iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mpu-066199

Ensembl Protein ID

ENSMPUP00000004270.1

UniProt Accession

M3XYW9; M3XYW9_MUSPF

Genbank Protein ID

ENSMPUP00000004270

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AEYP01081266

Gene Name

TRIP12

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMPUG00000004303.1	ENSMPUT00000004346.1	ENSMPUP00000004270.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.20e-96	324.1	1659	2038

Active Site

Position(s)	Description	Evidence
2005	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 6    kkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlq..pnpdsglknp.....................ehlk 69
           ++ le+++++E g++l G+t+ef+al+s+elq++dlgl++ +e   ++ +   + +++                         ++  
   Q: 1659 RAMLEIQYENEVGTGL-GPTLEFYALVSQELQRADLGLWRGEEVTLSNPKgsQEGTKY---IqnlqglfalpfgrtakpahiaKVKM 1741
           56899***********.**********************6665533332200222333...14458888999**********9999* PP
   S: 70   lFeflGrllgkalqdgrlldlplsksfyklllgkklsl..edleevdpelykslkeikena......es.................. 130
            F+flG+l++ka++d rl+dlpl  +fyk +l+++ sl  +dl ++dp +++s+  +++ +      e+                  
   Q: 1742 KFRFLGKLMAKAIMDFRLVDLPLGLPFYKWMLRQETSLtsHDLFDIDPVVARSVYHLEDIVrqkkrlEQdksqtkeslqyaletltm 1828
           **********************************654444**************999999855555511555666666554444444 PP
   S: 131  ...dieelgldltfsvseei.....lgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegikeqveafreGfneviplellslF 209
              ++e+            +     l+   + eLk gG++ipVt+ N+eeY +lv+ + l+eg+ +q+++fr+Gf++v+pl++l++F
   Q: 1829 ngcSVED------------LgldftLPGFPNIELKKGGKDIPVTIHNLEEYLRLVIFWALNEGVSRQFDSFRDGFESVFPLSHLQYF 1903
           4444444............25555578999********************************************************* PP
   S: 210  teeelellicGe..eeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelkprlfvirk... 291
            +eel++l+cG+  +++d+++l + ++ ++gyt+ds+a+++++e+l++f++e+++ fLqFvTgs+rlP+gGf++l+p l+++rk   
   Q: 1904 YPEELDQLLCGSkaDTWDAKTLMECCRPDHGYTHDSRAVKFLFEILSSFDNEQQRLFLQFVTGSPRLPVGGFRSLNPPLTIVRKtfe 1990
           ************7778999999999999*********************************************************** PP
   S: 292  ..dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieet.kgFels 336
             ++ dd lPs++TC+nyLkLP+Yss ei++ekLl+A +e+ ++F+ls
   Q: 1991 stENPDDFLPSVMTCVNYLKLPDYSSIEIMREKLLIAAREGqQSFHLS 2038
           988888***************************************985 PP

Organism

Mustela putorius furo

Protein Sequence
(Fasta)

MSNRPNNNPG GSLRRSQRNT AGAQPQDDSI GGRSHLGQAK HKGYSPPESR KSNSKAPKVQ 60
SNTTSELSRG HLSKRSCSSS SAVIVPQPED PDRANTSERQ KTGQVPKKDN SRGVKRSASP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGAATGGTAG TGTCTAGAAA GGGTATGTCC CTTCAAGAGA GAGGTGCCAA TGTCCAACCG 60
GCCTAATAAC AATCCAGGGG GGTCACTGCG ACGTTCACAG AGGAACACTG CCGGGGCCCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR000569--HECT_dom
IPR004170--WWE-dom
IPR018123--WWE-dom_subgr

PROSITE

PS50237--HECT
PS50918--WWE

Pfam

PF00632--HECT
PF02825--WWE

SMART

SM00119--HECTc
SM00678--WWE

Gene Ontology

GO:0016607--C:nuclear speck
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:0009790--P:embryo development
GO:2000780--P:negative regulation of double-strand break repair
GO:1901315--P:negative regulation of histone H2A K63-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000750	Aegilops tauschii	38.69	7.00e-127	449.00
IUUC-Aml-001502	Ailuropoda melanoleuca	96.71	0.00e+00	3637.00
IUUC-Atr-002821	Amborella trichopoda	37.45	3.00e-117	417.00
IUUC-Apl-003531	Anas platyrhynchos	89.79	0.00e+00	3302.00
IUUC-Aly-005962	Arabidopsis lyrata	38.94	3.00e-115	410.00
IUUC-Ath-006636	Arabidopsis thaliana	38.66	3.00e-114	407.00
IUUC-Ago-007875	Ashbya gossypii	36.20	5.00e-82	300.00
IUUC-Acl-008242	Aspergillus clavatus	35.70	1.00e-113	405.00
IUUC-Afl-008736	Aspergillus flavus	38.83	1.00e-110	395.00
IUUC-Afu-008812	Aspergillus fumigatus	35.55	1.00e-114	408.00
IUUC-Ani-009407	Aspergillus nidulans	36.82	8.00e-111	395.00
IUUC-Ang-009763	Aspergillus niger	40.00	4.00e-106	380.00
IUUC-Aor-009941	Aspergillus oryzae	30.76	1.00e-112	402.00
IUUC-Ate-010459	Aspergillus terreus	37.31	1.00e-85	312.00
IUUC-Ame-011761	Astyanax mexicanus	87.41	0.00e+00	2947.00
IUUC-Bgr-012265	Blumeria graminis	34.86	1.00e-104	375.00
IUUC-Bta-013070	Bos taurus	95.21	0.00e+00	3472.00
IUUC-Bci-013890	Botrytis cinerea	39.52	3.00e-102	367.00
IUUC-Bdi-014046	Brachypodium distachyon	38.47	5.00e-122	433.00
IUUC-Bol-015942	Brassica oleracea	44.23	2.00e-114	407.00
IUUC-Bra-016849	Brassica rapa	44.23	4.00e-114	407.00
IUUC-Cja-019046	Callithrix jacchus	94.97	0.00e+00	3562.00
IUUC-Cfa-020521	Canis familiaris	97.99	0.00e+00	3590.00
IUUC-Cpo-021639	Cavia porcellus	92.27	0.00e+00	3492.00
IUUC-Cre-022767	Chlamydomonas reinhardtii	40.08	2.00e-90	326.00
IUUC-Csa-023231	Chlorocebus sabaeus	97.44	0.00e+00	3647.00
IUUC-Cho-024380	Choloepus hoffmanni	93.46	0.00e+00	2161.00
IUUC-Cin-025482	Ciona intestinalis	51.21	7.00e-160	556.00
IUUC-Csv-026121	Ciona savignyi	48.67	0.00e+00	1541.00
IUUC-Cgl-026716	Colletotrichum gloeosporioides	34.94	1.00e-110	395.00
IUUC-Cne-026857	Cryptococcus neoformans	39.58	3.00e-94	340.00
IUUC-Cme-027226	Cyanidioschyzon merolae	35.14	2.00e-74	275.00
IUUC-Dre-028174	Danio rerio	86.75	0.00e+00	2972.00
IUUC-Dor-030939	Dipodomys ordii	86.72	0.00e+00	2762.00
IUUC-Dse-031444	Dothistroma septosporum	39.31	1.00e-105	378.00
IUUC-Dme-032162	Drosophila melanogaster	67.95	1.00e-174	608.00
IUUC-Ete-032345	Echinops telfairi	90.65	0.00e+00	2296.00
IUUC-Eca-033229	Equus caballus	96.03	0.00e+00	3525.00
IUUC-Eeu-035205	Erinaceus europaeus	83.31	0.00e+00	3006.00
IUUC-Fca-036444	Felis catus	95.89	0.00e+00	3571.00
IUUC-Fal-037131	Ficedula albicollis	92.84	0.00e+00	3462.00
IUUC-Fox-038035	Fusarium oxysporum	36.57	4.00e-110	392.00
IUUC-Fso-038320	Fusarium solani	36.91	4.00e-110	393.00
IUUC-Gmo-039497	Gadus morhua	85.30	0.00e+00	2917.00
IUUC-Ggr-040057	Gaeumannomyces graminis	34.90	1.00e-108	389.00
IUUC-Gga-041021	Gallus gallus	93.28	0.00e+00	3469.00
IUUC-Gac-042474	Gasterosteus aculeatus	79.30	0.00e+00	2965.00
IUUC-Gma-043060	Glycine max	38.92	5.00e-122	433.00
IUUC-Ggo-044855	Gorilla gorilla	95.02	0.00e+00	3566.00
IUUC-Hsa-046147	Homo sapiens	92.55	0.00e+00	3470.00
IUUC-Hvu-047775	Hordeum vulgare	38.69	8.00e-125	442.00
IUUC-Itr-048131	Ictidomys tridecemlineatus	95.12	0.00e+00	3467.00
IUUC-Kpa-049098	Komagataella pastoris	38.10	5.00e-86	313.00
IUUC-Lch-049818	Latimeria chalumnae	83.45	0.00e+00	3035.00
IUUC-Lpe-051017	Leersia perrieri	38.44	1.00e-118	422.00
IUUC-Loc-051777	Lepisosteus oculatus	86.57	0.00e+00	3302.00
IUUC-Lma-052990	Leptosphaeria maculans	39.74	4.00e-112	400.00
IUUC-Laf-053727	Loxodonta africana	95.94	0.00e+00	3572.00
IUUC-Mcc-055799	Macaca mulatta	98.87	0.00e+00	3642.00
IUUC-Meu-056065	Macropus eugenii	94.40	0.00e+00	2107.00
IUUC-Mor-057054	Magnaporthe oryzae	34.39	2.00e-107	384.00
IUUC-Mpo-057417	Magnaporthe poae	39.55	2.00e-109	391.00
IUUC-Mtr-057849	Medicago truncatula	37.36	7.00e-114	406.00
IUUC-Mla-058870	Melampsora laricipopulina	42.57	8.00e-107	382.00
IUUC-Mga-059580	Meleagris gallopavo	91.27	0.00e+00	2925.00
IUUC-Mvi-060507	Microbotryum violaceum	40.37	2.00e-113	405.00
IUUC-Mmr-060816	Microcebus murinus	97.49	0.00e+00	3635.00
IUUC-Mdo-062866	Monodelphis domestica	96.21	0.00e+00	3473.00
IUUC-Mmu-063906	Mus musculus	94.24	0.00e+00	3526.00
IUUC-Mac-064675	Musa acuminata	38.92	9.00e-112	397.00
IUUC-Mlu-067110	Myotis lucifugus	94.82	0.00e+00	3529.00
IUUC-Nfi-068482	Neosartorya fischeri	35.82	2.00e-114	407.00
IUUC-Ncr-068906	Neurospora crassa	39.13	2.00e-109	391.00
IUUC-Nle-069410	Nomascus leucogenys	95.74	0.00e+00	3554.00
IUUC-Opr-070401	Ochotona princeps	86.42	0.00e+00	1948.00
IUUC-Ont-072100	Oreochromis niloticus	82.23	0.00e+00	3076.00
IUUC-Oan-073121	Ornithorhynchus anatinus	93.57	0.00e+00	3598.00
IUUC-Ocu-074623	Oryctolagus cuniculus	98.33	0.00e+00	3644.00
IUUC-Oba-075380	Oryza barthii	36.51	9.00e-114	405.00
IUUC-Obr-076915	Oryza brachyantha	37.77	4.00e-119	423.00
IUUC-Ogl-077055	Oryza glaberrima	38.70	2.00e-118	421.00
IUUC-Ogu-078892	Oryza glumaepatula	40.36	6.00e-113	402.00
IUUC-Oin-079256	Oryza indica	38.52	2.00e-117	417.00
IUUC-Olo-080343	Oryza longistaminata	38.52	1.00e-117	418.00
IUUC-Ome-081422	Oryza meridionalis	38.24	4.00e-117	416.00
IUUC-Oni-083047	Oryza nivara	36.66	8.00e-115	409.00
IUUC-Opu-083641	Oryza punctata	36.44	2.00e-111	397.00
IUUC-Oru-084439	Oryza rufipogon	40.36	2.00e-113	404.00
IUUC-Osa-085972	Oryza sativa	38.44	1.00e-116	414.00
IUUC-Ola-087173	Oryzias latipes	80.15	0.00e+00	3006.00
IUUC-Olu-087871	Ostreococcus lucimarinus	36.70	2.00e-88	320.00
IUUC-Oga-087908	Otolemur garnettii	94.88	0.00e+00	3561.00
IUUC-Oar-090277	Ovis aries	96.32	0.00e+00	3543.00
IUUC-Ptr-091543	Pan troglodytes	92.65	0.00e+00	3473.00
IUUC-Pan-092243	Papio anubis	98.82	0.00e+00	3641.00
IUUC-Psi-093150	Pelodiscus sinensis	92.41	0.00e+00	3500.00
IUUC-Pno-094891	Phaeosphaeria nodorum	40.90	1.00e-112	402.00
IUUC-Ppa-095181	Physcomitrella patens	42.14	2.00e-107	383.00
IUUC-Pfo-096267	Poecilia formosa	86.90	0.00e+00	2982.00
IUUC-Pab-098072	Pongo abelii	96.03	0.00e+00	3567.00
IUUC-Pop-099190	Populus trichocarpa	41.34	4.00e-116	413.00
IUUC-Pca-100311	Procavia capensis	88.97	0.00e+00	3195.00
IUUC-Ppe-101284	Prunus persica	37.52	1.00e-116	415.00
IUUC-Pva-102215	Pteropus vampyrus	91.51	0.00e+00	1285.00
IUUC-Pgr-103694	Puccinia graminis	40.68	2.00e-104	374.00
IUUC-Ptt-103916	Puccinia triticina	39.00	4.00e-98	353.00
IUUC-Pte-104346	Pyrenophora teres	39.59	2.00e-110	394.00
IUUC-Pyt-104508	Pyrenophora triticirepentis	39.66	2.00e-110	394.00
IUUC-Rno-105315	Rattus norvegicus	98.09	0.00e+00	3581.00
IUUC-Sce-106273	Saccharomyces cerevisiae	35.00	3.00e-71	264.00
IUUC-Sha-106835	Sarcophilus harrisii	95.21	0.00e+00	3628.00
IUUC-Sja-107943	Schizosaccharomyces japonicus	37.58	1.00e-94	342.00
IUUC-Spo-108081	Schizosaccharomyces pombe	38.54	1.00e-94	342.00
IUUC-Ssl-108560	Sclerotinia sclerotiorum	39.72	9.00e-106	379.00
IUUC-Smo-109590	Selaginella moellendorffii	43.47	1.00e-112	402.00
IUUC-Sit-110717	Setaria italica	37.94	3.00e-120	427.00
IUUC-Sly-111469	Solanum lycopersicum	38.97	6.00e-122	432.00
IUUC-Stu-112896	Solanum tuberosum	38.22	5.00e-106	379.00
IUUC-Sar-113224	Sorex araneus	84.11	0.00e+00	1820.00
IUUC-Sbi-114313	Sorghum bicolor	38.02	7.00e-124	439.00
IUUC-Sre-114993	Sporisorium reilianum	34.24	7.00e-101	363.00
IUUC-Ssc-115535	Sus scrofa	91.27	0.00e+00	3413.00
IUUC-Tgu-117493	Taeniopygia guttata	90.65	0.00e+00	2662.00
IUUC-Tru-118669	Takifugu rubripes	79.79	0.00e+00	2991.00
IUUC-Tsy-119373	Tarsius syrichta	94.66	0.00e+00	1864.00
IUUC-Tni-120049	Tetraodon nigroviridis	77.98	0.00e+00	867.00
IUUC-Tca-121779	Theobroma cacao	38.76	1.00e-115	412.00
IUUC-Tre-122195	Trichoderma reesei	35.80	1.00e-105	379.00
IUUC-Tvi-122650	Trichoderma virens	35.93	4.00e-109	390.00
IUUC-Tae-123580	Triticum aestivum	38.58	8.00e-125	441.00
IUUC-Tur-126295	Triticum urartu	38.54	2.00e-125	444.00
IUUC-Tme-126964	Tuber melanosporum	40.48	1.00e-105	379.00
IUUC-Tbe-128149	Tupaia belangeri	81.85	0.00e+00	1464.00
IUUC-Ttr-128165	Tursiops truncatus	94.90	0.00e+00	3050.00
IUUC-Uma-129365	Ustilago maydis	36.25	2.00e-89	325.00
IUUC-Vda-129725	Verticillium dahliae	41.08	4.00e-109	390.00
IUUC-Vpa-130678	Vicugna pacos	97.01	0.00e+00	2672.00
IUUC-Vvi-131147	Vitis vinifera	39.23	2.00e-122	434.00
IUUC-Xtr-132636	Xenopus tropicalis	85.61	0.00e+00	3195.00
IUUC-Xma-133458	Xiphophorus maculatus	82.09	0.00e+00	3071.00
IUUC-Yli-134481	Yarrowia lipolytica	39.76	2.00e-98	354.00
IUUC-Zma-135782	Zea mays	37.87	4.00e-118	420.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence