iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ots-000019

Ensembl Protein ID

UniProt Accession

P0C6X7; P59641; Q6WGN0; Q7T697; Q808C0; Q80BV7; Q80BV8; Q80E51; R1AB_CVHSA

Genbank Protein ID

AAP13442.1; AAP13440.1; AAP41036.1; AAP13566.1; AAP30711.1; AAP49011.4; AAP30028.1; AAP51225.1; AAP37015.1; AAP50483.1; AAP33696.1; AAP72973.2; AAQ01594.1; AAQ01596.1; AAQ01606.1; AAQ01608.1; AAP97879.1; AAP97881.1; BAC81346.1; BAC81360.1; BAC81374.1; BAC81388.1; BAC81402.1; AAQ94058.1; AAP82966.1; AAP82975.1; AAP82967.1; AAP82978.2; AAP04003.1; AAP04587.1

Protein Name

Replicase polyprotein 1ab; ORF1ab polyprotein; Host translation inhibitor nsp1; Leader protein; Non-structural protein 2; p65 homolog; Papain-like proteinase; Non-structural protein 3; PL2-PRO; SARS coronavirus main proteinase; Non-structural protein 4; 3C-like proteinase; nsp5; Non-structural protein 6; Non-structural protein 7; Non-structural protein 8; Non-structural protein 9; Non-structural protein 10; Growth factor-like peptide; RNA-directed RNA polymerase; nsp12; Helicase; nsp13; Guanine-N7 methyltransferase; nsp14; Uridylate-specific endoribonuclease; NendoU; nsp15; 2'-O-methyltransferase; nsp16

Genbank Nucleotide ID

AY278741; AY278741; AY274119; AY278554; AY282752; AY304495; AY278488; AY278489; AY278490; AY310120; AY291315; AY323977; AY321118; AY338174; AY338175; AY338175; AY348314; AY348314; AP006557; AP006558; AP006559; AP006560; AP006561; AY427439; AY322205; AY322206; AY322207; AY463059; AY269391; AY268049

Gene Name

rep; 1a-1b

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID

Status

Reviewed

Details

Family	Domain	References (PMIDs)
ULD/UDP/UBQ/UBQ_Other	UBQ_Other	25694594; 25810552

Organism

Human SARS coronavirus

Functional Description
(View)

2'-O-methyltransferase: Methyltransferase that mediates mRNA cap 2'-O-ribose methylation to the 5'-cap structure of viral mRNAs. N7-methyl guanosine cap is a prerequisite for binding of nsp16. Therefore plays an essential role in viral mRNAs cap methylation which is essential to evade immune system.

Protein Sequence
(Fasta)

MESLVLGVNE KTHVQLSLPV LQVRDVLVRG FGDSVEEALS EAREHLKNGT CGLVELEKGV 60
LPQLEQPYVF IKRSDALSTN HGHKVVELVA EMDGIQYGRS GITLGVLVPH VGETPIAYRN 120

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Sequence Source

UniProt

Keyword

KW-0002--3D-structure
KW-1072--Activation of host autophagy by virus
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-1132--Decay of host mRNAs by virus
KW-0255--Endonuclease
KW-1262--Eukaryotic host gene expression shutoff by virus
KW-1193--Eukaryotic host translation shutoff by virus
KW-0269--Exonuclease
KW-0347--Helicase
KW-1035--Host cytoplasm
KW-1190--Host gene expression shutoff by virus
KW-1043--Host membrane
KW-1192--Host mRNA suppression by virus
KW-0945--Host-virus interaction
KW-0378--Hydrolase
KW-1090--Inhibition of host innate immune response by virus
KW-1114--Inhibition of host interferon signaling pathway by virus
KW-1095--Inhibition of host ISG15 by virus
KW-1100--Inhibition of host NF-kappa-B by virus
KW-0472--Membrane
KW-0479--Metal-binding
KW-0489--Methyltransferase
KW-1127--Modulation of host ubiquitin pathway by viral deubiquitinase
KW-1130--Modulation of host ubiquitin pathway by virus
KW-0540--Nuclease
KW-0547--Nucleotide-binding
KW-0548--Nucleotidyltransferase
KW-0645--Protease
KW-1185--Reference proteome
KW-0677--Repeat
KW-0688--Ribosomal frameshifting
KW-0694--RNA-binding
KW-0696--RNA-directed RNA polymerase
KW-0788--Thiol protease
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway
KW-0899--Viral immunoevasion
KW-0693--Viral RNA replication
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR027351--(+)RNA_virus_helicase_core_dom
IPR032505--Corona_NSP4_C
IPR009461--Coronavirus_NSP16
IPR027352--CV_ZBD
IPR002589--Macro_dom
IPR032592--NAR_dom
IPR021590--NSP1
IPR009466--NSP11
IPR024375--Nsp3_coronavir
IPR014828--NSP7
IPR014829--NSP8
IPR014822--NSP9
IPR027417--P-loop_NTPase
IPR008740--Peptidase_C30
IPR013016--Peptidase_C30/C16
IPR009003--Peptidase_S1_PA
IPR007094--RNA-dir_pol_PSvirus
IPR009469--RNA_pol_N_coronovir
IPR018995--RNA_synth_NSP10_coronavirus
IPR029063--SAM-dependent_MTases
IPR024358--SARS-CoV_Nsp3_N
IPR022733--SARS_polyprot_cleavage
IPR014827--Viral_protease

PROSITE

PS51653--CV_ZBD
PS51442--M_PRO
PS51154--MACRO
PS51124--PEPTIDASE_C16
PS51657--PSRV_HELICASE
PS50507--RDRP_SSRNA_POS

Pfam

PF16348--Corona_NSP4_C
PF06478--Corona_RPol_N
PF12379--DUF3655
PF01661--Macro
PF16251--NAR
PF11501--Nsp1
PF09401--NSP10
PF06471--NSP11
PF06460--NSP13
PF12124--Nsp3_PL2pro
PF08716--nsp7
PF08717--nsp8
PF08710--nsp9
PF05409--Peptidase_C30
PF11633--SUD-M
PF08715--Viral_protease

SMART

SM00506--A1pp

Gene Ontology

GO:0039714--C:cytoplasmic viral factory
GO:0044172--C:host cell endoplasmic reticulum-Golgi intermediate compartment
GO:0033644--C:host cell membrane
GO:0044220--C:host cell perinuclear region of cytoplasm
GO:0016021--C:integral component of membrane
GO:0000175--F:3'-5'-exoribonuclease activity
GO:0005524--F:ATP binding
GO:0004197--F:cysteine-type endopeptidase activity
GO:0003725--F:double-stranded RNA binding
GO:0004519--F:endonuclease activity
GO:0004386--F:helicase activity
GO:1990380--F:Lys48-specific deubiquitinase activity
GO:0008168--F:methyltransferase activity
GO:0004482--F:mRNA (guanine-N7-)-methyltransferase activity
GO:0004483--F:mRNA (nucleoside-2'-O-)-methyltransferase activity
GO:0008242--F:omega peptidase activity
GO:0003723--F:RNA binding
GO:0003968--F:RNA-directed 5'-3' RNA polymerase activity
GO:0003727--F:single-stranded RNA binding
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0008270--F:zinc ion binding
GO:0006370--P:7-methylguanosine mRNA capping
GO:0039595--P:induction by virus of catabolism of host mRNA
GO:0039520--P:induction by virus of host autophagy
GO:0039519--P:modulation by virus of host autophagy
GO:0039648--P:modulation by virus of host protein ubiquitination
GO:0080009--P:mRNA methylation
GO:2000158--P:positive regulation of ubiquitin-specific protease activity
GO:0039690--P:positive stranded viral RNA replication
GO:0090503--P:RNA phosphodiester bond hydrolysis, exonucleolytic
GO:0039549--P:suppression by virus of host IRF3 activity by inhibition of IRF3 phosphorylation
GO:0039579--P:suppression by virus of host ISG15 activity
GO:0039644--P:suppression by virus of host NF-kappaB transcription factor activity
GO:0039604--P:suppression by virus of host translation
GO:0039502--P:suppression by virus of host type I interferon-mediated signaling pathway
GO:0006351--P:transcription, DNA-templated
GO:0001172--P:transcription, RNA-templated
GO:0019082--P:viral protein processing
GO:0039694--P:viral RNA genome replication
GO:0019083--P:viral transcription

KEGG

vg:1489680

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence