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Tag Content
UUCD2 ID IUUC-Dre-028314
UUCD1 version UUC-DaR-01319
Ensembl Protein ID ENSDARP00000039257.5
UniProt Accession A0A0R4I9B2; A0A0R4I9B2_DANRE
Genbank Protein ID ENSDARP00000039257
Protein Name Lissencephaly-1 homolog
Genbank Nucleotide ID AL929193
Gene Name pafah1b1b; LIS1; PAFAH1B1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSDARG00000026595.5 ENSDART00000031470.5 ENSDARP00000039257.5
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 7.10e-60 197.2 336 374
UBD/Beta-Prp 1.70e-93 314.0 107 410
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllk 37
    gH ++v+++ f ++ +++vs++dD+t+++WD++ ++ k
   Q: 336 GHDNWVRGVLFhPGgRFVVSCADDKTLRIWDYKNKRCMK 374
    8***********99899**************99998876 PP
   


   UBD/Beta-Prp

   S: 9    hksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsv 97
    h s++t v f+p sl++++s+d+tikvwd++ g++ r+l+gh++ v++++f+++gk+l+++s D+tik+wd++ ++c++t++gh+++v
   Q: 107 HRSPVTRVIFHPVFSLMVSASEDATIKVWDYEAGDFERTLKGHTDSVQDISFDQTGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNV 195
    5668888********************************************************************************** PP
   S: 98 lslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvysl 186
    s++++p+gd++vs+s+d+t ++w++ tg+c++ t++gh+++v++v+ ++dg ll+s+s+D+tvr+W ++t+++ +l++ h++ v+++
   Q: 196 SSVAIMPNGDHIVSASRDKTMKMWEVATGYCVK-TFTGHREWVRMVRPNQDGTLLASCSNDQTVRVWVVATKECKAELRE-HEHVVECI 282
    *********************************.*********************************************9.******** PP
   S: 187 sfdsng....................kelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgd 255
    s+ +++ ++l+sgs+d+t+k+wd++tg c++tl gh+++v+ v f+p + ++vs+++D+++riWd++++
   Q: 283 SWAPESahptiseatgsenkksgkpgPFLLSGSRDKTIKMWDISTGMCLMTLVGHDNWVRGVLFHPGGRFVVSCADDKTLRIWDYKNKR 371
    ***************************************************************************************** PP
   S: 256 llktlqlhnssvisvavlsfgdnvlvlgsedskvniwklk 295
    ++ktl+ h++ v+s ++ + + +++v+gs d++v++w+++
   Q: 372 CMKTLSAHEHFVTSLDF-HKTSPYVVTGSVDQTVKVWECR 410
    *****************.999****************985 PP
   

Organism Danio rerio
Functional Description
(View)

Functional Description



     Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. May be required for proliferation of neuronal precursors and neuronal migration.
Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. May be required for proliferation of neuronal precursors and neuronal migration.
Protein Sequence
(Fasta)
MVLSQRQRDE LNRAIADYLR SNGYEEAYST FKKEAELDVN DELDKKFAGL LEKKWTSVIR 60
LQKKVMELES KLNEAKEEIT LGGPVGQKRD PKEWIPRPPE KYALSGHRSP VTRVIFHPVF 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Dre-028314|E3,WD_repeat;UBD,Beta-Prp|Danio rerio
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CCGTGCGCGT GCCCGGCACC AGTAGACGGT TATGCGGTGC AGAAATCAAG GAGGAGAAAC 60
AGCGCTGCTG ACTGAGCCGG AAAATCGGAA GTGACTTTCA GCAAGACACA TTTCTCATTG 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Dre-028314|E3,WD_repeat;UBD,Beta-Prp|Danio rerio
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0217--Developmental protein
KW-0221--Differentiation
KW-0493--Microtubule
KW-0498--Mitosis
KW-0524--Neurogenesis
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0853--WD repeat

Interpro

IPR017252--Dynein_regulator_LIS1
IPR020472--G-protein_beta_WD-40_rep
IPR006594--LisH
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50896--LISH
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08513--LisH
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00667--LisH
SM00320--WD40

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005874--C:microtubule
GO:0005875--C:microtubule associated complex
GO:0005815--C:microtubule organizing center
GO:0030154--P:cell differentiation
GO:0051301--P:cell division
GO:0000132--P:establishment of mitotic spindle orientation
GO:0007067--P:mitotic nuclear division
GO:0007399--P:nervous system development
GO:0006810--P:transport

Orthology
iUUCD ID Species Identity E-value Score
IUUC-Apl-004024 Anas platyrhynchos 94.15 0.00e+00 818.00
IUUC-Aca-004564 Anolis carolinensis 93.66 0.00e+00 811.00
IUUC-Acl-008360 Aspergillus clavatus 46.04 2.00e-104 373.00
IUUC-Afl-008502 Aspergillus flavus 45.69 2.00e-93 335.00
IUUC-Afu-008848 Aspergillus fumigatus 46.70 5.00e-106 378.00
IUUC-Ani-009173 Aspergillus nidulans 43.28 1.00e-90 326.00
IUUC-Aor-009973 Aspergillus oryzae 44.44 2.00e-91 329.00
IUUC-Ate-010523 Aspergillus terreus 41.85 2.00e-89 323.00
IUUC-Ame-010969 Astyanax mexicanus 97.07 0.00e+00 842.00
IUUC-Bgr-011972 Blumeria graminis 47.20 8.00e-104 370.00
IUUC-Bta-013106 Bos taurus 93.41 0.00e+00 816.00
IUUC-Bci-013615 Botrytis cinerea 44.94 9.00e-99 353.00
IUUC-Cel-018459 Caenorhabditis elegans 57.42 9.00e-149 520.00
IUUC-Cja-018755 Callithrix jacchus 90.98 0.00e+00 796.00
IUUC-Cfa-020749 Canis familiaris 93.41 0.00e+00 816.00
IUUC-Cpo-022371 Cavia porcellus 93.41 0.00e+00 816.00
IUUC-Cre-022578 Chlamydomonas reinhardtii 36.71 3.00e-52 198.00
IUUC-Csa-023524 Chlorocebus sabaeus 92.75 0.00e+00 686.00
IUUC-Cho-024764 Choloepus hoffmanni 83.29 0.00e+00 645.00
IUUC-Cin-025753 Ciona intestinalis 70.32 6.00e-179 620.00
IUUC-Csv-025817 Ciona savignyi 70.00 0.00e+00 640.00
IUUC-Cgl-026529 Colletotrichum gloeosporioides 47.22 2.00e-97 349.00
IUUC-Cne-027087 Cryptococcus neoformans 49.88 7.00e-112 397.00
IUUC-Dno-029050 Dasypus novemcinctus 93.66 0.00e+00 816.00
IUUC-Dme-031745 Drosophila melanogaster 70.56 1.00e-174 605.00
IUUC-Ete-032508 Echinops telfairi 77.56 0.00e+00 656.00
IUUC-Eeu-034984 Erinaceus europaeus 85.37 0.00e+00 731.00
IUUC-Fca-036498 Felis catus 93.41 0.00e+00 816.00
IUUC-Fal-036920 Ficedula albicollis 94.15 0.00e+00 818.00
IUUC-Fox-037996 Fusarium oxysporum 45.95 3.00e-102 365.00
IUUC-Gmo-039166 Gadus morhua 93.17 0.00e+00 817.00
IUUC-Gga-040623 Gallus gallus 94.15 0.00e+00 818.00
IUUC-Gac-041613 Gasterosteus aculeatus 94.15 0.00e+00 822.00
IUUC-Ggo-045410 Gorilla gorilla 82.71 0.00e+00 687.00
IUUC-Hsa-046358 Homo sapiens 93.66 0.00e+00 816.00
IUUC-Itr-047890 Ictidomys tridecemlineatus 93.41 0.00e+00 816.00
IUUC-Kpa-049351 Komagataella pastoris 29.11 3.00e-44 172.00
IUUC-Laf-053713 Loxodonta africana 91.44 0.00e+00 797.00
IUUC-Meu-055927 Macropus eugenii 80.14 2.00e-133 468.00
IUUC-Mor-056962 Magnaporthe oryzae 45.45 7.00e-98 350.00
IUUC-Mga-059945 Meleagris gallopavo 93.90 0.00e+00 817.00
IUUC-Mvi-060403 Microbotryum violaceum 49.44 6.00e-128 451.00
IUUC-Mmu-063253 Mus musculus 93.41 0.00e+00 816.00
IUUC-Mpu-066638 Mustela putorius furo 93.41 0.00e+00 816.00
IUUC-Nfi-068571 Neosartorya fischeri 45.57 3.00e-99 355.00
IUUC-Opr-070579 Ochotona princeps 93.66 0.00e+00 816.00
IUUC-Ont-072432 Oreochromis niloticus 94.15 0.00e+00 820.00
IUUC-Oan-073072 Ornithorhynchus anatinus 93.41 0.00e+00 816.00
IUUC-Ocu-074180 Oryctolagus cuniculus 93.66 0.00e+00 816.00
IUUC-Ola-086772 Oryzias latipes 94.63 0.00e+00 822.00
IUUC-Oar-090394 Ovis aries 93.41 0.00e+00 816.00
IUUC-Ptr-091517 Pan troglodytes 93.41 0.00e+00 816.00
IUUC-Psi-093370 Pelodiscus sinensis 93.90 0.00e+00 818.00
IUUC-Pma-094319 Petromyzon marinus 86.53 0.00e+00 636.00
IUUC-Pno-094815 Phaeosphaeria nodorum 46.06 3.00e-102 365.00
IUUC-Pfo-097089 Poecilia formosa 94.88 0.00e+00 828.00
IUUC-Pab-098421 Pongo abelii 93.41 0.00e+00 816.00
IUUC-Pgr-103538 Puccinia graminis 47.43 4.00e-118 418.00
IUUC-Pte-104261 Pyrenophora teres 46.94 2.00e-102 365.00
IUUC-Pyt-104780 Pyrenophora triticirepentis 47.19 8.00e-103 367.00
IUUC-Rno-105123 Rattus norvegicus 93.41 0.00e+00 816.00
IUUC-Ssl-108571 Sclerotinia sclerotiorum 45.07 3.00e-99 355.00
IUUC-Sre-115003 Sporisorium reilianum 49.32 1.00e-123 436.00
IUUC-Ssc-116148 Sus scrofa 93.41 0.00e+00 816.00
IUUC-Tgu-117299 Taeniopygia guttata 93.90 0.00e+00 815.00
IUUC-Tru-117721 Takifugu rubripes 94.88 0.00e+00 822.00
IUUC-Tsy-119493 Tarsius syrichta 92.93 0.00e+00 806.00
IUUC-Tni-120355 Tetraodon nigroviridis 94.39 0.00e+00 796.00
IUUC-Tvi-122661 Trichoderma virens 43.84 2.00e-99 356.00
IUUC-Tme-127031 Tuber melanosporum 48.89 2.00e-103 369.00
IUUC-Tbe-127492 Tupaia belangeri 76.92 5.00e-110 390.00
IUUC-Ttr-128929 Tursiops truncatus 93.41 0.00e+00 815.00
IUUC-Uma-129347 Ustilago maydis 47.15 9.00e-121 427.00
IUUC-Vda-129837 Verticillium dahliae 47.06 8.00e-100 357.00
IUUC-Vpa-130532 Vicugna pacos 79.79 0.00e+00 632.00
IUUC-Xma-133314 Xiphophorus maculatus 95.12 0.00e+00 828.00
Created Date 25-Jun-2017

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