iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Pma-094695

UUCD1 version

UUC-PeM-00293

Ensembl Protein ID

ENSPMAP00000008338.1

UniProt Accession

S4RSZ8; S4RSZ8_PETMA

Protein Name

Coatomer subunit beta'

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPMAG00000007551.1	ENSPMAT00000008376.1	ENSPMAP00000008338.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	7.80e-25	85.2	183	216
UBD/Beta-Prp	2.50e-57	193.5	12	285

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf...sd.tllvsGsdDgtikvWDl 30
           gH+ +v+c+++    d ++l+sG+dD  +k+WD+
   Q: 183  GHEKGVNCVDYysgGDkPYLISGADDRLVKIWDY 216
           8*********9999778****************5 PP

UBD/Beta-Prp

   S: 7    ghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghed 95
           ++++++++cv+ +p++++++++ ++g++ vw+ +t++l+++++ ++ +v+a kf  +++++v gs+D+ i+v++++t + vh +++h+d
   Q: 12   TARSDRVKCVDLHPSEPWMLASLYNGSVCVWNHETQTLVKTFEVCDLPVRAAKFVARKNWMVAGSDDMQIRVFNYNTLERVHMFEAHSD 100
           578899*********************************************************************************** PP
   S: 96   svlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdg.nllvsGslDrtvrlWdlktgkllrtltgghtdsv 183
           ++++++++ps+ +l++ s+d  i++wd+e+++  +++++gh++ v+ +v++p++ n ++s+slDrt+++W+l + +   tl+g h++ v
   Q: 101  YIRCIAVHPSQPFLLTSSDDMLIKLWDWEKKWTCSQVFEGHTHYVMQIVINPKDnNQFASASLDRTIKVWQLGSSTPNFTLEG-HEKGV 188
           *******************************99999**********************************************9.***** PP
   S: 184  yslsfdsng..kelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhnssvisv 270
           +++++ s g  ++l+sg++d+ vk+wd+q++  + t     +  +  + + + + +++    g++riW + +  l +tl++  ++ ++v
   Q: 189  NCVDYYSGGdkPYLISGADDRLVKIWDYQHK--ITTAMKKYKLKQLHQILIRAKTVYVLWYAGTVRIWHSSTYRLESTLNYGMERAWCV 275
           ****8887777******************99..55555555555555555667777777788*************************** PP
   S: 271  avlsfgdnvl 280
           ++l+ ++ + 
   Q: 276  SGLRGSNTIA 285
           **76655444 PP

Organism

Petromyzon marinus

Functional Description
(View)

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

Protein Sequence
(Fasta)

MPLRLEIKRK LTARSDRVKC VDLHPSEPWM LASLYNGSVC VWNHETQTLV KTFEVCDLPV 60
RAAKFVARKN WMVAGSDDMQ IRVFNYNTLE RVHMFEAHSD YIRCIAVHPS QPFLLTSSDD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGTCTTGGTG GGGCCGCATC AGCTGAGACG AAATGGTGAG TGGCACATCT ATTAGCATTA 60
CAATCAGAGC CGCTGCAATT ACACTAGTTA ACACAACACT CAACAATTAC AGATGTCGGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0931--ER-Golgi transport
KW-0333--Golgi apparatus
KW-0472--Membrane
KW-0653--Protein transport
KW-0813--Transport
KW-0853--WD repeat

Interpro

IPR006692--Coatomer_WD-assoc_reg
IPR016453--COPB2
IPR020472--G-protein_beta_WD-40_rep
IPR011044--Quino_amine_DH_bsu
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

PROSITE

PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF04053--Coatomer_WDAD
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0030663--C:COPI-coated vesicle membrane
GO:0000139--C:Golgi membrane
GO:0030117--C:membrane coat
GO:0005198--F:structural molecule activity
GO:0006886--P:intracellular protein transport
GO:0030903--P:notochord development
GO:0061053--P:somite development
GO:0016192--P:vesicle-mediated transport

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000654	Aegilops tauschii	52.07	0.00e+00	894.00
IUUC-Aml-002154	Ailuropoda melanoleuca	81.24	0.00e+00	1458.00
IUUC-Atr-003090	Amborella trichopoda	58.48	0.00e+00	964.00
IUUC-Apl-003976	Anas platyrhynchos	81.23	0.00e+00	1465.00
IUUC-Aca-004301	Anolis carolinensis	81.57	0.00e+00	1467.00
IUUC-Aly-006508	Arabidopsis lyrata	58.17	0.00e+00	979.00
IUUC-Ath-007630	Arabidopsis thaliana	58.19	0.00e+00	988.00
IUUC-Ago-007914	Ashbya gossypii	45.77	0.00e+00	708.00
IUUC-Acl-008237	Aspergillus clavatus	55.28	0.00e+00	914.00
IUUC-Afl-008535	Aspergillus flavus	54.24	0.00e+00	862.00
IUUC-Afu-008845	Aspergillus fumigatus	54.77	0.00e+00	885.00
IUUC-Ani-009135	Aspergillus nidulans	54.25	0.00e+00	861.00
IUUC-Ang-009654	Aspergillus niger	57.14	0.00e+00	816.00
IUUC-Aor-009939	Aspergillus oryzae	54.44	0.00e+00	912.00
IUUC-Ate-010355	Aspergillus terreus	53.87	0.00e+00	860.00
IUUC-Ame-010922	Astyanax mexicanus	77.24	0.00e+00	1356.00
IUUC-Bgr-012249	Blumeria graminis	53.31	0.00e+00	857.00
IUUC-Bta-013579	Bos taurus	86.96	0.00e+00	1319.00
IUUC-Bci-013866	Botrytis cinerea	55.15	0.00e+00	862.00
IUUC-Bdi-015046	Brachypodium distachyon	54.66	0.00e+00	984.00
IUUC-Bol-015731	Brassica oleracea	58.38	0.00e+00	1001.00
IUUC-Bra-017758	Brassica rapa	58.63	0.00e+00	1000.00
IUUC-Cel-018387	Caenorhabditis elegans	60.75	0.00e+00	1082.00
IUUC-Cja-019145	Callithrix jacchus	81.12	0.00e+00	1462.00
IUUC-Cfa-020564	Canis familiaris	81.37	0.00e+00	1463.00
IUUC-Cpo-022201	Cavia porcellus	80.98	0.00e+00	1460.00
IUUC-Cre-022938	Chlamydomonas reinhardtii	57.16	0.00e+00	909.00
IUUC-Csa-023383	Chlorocebus sabaeus	85.19	0.00e+00	1038.00
IUUC-Cho-024454	Choloepus hoffmanni	80.41	0.00e+00	1244.00
IUUC-Cin-025681	Ciona intestinalis	70.75	0.00e+00	1217.00
IUUC-Csv-026012	Ciona savignyi	70.19	0.00e+00	1213.00
IUUC-Cgl-026649	Colletotrichum gloeosporioides	51.55	0.00e+00	775.00
IUUC-Cne-026986	Cryptococcus neoformans	49.24	0.00e+00	840.00
IUUC-Cme-027219	Cyanidioschyzon merolae	47.00	0.00e+00	789.00
IUUC-Dre-027846	Danio rerio	78.02	0.00e+00	1471.00
IUUC-Dno-029303	Dasypus novemcinctus	25.47	2.00e-62	233.00
IUUC-Dor-030462	Dipodomys ordii	77.93	0.00e+00	1135.00
IUUC-Dse-031268	Dothistroma septosporum	54.87	0.00e+00	890.00
IUUC-Dme-031791	Drosophila melanogaster	68.20	0.00e+00	1161.00
IUUC-Ete-033166	Echinops telfairi	76.16	0.00e+00	885.00
IUUC-Eca-034180	Equus caballus	79.16	0.00e+00	1408.00
IUUC-Eeu-035086	Erinaceus europaeus	71.64	0.00e+00	680.00
IUUC-Fca-036265	Felis catus	81.12	0.00e+00	1462.00
IUUC-Fal-037202	Ficedula albicollis	80.84	0.00e+00	1412.00
IUUC-Fox-037711	Fusarium oxysporum	56.01	0.00e+00	822.00
IUUC-Fso-038268	Fusarium solani	55.71	0.00e+00	818.00
IUUC-Gmo-039046	Gadus morhua	80.07	0.00e+00	1434.00
IUUC-Ggr-039863	Gaeumannomyces graminis	54.64	0.00e+00	844.00
IUUC-Gga-041112	Gallus gallus	80.92	0.00e+00	1470.00
IUUC-Gac-041733	Gasterosteus aculeatus	80.66	0.00e+00	1405.00
IUUC-Gma-042910	Glycine max	58.82	0.00e+00	1002.00
IUUC-Ggo-044984	Gorilla gorilla	80.89	0.00e+00	1457.00
IUUC-Hsa-046698	Homo sapiens	80.77	0.00e+00	1456.00
IUUC-Hvu-047669	Hordeum vulgare	62.43	2.00e-146	510.00
IUUC-Itr-048212	Ictidomys tridecemlineatus	81.19	0.00e+00	1457.00
IUUC-Kpa-049265	Komagataella pastoris	47.43	0.00e+00	803.00
IUUC-Lch-050473	Latimeria chalumnae	74.47	0.00e+00	1459.00
IUUC-Lpe-051579	Leersia perrieri	55.69	0.00e+00	981.00
IUUC-Loc-052675	Lepisosteus oculatus	80.42	0.00e+00	1456.00
IUUC-Lma-053218	Leptosphaeria maculans	53.61	0.00e+00	866.00
IUUC-Laf-053757	Loxodonta africana	80.79	0.00e+00	1451.00
IUUC-Mcc-054859	Macaca mulatta	81.12	0.00e+00	1461.00
IUUC-Meu-056174	Macropus eugenii	76.74	6.00e-174	603.00
IUUC-Mor-057264	Magnaporthe oryzae	55.80	0.00e+00	844.00
IUUC-Mpo-057538	Magnaporthe poae	54.77	0.00e+00	854.00
IUUC-Mtr-058310	Medicago truncatula	59.07	0.00e+00	1005.00
IUUC-Mla-058937	Melampsora laricipopulina	50.51	0.00e+00	827.00
IUUC-Mga-059875	Meleagris gallopavo	80.97	0.00e+00	1463.00
IUUC-Mvi-060240	Microbotryum violaceum	49.36	0.00e+00	833.00
IUUC-Mmr-061261	Microcebus murinus	81.00	0.00e+00	1463.00
IUUC-Mdo-062076	Monodelphis domestica	82.24	0.00e+00	1469.00
IUUC-Mmu-063324	Mus musculus	81.18	0.00e+00	1463.00
IUUC-Mac-064636	Musa acuminata	58.48	0.00e+00	981.00
IUUC-Mpu-065961	Mustela putorius furo	81.26	0.00e+00	1460.00
IUUC-Mlu-067059	Myotis lucifugus	80.56	0.00e+00	1416.00
IUUC-Nfi-068277	Neosartorya fischeri	54.73	0.00e+00	876.00
IUUC-Ncr-068659	Neurospora crassa	52.44	0.00e+00	856.00
IUUC-Nle-069034	Nomascus leucogenys	81.00	0.00e+00	1459.00
IUUC-Opr-070334	Ochotona princeps	86.12	0.00e+00	1347.00
IUUC-Ont-071563	Oreochromis niloticus	76.33	0.00e+00	1455.00
IUUC-Oan-073416	Ornithorhynchus anatinus	81.04	0.00e+00	1405.00
IUUC-Ocu-074522	Oryctolagus cuniculus	81.14	0.00e+00	1458.00
IUUC-Oba-075760	Oryza barthii	56.96	0.00e+00	963.00
IUUC-Obr-076163	Oryza brachyantha	57.62	0.00e+00	985.00
IUUC-Ogl-077450	Oryza glaberrima	57.99	0.00e+00	988.00
IUUC-Ogu-078994	Oryza glumaepatula	56.96	0.00e+00	962.00
IUUC-Oin-079856	Oryza indica	54.50	0.00e+00	960.00
IUUC-Olo-080731	Oryza longistaminata	56.10	0.00e+00	945.00
IUUC-Ome-081762	Oryza meridionalis	52.70	0.00e+00	882.00
IUUC-Oni-082324	Oryza nivara	56.96	0.00e+00	963.00
IUUC-Opu-083400	Oryza punctata	53.26	0.00e+00	950.00
IUUC-Oru-084829	Oryza rufipogon	56.96	0.00e+00	963.00
IUUC-Osa-086026	Oryza sativa	57.99	0.00e+00	991.00
IUUC-Ola-087245	Oryzias latipes	76.05	0.00e+00	1457.00
IUUC-Olu-087655	Ostreococcus lucimarinus	55.80	0.00e+00	942.00
IUUC-Oga-088163	Otolemur garnettii	73.70	0.00e+00	1387.00
IUUC-Oar-089842	Ovis aries	81.37	0.00e+00	1464.00
IUUC-Ptr-090501	Pan troglodytes	81.00	0.00e+00	1459.00
IUUC-Pan-092011	Papio anubis	81.12	0.00e+00	1462.00
IUUC-Psi-093308	Pelodiscus sinensis	81.88	0.00e+00	1465.00
IUUC-Pno-094785	Phaeosphaeria nodorum	55.52	3.00e-96	344.00
IUUC-Ppa-095911	Physcomitrella patens	58.26	0.00e+00	1009.00
IUUC-Pfo-096587	Poecilia formosa	75.80	0.00e+00	1461.00
IUUC-Pab-097926	Pongo abelii	78.79	0.00e+00	1372.00
IUUC-Pop-099634	Populus trichocarpa	58.56	0.00e+00	990.00
IUUC-Pca-100965	Procavia capensis	79.81	0.00e+00	1419.00
IUUC-Ppe-101470	Prunus persica	58.94	0.00e+00	999.00
IUUC-Pva-102451	Pteropus vampyrus	80.30	0.00e+00	1117.00
IUUC-Pgr-103453	Puccinia graminis	52.19	0.00e+00	852.00
IUUC-Ptt-103868	Puccinia triticina	52.19	0.00e+00	852.00
IUUC-Pte-104274	Pyrenophora teres	54.38	0.00e+00	896.00
IUUC-Pyt-104794	Pyrenophora triticirepentis	54.17	0.00e+00	852.00
IUUC-Rno-105979	Rattus norvegicus	73.10	0.00e+00	1102.00
IUUC-Sce-106269	Saccharomyces cerevisiae	44.77	0.00e+00	724.00
IUUC-Sha-106905	Sarcophilus harrisii	82.12	0.00e+00	1467.00
IUUC-Sja-107838	Schizosaccharomyces japonicus	46.57	0.00e+00	780.00
IUUC-Spo-108299	Schizosaccharomyces pombe	45.15	0.00e+00	778.00
IUUC-Ssl-108643	Sclerotinia sclerotiorum	23.64	3.00e-65	242.00
IUUC-Smo-108695	Selaginella moellendorffii	58.12	0.00e+00	970.00
IUUC-Sit-110239	Setaria italica	55.46	0.00e+00	993.00
IUUC-Sly-111525	Solanum lycopersicum	58.62	0.00e+00	1011.00
IUUC-Stu-112906	Solanum tuberosum	56.12	0.00e+00	888.00
IUUC-Sar-113472	Sorex araneus	79.13	0.00e+00	1014.00
IUUC-Sbi-114052	Sorghum bicolor	59.02	0.00e+00	1006.00
IUUC-Sre-115040	Sporisorium reilianum	51.22	0.00e+00	843.00
IUUC-Ssc-115593	Sus scrofa	81.26	0.00e+00	1461.00
IUUC-Tgu-117239	Taeniopygia guttata	81.11	0.00e+00	1467.00
IUUC-Tru-118025	Takifugu rubripes	80.99	0.00e+00	1450.00
IUUC-Tsy-118824	Tarsius syrichta	78.66	0.00e+00	1026.00
IUUC-Tni-120142	Tetraodon nigroviridis	79.72	0.00e+00	1445.00
IUUC-Tca-121613	Theobroma cacao	58.69	0.00e+00	998.00
IUUC-Tre-122072	Trichoderma reesei	54.51	0.00e+00	874.00
IUUC-Tvi-122546	Trichoderma virens	53.99	0.00e+00	855.00
IUUC-Tae-125292	Triticum aestivum	57.53	0.00e+00	984.00
IUUC-Tur-126283	Triticum urartu	52.72	0.00e+00	888.00
IUUC-Tme-127041	Tuber melanosporum	55.60	0.00e+00	912.00
IUUC-Tbe-127770	Tupaia belangeri	81.33	0.00e+00	1130.00
IUUC-Ttr-129294	Tursiops truncatus	81.14	0.00e+00	1459.00
IUUC-Uma-129351	Ustilago maydis	50.06	0.00e+00	842.00
IUUC-Vda-129716	Verticillium dahliae	54.77	0.00e+00	887.00
IUUC-Vpa-130037	Vicugna pacos	71.31	0.00e+00	713.00
IUUC-Vvi-131689	Vitis vinifera	59.15	0.00e+00	997.00
IUUC-Xtr-132633	Xenopus tropicalis	80.32	0.00e+00	1460.00
IUUC-Xma-133347	Xiphophorus maculatus	76.98	0.00e+00	1469.00
IUUC-Yli-134455	Yarrowia lipolytica	48.53	0.00e+00	781.00
IUUC-Zma-135706	Zea mays	54.92	0.00e+00	1000.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence