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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Sce-106236
Ensembl Protein ID YOR346W
UniProt Accession P12689; D6W341; Q12323; REV1_YEAST
Genbank Protein ID AAA34967.1; CAA65033.1; CAA99674.1; DAA11107.1
Protein Name DNA repair protein REV1; Reversionless protein 1
Genbank Nucleotide ID M22222; X95720; Z75253; BK006948
Gene Name REV1; YOR346W; O6339
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
YOR346W YOR346W YOR346W
Annotation
mRNA Expression
GEOFFGED
Protein-protein Interaction
IIDHINT
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
dbPAFBioGRID
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/Alpha-Helix/UBM UBM 17517887
Classification
Family E-value Score Start End
UBD/Alpha-Helix/UBM 3.30e-15 53.7 809 837
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/Alpha-Helix/UBM
   S: 1    lPsqvDpeVfsqLPeeiQeEvmaelrqqk 29
           lPs+++++++++LP++i++Ev+++lr+qk
   Q: 809  LPSTMEEQFMNELPTQIRAEVRHDLRIQK 837
           8**************************97 PP
   
Organism Saccharomyces cerevisiae
Functional Description
(View)

Functional Description


     Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents. Involved in mitochondrial DNA mutagenesis.
 Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents. Involved in mitochondrial DNA mutagenesis.
Protein Sequence
(Fasta)
MGEHGGLVDL LDSDLEYSIN RETPDKNNCL SQQSVNDSHL TAKTGGLNAR SFLSTLSDDS 60
LIEYVNQLSQ TNKNNSNPTA GTLRFTTKNI SCDELHADLG GGEDSPIARS VIEIQESDSN 120
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Protein Fasta Sequence


>IUUC-Sce-106236|UBD,UBM|Saccharomyces cerevisiae
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Nucleotide Sequence
(Fasta)
ATGGGTGAAC ATGGTGGTCT TGTAGATTTA TTGGACAGCG ATTTGGAATA CTCTATAAAT 60
AGGGAAACAC CTGATAAAAA CAATTGCCTT AGCCAGCAAA GTGTCAATGA TTCACATTTA 120
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Nucleotide Fasta Sequence


>IUUC-Sce-106236|UBD,UBM|Saccharomyces cerevisiae
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0237--DNA synthesis
KW-0238--DNA-binding
KW-0460--Magnesium
KW-0479--Metal-binding
KW-0496--Mitochondrion
KW-0548--Nucleotidyltransferase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0808--Transferase
Interpro

IPR001357--BRCT_dom
IPR017961--DNA_pol_Y-fam_little_finger
IPR012112--REV1
IPR001126--UmuC
PROSITE

PS50172--BRCT
PS50173--UMUC
Pfam

PF16589--BRCT_2
PF00817--IMS
PF11799--IMS_C
SMART

SM00292--BRCT
Gene Ontology

GO:0005739--C:mitochondrion
GO:0005634--C:nucleus
GO:0005657--C:replication fork
GO:0003684--F:damaged DNA binding
GO:0017125--F:deoxycytidyl transferase activity
GO:0003887--F:DNA-directed DNA polymerase activity
GO:0046872--F:metal ion binding
GO:0070987--P:error-free translesion synthesis
GO:0042276--P:error-prone translesion synthesis
KEGG sce:YOR346W
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000375 Aegilops tauschii 33.57 3.00e-17 82.00
IUUC-Aml-001185 Ailuropoda melanoleuca 26.78 2.00e-41 162.00
IUUC-Atr-002915 Amborella trichopoda 30.48 4.00e-44 171.00
IUUC-Apl-004054 Anas platyrhynchos 31.23 2.00e-36 145.00
IUUC-Aca-004304 Anolis carolinensis 31.09 4.00e-38 151.00
IUUC-Aly-005696 Arabidopsis lyrata 29.98 1.00e-49 189.00
IUUC-Ath-006893 Arabidopsis thaliana 30.29 6.00e-51 194.00
IUUC-Ago-007722 Ashbya gossypii 36.79 3.00e-146 510.00
IUUC-Acl-008347 Aspergillus clavatus 32.49 9.00e-71 259.00
IUUC-Afl-008444 Aspergillus flavus 34.43 4.00e-73 268.00
IUUC-Afu-008837 Aspergillus fumigatus 32.36 9.00e-67 246.00
IUUC-Ani-009188 Aspergillus nidulans 35.36 2.00e-68 252.00
IUUC-Ang-009866 Aspergillus niger 33.89 3.00e-73 268.00
IUUC-Aor-010107 Aspergillus oryzae 34.43 4.00e-73 267.00
IUUC-Ate-010359 Aspergillus terreus 35.20 8.00e-69 253.00
IUUC-Ame-010664 Astyanax mexicanus 26.40 4.00e-42 165.00
IUUC-Bgr-012244 Blumeria graminis 31.43 1.00e-57 216.00
IUUC-Bta-013405 Bos taurus 26.45 2.00e-39 156.00
IUUC-Bci-013849 Botrytis cinerea 34.38 2.00e-67 249.00
IUUC-Bdi-014066 Brachypodium distachyon 28.60 3.00e-45 175.00
IUUC-Bol-015544 Brassica oleracea 30.30 5.00e-51 194.00
IUUC-Bra-017792 Brassica rapa 28.40 4.00e-46 178.00
IUUC-Cel-018148 Caenorhabditis elegans 28.45 3.00e-54 204.00
IUUC-Cja-019742 Callithrix jacchus 24.48 3.00e-20 92.00
IUUC-Cfa-020112 Canis familiaris 26.92 1.00e-41 163.00
IUUC-Cpo-022152 Cavia porcellus 26.58 1.00e-41 163.00
IUUC-Cre-022951 Chlamydomonas reinhardtii 27.16 2.00e-31 128.00
IUUC-Csa-023504 Chlorocebus sabaeus 27.04 2.00e-39 156.00
IUUC-Cho-024780 Choloepus hoffmanni 42.70 4.00e-16 78.60
IUUC-Cin-025276 Ciona intestinalis 32.46 2.00e-80 291.00
IUUC-Csv-026283 Ciona savignyi 30.72 2.00e-66 244.00
IUUC-Cgl-026726 Colletotrichum gloeosporioides 29.54 3.00e-69 255.00
IUUC-Cne-027079 Cryptococcus neoformans 31.10 6.00e-58 217.00
IUUC-Cme-027346 Cyanidioschyzon merolae 25.07 7.00e-43 167.00
IUUC-Dre-028073 Danio rerio 31.21 3.00e-37 149.00
IUUC-Dno-030038 Dasypus novemcinctus 26.53 5.00e-39 154.00
IUUC-Dor-031100 Dipodomys ordii 25.62 3.00e-34 138.00
IUUC-Dse-031310 Dothistroma septosporum 33.63 2.00e-66 245.00
IUUC-Dme-031991 Drosophila melanogaster 25.78 1.00e-59 223.00
IUUC-Ete-033082 Echinops telfairi 29.44 3.00e-18 85.90
IUUC-Eca-033471 Equus caballus 27.18 3.00e-40 158.00
IUUC-Eeu-034993 Erinaceus europaeus 30.77 2.00e-33 135.00
IUUC-Fca-035367 Felis catus 27.32 8.00e-43 167.00
IUUC-Fal-036973 Ficedula albicollis 30.95 1.00e-35 143.00
IUUC-Fox-037677 Fusarium oxysporum 31.87 2.00e-68 252.00
IUUC-Fso-038252 Fusarium solani 30.05 9.00e-65 240.00
IUUC-Gmo-039669 Gadus morhua 24.48 5.00e-42 164.00
IUUC-Ggr-039988 Gaeumannomyces graminis 34.08 4.00e-60 224.00
IUUC-Gga-040423 Gallus gallus 31.23 1.00e-36 146.00
IUUC-Gac-042134 Gasterosteus aculeatus 25.10 1.00e-36 147.00
IUUC-Gma-042929 Glycine max 29.89 6.00e-47 181.00
IUUC-Ggo-044528 Gorilla gorilla 27.57 8.00e-41 160.00
IUUC-Hsa-046259 Homo sapiens 27.57 9.00e-41 160.00
IUUC-Hvu-047139 Hordeum vulgare 33.09 3.00e-34 137.00
IUUC-Itr-048621 Ictidomys tridecemlineatus 27.64 6.00e-42 164.00
IUUC-Kpa-049169 Komagataella pastoris 33.15 7.00e-124 436.00
IUUC-Lch-050471 Latimeria chalumnae 30.97 9.00e-37 147.00
IUUC-Lpe-050800 Leersia perrieri 28.34 3.00e-41 162.00
IUUC-Loc-052320 Lepisosteus oculatus 23.30 6.00e-22 97.80
IUUC-Lma-053149 Leptosphaeria maculans 32.33 3.00e-68 251.00
IUUC-Laf-053810 Loxodonta africana 26.60 2.00e-37 149.00
IUUC-Mcc-055574 Macaca mulatta 27.38 3.00e-39 155.00
IUUC-Meu-055945 Macropus eugenii 24.42 6.00e-14 71.60
IUUC-Mor-057195 Magnaporthe oryzae 33.70 8.00e-62 230.00
IUUC-Mpo-057488 Magnaporthe poae 33.19 1.00e-60 226.00
IUUC-Mtr-057955 Medicago truncatula 30.33 1.00e-51 196.00
IUUC-Mla-059027 Melampsora laricipopulina 32.06 2.00e-76 278.00
IUUC-Mga-060156 Meleagris gallopavo 31.23 1.00e-36 146.00
IUUC-Mvi-060398 Microbotryum violaceum 33.76 7.00e-56 210.00
IUUC-Mmr-061113 Microcebus murinus 27.25 4.00e-40 158.00
IUUC-Mdo-063001 Monodelphis domestica 27.50 1.00e-39 156.00
IUUC-Mmu-063180 Mus musculus 27.91 5.00e-39 154.00
IUUC-Mac-065551 Musa acuminata 30.11 3.00e-19 88.60
IUUC-Mpu-066525 Mustela putorius furo 26.92 5.00e-41 161.00
IUUC-Mlu-067877 Myotis lucifugus 27.20 2.00e-38 152.00
IUUC-Nfi-068418 Neosartorya fischeri 32.85 5.00e-66 244.00
IUUC-Ncr-068648 Neurospora crassa 34.13 1.00e-65 243.00
IUUC-Nle-069959 Nomascus leucogenys 27.57 2.00e-40 159.00
IUUC-Opr-070522 Ochotona princeps 37.65 4.00e-22 99.00
IUUC-Ont-072293 Oreochromis niloticus 27.27 6.00e-27 114.00
IUUC-Oan-073519 Ornithorhynchus anatinus 32.55 2.00e-39 155.00
IUUC-Ocu-074492 Oryctolagus cuniculus 26.48 4.00e-38 151.00
IUUC-Oba-075567 Oryza barthii 28.67 1.00e-44 172.00
IUUC-Obr-076332 Oryza brachyantha 29.66 6.00e-46 177.00
IUUC-Ogl-077348 Oryza glaberrima 27.17 1.00e-44 173.00
IUUC-Ogu-078779 Oryza glumaepatula 28.67 1.00e-44 173.00
IUUC-Oin-079738 Oryza indica 25.83 1.00e-42 166.00
IUUC-Olo-080701 Oryza longistaminata 25.43 1.00e-42 166.00
IUUC-Ome-081708 Oryza meridionalis 29.06 9.00e-41 160.00
IUUC-Oni-082251 Oryza nivara 28.90 2.00e-43 169.00
IUUC-Opu-083528 Oryza punctata 27.52 2.00e-37 149.00
IUUC-Oru-084293 Oryza rufipogon 27.98 4.00e-41 161.00
IUUC-Osa-085549 Oryza sativa 28.90 5.00e-45 174.00
IUUC-Ola-086793 Oryzias latipes 30.64 2.00e-35 142.00
IUUC-Olu-087786 Ostreococcus lucimarinus 26.52 9.00e-38 149.00
IUUC-Oga-089006 Otolemur garnettii 27.29 7.00e-38 150.00
IUUC-Oar-089597 Ovis aries 25.77 3.00e-39 155.00
IUUC-Ptr-091520 Pan troglodytes 27.57 9.00e-41 160.00
IUUC-Pan-092333 Papio anubis 27.38 4.00e-39 155.00
IUUC-Psi-094004 Pelodiscus sinensis 31.59 2.00e-37 149.00
IUUC-Pma-094128 Petromyzon marinus 25.78 3.00e-26 111.00
IUUC-Pno-094849 Phaeosphaeria nodorum 33.05 6.00e-62 231.00
IUUC-Ppa-095714 Physcomitrella patens 30.41 2.00e-45 175.00
IUUC-Pfo-096569 Poecilia formosa 29.77 8.00e-35 140.00
IUUC-Pab-097960 Pongo abelii 27.77 3.00e-41 162.00
IUUC-Pop-098921 Populus trichocarpa 27.11 2.00e-42 165.00
IUUC-Pca-100509 Procavia capensis 24.28 3.00e-22 99.40
IUUC-Ppe-101730 Prunus persica 29.36 3.00e-51 195.00
IUUC-Pva-102142 Pteropus vampyrus 26.99 2.00e-39 156.00
IUUC-Pgr-103446 Puccinia graminis 27.79 6.00e-37 147.00
IUUC-Ptt-103849 Puccinia triticina 31.58 5.00e-45 175.00
IUUC-Pte-104128 Pyrenophora teres 33.04 4.00e-73 268.00
IUUC-Pyt-104754 Pyrenophora triticirepentis 32.21 3.00e-70 257.00
IUUC-Rno-104871 Rattus norvegicus 27.22 8.00e-39 154.00
IUUC-Sha-106962 Sarcophilus harrisii 27.88 7.00e-40 157.00
IUUC-Sja-107691 Schizosaccharomyces japonicus 27.00 1.00e-57 216.00
IUUC-Spo-108170 Schizosaccharomyces pombe 30.74 1.00e-73 269.00
IUUC-Ssl-108668 Sclerotinia sclerotiorum 36.30 3.00e-70 258.00
IUUC-Smo-109554 Selaginella moellendorffii 28.63 1.00e-60 226.00
IUUC-Sit-110479 Setaria italica 25.38 2.00e-32 132.00
IUUC-Sly-111752 Solanum lycopersicum 29.17 1.00e-46 179.00
IUUC-Stu-112284 Solanum tuberosum 25.81 2.00e-12 65.50
IUUC-Sar-113304 Sorex araneus 27.05 2.00e-38 152.00
IUUC-Sbi-114196 Sorghum bicolor 24.62 2.00e-43 169.00
IUUC-Sre-115151 Sporisorium reilianum 30.74 5.00e-55 208.00
IUUC-Ssc-116104 Sus scrofa 26.05 1.00e-37 150.00
IUUC-Tgu-117438 Taeniopygia guttata 30.95 9.00e-36 144.00
IUUC-Tru-118553 Takifugu rubripes 29.48 5.00e-34 138.00
IUUC-Tsy-119056 Tarsius syrichta 27.56 1.00e-41 163.00
IUUC-Tni-119933 Tetraodon nigroviridis 25.38 8.00e-39 154.00
IUUC-Tca-121376 Theobroma cacao 29.80 3.00e-46 179.00
IUUC-Tre-121972 Trichoderma reesei 31.00 1.00e-64 239.00
IUUC-Tvi-122342 Trichoderma virens 30.56 1.00e-59 223.00
IUUC-Tae-123898 Triticum aestivum 28.88 2.00e-48 185.00
IUUC-Tur-126735 Triticum urartu 36.17 1.00e-13 70.10
IUUC-Tme-126999 Tuber melanosporum 32.39 3.00e-64 238.00
IUUC-Tbe-127280 Tupaia belangeri 40.60 4.00e-22 98.60
IUUC-Ttr-129104 Tursiops truncatus 26.72 1.00e-38 153.00
IUUC-Uma-129562 Ustilago maydis 29.62 4.00e-51 195.00
IUUC-Vda-129862 Verticillium dahliae 30.72 8.00e-64 236.00
IUUC-Vpa-130819 Vicugna pacos 39.71 4.00e-21 95.10
IUUC-Vvi-131111 Vitis vinifera 29.26 5.00e-48 184.00
IUUC-Xtr-132629 Xenopus tropicalis 30.09 2.00e-33 136.00
IUUC-Xma-134065 Xiphophorus maculatus 25.29 1.00e-36 146.00
IUUC-Yli-134633 Yarrowia lipolytica 35.10 2.00e-66 246.00
IUUC-Zma-135176 Zea mays 31.32 3.00e-51 195.00
Created Date 25-Jun-2017

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