• HOME
  • BROWSE
  • SEARCH
  • LINK
  • DOWNLOAD
  • USER GUIDE
  • Protein
  • Gene
  • Annotation
  • Details
  • Classification
  • Domain Profile
  • Function
  • Protein Sequence
  • Nucleotide Sequence
  • Keyword
  • GO
  • Orthology
  • TOP

Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Sce-106353
UUCD1 version UUC-SaC-00264
Ensembl Protein ID YFR004W
UniProt Accession P43588; D6VTN4; Q8J0T5; RPN11_YEAST
Genbank Protein ID CAA56098.1; AAN77865.1; BAA09243.1; AAT92774.1; DAA12444.1
Protein Name Ubiquitin carboxyl-terminal hydrolase RPN11; 26S proteasome regulatory subunit RPN11; Protein MPR1
Genbank Nucleotide ID X79561; AY152546; D50617; AY692755; BK006940
Gene Name RPN11; MPR1; YFR004W
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
YFR004W YFR004W YFR004W
Annotation
mRNA Expression
GEOFFGED
DNA & RNA Element
TRANSFAC
Protein-protein Interaction
IIDiRefIndexHINTMentha
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
CPLMdbPAFdbPTMUniProt
BioGRID
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
DUB/JAMM JAMM 14581483; 18172023
UBD/Jab_MPN Jab_MPN 17317632; 20061387
Classification
Family E-value Score Start End
DUB/JAMM 1.90e-08 32.6 109 122
UBD/Jab_MPN 1.30e-48 162.9 22 145
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   DUB/JAMM
   S: 1    HSHPgftcwlSsVD 14
           HSHPgf+cwlSsVD
   Q: 109  HSHPGFGCWLSSVD 122
           *************9 PP
   

   UBD/Jab_MPN
   S: 1    eekevvvlpkrllkkflelsdvkiavavevyGlllgelvkdkevktvvlvpkqlagvgsvqvenvedvf.....dlldqeG..livlGWiHthpeelkflss 95
           ++ke+v++++++l+k+l+  +++++v++ev+Gl+lge+v+d++v++v++++++++g+g v+ve+v+dvf     d+l+q+G  ++v+GW+H+hp+++++lss
   Q: 22   DTKETVYISSIALLKMLK--HGRAGVPMEVMGLMLGEFVDDYTVNVVDVFAMPQSGTG-VSVEAVDDVFqakmmDMLKQTGrdQMVVGWYHSHPGFGCWLSS 120
           79****************..**************************************.******************************************* PP
   S: 96   vdvathsslealkkrsvaivsspkf 120
           vdv+t++s+e+l++r va+v  p  
   Q: 121  VDVNTQKSFEQLNSRAVAVVVDPIQ 145
           ********************99853 PP
   
Organism Saccharomyces cerevisiae
Functional Description
(View)

Functional Description


     Component of the lid subcomplex of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. RPN11 is the only catalytically active member of the lid and serves as the essential deubiquitinase of the proteasome.
 Component of the lid subcomplex of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. RPN11 is the only catalytically active member of the lid and serves as the essential deubiquitinase of the proteasome.
Protein Sequence
(Fasta)
MERLQRLMMN SKVGSADTGR DDTKETVYIS SIALLKMLKH GRAGVPMEVM GLMLGEFVDD 60
YTVNVVDVFA MPQSGTGVSV EAVDDVFQAK MMDMLKQTGR DQMVVGWYHS HPGFGCWLSS 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Sce-106353|DUB,JAMM;UBD,Jab_MPN|Saccharomyces cerevisiae
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGGAACGAC TACAGAGATT GATGATGAAT AGTAAGGTGG GGTCCGCGGA CACCGGCCGT 60
GACGATACGA AAGAAACTGT TTATATTTCT TCGATTGCGC TTTTAAAGAT GCTAAAGCAT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Sce-106353|DUB,JAMM;UBD,Jab_MPN|Saccharomyces cerevisiae
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0378--Hydrolase
KW-0645--Protease
KW-0647--Proteasome
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
Interpro

IPR000555--JAMM/MPN+_dom
IPR024969--Rpn11/EIF3F_C
Pfam

PF01398--JAB
PF13012--MitMem_reg
SMART

SM00232--JAB_MPN
Gene Ontology

GO:0005829--C:cytosol
GO:0005739--C:mitochondrion
GO:0005634--C:nucleus
GO:0008541--C:proteasome regulatory particle, lid subcomplex
GO:0034515--C:proteasome storage granule
GO:0008237--F:metallopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0000266--P:mitochondrial fission
GO:0016559--P:peroxisome fission
GO:1902906--P:proteasome storage granule assembly
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0016579--P:protein deubiquitination
KEGG sce:YFR004W
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000544 Aegilops tauschii 63.43 5.00e-102 361.00
IUUC-Aml-001416 Ailuropoda melanoleuca 67.59 6.00e-113 398.00
IUUC-Atr-002629 Amborella trichopoda 63.23 3.00e-99 352.00
IUUC-Apl-004046 Anas platyrhynchos 67.59 1.00e-112 397.00
IUUC-Aca-005228 Anolis carolinensis 67.59 1.00e-112 397.00
IUUC-Aly-005457 Arabidopsis lyrata 63.64 3.00e-101 359.00
IUUC-Ath-007290 Arabidopsis thaliana 63.64 4.00e-101 358.00
IUUC-Ago-007866 Ashbya gossypii 83.92 3.00e-147 512.00
IUUC-Acl-008338 Aspergillus clavatus 69.48 8.00e-99 351.00
IUUC-Afl-008431 Aspergillus flavus 71.17 2.00e-112 396.00
IUUC-Afu-008909 Aspergillus fumigatus 70.80 3.00e-111 392.00
IUUC-Ani-009174 Aspergillus nidulans 66.34 2.00e-112 396.00
IUUC-Ang-009854 Aspergillus niger 66.78 1.00e-113 400.00
IUUC-Aor-009942 Aspergillus oryzae 71.17 3.00e-112 396.00
IUUC-Ate-010377 Aspergillus terreus 70.44 7.00e-112 394.00
IUUC-Ame-011628 Astyanax mexicanus 70.93 1.00e-104 370.00
IUUC-Bgr-012263 Blumeria graminis 65.79 5.00e-103 365.00
IUUC-Bta-012375 Bos taurus 67.59 6.00e-113 398.00
IUUC-Bci-013850 Botrytis cinerea 70.25 6.00e-103 365.00
IUUC-Bdi-014488 Brachypodium distachyon 62.87 6.00e-100 355.00
IUUC-Bol-016172 Brassica oleracea 63.64 4.00e-101 358.00
IUUC-Bra-017926 Brassica rapa 63.64 4.00e-101 358.00
IUUC-Cel-018247 Caenorhabditis elegans 64.48 2.00e-106 376.00
IUUC-Cja-019210 Callithrix jacchus 67.59 7.00e-113 397.00
IUUC-Cfa-020926 Canis familiaris 66.78 6.00e-109 384.00
IUUC-Cpo-021572 Cavia porcellus 67.59 6.00e-113 398.00
IUUC-Cre-022925 Chlamydomonas reinhardtii 64.46 6.00e-99 351.00
IUUC-Csa-023496 Chlorocebus sabaeus 67.59 6.00e-113 398.00
IUUC-Cho-024525 Choloepus hoffmanni 64.48 2.00e-109 386.00
IUUC-Cin-025492 Ciona intestinalis 65.75 1.00e-109 387.00
IUUC-Cgl-026493 Colletotrichum gloeosporioides 66.67 5.00e-95 338.00
IUUC-Cne-026785 Cryptococcus neoformans 69.18 4.00e-112 395.00
IUUC-Cme-027105 Cyanidioschyzon merolae 56.89 3.00e-88 316.00
IUUC-Dre-028788 Danio rerio 66.44 5.00e-112 394.00
IUUC-Dno-029058 Dasypus novemcinctus 67.59 8.00e-113 397.00
IUUC-Dor-031015 Dipodomys ordii 60.00 2.00e-94 336.00
IUUC-Dse-031242 Dothistroma septosporum 67.55 4.00e-113 398.00
IUUC-Dme-031668 Drosophila melanogaster 64.29 4.00e-113 398.00
IUUC-Ete-033146 Echinops telfairi 62.02 2.00e-88 316.00
IUUC-Eca-033734 Equus caballus 67.59 6.00e-113 398.00
IUUC-Eeu-035168 Erinaceus europaeus 83.33 1.00e-73 267.00
IUUC-Fca-036426 Felis catus 67.59 6.00e-113 398.00
IUUC-Fal-036954 Ficedula albicollis 67.59 1.00e-112 397.00
IUUC-Fox-037838 Fusarium oxysporum 69.86 8.00e-112 394.00
IUUC-Fso-038374 Fusarium solani 69.86 8.00e-112 394.00
IUUC-Gmo-038918 Gadus morhua 67.24 7.00e-112 394.00
IUUC-Ggr-039954 Gaeumannomyces graminis 66.67 8.00e-113 397.00
IUUC-Gga-040377 Gallus gallus 67.59 1.00e-112 397.00
IUUC-Gac-042386 Gasterosteus aculeatus 65.16 4.00e-112 395.00
IUUC-Gma-042811 Glycine max 62.78 2.00e-101 359.00
IUUC-Ggo-044916 Gorilla gorilla 66.55 5.00e-113 398.00
IUUC-Hsa-045865 Homo sapiens 67.59 6.00e-113 398.00
IUUC-Hvu-047188 Hordeum vulgare 63.43 2.00e-102 363.00
IUUC-Itr-048154 Ictidomys tridecemlineatus 80.23 5.00e-81 291.00
IUUC-Kpa-049128 Komagataella pastoris 78.36 7.00e-123 431.00
IUUC-Lch-050167 Latimeria chalumnae 61.07 5.00e-101 358.00
IUUC-Lpe-050688 Leersia perrieri 63.84 1.00e-102 364.00
IUUC-Loc-052888 Lepisosteus oculatus 67.24 4.00e-112 395.00
IUUC-Lma-052962 Leptosphaeria maculans 67.22 2.00e-113 399.00
IUUC-Laf-053949 Loxodonta africana 67.59 6.00e-113 398.00
IUUC-Mcc-055279 Macaca mulatta 70.22 8.00e-111 390.00
IUUC-Meu-055956 Macropus eugenii 61.72 6.00e-99 351.00
IUUC-Mor-057166 Magnaporthe oryzae 67.55 1.00e-104 370.00
IUUC-Mpo-057344 Magnaporthe poae 66.67 7.00e-113 397.00
IUUC-Mtr-057857 Medicago truncatula 63.11 2.00e-101 359.00
IUUC-Mla-058938 Melampsora laricipopulina 64.31 1.00e-108 384.00
IUUC-Mga-060093 Meleagris gallopavo 67.59 1.00e-112 397.00
IUUC-Mvi-060565 Microbotryum violaceum 65.25 6.00e-108 381.00
IUUC-Mmr-060899 Microcebus murinus 70.22 9.00e-111 390.00
IUUC-Mdo-062175 Monodelphis domestica 67.59 9.00e-113 397.00
IUUC-Mmu-063416 Mus musculus 67.59 6.00e-113 398.00
IUUC-Mac-064901 Musa acuminata 62.26 3.00e-100 355.00
IUUC-Mpu-065946 Mustela putorius furo 67.59 6.00e-113 398.00
IUUC-Mlu-067835 Myotis lucifugus 67.59 6.00e-113 398.00
IUUC-Nfi-068279 Neosartorya fischeri 70.80 3.00e-111 392.00
IUUC-Ncr-068821 Neurospora crassa 70.80 5.00e-102 362.00
IUUC-Nle-069212 Nomascus leucogenys 67.59 6.00e-113 398.00
IUUC-Opr-070928 Ochotona princeps 46.84 5.00e-56 208.00
IUUC-Ont-072135 Oreochromis niloticus 67.24 4.00e-112 395.00
IUUC-Oan-072755 Ornithorhynchus anatinus 67.59 9.00e-113 397.00
IUUC-Ocu-074433 Oryctolagus cuniculus 70.83 4.00e-108 382.00
IUUC-Oba-075351 Oryza barthii 63.19 2.00e-100 356.00
IUUC-Obr-076756 Oryza brachyantha 63.84 2.00e-102 363.00
IUUC-Ogl-077831 Oryza glaberrima 63.19 2.00e-100 356.00
IUUC-Ogu-078028 Oryza glumaepatula 63.19 2.00e-100 356.00
IUUC-Oin-080184 Oryza indica 63.84 9.00e-103 364.00
IUUC-Olo-080580 Oryza longistaminata 66.19 2.00e-98 350.00
IUUC-Ome-081739 Oryza meridionalis 61.39 3.00e-98 349.00
IUUC-Oni-082861 Oryza nivara 63.19 2.00e-100 356.00
IUUC-Opu-083352 Oryza punctata 63.19 2.00e-100 356.00
IUUC-Oru-084210 Oryza rufipogon 63.19 2.00e-100 356.00
IUUC-Osa-086114 Oryza sativa 63.19 2.00e-100 356.00
IUUC-Ola-087317 Oryzias latipes 67.24 4.00e-112 395.00
IUUC-Olu-087889 Ostreococcus lucimarinus 62.54 1.00e-109 387.00
IUUC-Oga-088032 Otolemur garnettii 67.59 6.00e-113 398.00
IUUC-Oar-090237 Ovis aries 67.59 6.00e-113 398.00
IUUC-Ptr-090881 Pan troglodytes 67.59 6.00e-113 398.00
IUUC-Pan-092658 Papio anubis 67.59 8.00e-113 397.00
IUUC-Psi-093672 Pelodiscus sinensis 67.59 9.00e-113 397.00
IUUC-Pma-094213 Petromyzon marinus 66.78 4.00e-112 395.00
IUUC-Pno-095038 Phaeosphaeria nodorum 67.88 3.00e-114 402.00
IUUC-Ppa-095637 Physcomitrella patens 66.21 8.00e-102 361.00
IUUC-Pfo-096322 Poecilia formosa 67.24 4.00e-112 395.00
IUUC-Pab-098484 Pongo abelii 67.59 6.00e-113 398.00
IUUC-Pop-099564 Populus trichocarpa 62.78 4.00e-101 358.00
IUUC-Pca-100785 Procavia capensis 64.73 8.00e-92 327.00
IUUC-Ppe-101727 Prunus persica 62.78 1.00e-100 357.00
IUUC-Pva-102569 Pteropus vampyrus 67.59 7.00e-113 397.00
IUUC-Pgr-103351 Puccinia graminis 63.97 1.00e-108 384.00
IUUC-Ptt-103763 Puccinia triticina 61.62 2.00e-102 363.00
IUUC-Pte-104088 Pyrenophora teres 68.21 1.00e-114 403.00
IUUC-Pyt-104597 Pyrenophora triticirepentis 72.20 5.00e-106 375.00
IUUC-Rno-105115 Rattus norvegicus 67.59 6.00e-113 398.00
IUUC-Sha-107476 Sarcophilus harrisii 67.59 9.00e-113 397.00
IUUC-Sja-107807 Schizosaccharomyces japonicus 64.61 6.00e-114 401.00
IUUC-Spo-108255 Schizosaccharomyces pombe 64.29 2.00e-105 373.00
IUUC-Ssl-108392 Sclerotinia sclerotiorum 66.45 4.00e-104 369.00
IUUC-Smo-109413 Selaginella moellendorffii 63.14 4.00e-110 388.00
IUUC-Sit-110287 Setaria italica 63.84 1.00e-102 363.00
IUUC-Sly-111656 Solanum lycopersicum 62.87 6.00e-101 358.00
IUUC-Stu-112827 Solanum tuberosum 62.14 1.00e-100 357.00
IUUC-Sar-112979 Sorex araneus 59.31 9.00e-92 327.00
IUUC-Sbi-113841 Sorghum bicolor 63.84 2.00e-102 363.00
IUUC-Sre-114930 Sporisorium reilianum 68.23 9.00e-111 390.00
IUUC-Ssc-116058 Sus scrofa 65.15 2.00e-113 399.00
IUUC-Tgu-116499 Taeniopygia guttata 67.59 1.00e-112 397.00
IUUC-Tru-117576 Takifugu rubripes 67.24 4.00e-112 395.00
IUUC-Tsy-119371 Tarsius syrichta 59.66 4.00e-94 335.00
IUUC-Tni-120868 Tetraodon nigroviridis 67.24 2.00e-110 389.00
IUUC-Tca-121292 Theobroma cacao 62.78 3.00e-101 359.00
IUUC-Tre-122183 Trichoderma reesei 70.57 2.00e-112 396.00
IUUC-Tvi-122566 Trichoderma virens 70.57 3.00e-112 395.00
IUUC-Tae-125543 Triticum aestivum 64.77 3.00e-100 355.00
IUUC-Tur-126034 Triticum urartu 66.55 3.00e-99 352.00
IUUC-Tme-126903 Tuber melanosporum 69.44 1.00e-111 394.00
IUUC-Tbe-127525 Tupaia belangeri 59.63 6.00e-90 321.00
IUUC-Ttr-129072 Tursiops truncatus 67.59 6.00e-113 397.00
IUUC-Uma-129471 Ustilago maydis 68.23 4.00e-111 392.00
IUUC-Vda-129956 Verticillium dahliae 71.53 2.00e-102 363.00
IUUC-Vpa-130490 Vicugna pacos 67.59 6.00e-113 397.00
IUUC-Vvi-131302 Vitis vinifera 62.78 5.00e-101 358.00
IUUC-Xtr-132059 Xenopus tropicalis 67.24 5.00e-112 395.00
IUUC-Xma-133101 Xiphophorus maculatus 67.24 4.00e-112 395.00
IUUC-Yli-134638 Yarrowia lipolytica 68.81 4.00e-120 422.00
IUUC-Zma-135910 Zea mays 63.84 2.00e-102 363.00
Created Date 25-Jun-2017

https://dev.news.makassarkota.go.id/public/pgsoft-demo/ https://jdih.sumbawabaratkab.go.id/lato/pg-soft-demo/ https://dev.news.makassarkota.go.id/public/slot-gacor/ http://pbb.tanahbumbukab.go.id/-/slot-gacor/ slot gacor https://siakad.unipra.ac.id/sass/slot-gacor-x500/ http://kpm.dinus.ac.id/assets/images/berita/slot/
Copyright © 2004-2017.The CUCKOO Workgroup. All Rights Reserved