iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
Protein-protein Interaction
iRefIndex	Mentha
Post-translational Modifications (PTMs)
dbPPT
Protein Expression/Proteomics

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	12062802

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	2.80e-08	35.0	123	165

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledf..kdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C++Cl+ +   ++++ l+C Hvfh++Cl+ w     ++  +f+CPlCr
   Q: 123  CIVCLSKLktGEEVRKLDCRHVFHKQCLEGW-----LQHLNFNCPLCR 165
           ********66334******************.....7899*******8 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

E3 ubiquitin-protein ligase involved in the positive regulation of abscisic acid (ABA) signaling and responses to salt and osmotic stresses during seed germination and early seedling development. Acts additively with RHA2A in regulating ABA signaling and drought response. Possesses E3 ubiquitin ligase activity in vitro.

Protein Sequence
(Fasta)

MGPTTRGLCH FFFFSIHIKK KKEMRCKVVY AARTTTRTKV TKTISKTISM GLQGQLSDVS 60
SDSIPLMLLA LLATFFRHVR SLLLFPSSAP VVVVTSNLSV LADQLNLNRL FSYRYSDNAA 120

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Nucleotide Sequence
(Fasta)

GGGGCGAAAA GTATGAAGAT GGGAAAAAAC GAAAAGGACT GAAAGTGAAA GGGCTTAACC 60
AAAAGCAAAA TAATGGGTCC CACAACACGT GGCCTGTGTC ATTTCTTCTT CTTCTCCATC 120

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Sequence Source

Ensembl

Keyword

KW-0938--Abscisic acid signaling pathway
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0346--Stress response
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

Pfam

PF13639--zf-RING_2

SMART

SM00184--RING

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0009738--P:abscisic acid-activated signaling pathway
GO:0009789--P:positive regulation of abscisic acid-activated signaling pathway
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0016567--P:protein ubiquitination
GO:0047484--P:regulation of response to osmotic stress
GO:0080167--P:response to karrikin

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aly-006229	Arabidopsis lyrata	86.01	8.00e-56	207.00
IUUC-Ani-009448	Aspergillus nidulans	44.64	6.00e-11	58.50
IUUC-Bol-015550	Brassica oleracea	69.23	4.00e-51	192.00
IUUC-Bra-017124	Brassica rapa	71.23	5.00e-52	195.00
IUUC-Hvu-047125	Hordeum vulgare	59.62	3.00e-15	73.90
IUUC-Opu-083744	Oryza punctata	58.54	8.00e-11	59.70
IUUC-Pop-099326	Populus trichocarpa	46.21	1.00e-30	124.00
IUUC-Tae-123551	Triticum aestivum	45.05	5.00e-16	76.60

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence