iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
AT4G08590	AT4G08590.4	AT4G08590.4
AT4G08590	AT4G08590.3	AT4G08590.3
AT4G08590	AT4G08590.6	AT4G08590.6
AT4G08590	AT4G08590.2	AT4G08590.2
AT4G08590	AT4G08590.1	AT4G08590.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
Protein-protein Interaction
iRefIndex	HINT	Mentha
Protein Expression/Proteomics

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	18643997

Classification

Family	E-value	Score	Start	End
E3 activity/RING/U-box	3.00e-05	24.9	103	154
E3 activity/RING/RING	1.00e-05	26.8	109	148

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 2    vpeeflCpIslelMrdPvvlpsGitydrssIekwlasggktcPvtrqpltee 53
           ++e+++C++ ++l+  Pv++ +G+ +  ++  kw+++g++ c ++r+++ ++
   Q: 103  ICEDLNCSLCNQLPDRPVTILCGHNFCLKCFDKWIDQGNQICATCRSTIPDK 154
           7899**************************************9999998665 PP

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C++C + +++ p++  CgH f+++C+ kw       +++++C +Cr
   Q: 109  CSLCNQLPDR-PVTILCGHNFCLKCFDKW-----IDQGNQICATCR 148
           ****999999.99999*************.....6899999****8 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

E3 ubiquitin-protein ligase. May participate in methylation-dependent transcriptional regulation. Mediates ubiquitination with the E2 ubiquitin-conjugating enzyme UBC11.

Protein Sequence
(Fasta)

MTRVNQLPCD CVSTAEESLT SGTCITPTHV TSLSSPLDRS GDVDPLPVSD ESGGSKADES 60
MTDADETKKR KRILSGDCEA DENNKSDGEI ASLNDGVDAF TAICEDLNCS LCNQLPDRPV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAAATTTTTT TAAAACGCGC CTCTTCACAT TTCGTGTCCC TCTCATAAAA GAGCCCTACT 60
CTCTAGACTC TAGAGCATTC CTCTCTCCGA TCTTTGCCGT TGCTCTTTCG AAATGACGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0472--Membrane
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR015947--PUA-like_domain
IPR003105--SRA_YDG
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51015--YDG
PS50089--ZF_RING_2

Pfam

PF02182--SAD_SRA

SMART

SM00184--RING
SM00466--SRA

Gene Ontology

GO:0005737--C:cytoplasm
GO:0016021--C:integral component of membrane
GO:0005720--C:nuclear heterochromatin
GO:0005634--C:nucleus
GO:0042393--F:histone binding
GO:0008327--F:methyl-CpG binding
GO:0010428--F:methyl-CpNpG binding
GO:0010429--F:methyl-CpNpN binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0016569--P:covalent chromatin modification
GO:0010424--P:DNA methylation on cytosine within a CG sequence
GO:0010216--P:maintenance of DNA methylation
GO:0016567--P:protein ubiquitination
GO:0090308--P:regulation of methylation-dependent chromatin silencing

KEGG

ath:AT4G08590

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aly-005511	Arabidopsis lyrata	82.24	0.00e+00	744.00
IUUC-Bci-013703	Botrytis cinerea	31.34	6.00e-10	58.20

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence