iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
TRANSFAC
Protein-protein Interaction
iRefIndex	Mentha
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/U-box	U-box	19629177

Classification

Family	E-value	Score	Start	End
E3 activity/RING/U-box	6.20e-16	59.1	2	68
E3 adaptor/Cullin RING/DCX/DWD	2.20e-24	85.4	262	293
UBD/Beta-Prp	7.40e-43	147.7	219	433

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 7    lCpIslelMrdPvvlp.sGitydrssIekwlasggktcPvtrqplteedlvPnltlrrliqawceens 73
           +C+Is+e++++Pvv++ sG  y+++ I+ +++++gk cPvt++p t +d+vP +t + +  + +++ s
   Q: 2    NCAISGEVPEEPVVSKkSGLLYEKRLIQTHISDYGK-CPVTGEPHTLDDIVPIKTGKIVKPKPLHTAS 68
           7***********************************.*************************999877 PP

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDl 30
           gH+ +vt+++f  d +l++++s D+t+++W  
   Q: 262  GHSKKVTSIKFvGDtDLVLTASSDKTVRIWGC 293
           8***********6669**************85 PP

UBD/Beta-Prp

   S: 49   sgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqclee..tlsghdgvvncvv 144
           + +++++ ++++ +++++++tg+ D t+ ++d  +g++++tl+gh+++v+s++f  ++d ++++s+d+t+r+w  +++  + +  tl+ h++ v+ v+
   Q: 219  KTNKPGIFSMDILHSKDVIATGGIDTTAVLFDRPSGQILSTLTGHSKKVTSIKFVGDTDLVLTASSDKTVRIWGCSEDGNYTSrhTLKDHSAEVRAVT 316
           45566666666666666666666666666666666666666666666666666666666666666666666666666555544556666666666666 PP
   S: 145  vhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvysls..fdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsg 240
           vh +++++vs+slD+t  ++dl++g +l + t + +++v+ ++  f+++g  l +g   + vk+wd++++  v ++ gh+  ++s+ fs+n+ +l+++
   Q: 317  VHATNKYFVSASLDSTWCFYDLSSGLCLAQVTDASENDVNYTAaaFHPDGLILGTGTAQSIVKIWDVKSQANVAKFGGHNGEITSISFSENGYFLATA 414
           66666666666666666666666666666666666666666655666666666666666666666666666666666666666666666666666666 PP
   S: 241  ssDgsiriWdlrsgdllktl 260
           + Dg +r+Wdlr+ ++ +t+
   Q: 415  ALDG-VRLWDLRKLKNFRTF 433
           6665.566666666666665 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

Probable ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair (By similarity). Component of the MAC complex that probably regulates defense responses through transcriptional control and thereby is essential for plant innate immunity.

Protein Sequence
(Fasta)

MNCAISGEVP EEPVVSKKSG LLYEKRLIQT HISDYGKCPV TGEPHTLDDI VPIKTGKIVK 60
PKPLHTASIP GLLGTFQTEW DSLMLSNFAL EQQLHTARQE LSHALYQHDA ACRVIARLKK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTTCAGAAAA AAGCCTAATT AGTTATAAAT CAAGGTCTCG TTAAAAGGCC CATTTGTTTA 60
ACAAGAAATC TCTAACTTGT TGTCCTAAGC TTAAACAATT TTTGCATCTC TCTCTCTTTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0391--Immunity
KW-0399--Innate immunity
KW-0436--Ligase
KW-0507--mRNA processing
KW-0508--mRNA splicing
KW-0539--Nucleus
KW-0611--Plant defense
KW-1185--Reference proteome
KW-0677--Repeat
KW-0747--Spliceosome
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat

Interpro

IPR013915--Pre-mRNA_splic_Prp19
IPR003613--Ubox_domain
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51698--U_BOX
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08606--Prp19
PF00400--WD40

SMART

SM00504--Ubox
SM00320--WD40

Gene Ontology

GO:0005730--C:nucleolus
GO:0005634--C:nucleus
GO:0000974--C:Prp19 complex
GO:0071006--C:U2-type catalytic step 1 spliceosome
GO:0016874--F:ligase activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0042742--P:defense response to bacterium
GO:0006281--P:DNA repair
GO:0000349--P:generation of catalytic spliceosome for first transesterification step
GO:0045087--P:innate immune response
GO:0070534--P:protein K63-linked ubiquitination
GO:0046686--P:response to cadmium ion

KEGG

ath:AT1G04510

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000488	Aegilops tauschii	65.45	0.00e+00	706.00
IUUC-Atr-002594	Amborella trichopoda	68.80	0.00e+00	750.00
IUUC-Apl-003686	Anas platyrhynchos	41.46	1.00e-79	289.00
IUUC-Aly-005586	Arabidopsis lyrata	96.75	0.00e+00	1041.00
IUUC-Bdi-014896	Brachypodium distachyon	71.70	0.00e+00	787.00
IUUC-Bol-016045	Brassica oleracea	91.20	0.00e+00	993.00
IUUC-Bra-017902	Brassica rapa	91.40	0.00e+00	996.00
IUUC-Cho-025065	Choloepus hoffmanni	35.85	4.00e-43	167.00
IUUC-Cin-025699	Ciona intestinalis	44.57	3.00e-101	361.00
IUUC-Csv-026128	Ciona savignyi	42.01	2.00e-113	401.00
IUUC-Cne-026860	Cryptococcus neoformans	36.66	2.00e-92	332.00
IUUC-Dor-030150	Dipodomys ordii	41.77	5.00e-40	158.00
IUUC-Fox-037922	Fusarium oxysporum	31.32	1.00e-60	226.00
IUUC-Hvu-047442	Hordeum vulgare	70.51	1.00e-131	461.00
IUUC-Lpe-050976	Leersia perrieri	71.37	0.00e+00	766.00
IUUC-Oan-073498	Ornithorhynchus anatinus	32.44	8.00e-35	140.00
IUUC-Obr-076480	Oryza brachyantha	72.06	0.00e+00	780.00
IUUC-Olo-080376	Oryza longistaminata	70.24	0.00e+00	720.00
IUUC-Opu-083243	Oryza punctata	71.40	0.00e+00	778.00
IUUC-Psi-093777	Pelodiscus sinensis	43.48	2.00e-87	315.00
IUUC-Ppa-095924	Physcomitrella patens	67.18	0.00e+00	711.00
IUUC-Ppe-101383	Prunus persica	72.03	0.00e+00	758.00
IUUC-Sja-107697	Schizosaccharomyces japonicus	32.04	9.00e-46	177.00
IUUC-Spo-108315	Schizosaccharomyces pombe	29.48	2.00e-39	155.00
IUUC-Sly-111673	Solanum lycopersicum	74.52	0.00e+00	791.00
IUUC-Stu-112125	Solanum tuberosum	74.86	0.00e+00	793.00
IUUC-Tca-121807	Theobroma cacao	74.62	0.00e+00	820.00
IUUC-Tae-125713	Triticum aestivum	70.78	0.00e+00	779.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence