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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045717
Ensembl Protein ID ENSP00000350071.5
UniProt Accession Q13033; A2RTX7; A6NHZ7; Q9NRA5; STRN3_HUMAN
Genbank Protein ID AAB81551.1; BAG36750.1; AAI32674.1; AAF81201.1
Protein Name Striatin-3; Cell cycle autoantigen SG2NA; S/G2 antigen
Genbank Nucleotide ID U17989; AK314041; AL049830; AF243424
Gene Name STRN3; GS2NA; SG2NA
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000196792.11 ENST00000355683.9 ENSP00000347909.5
ENSG00000196792.11 ENST00000357479.9 ENSP00000350071.5
ENSG00000196792.11 ENST00000555358.5 ENSP00000451028.1
ENSG00000196792.11 ENST00000554991.5 ENSP00000452542.1
ENSG00000196792.11 ENST00000556577.1 ENSP00000452092.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
RepTarmiRNAMapSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Variation
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 1.70e-25 89.6 584 615
UBD/Beta-Prp 2.20e-53 183.0 574 794
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclafsd..tllvsGsdDgtikvWDl 30
           gHtd v++la+s+  + l+s+s Dgt+++W++
   Q: 584  GHTDAVWGLAYSGikNQLLSCSADGTVRLWNP 615
           8**********666689*************95 PP
   

   UBD/Beta-Prp
   S: 40   ttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdls.tgkcvhtlkghedsv..lslsfsp.sgdklvsGshdrtirvwdletgq 127
           ++  l  +l gh+++v+ + +s  ++ l+++s D+t+++w+++ + +c+ t++g ++    +s++f   +  ++v+  +   + ++dlet q
   Q: 574  EPNVLAGTLVGHTDAVWGLAYSGIKNQLLSCSADGTVRLWNPQeKLPCICTYNGDKKHGipTSVDFIGcDPAHMVTSFNTGSAVIYDLETSQ 665
           45567889********************************887699*******6555431244555554449******************** PP
   S: 128  clee......tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtge 213
            l           + +  +n vv+hp+  + ++++ Dr ++++d ktgk+++ +   h d+v+sl++d+ng +l+sgs+d +++lw+l +++
   Q: 666  SLVIlssqvdSGLQSNNHINRVVSHPTLPVTITAHEDRHIKFFDNKTGKMIHSMVA-HLDAVTSLAVDPNGIYLMSGSHDCSIRLWNLDSKT 756
           ***98888663334555699999***99**************************98.*********************************** PP
   S: 214  cvrtlnght....dnvksvrfspnderlvsgssDgsir 247
           cv++ ++h+    + +++v+f++ + +++s+++D   +
   Q: 757  CVQEITAHRkkldESIYDVAFHSSKAYIASAGADALAK 794
           *********99999*******************97655 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Interacts with protein phosphatase 2A (PP2A). Interacts with CDC42BPB (PubMed:25743393).
 Interacts with protein phosphatase 2A (PP2A). Interacts with CDC42BPB (PubMed:25743393).
Protein Sequence
(Fasta)
MDELAGGGGG GPGMAAPPRQ QQGPGGNLGL SPGGNGAAGG GGPPASEGAG PAAGPELSRP 60
QQYTIPGILH YIQHEWARFE MERAHWEVER AELQARIAFL QGERKGQENL KKDLVRRIKM 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045717|E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AAAGTGAGTG AGTGAGACGG GCAGATGGAG GAGGGATTGT AATGGCGGCA GCCGGCAGCT 60
CCCTGCTCTG ACCCACGGCA GGCACACAGC AACGACCCCT TCCCCGCCCC TCTCCCGGCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045717|E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0112--Calmodulin-binding
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR013258--Striatin_N
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF08232--Striatin
PF00400--WD40
PRINTS

PR00320--GPROTEINBRPT
SMART

SM00320--WD40
Gene Ontology

GO:0005737--C:cytoplasm
GO:0030425--C:dendrite
GO:0005794--C:Golgi apparatus
GO:0043025--C:neuronal cell body
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0043234--C:protein complex
GO:0070016--F:armadillo repeat domain binding
GO:0005516--F:calmodulin binding
GO:0032403--F:protein complex binding
GO:0051721--F:protein phosphatase 2A binding
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0033147--P:negative regulation of intracellular estrogen receptor signaling pathway
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0032355--P:response to estradiol
KEGG hsa:29966
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002046 Ailuropoda melanoleuca 96.49 0.00e+00 1351.00
IUUC-Apl-003472 Anas platyrhynchos 94.35 0.00e+00 1267.00
IUUC-Aca-005286 Anolis carolinensis 93.96 0.00e+00 1320.00
IUUC-Afl-008585 Aspergillus flavus 27.65 3.00e-36 147.00
IUUC-Ani-009405 Aspergillus nidulans 29.84 2.00e-35 144.00
IUUC-Aor-009982 Aspergillus oryzae 27.65 3.00e-36 147.00
IUUC-Bgr-012143 Blumeria graminis 26.12 3.00e-35 143.00
IUUC-Bta-012797 Bos taurus 97.24 0.00e+00 1399.00
IUUC-Bci-013742 Botrytis cinerea 25.85 1.00e-35 145.00
IUUC-Cel-018443 Caenorhabditis elegans 39.88 7.00e-102 365.00
IUUC-Cja-018786 Callithrix jacchus 98.79 0.00e+00 1394.00
IUUC-Cfa-021098 Canis familiaris 94.61 0.00e+00 1320.00
IUUC-Cpo-022357 Cavia porcellus 95.30 0.00e+00 1337.00
IUUC-Csa-023725 Chlorocebus sabaeus 99.46 0.00e+00 1403.00
IUUC-Cho-024338 Choloepus hoffmanni 92.18 0.00e+00 1199.00
IUUC-Cin-025167 Ciona intestinalis 49.27 0.00e+00 657.00
IUUC-Csv-026143 Ciona savignyi 52.39 0.00e+00 681.00
IUUC-Cgl-026487 Colletotrichum gloeosporioides 26.37 9.00e-32 132.00
IUUC-Cne-026783 Cryptococcus neoformans 32.51 1.00e-56 214.00
IUUC-Dno-029926 Dasypus novemcinctus 97.17 0.00e+00 1373.00
IUUC-Dse-031486 Dothistroma septosporum 28.41 3.00e-39 157.00
IUUC-Dme-032158 Drosophila melanogaster 63.86 2.00e-144 506.00
IUUC-Ete-032770 Echinops telfairi 82.75 0.00e+00 1137.00
IUUC-Eca-033309 Equus caballus 97.18 0.00e+00 1363.00
IUUC-Eeu-034939 Erinaceus europaeus 94.49 0.00e+00 1008.00
IUUC-Fca-035719 Felis catus 94.65 0.00e+00 1237.00
IUUC-Fal-037408 Ficedula albicollis 94.42 0.00e+00 1215.00
IUUC-Fox-037678 Fusarium oxysporum 26.67 4.00e-36 146.00
IUUC-Fso-038364 Fusarium solani 27.02 2.00e-37 151.00
IUUC-Gmo-039653 Gadus morhua 63.14 0.00e+00 867.00
IUUC-Ggr-039846 Gaeumannomyces graminis 26.47 8.00e-35 142.00
IUUC-Gga-041218 Gallus gallus 95.17 0.00e+00 1353.00
IUUC-Gac-042142 Gasterosteus aculeatus 71.54 0.00e+00 1051.00
IUUC-Ggo-045607 Gorilla gorilla 80.73 0.00e+00 1054.00
IUUC-Itr-048177 Ictidomys tridecemlineatus 97.69 0.00e+00 968.00
IUUC-Lch-050441 Latimeria chalumnae 89.80 0.00e+00 1320.00
IUUC-Loc-052193 Lepisosteus oculatus 85.96 0.00e+00 1272.00
IUUC-Lma-053183 Leptosphaeria maculans 28.83 9.00e-40 159.00
IUUC-Laf-053964 Loxodonta africana 97.24 0.00e+00 1360.00
IUUC-Mcc-055639 Macaca mulatta 99.46 0.00e+00 1404.00
IUUC-Mor-057148 Magnaporthe oryzae 42.31 1.00e-17 85.10
IUUC-Mpo-057337 Magnaporthe poae 25.60 5.00e-31 130.00
IUUC-Mla-058988 Melampsora laricipopulina 34.84 3.00e-64 240.00
IUUC-Mmr-061084 Microcebus murinus 98.38 0.00e+00 1393.00
IUUC-Mdo-063016 Monodelphis domestica 96.68 0.00e+00 1394.00
IUUC-Mmu-063914 Mus musculus 96.50 0.00e+00 1381.00
IUUC-Mpu-066348 Mustela putorius furo 88.81 0.00e+00 1253.00
IUUC-Mlu-067303 Myotis lucifugus 94.75 0.00e+00 1315.00
IUUC-Nle-070032 Nomascus leucogenys 99.73 0.00e+00 1415.00
IUUC-Opr-070496 Ochotona princeps 90.24 0.00e+00 647.00
IUUC-Ont-072075 Oreochromis niloticus 71.81 0.00e+00 1054.00
IUUC-Oan-072822 Ornithorhynchus anatinus 95.29 0.00e+00 1221.00
IUUC-Ocu-073876 Oryctolagus cuniculus 95.18 0.00e+00 1341.00
IUUC-Ola-086321 Oryzias latipes 69.26 0.00e+00 992.00
IUUC-Oga-088045 Otolemur garnettii 98.38 0.00e+00 1387.00
IUUC-Oar-089737 Ovis aries 96.88 0.00e+00 1285.00
IUUC-Ptr-090871 Pan troglodytes 99.57 0.00e+00 1332.00
IUUC-Pan-092139 Papio anubis 99.01 0.00e+00 1306.00
IUUC-Psi-093424 Pelodiscus sinensis 94.44 0.00e+00 1284.00
IUUC-Pma-094286 Petromyzon marinus 70.28 0.00e+00 678.00
IUUC-Pno-094905 Phaeosphaeria nodorum 28.42 7.00e-36 145.00
IUUC-Pfo-096564 Poecilia formosa 72.55 0.00e+00 1068.00
IUUC-Pab-098626 Pongo abelii 99.46 0.00e+00 1447.00
IUUC-Pva-102445 Pteropus vampyrus 91.47 0.00e+00 1266.00
IUUC-Ptt-103828 Puccinia triticina 37.42 3.00e-49 191.00
IUUC-Pte-104374 Pyrenophora teres 28.11 2.00e-33 137.00
IUUC-Pyt-104568 Pyrenophora triticirepentis 27.65 9.00e-37 149.00
IUUC-Rno-105999 Rattus norvegicus 94.87 0.00e+00 1395.00
IUUC-Sha-106786 Sarcophilus harrisii 94.86 0.00e+00 1295.00
IUUC-Ssl-108495 Sclerotinia sclerotiorum 26.53 2.00e-35 144.00
IUUC-Sar-113296 Sorex araneus 76.65 0.00e+00 857.00
IUUC-Sre-115115 Sporisorium reilianum 35.22 1.00e-63 238.00
IUUC-Tgu-117199 Taeniopygia guttata 91.10 0.00e+00 1194.00
IUUC-Tsy-119356 Tarsius syrichta 82.93 0.00e+00 979.00
IUUC-Tre-122113 Trichoderma reesei 28.48 7.00e-39 155.00
IUUC-Tvi-122312 Trichoderma virens 26.90 8.00e-37 149.00
IUUC-Tme-126990 Tuber melanosporum 26.88 2.00e-35 144.00
IUUC-Tbe-127691 Tupaia belangeri 80.89 0.00e+00 793.00
IUUC-Ttr-128600 Tursiops truncatus 88.93 0.00e+00 1258.00
IUUC-Uma-129659 Ustilago maydis 34.13 5.00e-64 239.00
IUUC-Vda-129673 Verticillium dahliae 25.95 5.00e-31 130.00
IUUC-Xtr-132330 Xenopus tropicalis 82.35 0.00e+00 1229.00
Created Date 25-Jun-2017

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