iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Bra-016847

Ensembl Protein ID

Bra000249.1-P

UniProt Accession

M4C7S1; M4C7S1_BRARP

Protein Name

E3 ubiquitin-protein ligase

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
Bra000249	Bra000249.1	Bra000249.1-P

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	35.43	2.00e-37	153.00	IUUC-Dme-031755

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Brassica rapa

Functional Description
(View)

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

Protein Sequence
(Fasta)

MAPGGTTYKE ALESNWIGLD YEVRMSKVEA TNKPAKSASG AIGKIRSSNG SGVHELLECP 60
VCTNLMYPPI NQCPNGHTLC SSCKQQVQNT CPTCRYELGN IRCLALEKVA ESLEVSCRYQ 120

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Nucleotide Sequence
(Fasta)

ATGGCTCCTG GTGGCACTAC TTACAAAGAA GCCTTGGAGT CTAACTGGAT AGGCTTGGAT 60
TACGAGGTTA GGATGTCTAA AGTGGAGGCT ACTAACAAAC CAGCCAAATC AGCTAGTGGC 120

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Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR018121--7-in-absentia-prot_TRAF-dom
IPR004162--SINA-like
IPR008974--TRAF-like
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR013010--Znf_SIAH

PROSITE

PS50089--ZF_RING_2
PS51081--ZF_SIAH

Pfam

PF03145--Sina

Gene Ontology

GO:0005634--C:nucleus
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007275--P:multicellular organism development
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aly-006207	Arabidopsis lyrata	83.17	2.00e-158	550.00
IUUC-Ath-007049	Arabidopsis thaliana	83.77	1.00e-158	551.00
IUUC-Bol-016263	Brassica oleracea	83.77	1.00e-158	551.00
IUUC-Dme-031755	Drosophila melanogaster	35.43	1.00e-38	153.00
IUUC-Mtr-057852	Medicago truncatula	74.19	9.00e-139	485.00
IUUC-Pop-099563	Populus trichocarpa	66.88	3.00e-129	454.00
IUUC-Ppe-101760	Prunus persica	70.03	2.00e-131	461.00
IUUC-Sly-111117	Solanum lycopersicum	70.68	2.00e-131	461.00
IUUC-Stu-112714	Solanum tuberosum	68.06	4.00e-129	453.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence