| Tag | Content | ||||||
|---|---|---|---|---|---|---|---|
| UUCD2 ID | IUUC-Ots-000030 | ||||||
| Ensembl Protein ID | |||||||
| UniProt Accession | Q4V837; DTLA_XENLA | ||||||
| Genbank Protein ID | AAH97560.1 | ||||||
| Protein Name | Denticleless protein homolog A | ||||||
| Genbank Nucleotide ID | BC097560 | ||||||
| Gene Name | dtl-a; cdt2-a | ||||||
| Ensembl Information |
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| Status | Reviewed | ||||||
| Details |
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| Organism | Xenopus laevis | ||||||
| Functional Description (View) |
Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1, CDKN1A/p21(CIP1) and KMT5A. CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication. CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing. KMT5A degradation is also important for a proper regulation of mechanisms such as TGF-beta signaling, cell cycle progression, DNA repair and cell migration. Most substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis. | ||||||
| Protein Sequence (Fasta) |
MLFRSVMNKP RLGYGQKGAP FTYPLQSLLQ CYQCVKQDEH ISYGELGMPV PPFGCAFSTV 60
PDMSHVLAVA NEEGIVRLYD TECRDMQRLL MKEFMAHTNA VFDIAWVPGE HKLVTASGDQ 120 It may take some time, please wait.
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| Sequence Source | UniProt | ||||||
| Keyword | KW-0158--Chromosome |
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| Interpro | IPR020472--G-protein_beta_WD-40_rep |
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| PROSITE | PS00678--WD_REPEATS_1 |
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| Pfam | PF00400--WD40 |
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| PRINTS | PR00320--GPROTEINBRPT |
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| SMART | SM00320--WD40 |
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| Gene Ontology | GO:0005813--C:centrosome |
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| KEGG | xla:735103 | ||||||
| Created Date | 25-Jun-2017 |
