iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Ath-007650

UUCD1 version

UUC-ArT-00155

Ensembl Protein ID

AT2G15530.4

UniProt Accession

Q9ZQF9; MBR1_ARATH

Genbank Protein ID

AAD17397.1; AEC06411.1; AEC06412.1; AEC06413.1; ANM62927.1; ANM62928.1; AT2G15530.1

Protein Name

E3 ubiquitin-protein ligase MBR1; MED25-binding RING-H2 protein 1; RING-H2 finger MBR1; RING-type E3 ubiquitin transferase MBR1

Genbank Nucleotide ID

AC006248; CP002685; CP002685; CP002685; CP002685; CP002685; BX820346

Gene Name

MBR1; At2g15530; F9O13

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
AT2G15530	AT2G15530.7	AT2G15530.7
AT2G15530	AT2G15530.4	AT2G15530.4
AT2G15530	AT2G15530.6	AT2G15530.6

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
Protein-protein Interaction
iRefIndex	Mentha
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	1.00e-06	30.0	656	695

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledf...kdgplvlpCgHvfhadClqkwpglknssskefrCPl 44
           C+iC+e++   ++ + +l CgH fh+dC+++w       + + +CP+
   Q: 656  CCICQEEYvegDN-LGTLKCGHEFHKDCIKQW------VMIKNLCPI 695
           ********77444.88999*************......999999*96 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

E3 ubiquitin-protein ligase that functions as regulator of MED25 stability by targeting MED25 for degradation in a RING-H2-dependent way. Proteasome-dependent degradation of MED25 seems to activate its function as positive regulator of FLOWERING LOCUS T (FT) and is important to induce the expression of FT and consequently to promote flowering.

Protein Sequence
(Fasta)

MNPMQGPRSI GGSSTEVNQV DGESIYCTET SLNTMLNPAD TGFPNNSTPS GRPTYASSSS 60
HAAQDHTWWR FGESSSIPGP SDQVNSIGIK TSHQLPQDGT HHFVGYGSEG RQTGLNGMMV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATTTCAACTT TTTATGAGAC CCATTTGATT CTTTAGGGAT TTTGAAGGTA CCATTTGTCT 60
CAATCTTATA AAAAATTTCA CCTTTTTTTT TTTTTTTTTG TTACCACTAT GTGTCTTTAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0287--Flowering
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

Pfam

PF13639--zf-RING_2

SMART

SM00184--RING

Gene Ontology

GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0009908--P:flower development
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0010228--P:vegetative to reproductive phase transition of meristem

KEGG

ath:AT2G15530

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aly-005960	Arabidopsis lyrata	92.25	0.00e+00	1088.00
IUUC-Bol-015116	Brassica oleracea	67.85	0.00e+00	797.00
IUUC-Bra-017872	Brassica rapa	63.37	0.00e+00	703.00
IUUC-Gmo-038696	Gadus morhua	29.58	6.00e-14	72.40
IUUC-Mla-059167	Melampsora laricipopulina	47.50	2.00e-07	50.80
IUUC-Ogu-078729	Oryza glumaepatula	50.00	1.00e-42	167.00
IUUC-Ppe-101866	Prunus persica	38.04	1.00e-89	323.00
IUUC-Sre-114942	Sporisorium reilianum	32.48	4.00e-12	66.20

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence