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Tag Content
UUCD2 ID IUUC-Ots-000030
Ensembl Protein ID
UniProt Accession Q4V837; DTLA_XENLA
Genbank Protein ID AAH97560.1
Protein Name Denticleless protein homolog A
Genbank Nucleotide ID BC097560
Gene Name dtl-a; cdt2-a
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/DCX/DWD WD_repeat 20606006
Organism Xenopus laevis
Functional Description
(View)

Functional Description



     Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1, CDKN1A/p21(CIP1) and KMT5A. CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication. CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing. KMT5A degradation is also important for a proper regulation of mechanisms such as TGF-beta signaling, cell cycle progression, DNA repair and cell migration. Most substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis.
Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1, CDKN1A/p21(CIP1) and KMT5A. CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication. CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing. KMT5A degradation is also important for a proper regulation of mechanisms such as TGF-beta signaling, cell cycle progression, DNA repair and cell migration. Most substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis.
Protein Sequence
(Fasta)
MLFRSVMNKP RLGYGQKGAP FTYPLQSLLQ CYQCVKQDEH ISYGELGMPV PPFGCAFSTV 60
PDMSHVLAVA NEEGIVRLYD TECRDMQRLL MKEFMAHTNA VFDIAWVPGE HKLVTASGDQ 120
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Protein Fasta Sequence



>IUUC-Ots-000030|E3,WD_repeat|Xenopus laevis
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Sequence Source UniProt
Keyword

KW-0158--Chromosome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0227--DNA damage
KW-0235--DNA replication
KW-0539--Nucleus
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005813--C:centrosome
GO:0005694--C:chromosome
GO:0031464--C:Cul4A-RING E3 ubiquitin ligase complex
GO:0031465--C:Cul4B-RING E3 ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0006974--P:cellular response to DNA damage stimulus
GO:0006260--P:DNA replication
GO:0031572--P:G2 DNA damage checkpoint
GO:0006513--P:protein monoubiquitination
GO:0000209--P:protein polyubiquitination
GO:0051726--P:regulation of cell cycle
GO:0009411--P:response to UV
GO:0019985--P:translesion synthesis
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG xla:735103
Created Date 25-Jun-2017

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