iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Bra-016738

Ensembl Protein ID

Bra011430.1-P

UniProt Accession

M4D4M6; M4D4M6_BRARP

Protein Name

Eukaryotic translation initiation factor 3 subunit K; eIF-3 p25

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
Bra011430	Bra011430.1	Bra011430.1-P

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/APC_C/CDC20	1.60e-124	416.2	130	436
E3 adaptor/Cullin RING/DCX/DWD	2.60e-26	91.6	265	295

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/APC_C/CDC20

   S: 2    ekvldapelrddfylnLldWssknvlavaLgssvylwsaktgdvskladl.eekdlvtsvswieegtllavGtkkgeveiyDveekkkvrtltg.h 95
           e+ ldap++ ddfylnLldW+s nvla+aLg++vylw+a++g+ s+l  + eek  vts++w ++g ++a+G +++ev+++D  +++++rtl+g h
   Q: 130  ERTLDAPDIVDDFYLNLLDWGSANVLAIALGHTVYLWDASSGSTSELVTIdEEKGPVTSINWAPDGRHVALGLNNSEVQLWDSGSNRQLRTLKGcH 225
           689***********************************************888999************************************6549 PP
   S: 96   sarvgaLsWnaevlssGsrdgeilhrdvrvkelklstlqahaqevCGlkwnedaklLasGGnDnsvsvwdassse......Plkkfkehkaavkai 185
           ++rvg+L+Wn+++l++G+ dg+i+ +dvr++ + ++t+++h+qevCGlkw+ ++++LasGGnDn+v++wd s  +       l++ +eh++avka+
   Q: 226  QSRVGSLAWNNHILTTGGMDGQIVNNDVRIRSHVVETYRGHTQEVCGLKWSGSGQQLASGGNDNVVHIWDRSAASsnsttqYLHRLEEHTSAVKAL 321
           9*********************************************************************88766566666788889********* PP
   S: 186  awsPwqkslLasGGGtaDrcikfwntltgalleeidtgsqvcsllwskkskelvsthGfaenkitlwkypslskvaelkgheaRvlslalspdgea 281
           aw+P+q +lLa+GGG  Dr+ikfwnt tga+l+++dtgsqvcsllwsk+++el+s+hGf++n++tlwkyps+ k+ael+gh++Rvl++a spdg +
   Q: 322  AWCPFQANLLATGGGGGDRTIKFWNTHTGACLNSVDTGSQVCSLLWSKNERELLSSHGFTQNQLTLWKYPSMVKMAELTGHTSRVLYMAQSPDGCT 417
           ************************************************************************************************ PP
   S: 282  ivtaagDetlrfwklfdkk 300
           +++aagDetlrfw++f   
   Q: 418  VASAAGDETLRFWNVFGVP 436
           ****************765 PP

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf..sdtllvsGsdDgtikvWD 29
           gHt +v++l++  s+  l+sG++D+++++WD
   Q: 265  GHTQEVCGLKWsgSGQQLASGGNDNVVHIWD 295
           8**********976699************** PP

Organism

Brassica rapa

Functional Description
(View)

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.

Protein Sequence
(Fasta)

MDAGMNTSTH LKAQARCPLQ EHFLPRKSSK ENLDRFIPNR SAMDFDYAHY ALTEGRNGKD 60
QVTAAVSSPS REAYRKQLAE TMNLNHTRIL AFRNKPQAPV ELLPTDHSAS LLHQQPKSVK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGATGCAG GTATGAACAC ATCTACGCAC TTGAAGGCTC AAGCTCGGTG CCCACTTCAA 60
GAACACTTCC TTCCCCGGAA GAGTTCCAAG GAAAACGTAA GTTTGCTCAG ATTCGATACC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0396--Initiation factor
KW-0648--Protein biosynthesis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR024977--Apc4_WD40_dom
IPR016024--ARM-type_fold
IPR033010--Cdc20/Fizzy
IPR033464--CSN8_PSD8_EIF3K
IPR009374--eIF3k
IPR016020--Transl_init_fac_sub12_N_euk
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR011991--WHTH_DNA-bd_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12894--ANAPC4_WD40
PF10075--CSN8_PSD8_EIF3K
PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0016282--C:eukaryotic 43S preinitiation complex
GO:0033290--C:eukaryotic 48S preinitiation complex
GO:0005852--C:eukaryotic translation initiation factor 3 complex
GO:0043022--F:ribosome binding
GO:0003743--F:translation initiation factor activity
GO:0097027--F:ubiquitin-protein transferase activator activity
GO:0001731--P:formation of translation preinitiation complex
GO:1904668--P:positive regulation of ubiquitin protein ligase activity
GO:0006446--P:regulation of translational initiation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000638	Aegilops tauschii	70.64	0.00e+00	674.00
IUUC-Aml-001545	Ailuropoda melanoleuca	46.36	6.00e-103	367.00
IUUC-Atr-002628	Amborella trichopoda	68.28	1.00e-173	602.00
IUUC-Apl-003255	Anas platyrhynchos	47.33	6.00e-108	384.00
IUUC-Aca-004920	Anolis carolinensis	46.77	3.00e-103	368.00
IUUC-Aly-006253	Arabidopsis lyrata	94.09	0.00e+00	898.00
IUUC-Ath-006795	Arabidopsis thaliana	94.10	0.00e+00	894.00
IUUC-Bta-012625	Bos taurus	45.63	6.00e-102	363.00
IUUC-Bdi-014344	Brachypodium distachyon	70.11	0.00e+00	675.00
IUUC-Bol-015851	Brassica oleracea	97.59	0.00e+00	918.00
IUUC-Cja-019132	Callithrix jacchus	46.84	3.00e-104	371.00
IUUC-Cfa-020780	Canis familiaris	46.36	1.00e-102	366.00
IUUC-Cpo-022223	Cavia porcellus	46.36	6.00e-93	334.00
IUUC-Cre-022701	Chlamydomonas reinhardtii	50.71	3.00e-119	421.00
IUUC-Csa-023666	Chlorocebus sabaeus	46.60	2.00e-103	369.00
IUUC-Cho-024920	Choloepus hoffmanni	64.86	8.00e-43	167.00
IUUC-Cin-025675	Ciona intestinalis	48.05	1.00e-109	389.00
IUUC-Csv-026019	Ciona savignyi	45.81	3.00e-101	362.00
IUUC-Cme-027234	Cyanidioschyzon merolae	48.24	3.00e-100	358.00
IUUC-Dre-028026	Danio rerio	43.15	1.00e-102	366.00
IUUC-Dno-028865	Dasypus novemcinctus	45.87	5.00e-101	361.00
IUUC-Dor-030958	Dipodomys ordii	46.01	6.00e-99	354.00
IUUC-Dme-031905	Drosophila melanogaster	47.18	4.00e-112	398.00
IUUC-Ete-032387	Echinops telfairi	42.48	4.00e-92	331.00
IUUC-Eeu-035059	Erinaceus europaeus	41.02	6.00e-84	304.00
IUUC-Fca-036346	Felis catus	44.21	3.00e-89	322.00
IUUC-Fal-037558	Ficedula albicollis	46.12	4.00e-105	375.00
IUUC-Gmo-039284	Gadus morhua	44.52	3.00e-103	368.00
IUUC-Gga-040790	Gallus gallus	47.83	6.00e-107	380.00
IUUC-Gac-041431	Gasterosteus aculeatus	43.41	2.00e-97	348.00
IUUC-Gma-043985	Glycine max	79.91	0.00e+00	714.00
IUUC-Ggo-045052	Gorilla gorilla	46.36	3.00e-103	368.00
IUUC-Hsa-046305	Homo sapiens	46.36	3.00e-103	368.00
IUUC-Hvu-047565	Hordeum vulgare	71.18	0.00e+00	667.00
IUUC-Itr-048461	Ictidomys tridecemlineatus	46.60	8.00e-94	337.00
IUUC-Lpe-050954	Leersia perrieri	71.84	0.00e+00	629.00
IUUC-Laf-053742	Loxodonta africana	46.12	3.00e-102	365.00
IUUC-Mcc-054948	Macaca mulatta	46.60	2.00e-103	369.00
IUUC-Mtr-057725	Medicago truncatula	78.12	0.00e+00	729.00
IUUC-Mga-060102	Meleagris gallopavo	47.82	2.00e-107	382.00
IUUC-Mmr-061615	Microcebus murinus	46.84	1.00e-103	370.00
IUUC-Mmu-063864	Mus musculus	45.15	1.00e-98	353.00
IUUC-Mac-064861	Musa acuminata	75.35	0.00e+00	680.00
IUUC-Mpu-066502	Mustela putorius furo	46.19	2.00e-105	375.00
IUUC-Mlu-067277	Myotis lucifugus	45.48	3.00e-103	368.00
IUUC-Nle-070149	Nomascus leucogenys	46.36	2.00e-101	362.00
IUUC-Ont-071660	Oreochromis niloticus	44.66	1.00e-97	350.00
IUUC-Oan-073677	Ornithorhynchus anatinus	54.11	7.00e-99	353.00
IUUC-Ocu-073797	Oryctolagus cuniculus	46.60	2.00e-103	369.00
IUUC-Oba-075514	Oryza barthii	71.59	0.00e+00	630.00
IUUC-Obr-076018	Oryza brachyantha	70.17	0.00e+00	659.00
IUUC-Ogl-077254	Oryza glaberrima	71.59	0.00e+00	632.00
IUUC-Ogu-078562	Oryza glumaepatula	71.37	0.00e+00	630.00
IUUC-Oin-080094	Oryza indica	71.59	0.00e+00	632.00
IUUC-Olo-080449	Oryza longistaminata	71.40	0.00e+00	640.00
IUUC-Ome-081186	Oryza meridionalis	69.31	0.00e+00	654.00
IUUC-Oni-082243	Oryza nivara	71.59	0.00e+00	632.00
IUUC-Opu-084007	Oryza punctata	71.15	0.00e+00	627.00
IUUC-Oru-084357	Oryza rufipogon	71.37	0.00e+00	629.00
IUUC-Osa-086094	Oryza sativa	71.37	0.00e+00	630.00
IUUC-Ola-086907	Oryzias latipes	46.78	9.00e-101	360.00
IUUC-Olu-087647	Ostreococcus lucimarinus	54.65	5.00e-134	470.00
IUUC-Oga-088184	Otolemur garnettii	45.76	9.00e-100	357.00
IUUC-Oar-090023	Ovis aries	46.08	2.00e-99	355.00
IUUC-Ptr-090935	Pan troglodytes	46.19	2.00e-101	362.00
IUUC-Pan-091845	Papio anubis	46.60	2.00e-103	369.00
IUUC-Psi-093188	Pelodiscus sinensis	46.00	9.00e-105	373.00
IUUC-Pma-094187	Petromyzon marinus	44.93	4.00e-98	351.00
IUUC-Ppa-095687	Physcomitrella patens	66.59	2.00e-153	535.00
IUUC-Pab-098603	Pongo abelii	46.60	2.00e-103	369.00
IUUC-Pop-098890	Populus trichocarpa	82.97	0.00e+00	769.00
IUUC-Pca-101062	Procavia capensis	44.32	4.00e-103	368.00
IUUC-Ppe-101865	Prunus persica	79.04	0.00e+00	717.00
IUUC-Pva-102925	Pteropus vampyrus	46.12	2.00e-104	372.00
IUUC-Rno-106005	Rattus norvegicus	44.90	7.00e-99	353.00
IUUC-Sha-107472	Sarcophilus harrisii	45.79	1.00e-100	360.00
IUUC-Spo-108075	Schizosaccharomyces pombe	45.22	1.00e-94	339.00
IUUC-Smo-108922	Selaginella moellendorffii	62.08	7.00e-159	553.00
IUUC-Sit-110032	Setaria italica	70.95	0.00e+00	652.00
IUUC-Sly-111202	Solanum lycopersicum	80.23	0.00e+00	745.00
IUUC-Stu-112024	Solanum tuberosum	79.12	0.00e+00	764.00
IUUC-Sar-113092	Sorex araneus	43.51	8.00e-93	333.00
IUUC-Sbi-114558	Sorghum bicolor	71.46	0.00e+00	654.00
IUUC-Ssc-115710	Sus scrofa	46.36	1.00e-102	366.00
IUUC-Tgu-117100	Taeniopygia guttata	46.12	2.00e-105	375.00
IUUC-Tru-118184	Takifugu rubripes	42.48	4.00e-89	321.00
IUUC-Tni-120474	Tetraodon nigroviridis	44.15	5.00e-94	338.00
IUUC-Tca-120949	Theobroma cacao	83.19	0.00e+00	801.00
IUUC-Tvi-122531	Trichoderma virens	47.71	6.00e-96	344.00
IUUC-Tae-123918	Triticum aestivum	69.81	0.00e+00	674.00
IUUC-Tur-126193	Triticum urartu	63.72	0.00e+00	676.00
IUUC-Tbe-127384	Tupaia belangeri	51.06	3.00e-85	308.00
IUUC-Ttr-128511	Tursiops truncatus	46.36	3.00e-103	368.00
IUUC-Vvi-131245	Vitis vinifera	79.54	0.00e+00	695.00
IUUC-Xtr-131993	Xenopus tropicalis	48.09	8.00e-110	390.00
IUUC-Xma-133332	Xiphophorus maculatus	45.91	6.00e-103	367.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence