iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000275464.4	ENST00000617716.3	ENSP00000482107.1
ENSG00000275464.4	ENST00000632537.1	ENSP00000488213.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
THPA
DNA & RNA Element
RAID2
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
THPA	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.50e-23	83.5	499	530
UBD/Beta-Prp	2.70e-57	195.9	290	491

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDl 30
           gH++++++l+f +    l+s+s+D+t+++WD+
   Q: 499  GHEGPISGLCFnPMkSVLASASWDKTVRLWDM 530
           8**********977778**************6 PP

UBD/Beta-Prp

   S: 12   vitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseD.rtikvwdlstgkcvhtlkghedsvlslsf 102
            +t+ +f++++ ll+tg+++g   ++++ + +l++sls  ++ +++v ++++g++++ g +  + + vw+ ++ ++v + +gh +s ++l++
   Q: 290  NLTAAAFHKKSHLLVTGFASGIFHLHELPEFNLIHSLSISDQSIASVAINSSGDWIAFGCSGlGQLLVWEWQSESYVLKQQGHFNSMVALAY 381
           578999********************************************************9***************************** PP
   S: 103  spsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngke 194
           sp+g+++v+G++d  ++vw++ +g c+  t+++h++ v++v++  +g ++v++s D+tvr +dl + +  rt+t+    +  ++++d +g+ 
   Q: 382  SPDGQYIVTGGDDGKVKVWNTLSGFCFV-TFTEHSSGVTGVTFTATGYVVVTSSMDGTVRAFDLHRYRNFRTFTSPRPTQFSCVAVDASGEI 472
           ****************************.*************************************************************** PP
   S: 195  lvsgsldg.tvklwdlqtg 212
           + +g++d+  + +w++qtg
   Q: 473  VSAGAQDSfEIFVWSMQTG 491
           *******956999****98 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MKFAYRFSNL LGTVYRRGNL NFTCNGNSVI SPVGNRVTVF DLKNNKSDTL PLATRYNVKC 60
VGLSPDGRLA IIVDEGGDAL LVSLVCRSVL HHFHFKGSVH SVSFSPDGRK FVVTKGNIAQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAGTGCGTGC TGTGGGCGGT GCCGCGCGGA CCCCCGGGAA GTGTCTCTGT GGGCGGCCGC 60
CGGGTTGAGC TGCGGCACAC GTGCGACAGC CGTGATGAAG TTCGCTTACC GGGTGAGCGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR003143--Cyt_cd1_C
IPR020472--G-protein_beta_WD-40_rep
IPR023302--Pept_S9A_N
IPR027145--PWP2
IPR011047--Quinoprotein_ADH-like_supfam
IPR007148--SSU_processome_Utp12
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF04003--Utp12
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0034388--C:Pwp2p-containing subcomplex of 90S preribosome
GO:0032040--C:small-subunit processome
GO:0030515--F:snoRNA binding
GO:0000462--P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000028--P:ribosomal small subunit assembly

KEGG

hsa:102724159

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aly-006213	Arabidopsis lyrata	40.65	0.00e+00	664.00
IUUC-Ath-006593	Arabidopsis thaliana	39.96	0.00e+00	659.00
IUUC-Bci-013757	Botrytis cinerea	50.41	6.00e-172	598.00
IUUC-Bol-016521	Brassica oleracea	42.09	0.00e+00	670.00
IUUC-Bra-017096	Brassica rapa	41.53	0.00e+00	672.00
IUUC-Csv-026194	Ciona savignyi	50.87	0.00e+00	913.00
IUUC-Dre-027514	Danio rerio	67.63	0.00e+00	1268.00
IUUC-Dno-029191	Dasypus novemcinctus	87.55	0.00e+00	1409.00
IUUC-Dse-031260	Dothistroma septosporum	49.56	9.00e-165	573.00
IUUC-Ete-033102	Echinops telfairi	86.77	0.00e+00	1032.00
IUUC-Gma-043034	Glycine max	41.39	0.00e+00	695.00
IUUC-Lch-049460	Latimeria chalumnae	72.05	0.00e+00	1231.00
IUUC-Mtr-058700	Medicago truncatula	42.05	0.00e+00	714.00
IUUC-Mpu-066098	Mustela putorius furo	86.88	0.00e+00	1411.00
IUUC-Opr-070966	Ochotona princeps	94.79	0.00e+00	650.00
IUUC-Pop-099635	Populus trichocarpa	42.26	0.00e+00	707.00
IUUC-Ppe-101552	Prunus persica	41.92	0.00e+00	717.00
IUUC-Sha-107264	Sarcophilus harrisii	77.45	0.00e+00	644.00
IUUC-Sly-111620	Solanum lycopersicum	48.58	1.00e-164	573.00
IUUC-Stu-112877	Solanum tuberosum	42.43	0.00e+00	733.00
IUUC-Ssc-115931	Sus scrofa	87.24	0.00e+00	711.00
IUUC-Tca-121685	Theobroma cacao	42.79	0.00e+00	728.00
IUUC-Tae-125397	Triticum aestivum	45.57	8.00e-123	435.00
IUUC-Tbe-128102	Tupaia belangeri	91.87	0.00e+00	1006.00
IUUC-Vvi-131572	Vitis vinifera	42.50	0.00e+00	687.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence