iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
ICGC	COSMIC
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
TRANSFAC
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
Protein Expression/Proteomics
THPA	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	2.80e-08	35.8	64	112

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlp....CgHvfhadClqkwpglknssskefrCPlCr 46
           C+iC ++f+  ++ lp    CgHvf+++Cl ++ +      ++  CP+Cr
   Q: 64   CLICVSSFDG-VFKLPkrldCGHVFCLECLARLSLATAGGGNAVACPVCR 112
           ********55.777666666**********99988888899999*****8 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MPCPRPFWLR HSRAPQGSGP SSPGSLSAPR SPSRGEDQEE EEEEEGDGSP GSGPILPPAS 60
PVECLICVSS FDGVFKLPKR LDCGHVFCLE CLARLSLATA GGGNAVACPV CRAPTRLAPR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCCCTGCC CTCGGCCGTT CTGGCTCCGC CATTCCCGGG CCCCCCAGGG CTCGGGTCCC 60
AGCTCCCCAG GCTCGCTCTC TGCGCCCCGC TCCCCAAGCA GAGGGGAAGA CCAGGAGGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF13639--zf-RING_2

SMART

SM00184--RING

Gene Ontology

GO:0016021--C:integral component of membrane
GO:0008270--F:zinc ion binding

KEGG

hsa:646862

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Cja-019712	Callithrix jacchus	91.33	2.00e-51	195.00
IUUC-Cfa-020515	Canis familiaris	81.08	3.00e-76	278.00
IUUC-Csa-023296	Chlorocebus sabaeus	87.07	9.00e-93	333.00
IUUC-Dno-029116	Dasypus novemcinctus	40.85	3.00e-08	51.60
IUUC-Dor-031130	Dipodomys ordii	40.00	1.00e-07	49.30
IUUC-Gac-042137	Gasterosteus aculeatus	44.55	1.00e-18	87.00
IUUC-Ggo-044823	Gorilla gorilla	100.00	1.00e-28	119.00
IUUC-Lch-050304	Latimeria chalumnae	46.08	5.00e-22	97.40
IUUC-Loc-052136	Lepisosteus oculatus	48.78	2.00e-13	68.60
IUUC-Meu-056717	Macropus eugenii	43.66	2.00e-10	58.90
IUUC-Mmr-061708	Microcebus murinus	77.86	1.00e-77	283.00
IUUC-Mdo-062101	Monodelphis domestica	43.66	1.00e-10	59.70
IUUC-Mmu-063087	Mus musculus	68.94	4.00e-59	221.00
IUUC-Nle-069438	Nomascus leucogenys	88.79	9.00e-100	356.00
IUUC-Ocu-074595	Oryctolagus cuniculus	56.76	2.00e-07	48.90
IUUC-Ola-086363	Oryzias latipes	46.34	2.00e-15	75.50
IUUC-Oga-088916	Otolemur garnettii	74.36	1.00e-73	270.00
IUUC-Pfo-097287	Poecilia formosa	48.00	2.00e-17	83.20
IUUC-Pab-098138	Pongo abelii	94.95	1.00e-74	273.00
IUUC-Pte-104269	Pyrenophora teres	29.69	3.00e-04	38.90
IUUC-Rno-105774	Rattus norvegicus	68.60	9.00e-58	217.00
IUUC-Sre-115193	Sporisorium reilianum	41.67	6.00e-08	53.10
IUUC-Tru-118029	Takifugu rubripes	41.41	8.00e-17	81.30
IUUC-Tni-120086	Tetraodon nigroviridis	40.00	5.00e-17	81.60
IUUC-Tur-126799	Triticum urartu	34.55	2.00e-03	34.30
IUUC-Tbe-128022	Tupaia belangeri	45.07	3.00e-08	50.10
IUUC-Ttr-128432	Tursiops truncatus	40.85	5.00e-08	50.80
IUUC-Uma-129518	Ustilago maydis	40.28	4.00e-07	50.40
IUUC-Vpa-130551	Vicugna pacos	40.85	1.00e-08	52.80

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence