iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mlu-067253

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAPE02049591

Gene Name

WDR1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMLUG00000013463.2	ENSMLUT00000013465.2	ENSMLUP00000012251.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	5.30e-38	127.4	223	253
UBD/Beta-Prp	3.10e-61	207.2	46	267

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDl 30
           H ++++++++ +d t+l+s+s+D+t k+WD+
   Q: 223  HDGGIYAISWsPDsTHLLSASGDKTSKIWDV 253
           99*********999****************7 PP

UBD/Beta-Prp

   S: 8    hhksvitcvkfspdksllatgsrdgtikvwdvttgkllrsl..sgheaevtavkfspdgkilvtgseD..rtikvwdlstgkcvhtlkg 92
           +h +++ + k++p++ ++a+g  +g++++wd+t++  l ++  +   ++++++ + +d+k ++ ++e   ++  v+  ++g+ v  ++g
   Q: 46   EHAHQVVVAKYAPSGFYIASGDVSGKLRIWDTTQKEHLLKYeyQPFAGKIKDIAWTEDSKRIAVVGEGreKFGAVFLWDSGSSVGEITG 134
           455566668*************************998777742334567***********99999999887777777789********* PP
   S: 93   hedsvlslsfspsg.dklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtl..tgg 178
           h++ + s+++ +++ ++lv+Gs+d+ +  ++ +  +    t   h+++vncv+++pdgn ++++s+D+++ ++d ktg+ +  l  +++
   Q: 135  HNKVINSVDIKQTRpYRLVTGSDDNCAAFFEGPPFKFKF-TIGDHSRFVNCVRFSPDGNRFATASADGQIHIYDGKTGENVCALggSKA 222
           ************999*****************9999998.99********************************************888 PP
   S: 179  htdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtd 223
           h++ +y +s+++++++l+s+s d+t k+wd+  +++v t++  ++
   Q: 223  HDGGIYAISWSPDSTHLLSASGDKTSKIWDVNVNSVVTTFTMGSN 267
           **********************************99999986554 PP

Organism

Myotis lucifugus

Protein Sequence
(Fasta)

XSLPQVERGV SKILGGGPKG NFLYTNGKCV IIRNIDNPAL ADIYTEHAHQ VVVAKYAPSG 60
FYIASGDVSG KLRIWDTTQK EHLLKYEYQP FAGKIKDIAW TEDSKRIAVV GEGREKFGAV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

NCCAGCCTCC CCCAGGTGGA GAGGGGGGTT TCCAAAATCC TCGGCGGCGG CCCCAAGGGC 60
AATAAATTTT CTTTACACCA ATGGCAAGTG CGTCATCATA AGGAACATCG ATGTGAGTAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR011045--N2O_reductase_N
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0005911--C:cell-cell junction
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0043209--C:myelin sheath
GO:0030043--P:actin filament fragmentation
GO:0043297--P:apical junction assembly
GO:0030865--P:cortical cytoskeleton organization
GO:0042247--P:establishment of planar polarity of follicular epithelium
GO:0045199--P:maintenance of epithelial cell apical/basal polarity
GO:0002446--P:neutrophil mediated immunity
GO:1990266--P:neutrophil migration
GO:0030220--P:platelet formation
GO:0030836--P:positive regulation of actin filament depolymerization
GO:0008360--P:regulation of cell shape
GO:0060307--P:regulation of ventricular cardiac muscle cell membrane repolarization
GO:0045214--P:sarcomere organization

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000457	Aegilops tauschii	35.05	6.00e-81	294.00
IUUC-Aml-002368	Ailuropoda melanoleuca	95.01	0.00e+00	1155.00
IUUC-Atr-003160	Amborella trichopoda	36.45	1.00e-107	384.00
IUUC-Apl-004012	Anas platyrhynchos	88.19	0.00e+00	1061.00
IUUC-Aca-004707	Anolis carolinensis	83.19	0.00e+00	1027.00
IUUC-Aly-006465	Arabidopsis lyrata	37.58	7.00e-105	374.00
IUUC-Ath-006740	Arabidopsis thaliana	37.58	3.00e-104	372.00
IUUC-Ago-007920	Ashbya gossypii	28.32	7.00e-69	254.00
IUUC-Acl-008262	Aspergillus clavatus	36.75	8.00e-104	370.00
IUUC-Afl-008471	Aspergillus flavus	29.85	4.00e-65	243.00
IUUC-Afu-008989	Aspergillus fumigatus	38.54	1.00e-96	347.00
IUUC-Ani-009167	Aspergillus nidulans	38.13	3.00e-112	399.00
IUUC-Ang-009595	Aspergillus niger	37.80	1.00e-99	357.00
IUUC-Aor-009908	Aspergillus oryzae	35.99	7.00e-100	357.00
IUUC-Ate-010580	Aspergillus terreus	38.18	1.00e-105	378.00
IUUC-Ame-011269	Astyanax mexicanus	60.61	2.00e-128	452.00
IUUC-Bgr-011996	Blumeria graminis	34.87	3.00e-103	369.00
IUUC-Bta-013278	Bos taurus	94.84	0.00e+00	1175.00
IUUC-Bci-013925	Botrytis cinerea	35.69	3.00e-103	369.00
IUUC-Bdi-014659	Brachypodium distachyon	35.97	8.00e-100	357.00
IUUC-Bol-016043	Brassica oleracea	35.80	2.00e-102	366.00
IUUC-Bra-017139	Brassica rapa	36.93	1.00e-103	370.00
IUUC-Cel-018417	Caenorhabditis elegans	39.93	3.00e-118	419.00
IUUC-Cja-019952	Callithrix jacchus	93.84	0.00e+00	1125.00
IUUC-Cfa-020225	Canis familiaris	95.51	0.00e+00	1158.00
IUUC-Cpo-021900	Cavia porcellus	92.68	0.00e+00	1140.00
IUUC-Csa-023028	Chlorocebus sabaeus	94.51	0.00e+00	1129.00
IUUC-Cho-025030	Choloepus hoffmanni	67.22	0.00e+00	735.00
IUUC-Cin-025152	Ciona intestinalis	56.10	9.00e-77	279.00
IUUC-Csv-025986	Ciona savignyi	37.23	7.00e-92	330.00
IUUC-Cgl-026597	Colletotrichum gloeosporioides	38.06	7.00e-106	377.00
IUUC-Cne-026814	Cryptococcus neoformans	34.48	8.00e-95	341.00
IUUC-Dre-027498	Danio rerio	82.16	1.00e-89	321.00
IUUC-Dno-029383	Dasypus novemcinctus	93.01	0.00e+00	1108.00
IUUC-Dor-030633	Dipodomys ordii	93.27	0.00e+00	1091.00
IUUC-Dse-031526	Dothistroma septosporum	38.66	1.00e-112	400.00
IUUC-Dme-031597	Drosophila melanogaster	47.84	2.00e-161	561.00
IUUC-Ete-032780	Echinops telfairi	84.90	0.00e+00	1026.00
IUUC-Eca-034306	Equus caballus	93.69	0.00e+00	1137.00
IUUC-Eeu-034531	Erinaceus europaeus	72.39	3.00e-135	475.00
IUUC-Fca-036301	Felis catus	94.84	0.00e+00	1178.00
IUUC-Fal-037361	Ficedula albicollis	88.35	0.00e+00	1111.00
IUUC-Fox-037924	Fusarium oxysporum	35.56	1.00e-98	353.00
IUUC-Fso-038199	Fusarium solani	35.18	7.00e-96	344.00
IUUC-Gmo-039238	Gadus morhua	71.93	0.00e+00	875.00
IUUC-Ggr-039830	Gaeumannomyces graminis	36.48	2.00e-92	332.00
IUUC-Gga-040235	Gallus gallus	88.85	0.00e+00	1081.00
IUUC-Gac-042363	Gasterosteus aculeatus	71.43	0.00e+00	901.00
IUUC-Gma-044189	Glycine max	36.35	2.00e-105	376.00
IUUC-Ggo-044632	Gorilla gorilla	92.36	0.00e+00	1101.00
IUUC-Hsa-045792	Homo sapiens	94.01	0.00e+00	1143.00
IUUC-Hvu-047517	Hordeum vulgare	35.36	5.00e-104	372.00
IUUC-Itr-048076	Ictidomys tridecemlineatus	94.84	0.00e+00	1150.00
IUUC-Kpa-049183	Komagataella pastoris	32.83	7.00e-83	301.00
IUUC-Lch-050428	Latimeria chalumnae	76.87	0.00e+00	979.00
IUUC-Lpe-051306	Leersia perrieri	36.35	3.00e-105	375.00
IUUC-Loc-052096	Lepisosteus oculatus	71.19	0.00e+00	872.00
IUUC-Lma-053313	Leptosphaeria maculans	38.95	7.00e-112	400.00
IUUC-Laf-054060	Loxodonta africana	92.01	0.00e+00	1115.00
IUUC-Mcc-055619	Macaca mulatta	93.69	0.00e+00	1119.00
IUUC-Meu-056689	Macropus eugenii	76.34	3.00e-173	601.00
IUUC-Mor-056940	Magnaporthe oryzae	35.78	3.00e-93	335.00
IUUC-Mpo-057557	Magnaporthe poae	30.97	4.00e-65	242.00
IUUC-Mtr-057922	Medicago truncatula	35.42	3.00e-103	369.00
IUUC-Mla-059103	Melampsora laricipopulina	33.97	5.00e-79	288.00
IUUC-Mga-060150	Meleagris gallopavo	89.18	0.00e+00	1081.00
IUUC-Mvi-060448	Microbotryum violaceum	31.85	9.00e-76	277.00
IUUC-Mmr-061226	Microcebus murinus	93.18	0.00e+00	1126.00
IUUC-Mdo-062674	Monodelphis domestica	91.18	0.00e+00	1113.00
IUUC-Mmu-064170	Mus musculus	94.34	0.00e+00	1150.00
IUUC-Mac-065124	Musa acuminata	37.13	4.00e-108	385.00
IUUC-Mpu-066001	Mustela putorius furo	91.19	0.00e+00	1130.00
IUUC-Nfi-068550	Neosartorya fischeri	38.66	2.00e-107	382.00
IUUC-Ncr-068948	Neurospora crassa	35.98	6.00e-108	384.00
IUUC-Nle-070115	Nomascus leucogenys	91.99	0.00e+00	1064.00
IUUC-Opr-070254	Ochotona princeps	91.51	0.00e+00	1087.00
IUUC-Ont-071666	Oreochromis niloticus	74.04	0.00e+00	923.00
IUUC-Oan-073594	Ornithorhynchus anatinus	91.42	9.00e-168	582.00
IUUC-Ocu-074824	Oryctolagus cuniculus	92.51	0.00e+00	1098.00
IUUC-Oba-075010	Oryza barthii	36.74	6.00e-106	378.00
IUUC-Obr-076364	Oryza brachyantha	37.27	1.00e-107	383.00
IUUC-Ogl-077019	Oryza glaberrima	36.74	6.00e-106	378.00
IUUC-Ogu-078496	Oryza glumaepatula	36.74	6.00e-106	378.00
IUUC-Oin-080116	Oryza indica	36.90	2.00e-106	379.00
IUUC-Olo-080290	Oryza longistaminata	36.74	1.00e-105	377.00
IUUC-Ome-081969	Oryza meridionalis	36.74	8.00e-106	377.00
IUUC-Oni-082075	Oryza nivara	36.74	6.00e-106	378.00
IUUC-Opu-083959	Oryza punctata	36.78	6.00e-106	378.00
IUUC-Oru-084711	Oryza rufipogon	36.74	6.00e-106	378.00
IUUC-Osa-085958	Oryza sativa	36.90	2.00e-106	379.00
IUUC-Ola-086968	Oryzias latipes	75.37	0.00e+00	939.00
IUUC-Oga-089108	Otolemur garnettii	94.51	0.00e+00	1182.00
IUUC-Oar-089986	Ovis aries	89.51	0.00e+00	1096.00
IUUC-Ptr-091281	Pan troglodytes	94.18	0.00e+00	1147.00
IUUC-Pan-092585	Papio anubis	94.68	0.00e+00	1132.00
IUUC-Psi-093811	Pelodiscus sinensis	87.35	0.00e+00	1102.00
IUUC-Pma-094396	Petromyzon marinus	71.03	0.00e+00	889.00
IUUC-Pno-095086	Phaeosphaeria nodorum	36.98	8.00e-103	367.00
IUUC-Ppa-095876	Physcomitrella patens	36.12	3.00e-106	379.00
IUUC-Pfo-096973	Poecilia formosa	74.38	0.00e+00	957.00
IUUC-Pab-098391	Pongo abelii	94.01	0.00e+00	1129.00
IUUC-Pop-098850	Populus trichocarpa	37.15	5.00e-106	378.00
IUUC-Pca-100257	Procavia capensis	60.93	2.00e-93	336.00
IUUC-Ppe-101578	Prunus persica	37.60	2.00e-107	383.00
IUUC-Pva-102872	Pteropus vampyrus	90.35	0.00e+00	1113.00
IUUC-Pgr-103593	Puccinia graminis	33.61	3.00e-81	296.00
IUUC-Pte-104365	Pyrenophora teres	38.79	1.00e-105	377.00
IUUC-Pyt-104689	Pyrenophora triticirepentis	38.46	3.00e-108	385.00
IUUC-Rno-105737	Rattus norvegicus	95.01	0.00e+00	1179.00
IUUC-Sce-106383	Saccharomyces cerevisiae	29.51	8.00e-67	248.00
IUUC-Sha-107084	Sarcophilus harrisii	89.20	0.00e+00	1010.00
IUUC-Sja-107688	Schizosaccharomyces japonicus	34.94	3.00e-106	379.00
IUUC-Spo-108309	Schizosaccharomyces pombe	33.28	1.00e-89	323.00
IUUC-Ssl-108408	Sclerotinia sclerotiorum	35.36	3.00e-102	365.00
IUUC-Smo-109255	Selaginella moellendorffii	35.26	1.00e-95	343.00
IUUC-Sit-109962	Setaria italica	37.83	8.00e-109	387.00
IUUC-Sly-110897	Solanum lycopersicum	37.87	1.00e-108	386.00
IUUC-Stu-111971	Solanum tuberosum	37.38	5.00e-107	381.00
IUUC-Sar-113415	Sorex araneus	72.32	1.00e-108	386.00
IUUC-Sbi-114857	Sorghum bicolor	37.50	5.00e-107	381.00
IUUC-Sre-114900	Sporisorium reilianum	34.54	3.00e-89	322.00
IUUC-Tgu-117256	Taeniopygia guttata	87.85	0.00e+00	1104.00
IUUC-Tru-117871	Takifugu rubripes	69.72	0.00e+00	864.00
IUUC-Tsy-119172	Tarsius syrichta	95.42	5.00e-137	481.00
IUUC-Tni-120339	Tetraodon nigroviridis	69.72	0.00e+00	897.00
IUUC-Tca-121609	Theobroma cacao	36.41	2.00e-105	376.00
IUUC-Tre-122076	Trichoderma reesei	35.96	4.00e-90	325.00
IUUC-Tvi-122528	Trichoderma virens	34.76	3.00e-92	332.00
IUUC-Tae-124549	Triticum aestivum	35.69	6.00e-105	374.00
IUUC-Tur-126845	Triticum urartu	35.02	5.00e-80	291.00
IUUC-Tme-127217	Tuber melanosporum	34.99	5.00e-99	355.00
IUUC-Tbe-127526	Tupaia belangeri	92.69	0.00e+00	1135.00
IUUC-Ttr-128898	Tursiops truncatus	87.21	0.00e+00	1075.00
IUUC-Uma-129631	Ustilago maydis	33.17	2.00e-92	333.00
IUUC-Vda-129732	Verticillium dahliae	36.12	3.00e-90	325.00
IUUC-Vvi-131217	Vitis vinifera	37.44	4.00e-106	378.00
IUUC-Xtr-132860	Xenopus tropicalis	74.59	0.00e+00	923.00
IUUC-Xma-133830	Xiphophorus maculatus	74.38	0.00e+00	957.00
IUUC-Yli-134335	Yarrowia lipolytica	33.22	2.00e-74	273.00
IUUC-Zma-135907	Zea mays	37.34	2.00e-107	383.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence