iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

   S: 7    ewleLesdPglftllvedfgvkrdiqveelysLdpenlglyqepvegllllFkinekressrksqvtsndlevvdediiktiffakqvigNsCatyAl 104
           +wl++esdPg+ft+++++  vk++ qveelysLd ++l+ + +pv+gl+ll+k+ ++++++r          vv  +   + ffa q i+N+Cat+A+
   Q: 2    SWLPVESDPGIFTEIIQQMQVKGV-QVEELYSLDFNSLDEI-RPVYGLILLYKWRPEEKENR----------VVITEPNPNFFFASQIINNACATQAI 87
           7***********************.***************9.***************99998..........44456678****************** PP
   S: 105  lsvllncedklldlGttlsrlkestkaespenkalalgnqqvlecihnslariesrseperqdedneqy...tkeafhfvsyvningrlyeldglkpf 199
           lsvl n ++   d+G++ls+lk++ k + pe k+la++n+++++++hn++ar++++s  e ++   ++    +++++h++sy +++g lyeldglk+ 
   Q: 88   LSVLMNSSSI--DIGSELSELKQFAKEFPPELKGLAINNNEAIRAAHNTFARPDPSSIMEDEELAAAKNldeDDDVYHYISYLPVDGILYELDGLKEG 183
           ******9998..*******************************************99877765444444566999*********************** PP
   S: 200  Pldlgkkketeelkdklkvvr.aflerikllesdeirfnllaivadrrviktlrlnvlkid......................keLlkLlkdieseee 274
           P+ lg++  + e  + l+ v+    e+i+ ++++eirf+lla+v++r+ ++ + l+  +                        + L   l++++  +e
   Q: 184  PISLGQCLGEPEGIEWLRMVQpVVQEQIDRYSQNEIRFSLLAVVKNRKEMYVAELKEYQRKrervlqqlgalqadkyaekssyEALDRELSEVNIGIE 281
           *******777777777777776679***********************9988887655555789******************978888899******* PP
   S: 275  kieaqlddekekrkkfkiddirRtenydeficifikdlaregilrklve 323
             ++++  e+ek k++k +++rR++ny+ f++ f+k la ++ l+ l  
   Q: 282  TVSQKIVMEEEKSKNWKKENMRRKHNYVPFLFNFLKILADKKKLKPLIA 330
           ***************************************9999988765 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

Ubiquitin-protein hydrolase involved in the release of ubiquitin attached via both peptide and isopeptide linkages. Able to cleave 'Lys-48'-linked polyubiquitin chains. Involved in the direct or indirect regulation of AUX/IAA proteins stability (Probable). Acts as a linker between the TREX-2 complex and 26S proteasome (PubMed:22951400).

Protein Sequence
(Fasta)

MSWLPVESDP GIFTEIIQQM QVKGVQVEEL YSLDFNSLDE IRPVYGLILL YKWRPEEKEN 60
RVVITEPNPN FFFASQIINN ACATQAILSV LMNSSSIDIG SELSELKQFA KEFPPELKGL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATAGTCTCTC TTTCGAGTCT GCAGCTAGCG TGAAGACGAT GAAATCGATG GGAGGAGATA 60
GATAAGCGCG AATTTGAGAG TGAAAATTCT AAATTCAGAC CCATTTTCAC CGGCGCGAGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0378--Hydrolase
KW-0539--Nucleus
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001578--Peptidase_C12_UCH
IPR017390--Ubiquitinyl_hydrolase_UCH37

Pfam

PF01088--Peptidase_C12

PRINTS

PR00707--UBCTHYDRLASE

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0016579--P:protein deubiquitination
GO:0010016--P:shoot system morphogenesis
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

ath:AT5G16310

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aly-006047	Arabidopsis lyrata	96.41	0.00e+00	629.00
IUUC-Tur-126366	Triticum urartu	59.50	2.00e-99	355.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence