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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Sce-106333
UUCD1 version UUC-SaC-00046
Ensembl Protein ID YDR409W
UniProt Accession Q04195; D6VT41; Q06762; Q7LIJ4; SIZ1_YEAST
Genbank Protein ID AAB64849.1; AAA16519.1; DAA12251.1
Protein Name E3 SUMO-protein ligase SIZ1; SAP and Miz-finger domain-containing protein 1; Ubiquitin-like protein ligase 1
Genbank Nucleotide ID U32274; L07952; BK006938
Gene Name SIZ1; ULL1; YDR409W
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
YDR409W YDR409W YDR409W
Annotation
mRNA Expression
GEOFFGED
Protein-protein Interaction
IIDiRefIndexHINTMentha
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
CPLMdbPAFdbPTMUniProt
PHOSIDABioGRID
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 19748360; 20592809; 21151918; 19837819
Classification
Family E-value Score Start End
E3 activity/RING/RING 4.30e-07 28.8 361 404
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+i ++++k++ ++ +C+H+ ++d l  w+++++++ ++++CP+C+
   Q: 361  CPISYTRMKYPSKSINCKHLQCFDAL--WFLHSQLQIPTWQCPVCQ 404
           *************************9..*****************7 PP
   
Organism Saccharomyces cerevisiae
Functional Description
(View)

Functional Description


     Acts as an E3 ligase mediating SUMO/Smt3 attachment to septins and PCNA. May be involved in chromosome maintenance.
 Acts as an E3 ligase mediating SUMO/Smt3 attachment to septins and PCNA. May be involved in chromosome maintenance.
Protein Sequence
(Fasta)
MINLEDYWED ETPGPDREPT NELRNEVEET ITLMELLKVS ELKDICRSVS FPVSGRKAVL 60
QDLIRNFLQN ALVVGKSDPY RVQAVKFLIE RIRKNEPLPV YKDLWNALRK GTPLSAITVR 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Sce-106333|E3,RING|Saccharomyces cerevisiae
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGATAAATT TAGAGGATTA CTGGGAAGAT GAAACGCCTG GGCCTGATAG GGAACCGACT 60
AATGAACTAA GAAACGAGGT GGAGGAAACC ATCACTCTGA TGGAACTGCT GAAAGTGTCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Sce-106333|E3,RING|Saccharomyces cerevisiae
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0436--Ligase
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR023321--PINIT
IPR003034--SAP_dom
IPR027229--SIZ1/SIZ2/Pli1/Gei17
IPR004181--Znf_MIZ
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS51466--PINIT
PS50800--SAP
PS51044--ZF_SP_RING
Pfam

PF14324--PINIT
PF02037--SAP
PF02891--zf-MIZ
SMART

SM00513--SAP
Gene Ontology

GO:0005935--C:cellular bud neck
GO:0000790--C:nuclear chromatin
GO:0005940--C:septin ring
GO:0016874--F:ligase activity
GO:0019789--F:SUMO transferase activity
GO:0008270--F:zinc ion binding
GO:0007059--P:chromosome segregation
GO:1990683--P:DNA double-strand break attachment to nuclear envelope
GO:0031397--P:negative regulation of protein ubiquitination
GO:0016925--P:protein sumoylation
KEGG sce:YDR409W
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ago-007762 Ashbya gossypii 43.59 8.00e-94 336.00
IUUC-Acl-008204 Aspergillus clavatus 33.70 2.00e-38 150.00
IUUC-Afl-008672 Aspergillus flavus 31.18 6.00e-46 176.00
IUUC-Afu-008758 Aspergillus fumigatus 31.83 5.00e-46 176.00
IUUC-Ani-009389 Aspergillus nidulans 36.06 2.00e-44 171.00
IUUC-Ang-009590 Aspergillus niger 29.51 8.00e-41 159.00
IUUC-Aor-009912 Aspergillus oryzae 30.32 1.00e-39 155.00
IUUC-Ate-010496 Aspergillus terreus 35.02 2.00e-39 154.00
IUUC-Bgr-012177 Blumeria graminis 31.32 8.00e-34 136.00
IUUC-Bci-013700 Botrytis cinerea 34.56 3.00e-42 164.00
IUUC-Cel-018231 Caenorhabditis elegans 27.68 3.00e-19 88.20
IUUC-Csv-026329 Ciona savignyi 33.14 5.00e-20 90.90
IUUC-Cgl-026533 Colletotrichum gloeosporioides 29.93 2.00e-47 181.00
IUUC-Cne-026824 Cryptococcus neoformans 28.25 1.00e-20 92.80
IUUC-Dse-031254 Dothistroma septosporum 27.45 2.00e-42 164.00
IUUC-Fso-038103 Fusarium solani 34.41 8.00e-41 159.00
IUUC-Ggr-039896 Gaeumannomyces graminis 38.05 9.00e-43 166.00
IUUC-Gma-043279 Glycine max 27.24 5.00e-20 90.90
IUUC-Kpa-049203 Komagataella pastoris 36.78 3.00e-73 268.00
IUUC-Lma-053196 Leptosphaeria maculans 34.19 9.00e-38 149.00
IUUC-Mor-057185 Magnaporthe oryzae 32.16 8.00e-41 159.00
IUUC-Nfi-068586 Neosartorya fischeri 31.91 6.00e-45 173.00
IUUC-Ncr-068929 Neurospora crassa 35.07 2.00e-44 171.00
IUUC-Pno-094862 Phaeosphaeria nodorum 36.20 2.00e-38 151.00
IUUC-Pop-099241 Populus trichocarpa 22.80 7.00e-10 57.40
IUUC-Pte-104331 Pyrenophora teres 36.46 1.00e-41 162.00
IUUC-Pyt-104673 Pyrenophora triticirepentis 36.10 3.00e-37 147.00
IUUC-Sja-107662 Schizosaccharomyces japonicus 33.58 3.00e-41 161.00
IUUC-Spo-108339 Schizosaccharomyces pombe 34.20 2.00e-40 158.00
IUUC-Ssl-108401 Sclerotinia sclerotiorum 24.37 4.00e-13 68.60
IUUC-Sre-115069 Sporisorium reilianum 31.39 5.00e-35 140.00
IUUC-Tre-122003 Trichoderma reesei 32.51 8.00e-40 155.00
IUUC-Tvi-122408 Trichoderma virens 30.82 1.00e-38 151.00
IUUC-Tme-126880 Tuber melanosporum 35.64 3.00e-45 174.00
IUUC-Uma-129549 Ustilago maydis 32.00 2.00e-36 145.00
IUUC-Vda-129985 Verticillium dahliae 35.77 3.00e-48 184.00
IUUC-Yli-134583 Yarrowia lipolytica 28.32 3.00e-34 137.00
Created Date 25-Jun-2017

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