iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Cpo-022109

Ensembl Protein ID

ENSCPOP00000011234.2

UniProt Accession

H0VLJ5; H0VLJ5_CAVPO

Genbank Protein ID

ENSCPOP00000011234

Protein Name

Eukaryotic translation initiation factor 3 subunit F; Eukaryotic translation initiation factor 3 subunit 5; eIF-3-epsilon; eIF3 p47

Genbank Nucleotide ID

AAKN02053681

Gene Name

EIF3F; EIF3S5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCPOG00000012486.3	ENSCPOT00000012605.2	ENSCPOP00000011234.2

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
DUB/JAMM	87.64	2.00e-135	479.00	IUUC-Hsa-046860

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Cavia porcellus

Functional Description
(View)

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.

Protein Sequence
(Fasta)

SSSQRVTPPS GPGFLFRVKM ATPAAPTSAP PASQTAAPAL SGPALPGPFP GGRVVRLHPV 60
ILASIVDSYE RRNEGAARVI GTLLGTVDKH SVEVTNCFSV PHNESEDEVA VDMEFAKNMY 120

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Nucleotide Sequence
(Fasta)

AGCTCCAGTC AACGAGTGAC TCCCCCTTCC GGTCCAGGCT TCCTCTTTCG CGTCAAGATG 60
GCTACGCCGG CGGCGCCCAC GAGTGCTCCT CCCGCCTCTG CGGCCCCAGC TCCGGACCCG 120

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Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0396--Initiation factor
KW-0597--Phosphoprotein
KW-0648--Protein biosynthesis
KW-1185--Reference proteome

Interpro

IPR027531--eIF3f
IPR000555--JAMM/MPN+_dom
IPR024969--Rpn11/EIF3F_C

Pfam

PF01398--JAB
PF13012--MitMem_reg

SMART

SM00232--JAB_MPN

Gene Ontology

GO:0016282--C:eukaryotic 43S preinitiation complex
GO:0033290--C:eukaryotic 48S preinitiation complex
GO:0071541--C:eukaryotic translation initiation factor 3 complex, eIF3m
GO:0016020--C:membrane
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0003743--F:translation initiation factor activity
GO:0001731--P:formation of translation preinitiation complex
GO:0075522--P:IRES-dependent viral translational initiation
GO:0016579--P:protein deubiquitination
GO:0006446--P:regulation of translational initiation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001150	Aegilops tauschii	34.59	2.00e-36	145.00
IUUC-Aml-001527	Ailuropoda melanoleuca	87.64	1.00e-137	482.00
IUUC-Atr-002686	Amborella trichopoda	42.62	1.00e-43	169.00
IUUC-Apl-003977	Anas platyrhynchos	78.35	1.00e-101	362.00
IUUC-Aca-004335	Anolis carolinensis	80.51	6.00e-129	453.00
IUUC-Aly-005945	Arabidopsis lyrata	35.56	8.00e-42	163.00
IUUC-Ath-007045	Arabidopsis thaliana	36.30	5.00e-42	164.00
IUUC-Acl-008365	Aspergillus clavatus	34.29	2.00e-36	146.00
IUUC-Afl-008742	Aspergillus flavus	35.00	2.00e-35	142.00
IUUC-Afu-009030	Aspergillus fumigatus	33.93	7.00e-36	144.00
IUUC-Ani-009212	Aspergillus nidulans	34.92	9.00e-37	147.00
IUUC-Ang-009712	Aspergillus niger	33.93	4.00e-35	141.00
IUUC-Aor-009885	Aspergillus oryzae	35.00	5.00e-37	147.00
IUUC-Ate-010315	Aspergillus terreus	35.00	2.00e-34	139.00
IUUC-Ame-010801	Astyanax mexicanus	44.77	7.00e-50	190.00
IUUC-Bgr-011982	Blumeria graminis	34.40	1.00e-33	137.00
IUUC-Bta-012804	Bos taurus	87.85	3.00e-145	508.00
IUUC-Bci-013891	Botrytis cinerea	33.69	3.00e-28	119.00
IUUC-Bdi-014328	Brachypodium distachyon	34.93	4.00e-37	147.00
IUUC-Bol-015446	Brassica oleracea	35.56	3.00e-42	165.00
IUUC-Bra-016862	Brassica rapa	35.93	9.00e-43	166.00
IUUC-Cel-018171	Caenorhabditis elegans	33.22	1.00e-40	159.00
IUUC-Cja-019335	Callithrix jacchus	87.81	1.00e-140	492.00
IUUC-Cfa-020138	Canis familiaris	87.27	2.00e-137	481.00
IUUC-Cre-022664	Chlamydomonas reinhardtii	34.91	2.00e-46	178.00
IUUC-Csa-023994	Chlorocebus sabaeus	87.81	2.00e-140	491.00
IUUC-Cho-024351	Choloepus hoffmanni	74.91	2.00e-113	401.00
IUUC-Cin-025801	Ciona intestinalis	50.72	6.00e-75	273.00
IUUC-Csv-025805	Ciona savignyi	50.00	9.00e-74	270.00
IUUC-Cgl-026643	Colletotrichum gloeosporioides	31.43	8.00e-30	124.00
IUUC-Cne-026868	Cryptococcus neoformans	33.53	3.00e-24	105.00
IUUC-Cme-027328	Cyanidioschyzon merolae	25.70	2.00e-17	82.80
IUUC-Dre-028085	Danio rerio	70.76	5.00e-111	393.00
IUUC-Dno-030099	Dasypus novemcinctus	87.27	3.00e-137	481.00
IUUC-Dor-030324	Dipodomys ordii	78.91	3.00e-119	421.00
IUUC-Dse-031314	Dothistroma septosporum	34.90	8.00e-38	150.00
IUUC-Dme-031926	Drosophila melanogaster	45.49	2.00e-63	235.00
IUUC-Ete-032569	Echinops telfairi	81.75	1.00e-131	462.00
IUUC-Eca-033502	Equus caballus	82.99	1.00e-133	468.00
IUUC-Eeu-034883	Erinaceus europaeus	65.10	2.00e-61	228.00
IUUC-Fca-035873	Felis catus	87.64	9.00e-138	483.00
IUUC-Fal-036921	Ficedula albicollis	81.59	3.00e-129	454.00
IUUC-Fox-037765	Fusarium oxysporum	31.21	6.00e-24	104.00
IUUC-Fso-038240	Fusarium solani	30.85	7.00e-25	107.00
IUUC-Gmo-038864	Gadus morhua	69.57	1.00e-110	392.00
IUUC-Ggr-039862	Gaeumannomyces graminis	31.10	2.00e-24	106.00
IUUC-Gga-040952	Gallus gallus	81.72	1.00e-130	458.00
IUUC-Gac-041677	Gasterosteus aculeatus	70.29	8.00e-111	392.00
IUUC-Gma-043061	Glycine max	38.52	3.00e-43	168.00
IUUC-Ggo-045591	Gorilla gorilla	87.81	6.00e-141	493.00
IUUC-Hsa-046860	Homo sapiens	87.81	2.00e-140	491.00
IUUC-Itr-048211	Ictidomys tridecemlineatus	87.27	2.00e-137	481.00
IUUC-Lch-049410	Latimeria chalumnae	74.27	4.00e-87	313.00
IUUC-Lpe-051102	Leersia perrieri	37.40	6.00e-38	150.00
IUUC-Loc-052016	Lepisosteus oculatus	60.81	6.00e-96	343.00
IUUC-Lma-053157	Leptosphaeria maculans	34.35	5.00e-37	147.00
IUUC-Laf-054568	Loxodonta africana	87.46	3.00e-140	491.00
IUUC-Mcc-054613	Macaca mulatta	87.81	1.00e-140	492.00
IUUC-Meu-056832	Macropus eugenii	59.45	3.00e-62	231.00
IUUC-Mor-057104	Magnaporthe oryzae	30.56	1.00e-24	107.00
IUUC-Mtr-058445	Medicago truncatula	38.75	5.00e-47	181.00
IUUC-Mla-059038	Melampsora laricipopulina	29.68	4.00e-26	111.00
IUUC-Mga-059548	Meleagris gallopavo	79.84	3.00e-109	387.00
IUUC-Mvi-060520	Microbotryum violaceum	34.81	5.00e-17	81.60
IUUC-Mdo-062376	Monodelphis domestica	83.27	4.00e-130	457.00
IUUC-Mmu-063254	Mus musculus	86.91	3.00e-136	478.00
IUUC-Mac-065635	Musa acuminata	37.59	7.00e-42	164.00
IUUC-Mpu-066314	Mustela putorius furo	87.64	9.00e-138	482.00
IUUC-Mlu-067512	Myotis lucifugus	86.18	4.00e-136	477.00
IUUC-Nfi-068262	Neosartorya fischeri	33.93	7.00e-36	144.00
IUUC-Ncr-068872	Neurospora crassa	31.56	8.00e-27	114.00
IUUC-Nle-070118	Nomascus leucogenys	87.64	1.00e-137	483.00
IUUC-Opr-071228	Ochotona princeps	85.54	2.00e-117	414.00
IUUC-Ont-072600	Oreochromis niloticus	71.38	9.00e-114	402.00
IUUC-Oan-073584	Ornithorhynchus anatinus	81.07	1.00e-112	398.00
IUUC-Ocu-074542	Oryctolagus cuniculus	87.27	6.00e-137	480.00
IUUC-Oba-075923	Oryza barthii	36.24	1.00e-40	159.00
IUUC-Obr-076313	Oryza brachyantha	36.55	9.00e-39	153.00
IUUC-Ogl-076932	Oryza glaberrima	36.24	1.00e-40	159.00
IUUC-Ogu-078152	Oryza glumaepatula	36.24	1.00e-40	159.00
IUUC-Oin-079528	Oryza indica	36.24	1.00e-40	159.00
IUUC-Olo-080401	Oryza longistaminata	36.24	1.00e-40	159.00
IUUC-Ome-081553	Oryza meridionalis	35.89	3.00e-40	158.00
IUUC-Oni-082090	Oryza nivara	36.24	1.00e-40	159.00
IUUC-Opu-083583	Oryza punctata	36.21	3.00e-38	152.00
IUUC-Oru-084492	Oryza rufipogon	36.24	1.00e-40	159.00
IUUC-Osa-085383	Oryza sativa	36.24	1.00e-40	159.00
IUUC-Ola-086835	Oryzias latipes	70.65	6.00e-111	393.00
IUUC-Olu-087716	Ostreococcus lucimarinus	28.21	2.00e-21	95.90
IUUC-Oga-088886	Otolemur garnettii	87.27	5.00e-137	480.00
IUUC-Oar-090079	Ovis aries	87.54	1.00e-145	508.00
IUUC-Ptr-091457	Pan troglodytes	87.81	2.00e-140	491.00
IUUC-Pan-092317	Papio anubis	82.29	3.00e-85	307.00
IUUC-Psi-093129	Pelodiscus sinensis	74.81	2.00e-109	389.00
IUUC-Pma-094488	Petromyzon marinus	64.29	3.00e-105	374.00
IUUC-Pno-095049	Phaeosphaeria nodorum	34.35	3.00e-37	149.00
IUUC-Ppa-095341	Physcomitrella patens	37.59	1.00e-51	196.00
IUUC-Pfo-096286	Poecilia formosa	69.93	4.00e-111	394.00
IUUC-Pab-097765	Pongo abelii	87.81	2.00e-140	491.00
IUUC-Pop-099131	Populus trichocarpa	36.67	4.00e-45	174.00
IUUC-Pca-100524	Procavia capensis	69.71	4.00e-87	313.00
IUUC-Ppe-101934	Prunus persica	37.78	1.00e-47	182.00
IUUC-Pva-102577	Pteropus vampyrus	86.91	7.00e-137	479.00
IUUC-Pgr-103521	Puccinia graminis	29.60	1.00e-26	113.00
IUUC-Pte-104304	Pyrenophora teres	35.03	1.00e-37	150.00
IUUC-Pyt-104563	Pyrenophora triticirepentis	35.03	7.00e-38	150.00
IUUC-Rno-105717	Rattus norvegicus	87.27	3.00e-137	481.00
IUUC-Sha-107190	Sarcophilus harrisii	83.21	3.00e-126	444.00
IUUC-Sja-107918	Schizosaccharomyces japonicus	33.45	2.00e-37	149.00
IUUC-Spo-108355	Schizosaccharomyces pombe	34.03	3.00e-38	152.00
IUUC-Smo-109374	Selaginella moellendorffii	39.57	2.00e-55	208.00
IUUC-Sit-110119	Setaria italica	36.30	1.00e-38	153.00
IUUC-Sly-111570	Solanum lycopersicum	38.74	2.00e-41	162.00
IUUC-Stu-112308	Solanum tuberosum	40.39	2.00e-43	169.00
IUUC-Sar-113515	Sorex araneus	97.87	5.00e-52	196.00
IUUC-Sbi-114605	Sorghum bicolor	35.93	1.00e-38	154.00
IUUC-Sre-114906	Sporisorium reilianum	36.30	3.00e-42	165.00
IUUC-Tgu-117087	Taeniopygia guttata	78.19	1.00e-106	379.00
IUUC-Tru-117700	Takifugu rubripes	70.65	2.00e-111	395.00
IUUC-Tni-120470	Tetraodon nigroviridis	70.65	1.00e-111	395.00
IUUC-Tca-121109	Theobroma cacao	40.98	7.00e-40	157.00
IUUC-Tre-122095	Trichoderma reesei	31.69	7.00e-26	111.00
IUUC-Tvi-122580	Trichoderma virens	31.34	3.00e-25	108.00
IUUC-Tae-125129	Triticum aestivum	36.58	1.00e-40	160.00
IUUC-Tur-126658	Triticum urartu	33.70	5.00e-32	131.00
IUUC-Tme-127043	Tuber melanosporum	37.87	2.00e-41	162.00
IUUC-Tbe-127927	Tupaia belangeri	87.64	9.00e-138	483.00
IUUC-Ttr-129231	Tursiops truncatus	87.64	8.00e-138	483.00
IUUC-Uma-129578	Ustilago maydis	36.30	1.00e-40	159.00
IUUC-Vda-129730	Verticillium dahliae	31.91	2.00e-30	126.00
IUUC-Vpa-130677	Vicugna pacos	61.64	5.00e-40	158.00
IUUC-Vvi-130968	Vitis vinifera	41.87	2.00e-43	169.00
IUUC-Xtr-132203	Xenopus tropicalis	74.64	3.00e-118	417.00
IUUC-Xma-133972	Xiphophorus maculatus	69.57	7.00e-111	392.00
IUUC-Yli-134553	Yarrowia lipolytica	34.56	3.00e-37	148.00
IUUC-Zma-134941	Zea mays	35.56	1.00e-34	139.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence