| Tag | Content | ||||||
|---|---|---|---|---|---|---|---|
| UUCD2 ID | IUUC-Ots-000028 | ||||||
| Ensembl Protein ID | |||||||
| UniProt Accession | Q1L721; RN138_XENLA | ||||||
| Genbank Protein ID | AAY68290.1 | ||||||
| Protein Name | E3 ubiquitin-protein ligase RNF138; Nemo-like kinase-associated RING finger protein; RING finger protein 138; RING-type E3 ubiquitin transferase RNF138 | ||||||
| Genbank Nucleotide ID | DQ011285 | ||||||
| Gene Name | rnf138; narf | ||||||
| Ensembl Information |
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| Status | Reviewed | ||||||
| Details |
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| Organism | Xenopus laevis | ||||||
| Functional Description (View) |
E3 ubiquitin-protein ligase involved in DNA damage response by promoting DNA resection and homologous recombination. Recruited to sites of double-strand breaks following DNA damage and specifically promotes double-strand break repair via homologous recombination (By similarity). Together with nlk.2, involved in the ubiquitination and degradation of TCF/LEF. Also exhibits auto-ubiquitination activity in combination with ube2k. May act as a negative regulator in the Wnt/beta-catenin-mediated signaling pathway (PubMed:16714285). | ||||||
| Protein Sequence (Fasta) |
MAEAMSCSSE ITEEFLCPVC QEILQTPVRT QTCRHVFCRK CFMLAMKSGG AYCPLCRGPV 60
NKSERSAPVR ATDIDLEMRM LSGGCMYCGK MMKLHYMKLH YKSCRKYQEE YGLSPKNVTI 120 It may take some time, please wait.
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| Sequence Source | UniProt | ||||||
| Keyword | KW-0158--Chromosome |
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| Interpro | IPR008598--Di19_Zn_binding_dom |
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| PROSITE | |||||||
| Pfam | PF05605--zf-Di19 |
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| SMART | SM00184--RING |
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| Gene Ontology | GO:0035861--C:site of double-strand break |
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| KEGG | xla:735045 | ||||||
| Created Date | 25-Jun-2017 |
