00	1088.00
IUUC-Bol-015530	Brassica oleracea	88.87	0.00e+00	954.00
IUUC-Gmo-039367	Gadus morhua	30.77	2.00e-14	73.20
IUUC-Gac-042413	Gasterosteus aculeatus	26.44	2.00e-14	73.60
IUUC-Laf-054398	Loxodonta africana	28.48	3.00e-14	72.80
IUUC-Ont-071960	Oreochromis niloticus	26.18	5.00e-15	75.50
IUUC-Pno-094795	Phaeosphaeria nodorum	26.98	5.20e-02	32.70
IUUC-Ppa-095956	Physcomitrella patens	59.67	0.00e+00	626.00
IUUC-Spo-108139	Schizosaccharomyces pombe	26.42	2.30e-01	28.90
IUUC-Tgu-116494	Taeniopygia guttata	29.12	8.00e-14	71.60
IUUC-Tru-117792	Takifugu rubripes	26.18	7.00e-14	71.60

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence