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Tag Content
UUCD2 ID IUUC-Bta-012700
UUCD1 version UUC-BoT-00968
Ensembl Protein ID ENSBTAP00000023702.5
UniProt Accession Q3ZCC9; SEC13_BOVIN
Genbank Protein ID AAI02515.1
Protein Name Protein SEC13 homolog; SEC13-like protein 1
Genbank Nucleotide ID BC102514
Gene Name SEC13; SEC13L1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSBTAG00000017825.5 ENSBTAT00000023702.5 ENSBTAP00000023702.5
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 4.90e-29 99.3 55 87
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf..sd..tllvsGsdDgtikvWD 29
           gH+++v+ +a+  +   ++l+s+s+D ++ +W 
   Q: 55   GHEGPVWQVAWahPMygNILASCSYDRKVIIWK 87
           8***********9666699*************8 PP
   
Organism Bos taurus
Functional Description
(View)

Functional Description


     As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex. It is negatively regulated by the upstream amino acid sensors SESN2 and GATSL3.
 As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex. It is negatively regulated by the upstream amino acid sensors SESN2 and GATSL3.
Protein Sequence
(Fasta)
MVSVINTVDT SHEDMIHDAQ MDYYGTRLAT CSSDRSVKIF DVRNGGQILV ADLRGHEGPV 60
WQVAWAHPMY GNILASCSYD RKVIIWKEEN GTWEKTHEHT GHDSSVNSVC WAPHDYGLIL 120
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Protein Fasta Sequence


>IUUC-Bta-012700|E3,WD_repeat|Bos taurus
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Nucleotide Sequence
(Fasta)
GAAGCGACGC CGGGTCTTGC CACGTCTGAG TCCTGAAGTC GCTGCTGCTG CTACAACCAT 60
GGTAAGTGTT GGGGTCGGGG TCGCGGCCCT CCCGGGTCCT CGCCGCGCTG AAGTTCAAGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Bta-012700|E3,WD_repeat|Bos taurus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0968--Cytoplasmic vesicle
KW-0256--Endoplasmic reticulum
KW-0931--ER-Golgi transport
KW-0472--Membrane
KW-0509--mRNA transport
KW-0906--Nuclear pore complex
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0677--Repeat
KW-0811--Translocation
KW-0813--Transport
KW-0853--WD repeat
Interpro

IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom
PROSITE

PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00400--WD40
SMART

SM00320--WD40
Gene Ontology

GO:0005789--C:endoplasmic reticulum membrane
GO:0012507--C:ER to Golgi transport vesicle membrane
GO:0070062--C:extracellular exosome
GO:0061700--C:GATOR2 complex
GO:0000776--C:kinetochore
GO:0031080--C:nuclear pore outer ring
GO:0005654--C:nucleoplasm
GO:0051028--P:mRNA transport
GO:0032008--P:positive regulation of TOR signaling
GO:0015031--P:protein transport
GO:0016192--P:vesicle-mediated transport
KEGG bta:512530
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000671 Aegilops tauschii 54.15 2.00e-90 325.00
IUUC-Aml-001832 Ailuropoda melanoleuca 96.27 0.00e+00 643.00
IUUC-Atr-002914 Amborella trichopoda 54.52 2.00e-89 322.00
IUUC-Apl-003992 Anas platyrhynchos 93.79 5.00e-170 589.00
IUUC-Aca-005283 Anolis carolinensis 93.17 5.00e-179 620.00
IUUC-Aly-005654 Arabidopsis lyrata 55.00 2.00e-89 322.00
IUUC-Ath-006816 Arabidopsis thaliana 55.67 8.00e-90 323.00
IUUC-Ago-007827 Ashbya gossypii 50.00 2.00e-82 298.00
IUUC-Acl-008205 Aspergillus clavatus 50.50 3.00e-79 288.00
IUUC-Afl-008748 Aspergillus flavus 50.49 1.00e-81 296.00
IUUC-Afu-008791 Aspergillus fumigatus 50.17 7.00e-79 286.00
IUUC-Ani-009152 Aspergillus nidulans 50.16 5.00e-82 297.00
IUUC-Ang-009765 Aspergillus niger 49.84 1.00e-81 296.00
IUUC-Aor-009927 Aspergillus oryzae 50.33 9.00e-79 286.00
IUUC-Ate-010248 Aspergillus terreus 50.16 1.00e-81 296.00
IUUC-Ame-011478 Astyanax mexicanus 87.27 9.00e-168 582.00
IUUC-Bgr-012276 Blumeria graminis 49.66 5.00e-79 287.00
IUUC-Bci-013722 Botrytis cinerea 48.84 5.00e-81 294.00
IUUC-Bdi-014818 Brachypodium distachyon 54.49 1.00e-90 325.00
IUUC-Bol-015779 Brassica oleracea 56.46 2.00e-89 322.00
IUUC-Bra-016973 Brassica rapa 55.63 2.00e-89 323.00
IUUC-Cel-018479 Caenorhabditis elegans 41.32 7.00e-69 253.00
IUUC-Cja-019956 Callithrix jacchus 97.22 1.00e-167 582.00
IUUC-Cfa-020752 Canis familiaris 97.83 0.00e+00 649.00
IUUC-Cpo-021871 Cavia porcellus 94.70 0.00e+00 630.00
IUUC-Cre-022797 Chlamydomonas reinhardtii 55.30 3.00e-95 341.00
IUUC-Csa-023393 Chlorocebus sabaeus 96.89 0.00e+00 646.00
IUUC-Cho-024786 Choloepus hoffmanni 76.09 1.00e-134 472.00
IUUC-Cin-025332 Ciona intestinalis 70.78 2.00e-132 464.00
IUUC-Csv-025926 Ciona savignyi 68.69 4.00e-128 450.00
IUUC-Cgl-026413 Colletotrichum gloeosporioides 50.51 1.00e-77 282.00
IUUC-Cne-027054 Cryptococcus neoformans 49.69 6.00e-78 284.00
IUUC-Cme-027165 Cyanidioschyzon merolae 34.66 2.00e-49 190.00
IUUC-Dre-027782 Danio rerio 88.20 2.00e-169 587.00
IUUC-Dno-029628 Dasypus novemcinctus 97.20 0.00e+00 644.00
IUUC-Dor-030650 Dipodomys ordii 79.19 7.00e-144 503.00
IUUC-Dse-031206 Dothistroma septosporum 45.98 2.00e-76 278.00
IUUC-Dme-031854 Drosophila melanogaster 59.41 1.00e-102 366.00
IUUC-Ete-032618 Echinops telfairi 67.60 8.00e-119 419.00
IUUC-Eca-033268 Equus caballus 98.13 0.00e+00 649.00
IUUC-Fca-035918 Felis catus 97.83 0.00e+00 648.00
IUUC-Fal-037551 Ficedula albicollis 92.53 8.00e-159 552.00
IUUC-Fox-037763 Fusarium oxysporum 48.68 2.00e-80 292.00
IUUC-Fso-038341 Fusarium solani 47.90 3.00e-79 288.00
IUUC-Gmo-038638 Gadus morhua 87.23 7.00e-169 585.00
IUUC-Ggr-039865 Gaeumannomyces graminis 48.66 3.00e-77 281.00
IUUC-Gga-040193 Gallus gallus 93.48 4.00e-178 616.00
IUUC-Gma-044311 Glycine max 54.52 8.00e-90 323.00
IUUC-Ggo-045252 Gorilla gorilla 96.58 0.00e+00 644.00
IUUC-Hsa-046565 Homo sapiens 96.27 0.00e+00 642.00
IUUC-Hvu-047835 Hordeum vulgare 55.48 3.00e-92 331.00
IUUC-Itr-048587 Ictidomys tridecemlineatus 97.20 0.00e+00 641.00
IUUC-Kpa-049148 Komagataella pastoris 52.65 2.00e-86 311.00
IUUC-Lch-050421 Latimeria chalumnae 90.06 2.00e-173 601.00
IUUC-Lpe-051187 Leersia perrieri 53.16 4.00e-91 330.00
IUUC-Loc-052167 Lepisosteus oculatus 88.24 5.00e-170 589.00
IUUC-Lma-053250 Leptosphaeria maculans 50.33 2.00e-79 288.00
IUUC-Laf-054304 Loxodonta africana 97.20 0.00e+00 642.00
IUUC-Mcc-055519 Macaca mulatta 96.58 0.00e+00 644.00
IUUC-Meu-056439 Macropus eugenii 94.39 0.00e+00 630.00
IUUC-Mor-057241 Magnaporthe oryzae 48.63 5.00e-77 280.00
IUUC-Mpo-057373 Magnaporthe poae 43.39 6.00e-63 233.00
IUUC-Mtr-058412 Medicago truncatula 54.52 6.00e-88 317.00
IUUC-Mla-058966 Melampsora laricipopulina 50.30 1.00e-86 313.00
IUUC-Mga-060066 Meleagris gallopavo 93.79 5.00e-170 589.00
IUUC-Mvi-060290 Microbotryum violaceum 46.48 3.00e-80 294.00
IUUC-Mmr-060717 Microcebus murinus 96.89 0.00e+00 644.00
IUUC-Mdo-062496 Monodelphis domestica 94.72 0.00e+00 633.00
IUUC-Mmu-063490 Mus musculus 96.58 0.00e+00 645.00
IUUC-Mac-065307 Musa acuminata 55.29 1.00e-87 316.00
IUUC-Mpu-066601 Mustela putorius furo 97.83 0.00e+00 649.00
IUUC-Mlu-067501 Myotis lucifugus 97.51 0.00e+00 645.00
IUUC-Nfi-068360 Neosartorya fischeri 48.87 2.00e-64 238.00
IUUC-Ncr-068928 Neurospora crassa 49.16 1.00e-81 296.00
IUUC-Nle-069028 Nomascus leucogenys 96.27 0.00e+00 643.00
IUUC-Opr-070446 Ochotona princeps 97.06 6.00e-177 612.00
IUUC-Ont-071587 Oreochromis niloticus 87.23 4.00e-170 590.00
IUUC-Oan-073211 Ornithorhynchus anatinus 91.93 4.00e-179 620.00
IUUC-Ocu-074306 Oryctolagus cuniculus 95.03 0.00e+00 631.00
IUUC-Oba-075069 Oryza barthii 54.15 2.00e-90 325.00
IUUC-Obr-076667 Oryza brachyantha 54.49 5.00e-91 327.00
IUUC-Ogl-077208 Oryza glaberrima 54.15 2.00e-90 325.00
IUUC-Ogu-078513 Oryza glumaepatula 54.15 2.00e-90 325.00
IUUC-Oin-079094 Oryza indica 54.15 2.00e-90 325.00
IUUC-Olo-080473 Oryza longistaminata 54.15 2.00e-90 325.00
IUUC-Ome-081643 Oryza meridionalis 54.15 2.00e-90 325.00
IUUC-Oni-082589 Oryza nivara 54.15 2.00e-90 325.00
IUUC-Opu-083677 Oryza punctata 54.15 2.00e-90 325.00
IUUC-Oru-084537 Oryza rufipogon 54.15 2.00e-90 325.00
IUUC-Osa-085449 Oryza sativa 54.15 2.00e-90 325.00
IUUC-Ola-087226 Oryzias latipes 87.27 9.00e-169 585.00
IUUC-Olu-087893 Ostreococcus lucimarinus 51.71 1.00e-78 286.00
IUUC-Oga-088837 Otolemur garnettii 97.20 0.00e+00 647.00
IUUC-Oar-089594 Ovis aries 98.14 0.00e+00 651.00
IUUC-Ptr-091132 Pan troglodytes 96.27 0.00e+00 642.00
IUUC-Psi-093568 Pelodiscus sinensis 93.51 2.00e-171 594.00
IUUC-Pma-094172 Petromyzon marinus 73.25 2.00e-63 234.00
IUUC-Pno-094955 Phaeosphaeria nodorum 49.34 4.00e-78 284.00
IUUC-Ppa-095578 Physcomitrella patens 55.78 3.00e-91 328.00
IUUC-Pfo-096063 Poecilia formosa 88.20 8.00e-170 589.00
IUUC-Pab-098674 Pongo abelii 95.96 0.00e+00 640.00
IUUC-Pop-099402 Populus trichocarpa 54.67 9.00e-90 323.00
IUUC-Pca-100824 Procavia capensis 78.26 9.00e-144 503.00
IUUC-Ppe-101707 Prunus persica 54.52 1.00e-87 316.00
IUUC-Pva-103161 Pteropus vampyrus 93.17 2.00e-178 618.00
IUUC-Pgr-103573 Puccinia graminis 54.49 6.00e-90 323.00
IUUC-Ptt-103700 Puccinia triticina 52.87 9.00e-83 300.00
IUUC-Pte-104267 Pyrenophora teres 48.98 1.00e-76 279.00
IUUC-Pyt-104535 Pyrenophora triticirepentis 48.30 4.00e-69 254.00
IUUC-Rno-104833 Rattus norvegicus 96.89 0.00e+00 646.00
IUUC-Sce-106437 Saccharomyces cerevisiae 50.65 3.00e-76 278.00
IUUC-Sha-106611 Sarcophilus harrisii 94.39 0.00e+00 630.00
IUUC-Sja-107654 Schizosaccharomyces japonicus 49.50 1.00e-81 295.00
IUUC-Spo-108362 Schizosaccharomyces pombe 52.25 4.00e-85 307.00
IUUC-Smo-109674 Selaginella moellendorffii 54.61 7.00e-92 330.00
IUUC-Sit-110132 Setaria italica 53.82 1.00e-90 326.00
IUUC-Sly-111254 Solanum lycopersicum 52.67 2.00e-85 308.00
IUUC-Stu-112195 Solanum tuberosum 52.98 1.00e-85 309.00
IUUC-Sbi-114229 Sorghum bicolor 53.67 1.00e-90 325.00
IUUC-Sre-114898 Sporisorium reilianum 49.00 3.00e-90 325.00
IUUC-Ssc-115995 Sus scrofa 98.68 2.00e-87 313.00
IUUC-Tgu-116793 Taeniopygia guttata 93.15 2.00e-166 578.00
IUUC-Tru-117797 Takifugu rubripes 86.92 3.00e-168 583.00
IUUC-Tsy-118967 Tarsius syrichta 92.06 2.00e-28 119.00
IUUC-Tni-120366 Tetraodon nigroviridis 86.60 3.00e-168 583.00
IUUC-Tca-121068 Theobroma cacao 54.61 9.00e-88 316.00
IUUC-Tre-121899 Trichoderma reesei 49.83 6.00e-81 293.00
IUUC-Tvi-122380 Trichoderma virens 50.00 5.00e-81 294.00
IUUC-Tae-123998 Triticum aestivum 56.15 2.00e-93 335.00
IUUC-Tur-126202 Triticum urartu 55.48 4.00e-92 331.00
IUUC-Tme-127181 Tuber melanosporum 52.92 5.00e-88 317.00
IUUC-Ttr-128448 Tursiops truncatus 86.34 1.00e-160 558.00
IUUC-Uma-129661 Ustilago maydis 49.57 5.00e-91 327.00
IUUC-Vda-129666 Verticillium dahliae 50.33 4.00e-78 284.00
IUUC-Vpa-130318 Vicugna pacos 98.45 0.00e+00 654.00
IUUC-Vvi-130868 Vitis vinifera 53.67 5.00e-88 317.00
IUUC-Xtr-131859 Xenopus tropicalis 89.75 5.00e-172 596.00
IUUC-Xma-133898 Xiphophorus maculatus 88.20 4.00e-170 590.00
IUUC-Yli-134559 Yarrowia lipolytica 53.06 2.00e-83 301.00
Created Date 25-Jun-2017

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